The lymphotoxin-alpha (LTalpha) subunit is essential for the assembly, but not for the receptor specificity, of the membrane-anchored LTalpha1beta2 heterotrimeric ligand

scientific article (publication date: August 1997)

The lymphotoxin-alpha (LTalpha) subunit is essential for the assembly, but not for the receptor specificity, of the membrane-anchored LTalpha1beta2 heterotrimeric ligand is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.272.31.19451
P698PubMed publication ID9235946

P2093author name stringC F Ware
L Williams-Abbott
A G Porter
C R Goh
T C Cheung
B N Walter
Carl F. Ware
Alan G. Porter
Barbara N. Walter
Cynthia R. Goh
Laura Williams-Abbott
Timothy C. Cheung
P2860cites workMolecular cloning and expression of a receptor for human tumor necrosis factorQ24303604
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Lymphotoxin beta, a novel member of the TNF family that forms a heteromeric complex with lymphotoxin on the cell surfaceQ24320309
Lymphotoxin-beta receptor signaling complex: role of tumor necrosis factor receptor-associated factor 3 recruitment in cell death and activation of nuclear factor kappaBQ24564927
Crystal structure of the soluble human 55 kd TNF receptor-human TNF beta complex: implications for TNF receptor activationQ27732032
TRAF5, an activator of NF-kappaB and putative signal transducer for the lymphotoxin-beta receptorQ28282051
Abnormal development of peripheral lymphoid organs in mice deficient in lymphotoxinQ28507630
Mice deficient for the 55 kd tumor necrosis factor receptor are resistant to endotoxic shock, yet succumb to L. monocytogenes infectionQ28509078
Mice lacking the tumour necrosis factor receptor 1 are resistant to TNF-mediated toxicity but highly susceptible to infection by Listeria monocytogenesQ28593744
Decreased sensitivity to tumour-necrosis factor but normal T-cell development in TNF receptor-2-deficient miceQ28593915
Immune and inflammatory responses in TNF alpha-deficient mice: a critical requirement for TNF alpha in the formation of primary B cell follicles, follicular dendritic cell networks and germinal centers, and in the maturation of the humoral immune reQ28594116
The transmembrane form of tumor necrosis factor is the prime activating ligand of the 80 kDa tumor necrosis factor receptorQ28610826
The TNF receptor superfamily of cellular and viral proteins: activation, costimulation, and deathQ29620519
Molecular cloning and expression of the human 55 kd tumor necrosis factor receptorQ33903826
A receptor for tumor necrosis factor defines an unusual family of cellular and viral proteinsQ33909940
Signaling through the lymphotoxin beta receptor induces the death of some adenocarcinoma tumor linesQ34381306
Peyer's patch organogenesis is intact yet formation of B lymphocyte follicles is defective in peripheral lymphoid organs of mice deficient for tumor necrosis factor and its 55-kDa receptorQ36184139
Disrupted splenic architecture, but normal lymph node development in mice expressing a soluble lymphotoxin-beta receptor-IgG1 fusion protein.Q36688075
Surface-specific iodination of membrane proteins of viruses and eucaryotic cells using 1,3,4,6-tetrachloro-3α,6α-diphenylglycolurilQ40196106
Tumor necrosis factor: a pleiotropic cytokine and therapeutic targetQ40759728
Regulation of tumour necrosis factor-alpha processing by a metalloproteinase inhibitorQ41447978
Protection against a lethal dose of endotoxin by an inhibitor of tumour necrosis factor processingQ41454044
Preparation and characterization of soluble recombinant heterotrimeric complexes of human lymphotoxins alpha and beta.Q42064466
Surface lymphotoxin alpha/beta complex is required for the development of peripheral lymphoid organsQ42196937
Production of lymphotoxin (LT alpha) and a soluble dimeric form of its receptor using the baculovirus expression system.Q46013000
Rapid colorimetric assay for cell viability: application to the quantitation of cytotoxic and growth inhibitory lymphokines.Q50922303
Affinity maturation without germinal centres in lymphotoxin-alpha-deficient mice.Q52047087
Aspartic acid 50 and tyrosine 108 are essential for receptor binding and cytotoxic activity of tumour necrosis factor beta (lymphotoxin)Q54691311
Processing of tumour necrosis factor-α precursor by metalloproteinasesQ59059630
P433issue31
P407language of work or nameEnglishQ1860
P1104number of pages6
P304page(s)19451-19456
19451-6
P577publication date1997-08-01
P1433published inJournal of Biological ChemistryQ867727
P1476titleThe lymphotoxin-alpha (LTalpha) subunit is essential for the assembly, but not for the receptor specificity, of the membrane-anchored LTalpha1beta2 heterotrimeric ligand
The Lymphotoxin-α (LTα) Subunit Is Essential for the Assembly, but Not for the Receptor Specificity, of the Membrane-anchored LTα1β2 Heterotrimeric Ligand
P478volume272

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cites work (P2860)
Q47895892Abnormal gene and protein expression of inflammatory cytokines in the postmortem brain of schizophrenia patients.
Q41728935Discrete signaling regions in the lymphotoxin-beta receptor for tumor necrosis factor receptor-associated factor binding, subcellular localization, and activation of cell death and NF-kappaB pathways
Q33561622GWAS of self-reported mosquito bite size, itch intensity and attractiveness to mosquitoes implicates immune-related predisposition loci
Q30712456Inhibition of herpes simplex virus gD and lymphotoxin-alpha binding to HveA by peptide antagonists.
Q24308657LIGHT, a new member of the TNF superfamily, and lymphotoxin alpha are ligands for herpesvirus entry mediator
Q37921382Lymphotoxin α revisited: general features and implications in rheumatoid arthritis
Q44130049Lymphotoxins and cytomegalovirus cooperatively induce interferon-beta, establishing host-virus détente.
Q40800554Methods of study of tumor necrosis factor-related ligands in apoptosis
Q36557767Restoring immune defenses via lymphotoxin signaling: lessons from cytomegalovirus
Q37036159Targeting lymphocyte activation through the lymphotoxin and LIGHT pathways
Q22254033The lymphotoxin-beta receptor is necessary and sufficient for LIGHT-mediated apoptosis of tumor cells
Q77362495Tumor necrosis factor locus: genetic organisation and biological implications

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