The urokinase receptor (uPAR) and the uPAR-associated protein (uPARAP/Endo180): membrane proteins engaged in matrix turnover during tissue remodeling

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The urokinase receptor (uPAR) and the uPAR-associated protein (uPARAP/Endo180): membrane proteins engaged in matrix turnover during tissue remodeling is …
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scholarly articleQ13442814
review articleQ7318358

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P356DOI10.1515/BC.2004.031
P698PubMed publication ID15101555
P5875ResearchGate publication ID8602462

P50authorNiels BehrendtQ57167310
P2093author name stringNiels Behrendt
P2860cites workThe urokinase-type plasminogen activator receptor mediates tyrosine phosphorylation of focal adhesion proteins and activation of mitogen-activated protein kinase in cultured endothelial cellsQ47859760
Characterization of a novel member of the macrophage mannose receptor type C lectin familyQ48060936
Differential binding of urokinase and peptide antagonists to the urokinase receptor: evidence from characterization of the receptor in four primate speciesQ48365509
Urokinase receptor is necessary for adequate host defense against pneumococcal pneumonia.Q51723107
LDL receptor-related protein internalizes and degrades uPA-PAI-1 complexes and is essential for embryo implantationQ52478181
Structural analysis of the interaction between urokinase-type plasminogen activator and its receptor: a potential target for anti-invasive cancer therapyQ55952245
Physiological consequences of loss of plasminogen activator gene function in miceQ59069678
A urokinase receptor-associated protein with specific collagen binding propertiesQ22011054
Genes expressed in human tumor endotheliumQ24290105
An alternatively spliced variant of mRNA for the human receptor for urokinase plasminogen activatorQ24316221
A novel, specific pro-urokinase complex on monocyte-like cells, detected by transglutaminase-catalyzed cross-linkingQ24318514
Identification and characterization of the endocytic transmembrane glycoprotein Endo180 as a novel collagen receptorQ24322753
Recycling of the urokinase receptor upon internalization of the uPA:serpin complexesQ24532196
Direct binding of occupied urokinase receptor (uPAR) to LDL receptor-related protein is required for endocytosis of uPAR and regulation of cell surface urokinase activityQ24633333
The receptor for urokinase type plasminogen activator polarizes expression of the protease to the leading edge of migrating monocytes and promotes degradation of enzyme inhibitor complexesQ24678932
Mannose 6-phosphate/insulin-like growth factor-II receptor targets the urokinase receptor to lysosomes via a novel binding interactionQ24683196
A cysteine-rich domain of the "mannose" receptor mediates GalNAc-4-SO4 bindingQ24685889
Crystal structure of the cysteine-rich domain of mannose receptor complexed with a sulfated carbohydrate ligandQ27622086
Structure of a C-type carbohydrate recognition domain from the macrophage mannose receptorQ27622317
Gelatin-binding region of human matrix metalloproteinase-2: solution structure, dynamics, and function of the COL-23 two-domain constructQ27631337
Structure of a C-type mannose-binding protein complexed with an oligosaccharideQ27642164
Structure of the Calcium-Dependent Lectin Domain from a Rat Mannose-Binding Protein Determined by MAD PhasingQ27643496
Three-dimensional solution structure of the extracellular region of the complement regulatory protein CD59, a new cell-surface protein domain related to snake venom neurotoxinsQ27729364
Structure of a soluble, glycosylated form of the human complement regulatory protein CD59Q27729400
Lipid rafts and signal transductionQ28131735
Urokinase induces activation and formation of Stat4 and Stat1-Stat2 complexes in human vascular smooth muscle cellsQ28142061
Activation of hepatocyte growth factor and urokinase/plasminogen activator by matriptase, an epithelial membrane serine proteaseQ28144714
Human and mouse proteases: a comparative genomic approachQ28184208
The mannose receptor familyQ28201143
The urokinase plasminogen activator receptor in the regulation of the actin cytoskeleton and cell motilityQ28212178
Serpins and other covalent protease inhibitorsQ28212469
Urokinase receptor is associated with the components of the JAK1/STAT1 signaling pathway and leads to activation of this pathway upon receptor clustering in the human kidney epithelial tumor cell line TCL-598Q28253229
Role of vitronectin and its receptors in haemostasis and vascular remodelingQ28272554
Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitroQ28282164
Effective activation of the proenzyme form of the urokinase-type plasminogen activator (pro-uPA) by the cysteine protease cathepsin LQ28290438
The receptor for urokinase plasminogen activator is present in plasma from healthy donors and elevated in patients with paroxysmal nocturnal haemoglobinuriaQ40993621
A targeted deletion in the endocytic receptor gene Endo180 results in a defect in collagen uptakeQ41007686
Three-dimensional interplay among the ligand-binding domains of the urokinase-plasminogen-activator-receptor-associated protein, Endo180.Q41008420
Expression of the receptor for urokinase-type plasminogen activator in normal and neoplastic blood cells and hematopoietic tissueQ41011037
Phagocytosis and intracellular digestion of collagen, its role in turnover and remodelling.Q41077587
A soluble form of the glycolipid-anchored receptor for urokinase-type plasminogen activator is secreted from peripheral blood leukocytes from patients with paroxysmal nocturnal hemoglobinuriaQ41085646
Domain interplay in the urokinase receptor. Requirement for the third domain in high affinity ligand binding and demonstration of ligand contact sites in distinct receptor domains.Q41168123
Regulation of integrin function by the urokinase receptorQ41168373
Very Low Density Lipoprotein Receptor Binds and Mediates Endocytosis of Urokinase-type Plasminogen Activator-Type-1 Plasminogen Activator Inhibitor ComplexQ41301968
The receptor for urokinase-type plasminogen activator is expressed by keratinocytes at the leading edge during re-epithelialization of mouse skin woundsQ41475599
The urokinase-type plasminogen activator system in cancer metastasis: A reviewQ41522331
Ultrastructural localization of plasma membrane-associated urokinase-type plasminogen activator at focal contactsQ41543313
Structural requirements for glycosyl-phosphatidylinositol-anchor attachment in the cellular receptor for urokinase plasminogen activatorQ41606805
ECM and cell surface proteolysis: regulating cellular ecologyQ41656253
Cell-induced potentiation of the plasminogen activation system is abolished by a monoclonal antibody that recognizes the NH2-terminal domain of the urokinase receptorQ41669188
Disruption of the plasminogen gene in mice abolishes wound healing after myocardial infarctionQ41787217
Rac mediates cytoskeletal rearrangements and increased cell motility induced by urokinase-type plasminogen activator receptor binding to vitronectinQ41812511
Two alternatively spliced mouse urokinase receptor mRNAs with different histological localization in the gastrointestinal tractQ41877722
Urokinase plasminogen activator receptor, beta 2-integrins, and Src-kinases within a single receptor complex of human monocytesQ42163142
Phosphorylation of human pro-urokinase on Ser138/303 impairs its receptor-dependent ability to promote myelomonocytic adherence and motilityQ42209596
Tumor dormancy induced by downregulation of urokinase receptor in human carcinoma involves integrin and MAPK signalingQ42478267
Cancer cell expression of urokinase-type plasminogen activator receptor mRNA in squamous cell carcinomas of the skinQ42500699
Functional overlap between two classes of matrix-degrading proteases in wound healingQ42679931
The C-type lectin receptor Endo180 displays internalization and recycling properties distinct from other members of the mannose receptor familyQ42813761
Urokinase-catalysed cleavage of the urokinase receptor requires an intact glycolipid anchor.Q43000092
The pro-urokinase plasminogen-activation system in the presence of serpin-type inhibitors and the urokinase receptor: rescue of activity through reciprocal pro-enzyme activation.Q43002806
An extended conformation of the macrophage mannose receptorQ43560257
Cutting edge: evidence for a signaling partnership between urokinase receptors (CD87) and L-selectin (CD62L) in human polymorphonuclear neutrophilsQ43567106
The urokinase plasminogen activator receptor-associated protein/endo180 is coexpressed with its interaction partners urokinase plasminogen activator receptor and matrix metalloprotease-13 during osteogenesisQ43764719
Activation of pro-urokinase by the human T cell-associated serine proteinase HuTSP-1.Q43933765
Inhibition of receptor-dependent urokinase signaling by specific Ser to Glu substitutions.Q43944113
uPARAP/endo180 directs lysosomal delivery and degradation of collagen IV.Q44732185
Targeting of tumor cells by cell surface urokinase plasminogen activator-dependent anthrax toxinQ44779601
Reduced metastasis of Polyoma virus middle T antigen-induced mammary cancer in plasminogen-deficient miceQ45754755
Urokinase but not tissue plasminogen activator mediates arterial neointima formation in miceQ45884112
Optimal subsite occupancy and design of a selective inhibitor of urokinase.Q45940894
Urokinase receptor is up-regulated in endothelial cells and macrophages associated with fibrinoid deposits in the human placentaQ47800906
Kinetics of reciprocal pro-urokinase/plasminogen activation--stimulation by a template formed by the urokinase receptor bound to poly(D-lysine).Q47853148
Human bladder cancer invasion model using rat bladder in vitro and its use to test mechanisms and therapeutic inhibitors of invasionQ28350937
A plasma kallikrein-dependent plasminogen cascade required for adipocyte differentiationQ28357136
A functional overlap of plasminogen and MMPs regulates vascularization during placental developmentQ28507163
Matrix metalloproteinases: effectors of development and normal physiologyQ28679038
Inhibition of cell surface mediated plasminogen activation by a monoclonal antibody against alpha-EnolaseQ28910334
How matrix metalloproteinases regulate cell behaviorQ29620360
The very low density lipoprotein receptor regulates urokinase receptor catabolism and breast cancer cell motility in vitroQ30303631
Epidermal growth factor receptor-dependent and -independent cell-signaling pathways originating from the urokinase receptorQ30310205
Binding of urokinase-type plasminogen activator to its receptor in MCF-7 cells activates extracellular signal-regulated kinase 1 and 2 which is required for increased cellular motilityQ30471919
Association of a protease (plasminogen activator) with a specific membrane fraction isolated from transformed cellsQ30494593
Imaging proteolysis by living human glioma cellsQ30703032
Identification of specific sites involved in ligand binding by photoaffinity labeling of the receptor for the urokinase-type plasminogen activator. Residues located at equivalent positions in uPAR domains I and III participate in the assembly [...]Q31960282
Glycosylation profile of a recombinant urokinase-type plasminogen activator receptor expressed in Chinese hamster ovary cellsQ32063287
MMP-9 supplied by bone marrow-derived cells contributes to skin carcinogenesisQ33744153
Proteolysis and cell migration: creating a path?Q33744936
A urokinase-sensitive region of the human urokinase receptor is responsible for its chemotactic activity.Q33887878
Urokinase receptors promote beta1 integrin function through interactions with integrin alpha3beta1.Q33948206
Ligneous conjunctivitisQ33967011
The plasminogen activation system in tumor growth, invasion, and metastasisQ34008816
The fibrinolytic receptor for urokinase activates the G protein-coupled chemotactic receptor FPRL1/LXA4R.Q34009345
The urokinase receptor is required for human monocyte chemotaxis in vitroQ34137611
uPAR: a versatile signalling orchestratorQ34162183
The urokinase receptor associated protein (uPARAP/endo180): a novel internalization receptor connected to the plasminogen activation systemQ34286244
Potent antitumor activity of a urokinase-activated engineered anthrax toxinQ34470439
Urokinase-type plasminogen activator and its receptor synergize to promote pathogenic proteolysisQ34489359
Matrix metalloproteinases in tumor invasion: role for cell migrationQ34657461
Role of plasminogen activator-plasmin system in tumor angiogenesisQ35123778
Pericellular cathepsin B and malignant progressionQ35144589
Urokinase-type plasminogen activator (uPA) and its receptor (uPAR): development of antagonists of uPA/uPAR interaction and their effects in vitro and in vivoQ35181139
Molecular and functional interdependence of the urokinase-type plasminogen activator system with integrinsQ35219000
High-affinity urokinase receptor antagonists identified with bacteriophage peptide displayQ35617966
A cellular binding site for the Mr 55,000 form of the human plasminogen activator, urokinaseQ36211634
The plasminogen system and cell surfaces: evidence for plasminogen and urokinase receptors on the same cell typeQ36216545
Activation of pro-urokinase and plasminogen on human sarcoma cells: a proteolytic system with surface-bound reactantsQ36220582
Induction of cell migration by pro-urokinase binding to its receptor: possible mechanism for signal transduction in human epithelial cellsQ36234366
Is plasminogen activator inhibitor-1 the molecular switch that governs urokinase receptor-mediated cell adhesion and release?Q36237406
Receptor-independent role of urokinase-type plasminogen activator in pericellular plasmin and matrix metalloproteinase proteolysis during vascular wound healing in miceQ36254926
uPARAP/Endo180 is essential for cellular uptake of collagen and promotes fibroblast collagen adhesionQ36323184
GPI-anchored uPAR requires Endo180 for rapid directional sensing during chemotaxis.Q36323266
Prevention of metastasis by inhibition of the urokinase receptorQ36332391
The urokinase-type plasminogen activator receptor, a GPI-linked protein, is localized in caveolaeQ36382514
Urokinase receptor (CD87) regulates leukocyte recruitment via beta 2 integrins in vivo.Q36401755
Chemical modification of the urokinase-type plasminogen activator and its receptor using tetranitromethane. Evidence for the involvement of specific tyrosine residues in both molecules during receptor-ligand interactionQ36679850
p180, a novel recycling transmembrane glycoprotein with restricted cell type expressionQ36710108
Isolation and characterization of multiple isoforms of the rat urokinase receptor in osteoblastsQ36762530
Differences in intracellular distribution of plasminogen activator in growing, confluent, and transformed 3T3 cellsQ37311345
Generation and characterization of urokinase receptor-deficient miceQ37351869
The urokinase receptor (CD87) facilitates CD11b/CD18-mediated adhesion of human monocytesQ37354367
Binding of high molecular weight kininogen to human endothelial cells is mediated via a site within domains 2 and 3 of the urokinase receptorQ37372571
Differentiation-enhanced binding of the amino-terminal fragment of human urokinase plasminogen activator to a specific receptor on U937 monocytesQ37524689
Urokinase-type plasminogen activator is effective in fibrin clearance in the absence of its receptor or tissue-type plasminogen activatorQ37561638
Plasminogen activator inhibitors: hormonally regulated serpinsQ37807999
Tissue factor is the receptor for plasminogen type 1 on 1-LN human prostate cancer cellsQ38288786
Multifunctional activity of the extracellular domain of the M-type (180 kDa) membrane receptor for secretory phospholipases A2.Q38290493
Peptide-derived antagonists of the urokinase receptor. affinity maturation by combinatorial chemistry, identification of functional epitopes, and inhibitory effect on cancer cell intravasationQ38296358
The gelatin-binding site of human 72 kDa type IV collagenase (gelatinase A).Q38310500
Mapping part of the functional epitope for ligand binding on the receptor for urokinase-type plasminogen activator by site-directed mutagenesisQ38317155
Sequences within domain II of the urokinase receptor critical for differential ligand recognitionQ38354388
Characterization of sugar binding by the mannose receptor family member, Endo180.Q38361627
Dimerization controls the lipid raft partitioning of uPAR/CD87 and regulates its biological functionsQ40240320
Distribution of Endo180 receptor and ligand in developing articular cartilage.Q40603509
Structure-function relationships in the receptor for urokinase-type plasminogen activator. Comparison to other members of the Ly-6 family and snake venom alpha-neurotoxinsQ40683497
Convergence of the adhesive and fibrinolytic systems: recognition of urokinase by integrin alpha Mbeta 2 as well as by the urokinase receptor regulates cell adhesion and migrationQ40695132
The cleavage of the urokinase receptor regulates its multiple functionsQ40701611
Urokinase receptor-deficient mice have impaired neutrophil recruitment in response to pulmonary Pseudomonas aeruginosa infectionQ40867377
Identification of a urokinase receptor-integrin interaction site. Promiscuous regulator of integrin functionQ40890085
Polysulfated heparinoids selectively inactivate heparin-binding angiogenesis factorsQ40901139
Cell-specific glycoforms of sialoadhesin and CD45 are counter-receptors for the cysteine-rich domain of the mannose receptorQ40915798
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectmembrane proteinQ423042
P304page(s)103-136
P577publication date2004-02-01
P1433published inBiological ChemistryQ4914948
P1476titleThe urokinase receptor (uPAR) and the uPAR-associated protein (uPARAP/Endo180): membrane proteins engaged in matrix turnover during tissue remodeling
P478volume385

Reverse relations

cites work (P2860)
Q39999171A composite role of vitronectin and urokinase in the modulation of cell morphology upon expression of the urokinase receptor
Q35213422A novel functional role of collagen glycosylation: interaction with the endocytic collagen receptor uparap/ENDO180
Q40302526A region in urokinase plasminogen receptor domain III controlling a functional association with alpha5beta1 integrin and tumor growth
Q33546389A role for fibrillar collagen deposition and the collagen internalization receptor endo180 in glioma invasion
Q21092454Balancing selection of a frame-shift mutation in the MRC2 gene accounts for the outbreak of the Crooked Tail Syndrome in Belgian Blue Cattle
Q40174568CEBPbeta, JunD and c-Jun contribute to the transcriptional activation of the metastasis-associated C4.4A gene.
Q41908264Challenges for drug discovery - a case study of urokinase receptor inhibition
Q36600996Cysteine cathepsins: multifunctional enzymes in cancer
Q38340838Downregulation of uPARAP mediates cytoskeletal rearrangements and decreases invasion and migration properties in glioma cells
Q44008835Effect of surface charge and ligand organization on the specific cell-uptake of uPAR-targeted nanoparticles
Q24306849Endosomes generate localized Rho-ROCK-MLC2-based contractile signals via Endo180 to promote adhesion disassembly
Q37399542Epidermal development and wound healing in matrix metalloproteinase 13-deficient mice
Q42505431Expression of Endo180 is spatially and temporally regulated during wound healing.
Q53541672Extracellular collagenases and the endocytic receptor, urokinase plasminogen activator receptor-associated protein/Endo180, cooperate in fibroblast-mediated collagen degradation.
Q35116202Extracellular proteases as targets for drug development
Q39181943Hepatitis B virus inhibits liver regeneration via epigenetic regulation of urokinase-type plasminogen activator
Q33248476Inhibition of plasminogen activator inhibitor-1 binding to endocytosis receptors of the low-density-lipoprotein receptor family by a peptide isolated from a phage display library
Q36063553Inhibitory Monoclonal Antibodies against Mouse Proteases Raised in Gene-Deficient Mice Block Proteolytic Functions in vivo
Q36321204Intracellular collagen degradation mediated by uPARAP/Endo180 is a major pathway of extracellular matrix turnover during malignancy
Q38370676Involvement of fibrocytes in asthma and clinical implications
Q37181208Live-cell imaging demonstrates extracellular matrix degradation in association with active cathepsin B in caveolae of endothelial cells during tube formation
Q34359058MRC2 expression correlates with TGFβ1 and survival in hepatocellular carcinoma
Q35715763Mannose receptor 2 attenuates renal fibrosis
Q57082617Matrix Proteases and the Degradome
Q39782763Membrane type-1 matrix metalloproteinase activity is regulated by the endocytic collagen receptor Endo180.
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Q27666756Peptide Length and Leaving-Group Sterics Influence Potency of Peptide Phosphonate Protease Inhibitors
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Q41886368uPARAP expression during murine lung development
Q28541398uPARAP function in cutaneous wound repair
Q59792569uPARAP/Endo180 receptor is a gatekeeper of VEGFR-2/VEGFR-3 heterodimerisation during pathological lymphangiogenesis

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