A novel cyclin encoded by a bcl1-linked candidate oncogene

scientific article published on April 11, 1991

A novel cyclin encoded by a bcl1-linked candidate oncogene is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1014976902
P356DOI10.1038/350512A0
P953full work available at URLhttp://www.nature.com/articles/350512a0
http://www.nature.com/articles/350512a0.pdf
P3181OpenCitations bibliographic resource ID615416
P698PubMed publication ID1826542

P50authorHarald JüppnerQ103034311
Theodora BloomQ43250504
P2093author name stringH G Kim
Kronenberg HM
Kim HG
H M Kronenberg
Ruderman JV
Arnold A
J V Ruderman
Motokura T
P2860cites workGenetic abnormalities in sporadic parathyroid adenomasQ68531469
Cdc2 protein kinase is complexed with both cyclin A and B: evidence for proteolytic inactivation of MPFQ69333828
Protein-DNA interactions in vivo upstream of a cell cycle-regulated human H4 histone geneQ22254868
DAF1, a mutant gene affecting size control, pheromone arrest, and cell cycle kinetics of Saccharomyces cerevisiaeQ24627252
Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform ExtractionQ25938986
A comprehensive set of sequence analysis programs for the VAXQ26778432
Use of T7 RNA polymerase to direct expression of cloned genesQ27860692
Isolation of a human cyclin cDNA: evidence for cyclin mRNA and protein regulation in the cell cycle and for interaction with p34cdc2Q28257603
Cyclin: a protein specified by maternal mRNA in sea urchin eggs that is destroyed at each cleavage divisionQ28261164
Molecular cloning of the chromosomal breakpoint of B-cell lymphomas and leukemias with the t(11;14) chromosome translocationQ28270848
Universal control mechanism regulating onset of M-phaseQ29616481
Hepatitis B virus integration in a cyclin A gene in a hepatocellular carcinomaQ33493133
The A- and B-type cyclin associated cdc2 kinases in Xenopus turn on and off at different times in the cell cycle.Q33921443
Human cyclin A is adenovirus E1A-associated protein p60 and behaves differently from cyclin B.Q34173355
Molecular cloning and chromosomal mapping of DNA rearranged with the parathyroid hormone gene in a parathyroid adenomaQ34575421
The role of cyclin B in meiosis I.Q36220481
Control of programmed cyclin destruction in a cell-free systemQ36221788
Regulation of human histone gene expression: kinetics of accumulation and changes in the rate of synthesis and in the half-lives of individual histone mRNAs during the HeLa cell cycleQ36937872
Cooperation between oncogenesQ37625799
FAR-reaching discoveries about the regulation of START.Q38012138
Dominoes and clocks: the union of two views of the cell cycleQ38718174
The clam embryo protein cyclin A induces entry into M phase and the resumption of meiosis in Xenopus oocytesQ48354406
Monoclonality and abnormal parathyroid hormone genes in parathyroid adenomasQ68270144
Gene amplification on chromosome band 11q13 and oestrogen receptor status in breast cancerQ68420205
P433issue6318
P407language of work or nameEnglishQ1860
P304page(s)512-5
P577publication date1991-04-11
P1433published inNatureQ180445
P1476titleA novel cyclin encoded by a bcl1-linked candidate oncogene
P478volume350

Reverse relations

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Q24596448Characterization of a candidate bcl-1 gene
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Q37641907Concerted overexpression of the genes encoding p21 and cyclin D1 is associated with growth inhibition and differentiation in various carcinomas
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Q40886474Cyclin D and oncogenesis
Q35833787Cyclin D1 (Bcl-1, PRAD1) protein expression in low-grade B-cell lymphomas and reactive hyperplasia
Q73145251Cyclin D1 (PRAD1) alternative transcript b: full-length cDNA cloning and expression in breast cancers
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Q47975825Cyclin D1 and Cyclin E expression in malignant thyroid cells and in human thyroid carcinomas
Q40959992Cyclin D1 and D3 associate with the SCF complex and are coordinately elevated in breast cancer
Q40794379Cyclin D1 and human neoplasia
Q24796232Cyclin D1 and mammary carcinoma: new insights from transgenic mouse models
Q74116625Cyclin D1 and retinoblastoma protein expression in Kaposi's sarcoma
Q28295915Cyclin D1 associates with the TBP-associated factor TAF(II)250 to regulate Sp1-mediated transcription
Q28294725Cyclin D1 determines estrogen signaling in the mammary gland in vivo
Q33877550Cyclin D1 enhances the response to estrogen and progesterone by regulating progesterone receptor expression
Q37228185Cyclin D1 expression and HHV8 in Kaposi sarcoma
Q80342451Cyclin D1 expression and cervical metastases in squamous cell carcinoma of the mouth
Q77384616Cyclin D1 expression as a prognostic factor in advanced hypopharyngeal carcinoma
Q35764646Cyclin D1 expression in invasive breast cancer. Correlations and prognostic value.
Q36617988Cyclin D1 expression in non-small-cell lung cancers: its association with altered p53 expression, cell proliferation and clinical outcome
Q38379182Cyclin D1 expression is correlated with cell differentiation and cell proliferation in oral squamous cell carcinomas
Q35145847Cyclin D1 expression is regulated by the retinoblastoma protein
Q73745059Cyclin D1 expression is useful as a prognostic indicator for advanced esophageal carcinomas, but not for superficial tumors
Q47817903Cyclin D1 gene amplification in esophageal carcinosarcoma shown by differential polymerase chain reaction
Q73267965Cyclin D1 genotype in areca-associated oral squamous cell carcinoma
Q37698862Cyclin D1 in the Liver: Role of Noncanonical Signaling in Liver Steatosis and Hormone Regulation
Q35677993Cyclin D1 induction in breast cancer cells shortens G1 and is sufficient for cells arrested in G1 to complete the cell cycle
Q28235209Cyclin D1 inhibits peroxisome proliferator-activated receptor gamma-mediated adipogenesis through histone deacetylase recruitment
Q36550924Cyclin D1 is dispensable for G1 control in retinoblastoma gene-deficient cells independently of cdk4 activity.
Q55169980Cyclin D1 overexpression detected by a simple competitive reverse transcription-polymerase chain reaction assay for lymphoid malignancies.
Q36294947Cyclin D1 overexpression related to retinoblastoma protein expression as a prognostic marker in human oesophageal squamous cell carcinoma
Q35666693Cyclin D1 overexpression vs. retinoblastoma inactivation: implications for growth control evasion in non-small cell and small cell lung cancer
Q35788347Cyclin D1 polymorphism and expression in patients with squamous cell carcinoma of the head and neck
Q73662616Cyclin D1 protein expression is related to clinical progression in laryngeal squamous cell carcinomas
Q41493003Cyclin D1 regulates cellular migration through the inhibition of thrombospondin 1 and ROCK signaling
Q42801826Cyclin D1 splice variants. Differential effects on localization, RB phosphorylation, and cellular transformation
Q37631754Cyclin D1 transgene impedes lymphocyte maturation and collaborates in lymphomagenesis with the myc gene
Q36559825Cyclin D1 triggers autonomous growth of breast cancer cells by governing cell cycle exit
Q41578764Cyclin D1/PRAD1 as a central target in oncogenesis
Q40792693Cyclin D1/bcl-1 cooperates with myc genes in the generation of B-cell lymphoma in transgenic mice.
Q28303053Cyclin D1: polymorphism, aberrant splicing and cancer risk
Q40806544Cyclin D2 and Ha-Ras transformed rat embryo fibroblasts exhibit a novel deregulation of cell size control and early S phase arrest in low serum
Q59102116Cyclin D2 is essential for BCR-mediated proliferation and CD5 B cell development
Q59102120Cyclin D3 Compensates for Loss of Cyclin D2 in Mouse B-lymphocytes Activated via the Antigen Receptor and CD40
Q53543241Cyclin Dl expression in B-cell non Hodgkin lymphoma.
Q36136157Cyclin E overexpression, a negative prognostic factor in breast cancer with strong correlation to oestrogen receptor status
Q24309263Cyclin G1 and cyclin G2 comprise a new family of cyclins with contrasting tissue-specific and cell cycle-regulated expression
Q44752373Cyclin a is required for the onset of DNA replication in mammalian fibroblasts
Q35550165Cyclin alterations in diverse cancers: Outcome and co-amplification network
Q43005996Cyclin d1 induces chromosomal instability
Q38038670Cyclin-dependent kinase modulators and cancer therapy
Q37355981CyclinD1, a prominent prognostic marker for endometrial diseases
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Q28611449Cyclins and cyclin-dependent kinases: a biochemical view
Q40551569Cyclins and cyclin-dependent kinases: theme and variations
Q38497524Cytogenetic analysis of non Hodgkin's lymphomas by ratio-painting and comparative genomic hybridization reveals unsuspected chromosomal abnormalities
Q27690967D-type Cyclins are important downstream effectors of cytokine signaling that regulate the proliferation of normal and neoplastic mammary epithelial cells
Q29614966D-type cyclin-dependent kinase activity in mammalian cells
Q36234063DNA tumor virus oncoproteins and retinoblastoma gene mutations share the ability to relieve the cell's requirement for cyclin D1 function in G1
Q73114505Decreased p27(Kip1) expression and cyclin D1 overexpression, alone and in combination, influence recurrence and survival of patients with resectable extrahepatic bile duct carcinoma
Q35842080Deletion of 11q23 and cyclin D1 overexpression are frequent aberrations in parathyroid adenomas
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Q40963456Detection of chromosomal translocations in leukemia-lymphoma cells by polymerase chain reaction
Q30867713Determination of cyclin D1 and CD20 mRNA levels by real-time quantitative RT-PCR from archival tissue sections of mantle cell lymphoma and other non-Hodgkin's lymphomas
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Q41271543Different Regulation of the Human Thymidine Kinase Promoter in Normal Human Diploid IMR-90 Fibroblasts and HeLa Cells
Q70937769Different expression patterns of cyclins A, D1 and E in human colorectal cancer
Q41500328Differential diagnosis, causes, and management of hypercalcemia
Q49015677Differential expression of D-type G1 cyclins during mouse development and liver regeneration in vivo.
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Q40957469Diminished G1 checkpoint after gamma-irradiation and altered cell cycle regulation by insulin-like growth factor II overexpression
Q47996361Distinct cyclin D genes show mitotic accumulation or constant levels of transcripts in tobacco bright yellow-2 cells
Q41403912Distinct patterns of expression of the D-type cyclins during testicular development in the mouse
Q24293575Dual roles of p300 in chromatin assembly and transcriptional activation in cooperation with nucleosome assembly protein 1 in vitro
Q40811164Ectopic expression of cyclin D1 impairs the proliferation and enhances the apoptosis of a murine lymphoid cell line.
Q41450893Ectopic expression of cyclin D1 prevents activation of gene transcription by myogenic basic helix-loop-helix regulators
Q40385219Effects of exogenous wild-type P16 gene transfection on the expression of cell cycle-related proteins in bladder cancer cell line
Q41003401Effects of targeted silencing of FOXC1 gene on proliferation and in vitro migration of human non-small-cell lung carcinoma cells
Q36827075Elevated levels of cyclin D1 protein in response to increased expression of eukaryotic initiation factor 4E
Q34435745Elevation of cell cycle control proteins during spontaneous immortalization of human keratinocytes
Q36853438Elimination of cyclin D1 in vertebrate cells leads to an altered cell cycle phenotype, which is rescued by overexpression of murine cyclins D1, D2, or D3 but not by a mutant cyclin D1.
Q73662909Environmental chemical carcinogens induce transformation of breast epithelial cells from women with familial history of breast cancer
Q34621876Epidermal growth factor receptor gene copy number aberration at the primary tumour is significantly associated with extracapsular spread in oral cancer
Q33828576Epstein-Barr virus nuclear antigen 3C facilitates G1-S transition by stabilizing and enhancing the function of cyclin D1.
Q44126746ErbB-2-induced mammary tumor growth: the role of cyclin D1 and p27Kip1.
Q33191675Establishment of a highly sensitive and specific exon-trapping system
Q36539618Etiologies of parathyroid gland dysfunction in primary hyperparathyroidism
Q35174152Etiology and pathogenesis of AIDS-related non-Hodgkin's lymphoma
Q28297345Eukaryotic translation initiation factor 4E regulates expression of cyclin D1 at transcriptional and post-transcriptional levels
Q50850441Evaluation and management of the "new" lymphoma entities: mantle cell lymphoma, lymphoma of mucosa-associated lymphoid tissue, anaplastic large-cell lymphoma, and primary mediastinal B-cell lymphoma.
Q52834054Expanded range of 11q13 breakpoints with differing patterns of cyclin D1 expression in B-cell malignancies.
Q77933504Expression and prognostic roles of the G1-S modulators in hepatocellular carcinoma: p27 independently predicts the recurrence
Q36641066Expression and subcellular localization of cyclin D1 protein in epithelial ovarian tumour cells
Q54986217Expression of G1-->S transition regulatory molecules in human urothelial cancer.
Q74624181Expression of PRAD1/cyclin D1 in plasma cell malignancy: incidence and prognostic aspects
Q71869760Expression of cyclin D1 and c-Ki-ras gene product in human epithelial ovarian tumors
Q36431722Expression of cyclin D1 correlates with malignancy in human ovarian tumours
Q37429299Expression of cyclin D1 in epithelial tissues of transgenic mice results in epidermal hyperproliferation and severe thymic hyperplasia
Q71988957Expression of proliferation-associated antigens (PCNA, p120, p145) during the reentry of G0 cells into the cell cycle
Q35773697Expression of retinoblastoma gene product (pRb) in mantle cell lymphomas. Correlation with cyclin D1 (PRAD1/CCND1) mRNA levels and proliferative activity
Q35306247Expression patterns of cyclin D1 and related proteins regulating G1-S phase transition in uveal melanoma and retinoblastoma
Q31919175Expressional changes in alternative splicing affecting genes during cell passage of human diploid fibroblasts
Q39766173FISH is more sensitive than Southern analysis at identifying increased levels of cyclin D1 gene amplified in breast cancer cell lines
Q35229559Five FGF receptors with distinct expression patterns
Q37316601Following the cytokine signaling pathway to leukemogenesis: a chronology
Q77711537Frequency and prognostic relevance of cyclin D1 dysregulation in multiple myeloma
Q41332206Frequent amplification of the cyclin E gene in human gastric carcinomas
Q40402300Frequent loss of chromosome arm 1p DNA in parathyroid adenomas
Q35906984From chemoprevention to chemotherapy: common targets and common goals
Q34994859Function of a human cyclin gene as an oncogene
Q78348035Functional analysis of cyclin D2 and p27(Kip1) in cyclin D2 transgenic mouse mammary gland during development
Q28277731Functional analysis of the human cyclin D2 and cyclin D3 promoters
Q40965316Functional consequences of cyclin D1 overexpression in human mammary luminal epithelial cells
Q41616468Fusion and amplification of two originally non-syntenic chromosomal regions in a mammary carcinoma cell line
Q41421665G1 cyclins and control of the cell division cycle in normal and transformed cells
Q36530627G1/S control of anchorage-independent growth in the fibroblast cell cycle
Q40302213Gain of 11q/cyclin D1 overexpression is an essential early step in skin cancer development and causes abnormal tissue organization and differentiation
Q35184458Gamma herpesviruses: pathogenesis of infection and cell signaling
Q39035786Gastrokine-2 is downregulated in gastric cancer and its restoration suppresses gastric tumorigenesis and cancer metastasis
Q40291449Gene amplification and overexpression of protein phosphatase 1alpha in oral squamous cell carcinoma cell lines.
Q49229625Gene amplifications in advanced-stage human prostate cancer.
Q40972502Genetic alterations in breast cancer.
Q28285050Genetic alterations of cyclins, cyclin-dependent kinases, and Cdk inhibitors in human cancer
Q27025359Genetic and epigenetic changes in sporadic endocrine tumors: parathyroid tumors
Q85966775Genetic association between cyclin D1 polymorphism and breast cancer susceptibility
Q35697802Genetic reevaluation of the role of F-box proteins in cyclin D1 degradation
Q33714058Genetic replacement of cyclin D1 function in mouse development by cyclin D2.
Q45359916Genetic variant of CCND1: association with HPV-mediated cervical cancer in Indian population
Q39286328Genetics of Hyperparathyroidism, Including Parathyroid Cancer
Q41136743Genetics of colorectal and breast cancer.
Q35668788Genetics of endocrine and metabolic disorders: parathyroid
Q40975265Genetics of follicular thyroid cancer.
Q28212569Genomic organization of the human folate receptor genes on chromosome 11q13
Q37783548Genomic profiles in B cell lymphoma
Q30360213Genomic profiling reveals mutational landscape in parathyroid carcinomas
Q91677972Glycosylation and metastases
Q71804549Growth arrest associated changes of mRNA levels in breast cancer cells measured by semi-quantitative RT-PCR: potential early indicators of treatment response
Q41028226Growth arrest associated with 12-o-tetradecanoylphorbol-13-acetate-induced hematopoietic differentiation with a defective retinoblastoma tumor suppressor-mediated pathway
Q40241821Growth factor regulation of cyclin D1 mRNA expression through protein synthesis-dependent and -independent mechanisms
Q36686536Growth factor, steroid, and steroid antagonist regulation of cyclin gene expression associated with changes in T-47D human breast cancer cell cycle progression
Q24317567Growth suppression by p16ink4 requires functional retinoblastoma protein
Q37257805Growth-regulated expression of D-type cyclin genes in human diploid fibroblasts
Q38306079HSNF5/INI1 gene mutations in lymphoid malignancy
Q34293483HTLV-I Tax related dysfunction of cell cycle regulators and oncogenesis of adult T cell leukemia
Q40507756Haellpolymorphism within 3′ untranslated region of PRAD1
Q78156233Hairy cell leukemia with translocation (11;20)(q13;q11) and overexpression of cyclin D1
Q39520921Helicobacter pylori activates the cyclin D1 gene through mitogen-activated protein kinase pathway in gastric cancer cells
Q24672747Hereditary hyperparathyroidism-jaw tumor syndrome: the endocrine tumor gene HRPT2 maps to chromosome 1q21-q31
Q43566357Herpesvirus saimiri encodes homologues of G protein-coupled receptors and cyclins
Q40901633Human B cell lymphomas: in vitro and in vivo studies on growth factors and cell growth.
Q28268832Human D-type cyclin
Q33774432Human T-cell leukemia virus type 1 Tax and cell cycle progression: role of cyclin D-cdk and p110Rb
Q24652527Human cyclin E, a nuclear protein essential for the G1-to-S phase transition
Q24568186Human cyclin F
Q36923077Human cyclin-dependent kinase 2 is activated during the S and G2 phases of the cell cycle and associates with cyclin A.
Q28612313Human cyclins A and B1 are differentially located in the cell and undergo cell cycle-dependent nuclear transport
Q34733433Human papillomavirus infection and cyclin D1 gene amplification in laryngeal squamous cell carcinoma: biologic function and clinical significance.
Q44639159IGF-I stimulates human intestinal smooth muscle cell growth by regulation of G1phase cell cycle proteins
Q71376540INT2 and ERBB2 amplification and ERBB2 expression in breast tumors from patients with different outcomes
Q24324587Identification of G1 kinase activity for cdk6, a novel cyclin D partner
Q73359146Identification of heterologous translocation partner genes fused to the BCL6 gene in diffuse large B-cell lymphomas: 5'-RACE and LA - PCR analyses of biopsy samples
Q31676720Identification of the E2A gene products as regulatory targets of the G1 cyclin-dependent kinases
Q37374902Identification of the domains in cyclin A required for binding to, and activation of, p34cdc2 and p32cdk2 protein kinase subunits
Q28278623Identification of the p28 subunit of eukaryotic initiation factor 3(eIF3k) as a new interaction partner of cyclin D3
Q42181500Identifying gastric cancer related genes using the shortest path algorithm and protein-protein interaction network.
Q55026872Immunohistochemical analysis of cyclin D1 protein in hematopoietic neoplasms with special reference to mantle cell lymphoma.
Q35810205Immunohistochemical analysis of cyclin D1 shows deregulated expression in multiple myeloma with the t(11;14).
Q72566051Immunohistochemical detection of cyclin D and cyclin A in human hyperproliferative epidermis
Q38477902Immunohistochemistry of cyclin D3 in pulmonary carcinomas
Q43701627In vivo analysis of mammary and non-mammary tumorigenesis in MMTV-cyclin D1 transgenic mice deficient in p53.
Q41901560Independence of herpesvirus-induced T cell lymphoma from viral cyclin D homologue
Q35844125Inducing differentiation of transformed cells with hybrid polar compounds: a cell cycle-dependent process
Q41184054Infrequent alterations of the p16INK4A gene in liver cancer
Q77679664Inhibition of cell proliferation in head and neck squamous cell carcinoma cell lines with antisense cyclin D1
Q33773323Inhibition of cyclin D1 kinase activity is associated with E2F-mediated inhibition of cyclin D1 promoter activity through E2F and Sp1.
Q36710873Inhibition of granulocyte differentiation by G1 cyclins D2 and D3 but not D1
Q34167898Inhibition of tumor growth and metastasis by non-small cell lung cancer cells transfected with cyclin D1-targeted siRNA
Q34012822Inhibitors of soluble epoxide hydrolase attenuate vascular smooth muscle cell proliferation
Q28374702Inhibitory effect of mimosine on proliferation of human lung cancer cells is mediated by multiple mechanisms
Q44490328Inhibitory effects of troglitazone, a peroxisome proliferator-activated receptor gamma ligand, in rat tongue carcinogenesis initiated with 4-nitroquinoline 1-oxide
Q33643327Insights into cancer from transgenic mouse models
Q36776958Interferons and interleukin 6 suppress phosphorylation of the retinoblastoma protein in growth-sensitive hematopoietic cells
Q47835152Inverse association between cyclin D1 overexpression and retinoblastoma gene mutation in thyroid carcinomas
Q35250316Investigating breast cancer cell behavior using tissue engineering scaffolds
Q40901594Is the working formulation adequate for the classification of the low grade lymphomas?
Q36796845Isolation of Drosophila cyclin D, a protein expressed in the morphogenetic furrow before entry into S phase.
Q28272102Isolation of three novel human cyclins by rescue of G1 cyclin (cln) function in yeast
Q35872949Kaposi's sarcoma-associated herpesvirus contains G protein-coupled receptor and cyclin D homologs which are expressed in Kaposi's sarcoma and malignant lymphoma
Q39878517Kaposi's sarcoma-associated herpesvirus encodes a functional cyclin.
Q33671160Kaposi's sarcoma-associated herpesvirus: epidemiology, virology, and molecular biology
Q34475001Kinase-independent role of cyclin D1 in chromosomal instability and mammary tumorigenesis
Q36333774Learning about cancer genes through invertebrate genetics.
Q36708288Leukaemic non-Hodgkin's lymphomas with hyperdiploid cells and t(11;14)(q13;q32): a subtype of mantle cell lymphoma?
Q57279394Leukemic involvement is a common feature in mantle cell lymphoma
Q41622053Linkage map of a region of human chromosome band 11q13 amplified in breast and squamous cell tumors
Q35012861Linking cyclins to transcriptional control.
Q47672507Liver regeneration, liver cancers and cyclins
Q28243147Localization of the expressed human p58 protein kinase chromosomal gene to chromosome 1p36 and a highly related sequence to chromosome 15
Q35975697Loss of heterozygosity and amplification on chromosome 11q in human ovarian cancer
Q40717073Malignant hematopoietic cell lines: in vitro models for the study of mantle cell lymphoma
Q36796448Mammalian interphase cdks: dispensable master regulators of the cell cycle
Q34342812Mammary hyperplasia and carcinoma in MMTV-cyclin D1 transgenic mice
Q55240879Mantle cell lymphoma with the features of mucosa-associated lymphoid tissue (MALT) lymphoma in an HTLV-I-seropositive patient.
Q35663027Mantle cell lymphoma: an update
Q53356360Mantle cell lymphoma: presenting features, response to therapy, and prognostic factors.
Q30452448Mantle cell lymphoma: report of the 2010 Mantle Cell Lymphoma Consortium Workshop
Q41042080Mechanism of cyclin D1 (CCND1, PRAD1) overexpression in human cancer cells: analysis of allele-specific expression
Q34224865Mechanisms of action of flavopiridol
Q34119143Mechanisms of cell-cycle checkpoints: at the crossroads of carcinogenesis and drug discovery
Q34776998Mechanisms of secondary hyperparathyroidism
Q29616203Mice lacking p27(Kip1) display increased body size, multiple organ hyperplasia, retinal dysplasia, and pituitary tumors
Q34575813MicroRNA-195 inhibits the proliferation of human glioma cells by directly targeting cyclin D1 and cyclin E1.
Q34987420Molecular alterations in sporadic breast cancer
Q40917320Molecular and biochemical reprogramming of oncogenesis through the activity of prooxidants and antioxidants
Q41140205Molecular and cellular biomarkers for field cancerization and multistep process in head and neck tumorigenesis
Q38478886Molecular and immunochemical analyses of RB1 and cyclin D1 in human ductal pancreatic carcinomas and cell lines
Q72013090Molecular breakpoints of t(11;14)(q13;q32) in multiple myeloma
Q41200046Molecular characterization of an unusual non-Hodgkin's B-lymphoma cell line ("Farage") lacking the ability to produce immunoglobulin polypeptide chains
Q48077795Molecular cloning of a t(11;14)(q13;q32) translocation breakpoint centromeric to the BCL1-MTC.
Q40429882Molecular foundations of cancer: New targets for intervention
Q40832210Molecular genetic changes in human breast cancer
Q38806483Molecular genetics and epigenetics of nonfamilial (sporadic) parathyroid tumours
Q41252914Molecular genetics and lymphoproliferative disorders
Q40422429Molecular genetics of disorders of calcium homeostasis
Q37448279Molecular genetics of parathyroid disease.
Q34195878Molecular markers in head and neck squamous cell carcinoma: their biological function and prognostic significance
Q43609590Molecular mechanisms controlling the cell cycle: fundamental aspects and implications for oncology
Q41810203Molecular mechanisms of OLIG2 transcription factor in brain cancer.
Q40624233Molecular mechanisms of parathyroid neoplasia.
Q34437592Molecular mechanisms of primary hyperparathyroidism
Q37039386Molecular pathogenesis of oral squamous cell carcinoma: implications for therapy
Q40454641Molecular pathogenesis of pituitary tumours.
Q31889854Molecular pathology of parathyroid tumors
Q41444722Monoclonal antibody against PRAD1/cyclin D1 stains nuclei of tumor cells with translocation or amplification at BCL-1 locus
Q34215550Monoclonality of parathyroid tumors in chronic renal failure and in primary parathyroid hyperplasia
Q40471503Multiple endocrine neoplasia type 1 (MEN 1) revisited.
Q33851133Mutation of cell cycle regulators and their impact on superficial bladder cancer
Q36946892Mutational analysis of GCMB, a parathyroid-specific transcription factor, in parathyroid adenoma of primary hyperparathyroidism
Q28188807Mutations and aberrant DNA methylation of the PROX1 gene in hematologic malignancies
Q35798342Mutations of cell cycle regulators. Biological and clinical implications for human neoplasia.
Q90101472Neospora caninum Dense Granule Protein 7 Regulates the Pathogenesis of Neosporosis by Modulating Host Immune Response
Q36678011Nerve Growth factor regulation of cyclin D1 in PC12 cells through a p21RAS extracellular signal-regulated kinase pathway requires cooperative interactions between Sp1 and nuclear factor-kappaB
Q68069200New gene in the homologous human 11q13-q14 and mouse 7F chromosomal regions
Q56899391New nucleotide sequence data on the EMBL File Server
Q56899522New nucleotide sequence data on the EMBL File Server
Q38472480New twist in the regulation of cyclin D1.
Q40881085Nonrandom 4p13 rearrangements of the RhoH/TTF gene, encoding a GTP-binding protein, in non-Hodgkin's lymphoma and multiple myeloma
Q74576344Novel evidence of a role for chromosome 1 pericentric heterochromatin in the pathogenesis of B-cell lymphoma and multiple myeloma
Q28567562Novel interactions between NFATc1 (Nuclear Factor of Activated T cells c1) and STAT-3 (Signal Transducer and Activator of Transcription-3) mediate G protein-coupled receptor agonist, thrombin-induced biphasic expression of cyclin D1, with first phas
Q36811297Nuclear Binding of Purified Retinoblastoma Gene Product Is Determined by Cell Cycle-Regulated Phosphorylation
Q37470373Nuclear cyclin D1: an oncogenic driver in human cancer
Q42590333Oesophageal cancer and amplification of the human cyclin D gene CCND1/PRAD1.
Q67488545Oncogenes
Q40883891Oncogenic Ras-mediated cell growth arrest and apoptosis are associated with increased ubiquitin-dependent cyclin D1 degradation.
Q36006249Oncogenic capacity of the E2F1 gene
Q53454693Oncogenic collaboration of the cyclin D1 (PRAD1, bcl-1) gene with a mutated p53 and an activated ras oncogene in neoplastic transformation.
Q28507582Oncogenic potential of the DNA replication licensing protein CDT1
Q73689568Oncogenic transformation of normal enterocytes by overexpression of cyclin D1
Q35795143Overexpression and localization of cyclin D1 mRNA and antigen in esophageal cancer.
Q44319784Overexpression of Cdk6-cyclin D3 highly sensitizes cells to physical and chemical transformation
Q64064502Overexpression of IC53d promotes the proliferation of gastric cancer cells by activating the AKT/GSK3β/cyclin D1 signaling pathway
Q73507942Overexpression of cyclin D1 and p53 associated with disease recurrence in colorectal adenocarcinoma
Q41855173Overexpression of cyclin D1 correlates with early recurrence in superficial bladder cancers
Q54987357Overexpression of cyclin D1 in rat esophageal carcinogenesis model.
Q35923870Overexpression of human cyclin D1 reduces the transforming growth factor beta (TGF-beta) type II receptor and growth inhibition by TGF-beta 1 in an immortalized human esophageal epithelial cell line
Q41578929Overexpression of interleukin-18 protein reduces viability and induces apoptosis of tongue squamous cell carcinoma cells by activation of glycogen synthase kinase-3β signaling
Q58001037Overlapping morphologic and immunophenotypic profiles in small B-cell lymphoma. A report of two cases
Q38175443Overview of cyclins D1 function in cancer and the CDK inhibitor landscape: past and present.
Q33989869Oxidative stress and cell cycle checkpoint function.
Q37184060P21 and p27: roles in carcinogenesis and drug resistance
Q40038649PKR and PKR-like endoplasmic reticulum kinase induce the proteasome-dependent degradation of cyclin D1 via a mechanism requiring eukaryotic initiation factor 2alpha phosphorylation
Q24560056PRAD1, a candidate BCL1 oncogene: mapping and expression in centrocytic lymphoma
Q41201990PRAD1/Cyclin D1 gene overexpression in mantle cell lymphoma
Q28298193PRAD1/cyclin D1 proto-oncogene: genomic organization, 5' DNA sequence, and sequence of a tumor-specific rearrangement breakpoint
Q42702906PRMT5 is required for lymphomagenesis triggered by multiple oncogenic drivers
Q39015716PTH-C1: a rat continuous cell line expressing the parathyroid phenotype
Q42930137Parathyroid cell proliferation in normal and chronic renal failure rats. The effects of calcium, phosphate, and vitamin D.
Q40559871Pathogenesis of pituitary Cushing's syndrome. Pituitary versus hypothalamic.
Q73498547Pathologic features, proliferative activity, and cyclin D1 expression in Hurthle cell neoplasms of the thyroid
Q57287675Patterns of dna amplification at band q13 of chromosome 11 in human breast cancer
Q37355688Phosphorus restriction prevents parathyroid gland growth. High phosphorus directly stimulates PTH secretion in vitro
Q41077189Plant cells contain a novel member of the retinoblastoma family of growth regulatory proteins
Q41091749Platelet-activating factor (PAF) induces growth stimulation, inhibition, and suppression of oncogenic transformation in NRK cells overexpressing the PAF receptor
Q41367986Positive and negative regulation of D-type cyclin expression in skeletal myoblasts by basic fibroblast growth factor and transforming growth factor beta. A role for cyclin D1 in control of myoblast differentiation
Q34029063Possible prognostic significance of p53, cyclin D1 and Ki-67 in the second primary malignancy of patients with double primary malignancies
Q39946549Primary hyperparathyroidism caused by parathyroid-targeted overexpression of cyclin D1 in transgenic mice.
Q36701076Primary structure of the herpesvirus saimiri genome
Q36134992Prognostic significance of CCND1 (cyclin D1) overexpression in primary resected non-small-cell lung cancer
Q40434039Progress against cancer
Q35255782Progress in molecular biology of breast cancer
Q37375698Proliferating cell nuclear antigen and p21 are components of multiple cell cycle kinase complexes
Q24321135Proliferation-associated Brn-3b transcription factor can activate cyclin D1 expression in neuroblastoma and breast cancer cells
Q55002637Quantitative analysis of cyclin D1 messenger RNA expression in head and neck squamous cell carcinomas.
Q43572717Racial differences in the expression of cell cycle-regulatory proteins in breast carcinoma
Q36552538Ras transformation results in an elevated level of cyclin D1 and acceleration of G1 progression in NIH 3T3 cells
Q34164600Ras-dependent cell cycle commitment during G2 phase
Q78854562Rearrangements and increased expression of cyclin D1 (CCND1) in neuroblastoma
Q92896609Recent advances with cyclin-dependent kinase inhibitors: therapeutic agents for breast cancer and their role in immuno-oncology
Q41488826Recent insights into the functions of the retinoblastoma susceptibility gene product
Q30420795Recurrent ZFX mutations in human sporadic parathyroid adenomas
Q36090819Redundant cyclin overexpression and gene amplification in breast cancer cells
Q37279604Regulation of BALB/c 3T3 fibroblast proliferation by B-myb is accompanied by selective activation of cdc2 and cyclin D1 expression
Q41639250Regulation of CDK/cyclin complexes during the cell cycle
Q36599668Regulation of G1/S transition by cyclins D2 and D3 in hematopoietic cells
Q42834597Regulation of cyclin D1 by calpain protease
Q33635621Regulation of hormonal therapy resistance by cell cycle machinery
Q41523304Relocation and distinct subcellular localization of p34cdc2-cyclin B complex at meiosis reinitiation in starfish oocytes
Q35872212Repression of cyclin D1 expression does not contribute to initiation or maintenance of cell transformation by adenovirus type 5 E1
Q36654990Repression of cyclin D1: a novel function of MYC
Q36531419Requirement for p34cdc2 kinase is restricted to mitosis in the mammalian cdc2 mutant FT210
Q37367075Retinoid chemoprevention trials: cyclin D1 in the crosshairs
Q37827932Review article Alterations in cyclin D1, p53, and the cell cycle related elements Implications for distinct genetic pathways of urinary bladder carcinogenesis
Q36573600Role of cyclins in neuronal differentiation of immortalized hippocampal cells
Q53455197Role of the INK4a locus in tumor suppression and cell mortality.
Q35721985Role of transforming growth factor beta in breast carcinogenesis
Q36626696Signaling pathways that control cell proliferation.
Q73048637Significance of cyclin D1 overexpression in transitional cell carcinomas of the urinary bladder and its correlation with histopathologic features
Q45297822Significantly upregulated TACSTD2 and Cyclin D1 correlate with poor prognosis of invasive ductal breast cancer
Q36982125Slit2 inhibits growth and metastasis of fibrosarcoma and squamous cell carcinoma
Q46117758Sohlh2 inhibits ovarian cancer cell proliferation by upregulation of p21 and downregulation of cyclin D1.
Q41199433Specific transformation abolishes cyclin D1 fluctuation throughout the cell cycle
Q73980700Sporadic amplification of the insulin receptor gene in human breast cancer
Q35761279Squamous epithelial proliferation induced by walleye dermal sarcoma retrovirus cyclin in transgenic mice
Q59077271Starting and stopping
Q41252190Stem-cell factor regulates the expression of cyclin A and retinoblastoma gene product in the growth and differentiation pathway of human megakaryocytic cells
Q24300272Structure and expression of the human p58clk-1 protein kinase chromosomal gene
Q40814272Study on the role of G1 cyclins in Epstein-Barr virus-associated human lymphomas maintained in severe combined immune deficiency (SCID) mice
Q42578069Suberoylanilide hydroxamic acid (SAHA) inhibits EGF-induced cell transformation via reduction of cyclin D1 mRNA stability
Q36669107Suppression of cyclin-dependent kinase 4 during induced differentiation of erythroleukemia cells
Q34061513Surgical approaches to primary hyperparathyroidism
Q40871675Synergistic action of Drosophila cyclins A and B during the G2-M transition
Q41990579Systematic module approach identifies altered genes and pathways in four types of ovarian cancer
Q28082912Targeting CDK4 and CDK6: From Discovery to Therapy
Q57405732The Cell Cycle: A Review
Q67900062The Cell Cycle: Spinning Farther Afield
Q35100242The DNA methylome of benign and malignant parathyroid tumors
Q40370724The Drosophila cyclin D-Cdk4 complex promotes cellular growth
Q34057186The MO15 gene encodes the catalytic subunit of a protein kinase that activates cdc2 and other cyclin-dependent kinases (CDKs) through phosphorylation of Thr161 and its homologues
Q36980923The Mn1 transcription factor acts upstream of Tbx22 and preferentially regulates posterior palate growth in mice.
Q55237298The Positive Nuclear Staining Observed with Monoclonal Antibody against PRAD1/Cyclin D1 Correlates with mRNA Expression in Mantle Cell Lymphoma
Q85057853The RNA-binding protein La contributes to cell proliferation and CCND1 expression
Q40317015The Wnt pathway destabilizes adherens junctions and promotes cell migration via β-catenin and its target gene cyclin D1.
Q36644993The adenovirus E1A-associated kinase consists of cyclin E-p33cdk2 and cyclin A-p33cdk2.
Q39914245The antiproliferative effect of EPA in HL60 cells is mediated by alterations in calcium homeostasis
Q44998272The basic helix-loop-helix transcription factor neuroD is expressed in the rod lineage of the teleost retina.
Q40733277The cell cycle and the retinoblastoma protein family
Q35157537The cell cycle: a review of regulation, deregulation and therapeutic targets in cancer
Q52106307The developmental expression of cell cycle regulators in Xenopus laevis.
Q73268970The expression of cyclins D1 and E in predicting short-term survival in squamous cell carcinoma of the lung
Q33653192The folate receptor as a potential therapeutic anticancer target
Q34460347The history and future of targeting cyclin-dependent kinases in cancer therapy
Q58061470The insulin–like growth factor type–2 receptor gene is imprinted in the mouse but not in humans
Q40442663The involvement of the chromosome 11q13 region in human malignancies: Cyclin D1 and EMS1 are two new candidate oncogenes-a review
Q41175188The mammalian cell cycle in normal and abnormal growth
Q47920723The molecular genetics of endocrine tumours
Q57538318The plant cell cycle in context
Q24605485The product of the EMS1 gene, amplified and overexpressed in human carcinomas, is homologous to a v-src substrate and is located in cell-substratum contact sites
Q38473917The prognostic significance of p34cdc2 and cyclin D1 protein expression in prostate adenocarcinoma
Q36962414The retinoblastoma protein physically associates with the human cdc2 kinase
Q34088323The role and regulation of D-type cyclins in the plant cell cycle
Q40790429The role of Bcl-2 in the pathogenesis of B chronic lymphocytic leukemia
Q74215024The role of cell cycle regulatory protein, cyclin D1, in the progression of thyroid cancer
Q53428840The role of cell cycle regulatory proteins, cyclin D1, cyclin E, and p27 in thyroid carcinogenesis.
Q58068890The role of oncogenes and tumour-suppressor genes in the aetiology of oral, head and neck squamous cell carcinoma
Q34616409The role of oncogenes in gastrointestinal cancer
Q53396667The role of overexpression and gene amplification of cyclin D1 in intrahepatic cholangiocarcinoma.
Q38165149The role of polo-like kinase 1 in carcinogenesis: cause or consequence?
Q41035980The role of the insulin-like growth factor system in human cancer
Q38398088The transcription factor DEC1 (BHLHE40/STRA13/SHARP-2) is negatively associated with TNM stage in non-small-cell lung cancer and inhibits the proliferation through cyclin D1 in A549 and BE1 cells
Q33635587Tissue-specific regulatory regions of the PTH gene localized by novel chromosome 11 rearrangement breakpoints in a parathyroid adenoma.
Q40351474Transcription repressor activity of spleen tyrosine kinase mediates breast tumor suppression
Q33824768Transcriptional up-regulation of the cyclin D2 gene and acquisition of new cyclin-dependent kinase partners in human T-cell leukemia virus type 1-infected cells
Q36646526Transforming growth factor beta effects on expression of G1 cyclins and cyclin-dependent protein kinases
Q40959643Transgenic mouse models of breast cancer
Q41202018Translocation t(8;16)(p11;p13) in acute non-lymphocytic leukemia: report on two new cases and review of the literature.
Q42856274Tumor progression of skin carcinoma cells in vivo promoted by clonal selection, mutagenesis, and autocrine growth regulation by granulocyte colony-stimulating factor and granulocyte-macrophage colony-stimulating factor
Q36183682Tumor suppressor genes in the cell cycle
Q30499489Tumor-suppressor genes: cardinal factors in inherited predisposition to human cancers
Q64109942Turning Point in the Treatment of Mantle Cell Lymphoma
Q34346963Ubiquitin-dependent proteolysis in G1/S phase control and its relationship with tumor susceptibility
Q95824195Uncoupling of membrane ruffling and pinocytosis during Ras signal transduction
Q70565444Unexpected Prad-1 amplification in multiple simultaneous localisations of squamous cell carcinoma of the head and neck
Q35583393Update on genetic and clinical aspects of primary hyperparathyroidism
Q33860808Use of MMTV-Wnt-1 transgenic mice for studying the genetic basis of breast cancer
Q40675128Viral transformation of human T lymphocytes.
Q41431627Virus-encoded cyclin
Q33785258Walleye retroviruses associated with skin tumors and hyperplasias encode cyclin D homologs.
Q34362269Whole-exome sequencing studies of nonhereditary (sporadic) parathyroid adenomas
Q41024260Z-138: a new mature B-cell acute lymphoblastic leukemia cell line from a patient with transformed chronic lymphocytic leukemia
Q37024214Zebrafish cyclin Dx is required for development of motor neuron progenitors, and its expression is regulated by hypoxia-inducible factor 2α.
Q73826933[Cytogenetic abnormalities in malignant lymphoma and multiple myeloma]
Q24555683cdc2 family kinases phosphorylate a human cell DNA replication factor, RPA, and activate DNA replication
Q35933286cdc2 phosphorylation is required for its interaction with cyclin.
Q28145650cdk6 can shorten G(1) phase dependent upon the N-terminal INK4 interaction domain
Q45920518miR-148b Regulates Proliferation and Differentiation of Neural Stem Cells via Wnt/β-Catenin Signaling in Rat Ischemic Stroke Model.
Q36619103miR-150 inhibits terminal erythroid proliferation and differentiation
Q53098748miR-216a-3p Inhibits the Proliferation, Migration, and Invasion of Human Gastric Cancer Cells via Targeting RUNX1 and Activating the NF-κB Signaling Pathway.
Q52716876miRNA‑222 promotes liver cancer cell proliferation, migration and invasion and inhibits apoptosis by targeting BBC3.
Q74454269p27(kip1) and Other Cell-Cycle Protein Expression in Normal and Neoplastic Endocrine Tissues
Q40020773p27KIP1 blocks cyclin E-dependent transactivation of cyclin A gene expression
Q42755072p53 alterations in human squamous cell carcinomas and carcinoma cell lines
Q54964052p53 mutation in B-cell lymphoid neoplasms with reference to oncogene rearrangements associated with chromosomal translocations.
Q89896871p53, Cyclin-D1, β-catenin, APC and c-myc in Tumor Tissue from Colorectal and Gastric Cancer Patients with Suspected Lynch Syndrome by the Bethesda Criteria
Q47449243p53, Ki67 and cyclin D1 as prognosticators of lymph node metastases in laryngeal carcinoma
Q74453838p53/MDM2 Pathway Aberrations in Parathyroid Tumors: p21(WAF-1) and MDM2 Are Frequently Overexpressed in Parathyroid Adenomas
Q39517920shRNA targeting PLCε inhibits bladder cancer cell growth in vitro and in vivo

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