scholarly article | Q13442814 |
P2093 | author name string | Hong Zhu | |
Gregory R Hook | |||
Jin Yu | |||
Mark S Kindy | |||
Salim S El-Amouri | |||
Vivian Hook | |||
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BACE knockout mice are healthy despite lacking the primary beta-secretase activity in brain: implications for Alzheimer's disease therapeutics | Q28201876 | ||
The cysteine protease inhibitor, E64d, reduces brain amyloid-β and improves memory deficits in Alzheimer's disease animal models by inhibiting cathepsin B, but not BACE1, β-secretase activity | Q28238581 | ||
Cysteine protease inhibitors reduce brain beta-amyloid and beta-secretase activity in vivo and are potential Alzheimer's disease therapeutics | Q28240590 | ||
Genetic cathepsin B deficiency reduces beta-amyloid in transgenic mice expressing human wild-type amyloid precursor protein | Q28247574 | ||
Inhibitors of cathepsin B improve memory and reduce beta-amyloid in transgenic Alzheimer disease mice expressing the wild-type, but not the Swedish mutant, beta-secretase site of the amyloid precursor protein | Q28264162 | ||
Inhibition of cathepsin B reduces beta-amyloid production in regulated secretory vesicles of neuronal chromaffin cells: evidence for cathepsin B as a candidate beta-secretase of Alzheimer's disease | Q28272351 | ||
Cysteine protease inhibitors effectively reduce in vivo levels of brain beta-amyloid related to Alzheimer's disease | Q28285644 | ||
Cathepsins B and L differentially regulate amyloid precursor protein processing | Q28303285 | ||
Alzheimer's disease | Q29616743 | ||
BACE1, a major determinant of selective vulnerability of the brain to amyloid-beta amyloidogenesis, is essential for cognitive, emotional, and synaptic functions. | Q30483997 | ||
Mice deficient in BACE1, the Alzheimer's beta-secretase, have normal phenotype and abolished beta-amyloid generation | Q32063777 | ||
BACE1 is the major beta-secretase for generation of Abeta peptides by neurons | Q32063781 | ||
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Genetically altered transgenic models of Alzheimer's disease. | Q34015571 | ||
Partial reduction of BACE1 improves synaptic plasticity, recent and remote memories in Alzheimer's disease transgenic mice | Q34067152 | ||
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beta-site amyloid precursor protein cleaving enzyme 1 increases amyloid deposition in brain parenchyma but reduces cerebrovascular amyloid angiopathy in aging BACE x APP[V717I] double-transgenic mice | Q35103410 | ||
Does my mouse have Alzheimer's disease? | Q35186500 | ||
Involvement of beta-site APP cleaving enzyme 1 (BACE1) in amyloid precursor protein-mediated enhancement of memory and activity-dependent synaptic plasticity. | Q35768842 | ||
The Alzheimer's disease beta-secretase enzyme, BACE1. | Q36397690 | ||
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Pharmacogenetic features of cathepsin B inhibitors that improve memory deficit and reduce beta-amyloid related to Alzheimer's disease | Q37763948 | ||
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Mutant genes in familial Alzheimer's disease and transgenic models | Q41733323 | ||
BACE1 deficiency rescues memory deficits and cholinergic dysfunction in a mouse model of Alzheimer's disease | Q44722202 | ||
The Swedish APP mutation alters the effect of genetically reduced BACE1 expression on the APP processing. | Q45901500 | ||
Relation of neuronal APP-751/APP-695 mRNA ratio and neuritic plaque density in Alzheimer's disease | Q46121331 | ||
Partial reduction of BACE1 has dramatic effects on Alzheimer plaque and synaptic pathology in APP Transgenic Mice | Q46143430 | ||
Levels and alternative splicing of amyloid beta protein precursor (APP) transcripts in brains of APP transgenic mice and humans with Alzheimer's disease | Q48069116 | ||
BACE1 inhibition reduces endogenous Abeta and alters APP processing in wild-type mice | Q48379491 | ||
P433 | issue | 4 | |
P407 | language of work or name | English | Q1860 |
P921 | main subject | Alzheimer's disease | Q11081 |
P304 | page(s) | 827-840 | |
P577 | publication date | 2012-01-01 | |
P1433 | published in | Journal of Alzheimer's Disease | Q6294755 |
P1476 | title | Deletion of the cathepsin B gene improves memory deficits in a transgenic ALZHeimer's disease mouse model expressing AβPP containing the wild-type β-secretase site sequence | |
P478 | volume | 29 |
Q38731927 | Actin dynamics and cofilin-actin rods in alzheimer disease |
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Q28235248 | Brain pyroglutamate amyloid-β is produced by cathepsin B and is reduced by the cysteine protease inhibitor E64d, representing a potential Alzheimer's disease therapeutic |
Q40410864 | Cathepsin B Improves ß-Amyloidosis and Learning and Memory in Models of Alzheimer's Disease. |
Q26782938 | Cathepsin B is a New Drug Target for Traumatic Brain Injury Therapeutics: Evidence for E64d as a Promising Lead Drug Candidate |
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Q61814461 | Increased expression and altered subcellular distribution of cathepsin B in microglia induce cognitive impairment through oxidative stress and inflammatory response in mice |
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Q27024355 | Macrophage derived cystatin B/cathepsin B in HIV replication and neuropathogenesis |
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Q35171676 | Overexpression of the IGF-II/M6P receptor in mouse fibroblast cell lines differentially alters expression profiles of genes involved in Alzheimer's disease-related pathology |
Q34076284 | Pyroglutamate-amyloid-β and glutaminyl cyclase are colocalized with amyloid-β in secretory vesicles and undergo activity-dependent, regulated secretion |
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Q24601910 | The cysteine protease cathepsin B is a key drug target and cysteine protease inhibitors are potential therapeutics for traumatic brain injury |
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