Deletion of the cathepsin B gene improves memory deficits in a transgenic ALZHeimer's disease mouse model expressing AβPP containing the wild-type β-secretase site sequence

scientific article

Deletion of the cathepsin B gene improves memory deficits in a transgenic ALZHeimer's disease mouse model expressing AβPP containing the wild-type β-secretase site sequence is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.3233/JAD-2012-111604
P932PMC publication ID4309289
P698PubMed publication ID22337825

P2093author name stringHong Zhu
Gregory R Hook
Jin Yu
Mark S Kindy
Salim S El-Amouri
Vivian Hook
P2860cites workCell-specific expression of beta-amyloid precursor protein isoform mRNAs and proteins in neurons and astrocytesQ48672944
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Differential splicing of Alzheimer's disease amyloid A4 precursor RNA in rat tissues: PreA4(695) mRNA is predominantly produced in rat and human brainQ49100289
BACE1 gene deletion: impact on behavioral function in a model of Alzheimer's disease.Q51906403
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Early phenotypic changes in transgenic mice that overexpress different mutants of amyloid precursor protein in brainQ28137790
BACE knockout mice are healthy despite lacking the primary beta-secretase activity in brain: implications for Alzheimer's disease therapeuticsQ28201876
The cysteine protease inhibitor, E64d, reduces brain amyloid-β and improves memory deficits in Alzheimer's disease animal models by inhibiting cathepsin B, but not BACE1, β-secretase activityQ28238581
Cysteine protease inhibitors reduce brain beta-amyloid and beta-secretase activity in vivo and are potential Alzheimer's disease therapeuticsQ28240590
Genetic cathepsin B deficiency reduces beta-amyloid in transgenic mice expressing human wild-type amyloid precursor proteinQ28247574
Inhibitors of cathepsin B improve memory and reduce beta-amyloid in transgenic Alzheimer disease mice expressing the wild-type, but not the Swedish mutant, beta-secretase site of the amyloid precursor proteinQ28264162
Inhibition of cathepsin B reduces beta-amyloid production in regulated secretory vesicles of neuronal chromaffin cells: evidence for cathepsin B as a candidate beta-secretase of Alzheimer's diseaseQ28272351
Cysteine protease inhibitors effectively reduce in vivo levels of brain beta-amyloid related to Alzheimer's diseaseQ28285644
Cathepsins B and L differentially regulate amyloid precursor protein processingQ28303285
Alzheimer's diseaseQ29616743
BACE1, a major determinant of selective vulnerability of the brain to amyloid-beta amyloidogenesis, is essential for cognitive, emotional, and synaptic functions.Q30483997
Mice deficient in BACE1, the Alzheimer's beta-secretase, have normal phenotype and abolished beta-amyloid generationQ32063777
BACE1 is the major beta-secretase for generation of Abeta peptides by neuronsQ32063781
BACE1: the beta-secretase enzyme in Alzheimer's diseaseQ33202614
Genetically altered transgenic models of Alzheimer's disease.Q34015571
Partial reduction of BACE1 improves synaptic plasticity, recent and remote memories in Alzheimer's disease transgenic miceQ34067152
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Guinea pigs as a nontransgenic model for APP processing in vitro and in vivoQ35098538
beta-site amyloid precursor protein cleaving enzyme 1 increases amyloid deposition in brain parenchyma but reduces cerebrovascular amyloid angiopathy in aging BACE x APP[V717I] double-transgenic miceQ35103410
Does my mouse have Alzheimer's disease?Q35186500
Involvement of beta-site APP cleaving enzyme 1 (BACE1) in amyloid precursor protein-mediated enhancement of memory and activity-dependent synaptic plasticity.Q35768842
The Alzheimer's disease beta-secretase enzyme, BACE1.Q36397690
Neprilysin: an enzyme candidate to slow the progression of Alzheimer's diseaseQ36579852
Beta-site amyloid precursor protein-cleaving enzyme-1 (BACE1)-mediated changes of endogenous amyloid beta in wild-type and transgenic mice in vivoQ36649496
Molecular genetics of Alzheimer's disease: an updateQ37209771
Pharmacogenetic features of cathepsin B inhibitors that improve memory deficit and reduce beta-amyloid related to Alzheimer's diseaseQ37763948
Antiamyloidogenic and neuroprotective functions of cathepsin B: implications for Alzheimer's diseaseQ40230652
Mutant genes in familial Alzheimer's disease and transgenic modelsQ41733323
BACE1 deficiency rescues memory deficits and cholinergic dysfunction in a mouse model of Alzheimer's diseaseQ44722202
The Swedish APP mutation alters the effect of genetically reduced BACE1 expression on the APP processing.Q45901500
Relation of neuronal APP-751/APP-695 mRNA ratio and neuritic plaque density in Alzheimer's diseaseQ46121331
Partial reduction of BACE1 has dramatic effects on Alzheimer plaque and synaptic pathology in APP Transgenic MiceQ46143430
Levels and alternative splicing of amyloid beta protein precursor (APP) transcripts in brains of APP transgenic mice and humans with Alzheimer's diseaseQ48069116
BACE1 inhibition reduces endogenous Abeta and alters APP processing in wild-type miceQ48379491
P433issue4
P407language of work or nameEnglishQ1860
P921main subjectAlzheimer's diseaseQ11081
P304page(s)827-840
P577publication date2012-01-01
P1433published inJournal of Alzheimer's DiseaseQ6294755
P1476titleDeletion of the cathepsin B gene improves memory deficits in a transgenic ALZHeimer's disease mouse model expressing AβPP containing the wild-type β-secretase site sequence
P478volume29

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