The exocyst complex in polarized exocytosis

scientific article (publication date: 2004)

The exocyst complex in polarized exocytosis is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1016/S0074-7696(04)33006-8
P3181OpenCitations bibliographic resource ID4752122
P698PubMed publication ID15037366

P2093author name stringMathew Abraham
Wei Guo
Daniel TerBush
Shu-Chan Hsu
P2860cites workThe brain exocyst complex interacts with RalA in a GTP-dependent manner: identification of a novel mammalian Sec3 gene and a second Sec15 geneQ24291328
Structural basis of the interaction between RalA and Sec5, a subunit of the sec6/8 complexQ24306783
The syntaxin family of vesicular transport receptorsQ24310598
DelGEF, a homologue of the Ran guanine nucleotide exchange factor RanGEF, binds to the exocyst component Sec5 and modulates secretionQ24322704
Exocyst complex subunit sec8 binds to postsynaptic density protein-95 (PSD-95): a novel interaction regulated by cypin (cytosolic PSD-95 interactor)Q24530017
The mammalian septin MSF localizes with microtubules and is required for completion of cytokinesisQ24537250
Rho3 of Saccharomyces cerevisiae, which regulates the actin cytoskeleton and exocytosis, is a GTPase which interacts with Myo2 and Exo70Q24554501
The Sec6/8 complex in mammalian cells: characterization of mammalian Sec3, subunit interactions, and expression of subunits in polarized cellsQ24555772
The Rho GTPase Rho3 has a direct role in exocytosis that is distinct from its role in actin polarityQ24647386
Subunit structure of the mammalian exocyst complexQ24647770
Structure of the GTPase-binding domain of Sec5 and elucidation of its Ral binding siteQ27640656
Cdc42 interacts with the exocyst and regulates polarized secretion.Q27931224
Identification of 23 complementation groups required for post-translational events in the yeast secretory pathwayQ27931724
Compartmentalization of the cell cortex by septins is required for maintenance of cell polarity in yeast.Q27931967
Exo84p is an exocyst protein essential for secretionQ27932396
Sec3p is a spatial landmark for polarized secretion in budding yeastQ27932756
Order of events in the yeast secretory pathwayQ27932822
Sec9 is a SNAP-25-like component of a yeast SNARE complex that may be the effector of Sec4 function in exocytosisQ27933277
Vesicular transport: how many Ypt/Rab-GTPases make a eukaryotic cell?Q27934224
Spatial regulation of the exocyst complex by Rho1 GTPaseQ27934400
Sec8p and Sec15p are components of a plasma membrane-associated 19.5S particle that may function downstream of Sec4p to control exocytosisQ27935760
The septins: roles in cytokinesis and other processesQ27936270
Sec6, Sec8, and Sec15 are components of a multisubunit complex which localizes to small bud tips in Saccharomyces cerevisiaeQ27936607
Sec2p mediates nucleotide exchange on Sec4p and is involved in polarized delivery of post-Golgi vesiclesQ27939177
Filament formation of MSF-A, a mammalian septin, in human mammary epithelial cells depends on interactions with microtubulesQ28181820
The exocyst complex is required for targeting of Glut4 to the plasma membrane by insulinQ28190100
NMDA receptor trafficking through an interaction between PDZ proteins and the exocyst complexQ28203460
The septin protein Nedd5 associates with both the exocyst complex and microtubules and disruption of its GTPase activity promotes aberrant neurite sprouting in PC12 cellsQ28204831
PDZ domains: structural modules for protein complex assemblyQ28210680
The exocyst complex binds the small GTPase RalA to mediate filopodia formationQ28211412
Nedd5, a mammalian septin, is a novel cytoskeletal component interacting with actin-based structuresQ28242345
Sec6/8 complex is recruited to cell-cell contacts and specifies transport vesicle delivery to the basal-lateral membrane in epithelial cellsQ28273946
Subunit composition, protein interactions, and structures of the mammalian brain sec6/8 complex and septin filamentsQ28275861
The exocyst complex associates with microtubules to mediate vesicle targeting and neurite outgrowthQ28365291
Characterization of a cDNA encoding a subunit of the rat brain rsec6/8 complexQ28571644
The secretory protein Sec8 is required for paraxial mesoderm formation in the mouseQ28588476
Promoter traps in embryonic stem cells: a genetic screen to identify and mutate developmental genes in miceQ29616222
Self- and actin-templated assembly of Mammalian septinsQ29618509
Yeast syntaxins Sso1p and Sso2p belong to a family of related membrane proteins that function in vesicular transportQ29619583
The diversity of Rab proteins in vesicle transportQ29620216
A ras-like protein is required for a post-Golgi event in yeast secretionQ29620275
Targeting vesicles to specific sites on the plasma membrane: the role of the sec6/8 complexQ33594269
Septins: cytoskeletal polymers or signalling GTPases?Q33730378
Transport-vesicle targeting: tethers before SNAREsQ33772639
Functional cooperation between the microtubule and actin cytoskeletonsQ33840293
rSec6 and rSec8, mammalian homologs of yeast proteins essential for secretionQ33857254
Protein complexes in transport vesicle targetingQ33913418
Sec1/Munc18 proteins: mediators of membrane fusion moving to center stageQ34031651
Membrane tethering and fusion in the secretory and endocytic pathwaysQ34156712
Mutations in the exocyst component Sec5 disrupt neuronal membrane traffic, but neurotransmitter release persistsQ34176051
Immunological characterization of exocyst complex subunits in cell differentiationQ34227607
Insulin signaling pathways in time and space.Q34534983
Exocytosis: the many masters of the exocystQ34574356
Secretion and cell-surface growth are blocked in a temperature-sensitive mutant of Saccharomyces cerevisiaeQ34692247
Exocyst is involved in cystogenesis and tubulogenesis and acts by modulating synthesis and delivery of basolateral plasma membrane and secretory proteinsQ34783580
Cytoskeleton: what does GTP do for septins?Q35006060
Signaling complex organization by PDZ domain proteinsQ35059536
Conservation and specialization. The role of the exocyst in neuronal exocytosisQ35063154
A rat brain Sec1 homologue related to Rop and UNC18 interacts with syntaxinQ35087004
The molecular machinery for secretion is conserved from yeast to neuronsQ36184412
The Sec15 protein responds to the function of the GTP binding protein, Sec4, to control vesicular traffic in yeastQ36221387
Compromised cytoarchitecture and polarized trafficking in autosomal dominant polycystic kidney disease cellsQ36328246
Yeast Cdc42 functions at a late step in exocytosis, specifically during polarized growth of the emerging budQ36380043
Sec6/8 complexes on trans-Golgi network and plasma membrane regulate late stages of exocytosis in mammalian cellsQ36380060
Sec15 protein, an essential component of the exocytotic apparatus, is associated with the plasma membrane and with a soluble 19.5S particleQ36529409
cdc42 regulates the exit of apical and basolateral proteins from the trans-Golgi networkQ39645140
The Rho family of small GTPases is involved in epithelial cystogenesis and tubulogenesis.Q40658466
The exocyst affects protein synthesis by acting on the translocation machinery of the endoplasmic reticulumQ40660360
Three-dimensional analysis of post-Golgi carrier exocytosis in epithelial cellsQ40675232
Cdc42 controls secretory and endocytic transport to the basolateral plasma membrane of MDCK cellsQ40918582
Drosophila sec10 is required for hormone secretion but not general exocytosis or neurotransmissionQ44230260
ADPKD: a human disease altering Golgi function and basolateral exocytosis in renal epithelia.Q52542310
The C. elegans unc-18 gene encodes a protein expressed in motor neuronsQ70478386
Association of Ral GTP-binding protein with human platelet dense granulesQ71433548
The beta subunit of the Sec61p endoplasmic reticulum translocon interacts with the exocyst complex in Saccharomyces cerevisiaeQ73193182
Purification and characterization of yeast exocyst complexQ73517566
Ras family therapy: Rab, Rho and Ral talk to the exocystQ74327244
The exocyst is a Ral effector complexQ77342588
Membrane traffic: exocyst III--makes a familyQ77486378
P407language of work or nameEnglishQ1860
P921main subjectexocytosisQ323426
P304page(s)243-65
P577publication date2004-01-01
P1433published inInternational Review of CytologyQ2687019
P1476titleThe exocyst complex in polarized exocytosis
P478volume233

Reverse relations

cites work (P2860)
Q28000096A Rab8 guanine nucleotide exchange factor-effector interaction network regulates primary ciliogenesis
Q37511751A functional interplay between the small GTPase Rab11a and mitochondria-shaping proteins regulates mitochondrial positioning and polarization of the actin cytoskeleton downstream of Src family kinases
Q39634814A novel role for TNFAIP2: its correlation with invasion and metastasis in nasopharyngeal carcinoma.
Q27934432A phosphatidylinositol-transfer protein and phosphatidylinositol-4-phosphate 5-kinase control Cdc42 to regulate the actin cytoskeleton and secretory pathway in yeast
Q50460637A pollen coat-inducible autoinhibited Ca2+-ATPase expressed in stigmatic papilla cells is required for compatible pollination in the Brassicaceae.
Q24536241AS160, the Akt substrate regulating GLUT4 translocation, has a functional Rab GTPase-activating protein domain
Q35845730Activity-dependent synaptic GRIP1 accumulation drives synaptic scaling up in response to action potential blockade
Q84286071An emerging role for IQGAP1 in regulating protein traffic
Q50459026An exocyst complex functions in plant cell growth in Arabidopsis and tobacco.
Q38620790Arabidopsis EXO70A1 recruits Patellin3 to the cell membrane independent of its role as exocyst subunit.
Q92422856Arabidopsis Trichome Contains Two Plasma Membrane Domains with Different Lipid Compositions Which Attract Distinct EXO70 Subunits
Q33835182AtEXO70A1, a member of a family of putative exocyst subunits specifically expanded in land plants, is important for polar growth and plant development.
Q48239208Calcium signalling mediates self-incompatibility response in the Brassicaceae.
Q37505642Cell and molecular biology of invadopodia
Q36580830Cell polarity in filamentous fungi: shaping the mold
Q52722874Cell polarity protein Spa2 coordinates Chs2 incorporation at the division site in budding yeast.
Q48067705Cellular pathways regulating responses to compatible and self-incompatible pollen in Brassica and Arabidopsis stigmas intersect at Exo70A1, a putative component of the exocyst complex.
Q30501053Characterization of Mug33 reveals complementary roles for actin cable-dependent transport and exocyst regulators in fission yeast exocytosis
Q57936684Characterization of the Arabidopsis thaliana exocyst complex gene families by phylogenetic, expression profiling, and subcellular localization studies
Q38485826Chromium stress response effect on signal transduction and expression of signaling genes in rice
Q40046042Collaboration between Distinct Rab Small GTPase Trafficking Circuits Mediates Bacterial Clearance from the Bladder Epithelium
Q34559663Compartmentalization of the exocyst complex in lipid rafts controls Glut4 vesicle tethering
Q30447603Compartmentalizing the neuronal plasma membrane from axon initial segments to synapses
Q34891306Cortactin: a multifunctional regulator of cellular invasiveness
Q28000129Crosstalk of Arf and Rab GTPases en route to cilia
Q33914537Cyclical regulation of the exocyst and cell polarity determinants for polarized cell growth
Q46457149Decreased proteinase A excretion by strengthening its vacuolar sorting and weakening its constitutive secretion in Saccharomyces cerevisiae.
Q28512125Dlg1, Sec8, and Mtmr2 regulate membrane homeostasis in Schwann cell myelination
Q35973878ERK1/2 regulate exocytosis through direct phosphorylation of the exocyst component Exo70
Q39638312EXO70 protein influences dengue virus secretion
Q51892236EXPO, an exocyst-positive organelle distinct from multivesicular endosomes and autophagosomes, mediates cytosol to cell wall exocytosis in Arabidopsis and tobacco cells.
Q40045728Early Arabidopsis root hair growth stimulation by pathogenic strains of Pseudomonas syringae
Q37537921Endocytosis and spatial restriction of cell signaling
Q36321307Essential function of Drosophila Sec6 in apical exocytosis of epithelial photoreceptor cells
Q37146947Exo70 generates membrane curvature for morphogenesis and cell migration
Q27933752Exo70 interacts with phospholipids and mediates the targeting of the exocyst to the plasma membrane
Q42833931Exo70 interacts with the Arp2/3 complex and regulates cell migration
Q36962536Exo70 is transcriptionally up-regulated by hepatic nuclear factor 4α and contributes to cell cycle control in hepatoma cells
Q37537855Exo70 isoform switching upon epithelial-mesenchymal transition mediates cancer cell invasion
Q27940157Exo70p mediates the secretion of specific exocytic vesicles at early stages of the cell cycle for polarized cell growth
Q24598553Exocyst complex component 3-like 2 (EXOC3L2) associates with the exocyst complex and mediates directional migration of endothelial cells
Q45904711Exocyst complex component Sec8: a presumed component in the progression of human oral squamous-cell carcinoma by secretion of matrix metalloproteinases.
Q99418402Exocyst components promote an incompatible interaction between Glycine max (soybean) and Heterodera glycines (the soybean cyst nematode)
Q41862913Exocyst function is regulated by effector phosphorylation.
Q37256934Exocyst is involved in polarized cell migration and cerebral cortical development
Q27308745Exocyst subunits Exo70 and Exo84 cooperate with small GTPases to regulate behavior and endocytic trafficking in C. elegans
Q37508152Exocytosis and cell polarity in plants - exocyst and recycling domains.
Q35518837Functional test of Brassica self-incompatibility modifiers in Arabidopsis thaliana
Q24336708GOLPH3 bridges phosphatidylinositol-4- phosphate and actomyosin to stretch and shape the Golgi to promote budding
Q35119229Germ cell intercellular bridges
Q27938690Homologues of oxysterol-binding proteins affect Cdc42p- and Rho1p-mediated cell polarization in Saccharomyces cerevisiae
Q37060680How peptide hormone vesicles are transported to the secretion site for exocytosis
Q38702072How to bake a brain: yeast as a model neuron.
Q40179194Identification of Interacting Motifs Between Armadillo Repeat Containing 1 (ARC1) and Exocyst 70 A1 (Exo70A1) Proteins in Brassica oleracea
Q25256672Increased synaptic microtubules and altered synapse development in Drosophila sec8 mutants
Q24294708Interaction of BIG2, a brefeldin A-inhibited guanine nucleotide-exchange protein, with exocyst protein Exo70
Q35989025Intracellular trafficking in Drosophila visual system development: a basis for pattern formation through simple mechanisms.
Q39332459Invadosomes are coming: new insights into function and disease relevance
Q38387100Lethal (2) giant larvae: an indispensable regulator of cell polarity and cancer development
Q36320849Lethal giant larvae proteins interact with the exocyst complex and are involved in polarized exocytosis
Q39771216M-Sec promotes membrane nanotube formation by interacting with Ral and the exocyst complex
Q53232953M-sec regulates polarized secretion of inflammatory endothelial chemokines and facilitates CCL2-mediated lymphocyte transendothelial migration.
Q34778354Mechanisms and function of dendritic exocytosis
Q47412206Mediterranean views on epithelial polarity
Q39429237Membrane Trafficking in Plant Immunity
Q27930739Membrane association and functional regulation of Sec3 by phospholipids and Cdc42
Q37412692Membrane organization and dynamics in cell polarity
Q36994689Membrane trafficking in osteoblasts and osteoclasts: new avenues for understanding and treating skeletal diseases
Q36992966Mitotic phosphorylation of Exo84 disrupts exocyst assembly and arrests cell growth
Q92922438Modulation of Cell-Cell Interactions in Drosophila Oocyte Development
Q35649197Modulation of neurotransmitter release by the second messenger-activated protein kinases: implications for presynaptic plasticity
Q26860718Molecular complexes that direct rhodopsin transport to primary cilia
Q38245882Molecular mechanisms of de novo lumen formation
Q52653945Mosaic deletion of EXOC6B: further evidence for an important role of the exocyst complex in the pathogenesis of intellectual disability.
Q36957578Oncogenic BRAF-Mediated Melanoma Cell Invasion
Q35809213Organelles and trafficking machinery for postsynaptic plasticity
Q33432360POINeT: protein interactome with sub-network analysis and hub prioritization
Q30494269Phosphatidylinositol 4,5-bisphosphate directs spermatid cell polarity and exocyst localization in Drosophila.
Q36095751Phosphatidylinositol 4,5-bisphosphate mediates the targeting of the exocyst to the plasma membrane for exocytosis in mammalian cells
Q42481907Phytophthora infestans RXLR Effector AVR1 Interacts with Exocyst Component Sec5 to Manipulate Plant Immunity.
Q27935373Purification of active HOPS complex reveals its affinities for phosphoinositides and the SNARE Vam7p
Q41959519Quantitative proteomics of yeast post-Golgi vesicles reveals a discriminating role for Sro7p in protein secretion
Q35191801Rab11 function in Trypanosoma brucei: identification of conserved and novel interaction partners
Q33918372Rab11 is required for epithelial cell viability, terminal differentiation, and suppression of tumor-like growth in the Drosophila egg chamber.
Q30480761Rab11 is required for membrane trafficking and actomyosin ring constriction in meiotic cytokinesis of Drosophila males
Q37064855Ral GTPases and cancer: linchpin support of the tumorigenic platform
Q33557696RalA promotes a direct exocyst-Par6 interaction to regulate polarity in neuronal development
Q39791607RalA suppresses early stages of Ras-induced squamous cell carcinoma progression
Q22001510RalA-exocyst complex regulates integrin-dependent membrane raft exocytosis and growth signaling
Q40124894Receptor-mediated regulation of tomosyn-syntaxin 1A interactions in bovine adrenal chromaffin cells
Q37930060Revisiting the regulated secretory pathway: from frogs to human
Q30431874RhoGDI3 and RhoG: Vesicular trafficking and interactions with the Sec3 Exocyst subunit
Q33897855Role of Rab11 in planar cell polarity and apical constriction during vertebrate neural tube closure
Q28769316Role of septins and the exocyst complex in the function of hydrolytic enzymes responsible for fission yeast cell separation
Q33815352Role of the Small GTPase Rho3 in Golgi/Endosome trafficking through functional interaction with adaptin in Fission Yeast
Q34763238Role of the conserved oligomeric Golgi (COG) complex in protein glycosylation
Q80925199SEC8, a subunit of the putative Arabidopsis exocyst complex, facilitates pollen germination and competitive pollen tube growth
Q34338417Sec15 is an effector for the Rab11 GTPase in mammalian cells
Q34021555Sec5, a member of the exocyst complex, mediates Drosophila embryo cellularization.
Q33410396Sec61beta, a subunit of the Sec61 protein translocation channel at the endoplasmic reticulum, is involved in the transport of Gurken to the plasma membrane
Q22337345Self/non-self recognition mechanisms in sexual reproduction: New insight into the self-incompatibility system shared by flowering plants and hermaphroditic animals
Q64897967Spatial and Translational Regulation of Exocyst Subunits by Cell Cycle in Budding Yeast.
Q34450386Spatial restriction of receptor tyrosine kinase activity through a polarized endocytic cycle controls border cell migration
Q91642416Sphingolipids are required for exocyst polarity and exocytic secretion in Saccharomyces cerevisiae
Q27659629Structure-function study of the N-terminal domain of exocyst subunit Sec3
Q27967650Syntaxin 3 and SNAP-25 pairing, regulated by omega-3 docosahexaenoic acid, controls the delivery of rhodopsin for the biogenesis of cilia-derived sensory organelles, the rod outer segments
Q44474951The Arabidopsis exocyst subunit SEC3A is essential for embryo development and accumulates in transient puncta at the plasma membrane.
Q35102641The Caenorhabditis elegans GARP complex contains the conserved Vps51 subunit and is required to maintain lysosomal morphology
Q27939800The Exo70 subunit of the exocyst is an effector for both Cdc42 and Rho3 function in polarized exocytosis
Q33515025The GTPase RalA regulates different steps of the secretory process in pancreatic beta-cells
Q39446377The N-Terminal UND Motif of the Arabidopsis U-Box E3 Ligase PUB18 Is Critical for the Negative Regulation of ABA-Mediated Stomatal Movement and Determines Its Ubiquitination Specificity for Exocyst Subunit Exo70B1.
Q37696883The Neurospora crassa exocyst complex tethers Spitzenkörper vesicles to the apical plasma membrane during polarized growth.
Q52911172The ROP2-RIC7 pathway negatively regulates light-induced stomatal opening by inhibiting exocyst subunit Exo70B1 in Arabidopsis.
Q34960668The Rho-GEF Gef3 interacts with the septin complex and activates the GTPase Rho4 during fission yeast cytokinesis.
Q39013611The Role of the Cytoskeleton and Myosin-Vc in the Targeting of KCa3.1 to the Basolateral Membrane of Polarized Epithelial Cells
Q27323982The bud tip is the cellular hot spot of protein secretion in yeasts
Q27930273The critical role of Exo84p in the organization and polarized localization of the exocyst complex
Q26772111The exocyst in Candida albicans polarized secretion and filamentation
Q34803211The exocyst is required for trypanosome invasion and the repair of mechanical plasma membrane wounds.
Q36718374The interaction of IQGAP1 with the exocyst complex is required for tumor cell invasion downstream of Cdc42 and RhoA.
Q37222227The known unknowns of antigen processing and presentation.
Q28585208The neural cell adhesion molecule promotes FGFR-dependent phosphorylation and membrane targeting of the exocyst complex to induce exocytosis in growth cones
Q34697563The role for the exocyst complex subunits Exo70B2 and Exo70H1 in the plant-pathogen interaction
Q38702463The role of Exo70 in vascular smooth muscle cell migration
Q37422550The role of the exocyst in matrix metalloproteinase secretion and actin dynamics during tumor cell invadopodia formation
Q36992940The yeast LATS/Ndr kinase Cbk1 regulates growth via Golgi-dependent glycosylation and secretion
Q24669945The yeast actin cytoskeleton: from cellular function to biochemical mechanism
Q33346255Tip growth: signaling in the apical dome
Q36628114Unilateral nephrectomy elongates primary cilia in the remaining kidney via reactive oxygen species.
Q37460702par-1, atypical pkc, and PP2A/B55 sur-6 are implicated in the regulation of exocyst-mediated membrane trafficking in Caenorhabditis elegans

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