Targeted mutation of the MLN64 START domain causes only modest alterations in cellular sterol metabolism

scientific article (publication date: 30 April 2004)

Targeted mutation of the MLN64 START domain causes only modest alterations in cellular sterol metabolism is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M400717200
P3181OpenCitations bibliographic resource ID3319911
P698PubMed publication ID14963026

P2093author name stringJerome F Strauss
Zhibing Zhang
E Joan Blanchette-Mackie
Pei Liu
Glenn L Radice
Igor Kostetskii
Steven U Walkley
Federico Martinez
Nancy K Dwyer
Tatsuro Kishida
P2860cites workMice without phosphatidylcholine transfer protein have no defects in the secretion of phosphatidylcholine into bile or into lung airspacesQ22010580
Identification of HE1 as the second gene of Niemann-Pick C diseaseQ24290663
Crystal structure of the Mus musculus cholesterol-regulated START protein 4 (StarD4) containing a StAR-related lipid transfer domainQ24297570
Molecular machinery for non-vesicular trafficking of ceramideQ24302195
Niemann-Pick C1 disease gene: homology to mediators of cholesterol homeostasisQ24315133
MLN64 exhibits homology with the steroidogenic acute regulatory protein (STAR) and is over-expressed in human breast carcinomasQ24318825
The cholesterol-regulated StarD4 gene encodes a StAR-related lipid transfer protein with two closely related homologues, StarD5 and StarD6Q24531324
MLN64 contains a domain with homology to the steroidogenic acute regulatory protein (StAR) that stimulates steroidogenesisQ24654204
Structure and lipid transport mechanism of a StAR-related domainQ27622485
START: a lipid-binding domain in StAR, HD-ZIP and signalling proteinsQ28143812
Role of steroidogenic acute regulatory protein in adrenal and gonadal steroidogenesisQ28236461
Steroidogenic acute regulatory protein (StAR) is a sterol transfer proteinQ28284056
Targeted disruption of the mouse gene encoding steroidogenic acute regulatory protein provides insights into congenital lipoid adrenal hyperplasiaQ28512871
Interaction of hormone-sensitive lipase with steroidogenic acute regulatory protein: facilitation of cholesterol transfer in adrenalQ28580168
MENTHO, a MLN64 homologue devoid of the START domainQ31115272
Neurons in Niemann-Pick disease type C accumulate gangliosides as well as unesterified cholesterol and undergo dendritic and axonal alterationsQ32001512
The mechanism of action of steroidogenic acute regulatory protein (StAR). StAR acts on the outside of mitochondria to stimulate steroidogenesis.Q32060629
The Niemann-Pick C1 protein resides in a vesicular compartment linked to retrograde transport of multiple lysosomal cargoQ33856244
Steroidogenic acute regulatory protein (StAR) and the intramitochondrial translocation of cholesterolQ34101238
StAR-related Lipid Transfer (START) Proteins: Mediators of Intracellular Lipid MetabolismQ35118561
Dicistronic targeting constructs: reporters and modifiers of mammalian gene expression.Q35226497
The steroidogenic acute regulatory protein homolog MLN64, a late endosomal cholesterol-binding protein.Q38307236
Niemann-pick type C1 (NPC1) overexpression alters cellular cholesterol homeostasisQ42492641
Cholesterol overload promotes morphogenesis of a Niemann-Pick C (NPC)-like compartment independent of inhibition of NPC1 or HE1/NPC2 functionQ43746994
MLN64 mediates mobilization of lysosomal cholesterol to steroidogenic mitochondriaQ44031785
Cholesterol accumulates in cell bodies, but is decreased in distal axons, of Niemann-Pick C1-deficient neuronsQ44220275
Trafficking of cholesterol from cell bodies to distal axons in Niemann Pick C1-deficient neuronsQ44233699
Transport of plasma membrane-derived cholesterol and the function of Niemann-Pick C1 ProteinQ44320686
Spectrophotometric determination of phosphate esters in the presence and absence of orthophosphateQ44699176
Role of Niemann-Pick type C1 protein in intracellular trafficking of low density lipoprotein-derived cholesterolQ47887125
Murine Model of Niemann-Pick C Disease: Mutation in a Cholesterol Homeostasis GeneQ48047362
Fate of Endogenously Synthesized Cholesterol in Niemann-Pick Type C1 CellsQ57371939
P433issue18
P407language of work or nameEnglishQ1860
P921main subjectSTART domain containing 3Q21991492
P304page(s)19276-85
P577publication date2004-04-30
P1433published inJournal of Biological ChemistryQ867727
P1476titleTargeted mutation of the MLN64 START domain causes only modest alterations in cellular sterol metabolism
P478volume279

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cites work (P2860)
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Q42246205MLN64 induces mitochondrial dysfunction associated with increased mitochondrial cholesterol content
Q30476064MLN64 is involved in actin-mediated dynamics of late endocytic organelles
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Q34238547MLN64 transport to the late endosome is regulated by binding to 14-3-3 via a non-canonical binding site
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Q90026696Tissue-Specific Ablation of ACSL4 Results in Disturbed Steroidogenesis

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