Urokinase-catalysed cleavage of the urokinase receptor requires an intact glycolipid anchor.

scientific article published in September 2001

Urokinase-catalysed cleavage of the urokinase receptor requires an intact glycolipid anchor. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1042/0264-6021:3580673
P932PMC publication ID1222101
P698PubMed publication ID11535128
P5875ResearchGate publication ID11811519

P50authorNiels BehrendtQ57167310
P2093author name stringU Pessara
A Holm
K Danø
G Høyer-Hansen
U Weidle
J Pass
P2860cites workCloning and expression of the receptor for human urokinase plasminogen activator, a central molecule in cell surface, plasmin dependent proteolysisQ24299135
Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4Q25938983
Cellular receptor for urokinase plasminogen activator. Carboxyl-terminal processing and membrane anchoring by glycosyl-phosphatidylinositolQ28646983
The human receptor for urokinase plasminogen activator. NH2-terminal amino acid sequence and glycosylation variantsQ28647015
Plasminogen activation initiated by single-chain urokinase-type plasminogen activator. Potentiation by U937 monocytesQ28647051
Urokinase-type plasminogen activator stimulates the Ras/Extracellular signal-regulated kinase (ERK) signaling pathway and MCF-7 cell migration by a mechanism that requires focal adhesion kinase, Src, and Shc. Rapid dissociation of GRB2/Sps-Shc complQ30305582
A urokinase-sensitive region of the human urokinase receptor is responsible for its chemotactic activity.Q33887878
A ligand-free, soluble urokinase receptor is present in the ascitic fluid from patients with ovarian cancer.Q33907027
Amplification and expression of sequences cotransfected with a modular dihydrofolate reductase complementary DNA geneQ34253873
Localization of the disulfide bonds in the NH2-terminal domain of the cellular receptor for human urokinase-type plasminogen activator. A domain structure belonging to a novel superfamily of glycolipid-anchored membrane proteinsQ34356743
Urokinase-type plasminogen activator and its receptor synergize to promote pathogenic proteolysisQ34489359
The ligand-binding domain of the cell surface receptor for urokinase-type plasminogen activatorQ34781848
An epitope on carcinoembryonic antigen defined by the clinically relevant antibody PR1A3Q35227038
Transformation of mouse fibroblasts to methotrexate resistance by a recombinant plasmid expressing a prokaryotic dihydrofolate reductaseQ35323487
Monoclonal antibody that specifically inhibits a human Mr 52,000 plasminogen-activating enzymeQ36299757
Chemical modification of the urokinase-type plasminogen activator and its receptor using tetranitromethane. Evidence for the involvement of specific tyrosine residues in both molecules during receptor-ligand interactionQ36679850
Differentiation-enhanced binding of the amino-terminal fragment of human urokinase plasminogen activator to a specific receptor on U937 monocytesQ37524689
The glycosyl-phosphatidylinositol anchor of membrane proteinsQ38260289
Structure-function relationships in the receptor for urokinase-type plasminogen activator. Comparison to other members of the Ly-6 family and snake venom alpha-neurotoxinsQ40683497
A monoclonal antibody against the 66-kDa protein expressed in mouse spleen and thymus inhibits Ly-6A.2-dependent cell-cell adhesionQ40848643
The receptor for urokinase plasminogen activator is present in plasma from healthy donors and elevated in patients with paroxysmal nocturnal haemoglobinuriaQ40993621
Proteolytic cleavage of the urokinase receptor substitutes for the agonist-induced chemotactic effectQ41064411
Domain interplay in the urokinase receptor. Requirement for the third domain in high affinity ligand binding and demonstration of ligand contact sites in distinct receptor domains.Q41168123
The urokinase-type plasminogen activator system in cancer metastasis: A reviewQ41522331
Urokinase plasminogen activator cleaves its cell surface receptor releasing the ligand-binding domainQ41603641
Identification and characterization of the murine cell surface receptor for the urokinase-type plasminogen activatorQ41629036
Cell-induced potentiation of the plasminogen activation system is abolished by a monoclonal antibody that recognizes the NH2-terminal domain of the urokinase receptorQ41669188
Soluble receptor for urokinase plasminogen activator in both full-length and a cleaved form is present in high concentration in cystic fluid from ovarian cancerQ47704430
Plasma Urokinase Receptor Levels in Patients With Colorectal Cancer: Relationship to PrognosisQ63753630
A protease-hypersensitive deletion derivative of human tissue-type plasminogen activatorQ67248357
A novel method for producing anti-peptide antibodies. Production of site-specific antibodies to the T cell antigen receptor beta-chainQ68125311
Enzyme-linked immunosorbent assay for human urokinase-type plasminogen activator and its proenzyme using a combination of monoclonal and polyclonal antibodiesQ70302473
The urokinase receptor is a major vitronectin-binding protein on endothelial cellsQ71034141
Identification of the urokinase receptor as an adhesion receptor for vitronectinQ71663798
Ligand interaction between urokinase-type plasminogen activator and its receptor probed with 8-anilino-1-naphthalenesulfonate. Evidence for a hydrophobic binding site exposed only on the intact receptorQ72089738
A cleaved form of the receptor for urokinase-type plasminogen activator in invasive transplanted human and murine tumorsQ72721286
Quantitation of the receptor for urokinase plasminogen activator by enzyme-linked immunosorbent assayQ72773587
Cell-surface acceleration of urokinase-catalyzed receptor cleavageQ73067924
The intact urokinase receptor is required for efficient vitronectin binding: receptor cleavage prevents ligand interactionQ74121187
Differential expression of a truncated form of the urokinase-type plasminogen-activator receptor in normal and tumor thyroid cellsQ74356125
Different mechanisms are involved in the antibody mediated inhibition of ligand binding to the urokinase receptor: a study based on biosensor technologyQ74449428
Cleavage of the glycosylphosphatidylinositol anchor affects the reactivity of thy-1 with antibodiesQ77404855
Cellular glycosylphosphatidylinositol-specific phospholipase D regulates urokinase receptor shedding and cell surface expressionQ77966087
Src-dependence and pertussis-toxin sensitivity of urokinase receptor-dependent chemotaxis and cytoskeleton reorganization in rat smooth muscle cellsQ77974838
P433issuePt 3
P407language of work or nameEnglishQ1860
P304page(s)673-679
P577publication date2001-09-01
P1433published inBiochemical JournalQ864221
P1476titleUrokinase-catalysed cleavage of the urokinase receptor requires an intact glycolipid anchor
P478volume358

Reverse relations

cites work (P2860)
Q40105822A cleavage-resistant urokinase plasminogen activator receptor exhibits dysregulated cell-surface clearance
Q33709060Cleavage of the urokinase receptor (uPAR) on oral cancer cells: regulation by transforming growth factor - β1 (TGF-β1) and potential effects on migration and invasion.
Q40428098Cross-talk between fMLP and vitronectin receptors triggered by urokinase receptor-derived SRSRY peptide
Q40240320Dimerization controls the lipid raft partitioning of uPAR/CD87 and regulates its biological functions
Q35097486Epithelial and stromal cell urokinase plasminogen activator receptor expression differentially correlates with survival in rectal cancer stages B and C patients
Q46154986High mortality risk among individuals assumed to be TB-negative can be predicted using a simple test
Q36158746Increased soluble urokinase plasminogen activator receptor (suPAR) is associated with thrombosis and inhibition of plasmin generation in paroxysmal nocturnal hemoglobinuria (PNH) patients
Q37345362Intact and cleaved forms of the urokinase receptor enhance discrimination of cancer from non-malignant conditions in patients presenting with symptoms related to colorectal cancer
Q34466969Ligand binding alters dimerization and sequestering of urokinase receptors in raft-mimicking lipid mixtures
Q36844303Models, mechanisms and clinical evidence for cancer dormancy
Q57609583Plasma Levels of Intact and Cleaved Urokinase Receptor Decrease in HIV-1-Infected Patients Initiating Highly Active Antiretroviral Therapy
Q35749341Plasminogen binding and activation at the breast cancer cell surface: the integral role of urokinase activity
Q36549551Significance of the urokinase-type plasminogen activator and its receptor in the progression of focal segmental glomerulosclerosis in clinical and mouse models
Q35949789The Pseudomonas aeruginosa LasB metalloproteinase regulates the human urokinase-type plasminogen activator receptor through domain-specific endoproteolysis
Q40701611The cleavage of the urokinase receptor regulates its multiple functions
Q28257803The urokinase receptor (uPAR) and the uPAR-associated protein (uPARAP/Endo180): membrane proteins engaged in matrix turnover during tissue remodeling
Q39030266The urokinase receptor takes control of cell migration by recruiting integrins and FPR1 on the cell surface
Q34089936Tumour microenvironments induce expression of urokinase plasminogen activator receptor (uPAR) and concomitant activation of gelatinolytic enzymes

Search more.