| scholarly article | Q13442814 |
| P50 | author | Christoph Becker-Pauly | Q47008760 |
| P2093 | author name string | Christoph Becker-Pauly | |
| Claus U Pietrzik | |||
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| Purification and cloning of amyloid precursor protein beta-secretase from human brain | Q22010914 | ||
| A mutation in APP protects against Alzheimer’s disease and age-related cognitive decline | Q22251083 | ||
| APP binds DR6 to trigger axon pruning and neuron death via distinct caspases | Q22251088 | ||
| Quantitative modelling of amyloidogenic processing and its influence by SORLA in Alzheimer's disease | Q24293094 | ||
| Extracellular phosphorylation of the amyloid β-peptide promotes formation of toxic aggregates during the pathogenesis of Alzheimer's disease | Q24300656 | ||
| Homo- and heterodimerization of APP family members promotes intercellular adhesion | Q24337232 | ||
| Cloning and sequencing of the cDNA encoding a core protein of the paired helical filament of Alzheimer disease: identification as the microtubule-associated protein tau | Q24648590 | ||
| Human aspartic protease memapsin 2 cleaves the beta-secretase site of beta-amyloid precursor protein | Q24650599 | ||
| MEP1A allele for meprin A metalloprotease is a susceptibility gene for inflammatory bowel disease | Q24657607 | ||
| The amyloid precursor protein: beyond amyloid | Q24680465 | ||
| Structural basis for the sheddase function of human meprin metalloproteinase at the plasma membrane | Q27673367 | ||
| The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics | Q27860914 | ||
| Regulated intramembrane proteolysis: a control mechanism conserved from bacteria to humans | Q28145545 | ||
| BACE knockout mice are healthy despite lacking the primary beta-secretase activity in brain: implications for Alzheimer's disease therapeutics | Q28201876 | ||
| Evidence for a copper-binding superfamily of the amyloid precursor protein | Q28215600 | ||
| Brain pyroglutamate amyloid-β is produced by cathepsin B and is reduced by the cysteine protease inhibitor E64d, representing a potential Alzheimer's disease therapeutic | Q28235248 | ||
| Deletion of the cathepsin B gene improves memory deficits in a transgenic ALZHeimer's disease mouse model expressing AβPP containing the wild-type β-secretase site sequence | Q28259920 | ||
| Inhibition of cathepsin B reduces beta-amyloid production in regulated secretory vesicles of neuronal chromaffin cells: evidence for cathepsin B as a candidate beta-secretase of Alzheimer's disease | Q28272351 | ||
| BACE1 inhibition induces a specific cerebrospinal fluid β-amyloid pattern that identifies drug effects in the central nervous system | Q28480522 | ||
| Ligand-induced, receptor-mediated dimerization and activation of EGF receptor | Q28646134 | ||
| Multiple isoforms of human microtubule-associated protein tau: sequences and localization in neurofibrillary tangles of Alzheimer's disease | Q28910345 | ||
| Identification of a Novel Aspartic Protease (Asp 2) as β-Secretase | Q29042710 | ||
| Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction | Q29547778 | ||
| High-level neuronal expression of abeta 1-42 in wild-type human amyloid protein precursor transgenic mice: synaptotoxicity without plaque formation | Q29616564 | ||
| The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor | Q29618322 | ||
| Glutaminyl cyclases unfold glutamyl cyclase activity under mild acid conditions | Q30320504 | ||
| A heparin-binding domain in the amyloid protein precursor of Alzheimer's disease is involved in the regulation of neurite outgrowth | Q38309410 | ||
| Meprin α and meprin β: Procollagen proteinases in health and disease | Q38330769 | ||
| Regulation of amyloid protein precursor (APP) binding to collagen and mapping of the binding sites on APP and collagen type I. | Q38362649 | ||
| Extracellular regulation of metalloproteinases. | Q38363369 | ||
| Generation of aggregation prone N-terminally truncated amyloid β peptides by meprin β depends on the sequence specificity at the cleavage site | Q38559613 | ||
| Calcium negatively regulates meprin β activity and attenuates substrate cleavage | Q38877319 | ||
| Phosphorylation of amyloid-β peptide at serine 8 attenuates its clearance via insulin-degrading and angiotensin-converting enzymes | Q39407972 | ||
| Aminopeptidase A contributes to the N-terminal truncation of amyloid beta-peptide | Q39888501 | ||
| Subcellular localization and dimerization of APLP1 are strikingly different from APP and APLP2. | Q39898160 | ||
| Oral administration of a potent and selective non-peptidic BACE-1 inhibitor decreases beta-cleavage of amyloid precursor protein and amyloid-beta production in vivo | Q40199218 | ||
| Antiamyloidogenic and neuroprotective functions of cathepsin B: implications for Alzheimer's disease | Q40230652 | ||
| The novel beta-secretase inhibitor KMI-429 reduces amyloid beta peptide production in amyloid precursor protein transgenic and wild-type mice | Q40342362 | ||
| Metalloprotease meprin β is activated by transmembrane serine protease matriptase-2 at the cell surface thereby enhancing APP shedding | Q40649414 | ||
| Effect of alkalizing agents on the processing of the beta-amyloid precursor protein. | Q41205433 | ||
| The vacuolar H(+)-ATPase inhibitor bafilomycin A1 differentially affects proteolytic processing of mutant and wild-type beta-amyloid precursor protein | Q41359135 | ||
| Generation of amyloid β protein from its precursor is sequence specific | Q41365901 | ||
| Amyloid beta-peptide is produced by cultured cells during normal metabolism | Q41602809 | ||
| Processing of the Amyloid Protein Precursor to Potentially Amyloidogenic Derivatives | Q41640193 | ||
| Molecular mechanisms of Alzheimer disease protection by the A673T allele of amyloid precursor protein | Q41788034 | ||
| Amyloidogenic processing but not amyloid precursor protein (APP) intracellular C-terminal domain production requires a precisely oriented APP dimer assembled by transmembrane GXXXG motifs | Q41822677 | ||
| Human meprin alpha and beta homo-oligomers: cleavage of basement membrane proteins and sensitivity to metalloprotease inhibitors | Q41827780 | ||
| Analyzing the protease web in skin: meprin metalloproteases are activated specifically by KLK4, 5 and 8 vice versa leading to processing of proKLK7 thereby triggering its activation | Q42466771 | ||
| APP dimer formation is initiated in the endoplasmic reticulum and differs between APP isoforms | Q42563807 | ||
| The metalloprotease meprin β generates amino terminal-truncated amyloid β peptide species | Q42565677 | ||
| Structural design, solid-phase synthesis and activity of membrane-anchored β-secretase inhibitors on Aβ generation from wild-type and Swedish-mutant APP. | Q42785839 | ||
| Fetuin-A and cystatin C are endogenous inhibitors of human meprin metalloproteases | Q42921395 | ||
| Processing of procollagen III by meprins: new players in extracellular matrix assembly? | Q42969982 | ||
| Homodimerization of amyloid precursor protein and its implication in the amyloidogenic pathway of Alzheimer's disease. | Q43662767 | ||
| Oxidation of methionine 35 attenuates formation of amyloid beta -peptide 1-40 oligomers | Q43931371 | ||
| Methionine 35 oxidation reduces fibril assembly of the amyloid abeta-(1-42) peptide of Alzheimer's disease | Q44116115 | ||
| Beta-secretase protein and activity are increased in the neocortex in Alzheimer disease | Q44132132 | ||
| Pyroglutamate-modified amyloid beta-peptides--AbetaN3(pE)--strongly affect cultured neuron and astrocyte survival | Q44158602 | ||
| Reconstitution of gamma-secretase activity | Q44393107 | ||
| Phenotypic and biochemical analyses of BACE1- and BACE2-deficient mice | Q46574998 | ||
| Targeted disruption of the meprin metalloproteinase beta gene protects against renal ischemia-reperfusion injury in mice. | Q46825744 | ||
| Pyroglutamate amyloid β (Aβ) aggravates behavioral deficits in transgenic amyloid mouse model for Alzheimer disease | Q30512697 | ||
| Beta-secretase (BACE) as a drug target for Alzheimer's disease | Q30749785 | ||
| Quantification of Alzheimer pathology in ageing and dementia: age-related accumulation of amyloid-beta(42) peptide in vascular dementia. | Q30813216 | ||
| Elevation of beta-amyloid peptide 2-42 in sporadic and familial Alzheimer's disease and its generation in PS1 knockout cells. | Q31004962 | ||
| Mice deficient in BACE1, the Alzheimer's beta-secretase, have normal phenotype and abolished beta-amyloid generation | Q32063777 | ||
| Amyloid beta peptides in cerebrospinal fluid as profiled with surface enhanced laser desorption/ionization time-of-flight mass spectrometry: evidence of novel biomarkers in Alzheimer's disease | Q33199637 | ||
| Identification of a new presenilin-dependent zeta-cleavage site within the transmembrane domain of amyloid precursor protein. | Q33207923 | ||
| High sensitivity analysis of amyloid-beta peptide composition in amyloid deposits from human and PS2APP mouse brain | Q33258748 | ||
| GxxxG motifs within the amyloid precursor protein transmembrane sequence are critical for the etiology of Abeta42. | Q33276402 | ||
| Dimerization of the transmembrane domain of amyloid precursor proteins and familial Alzheimer's disease mutants | Q33317424 | ||
| Neuronal origin of a cerebral amyloid: neurofibrillary tangles of Alzheimer's disease contain the same protein as the amyloid of plaque cores and blood vessels | Q33931836 | ||
| Role of meprins to protect ileal mucosa of Crohn's disease patients from colonization by adherent-invasive E. coli | Q33940892 | ||
| Microbial-induced meprin β cleavage in MUC2 mucin and a functional CFTR channel are required to release anchored small intestinal mucus | Q34120082 | ||
| Isolation and quantification of soluble Alzheimer's beta-peptide from biological fluids | Q34255552 | ||
| Mutation of the beta-amyloid precursor protein in familial Alzheimer's disease increases beta-protein production | Q34280406 | ||
| The X-ray structure of an antiparallel dimer of the human amyloid precursor protein E2 domain | Q34340080 | ||
| The Alzheimer disease protective mutation A2T modulates kinetic and thermodynamic properties of amyloid-β (Aβ) aggregation | Q34467463 | ||
| Balance of meprin A and B in mice affects the progression of experimental inflammatory bowel disease. | Q34597685 | ||
| Site-specific characterization of threonine, serine, and tyrosine glycosylations of amyloid precursor protein/amyloid beta-peptides in human cerebrospinal fluid | Q35123119 | ||
| Metalloprotease meprin beta generates nontoxic N-terminal amyloid precursor protein fragments in vivo | Q35145029 | ||
| Proteomic analyses reveal an acidic prime side specificity for the astacin metalloprotease family reflected by physiological substrates | Q35264713 | ||
| Beta-amyloid peptide variants in brains and cerebrospinal fluid from amyloid precursor protein (APP) transgenic mice: comparison with human Alzheimer amyloid | Q35311113 | ||
| The use of urinary and kidney SILAM proteomics to monitor kidney response to high dose morpholino oligonucleotides in the mdx mouse | Q35881677 | ||
| Generation of beta-amyloid in the secretory pathway in neuronal and nonneuronal cells | Q36152115 | ||
| The substrate degradome of meprin metalloproteases reveals an unexpected proteolytic link between meprin β and ADAM10. | Q36503385 | ||
| The metalloproteases meprin α and meprin β: unique enzymes in inflammation, neurodegeneration, cancer and fibrosis | Q36613779 | ||
| Cerebrospinal fluid amyloid-β 2-42 is decreased in Alzheimer's, but not in frontotemporal dementia | Q36708123 | ||
| Characterization of beta-amyloid peptide from human cerebrospinal fluid | Q36754599 | ||
| The profile of soluble amyloid beta protein in cultured cell media. Detection and quantification of amyloid beta protein and variants by immunoprecipitation-mass spectrometry | Q36835366 | ||
| Prointerleukin-18 is activated by meprin beta in vitro and in vivo in intestinal inflammation | Q36968427 | ||
| Meprin A metalloproteases enhance renal damage and bladder inflammation after LPS challenge. | Q37086108 | ||
| Metalloproteases meprin α and meprin β are C- and N-procollagen proteinases important for collagen assembly and tensile strength | Q37143394 | ||
| ADAM30 Downregulates APP-Linked Defects Through Cathepsin D Activation in Alzheimer's Disease | Q37149914 | ||
| Proteolytic degradation of amyloid β-protein | Q38016899 | ||
| P304 | page(s) | 159 | |
| P577 | publication date | 2016-01-01 | |
| P1433 | published in | Frontiers in Molecular Neuroscience | Q27721913 |
| P1476 | title | The Metalloprotease Meprin β Is an Alternative β-Secretase of APP. | |
| P478 | volume | 9 |
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