α4βδ GABA(A) receptors are high-affinity targets for γ-hydroxybutyric acid (GHB)

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α4βδ GABA(A) receptors are high-affinity targets for γ-hydroxybutyric acid (GHB) is …
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scholarly articleQ13442814

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P819ADS bibcode2012PNAS..10913404A
P356DOI10.1073/PNAS.1204376109
P3181OpenCitations bibliographic resource ID1800238
P932PMC publication ID3421209
P698PubMed publication ID22753476
P5875ResearchGate publication ID228105268

P50authorGitte Moos KnudsenQ5565155
Jesper V. OlsenQ37382807
Petrine WellendorphQ37831011
Hans Bräuner-OsborneQ37831020
Rasmus P. ClausenQ41856993
Bente FrølundQ42775784
P2093author name stringMary Chebib
Nathan Absalom
Nasiara Karim
Inge S Villumsen
Laura F Eghorn
Tina Bay
P2860cites workBehavioral analyses of GHB: receptor mechanismsQ24645147
Segregation of different GABAA receptors to synaptic and extrasynaptic membranes of cerebellar granule cellsQ28261770
Failure of gamma-hydroxybutyrate to alter the function of the GABAA receptor complex in the rat cerebral cortexQ28324103
Fragrant dioxane derivatives identify beta1-subunit-containing GABAA receptorsQ28572529
Withdrawal from progesterone increases expression of alpha4, beta1, and delta GABA(A) receptor subunits in neurons in the periaqueductal gray matter in female Wistar ratsQ28572994
GABAA receptor alpha 4 subunits mediate extrasynaptic inhibition in thalamus and dentate gyrus and the action of gaboxadolQ28586656
Enhanced tonic GABAA inhibition in typical absence epilepsy.Q30493216
Cloning and characterization of a rat brain receptor that binds the endogenous neuromodulator gamma-hydroxybutyrate (GHB).Q30980440
Molecular and functional diversity of the expanding GABA-A receptor gene familyQ33691541
Limiting activity at beta1-subunit-containing GABAA receptor subtypes reduces ataxiaQ33714843
Point mutations affecting antagonist affinity and agonist dependent gating of GABAA receptor channels.Q33937793
A specific gamma-hydroxybutyrate receptor ligand possesses both antagonistic and anticonvulsant propertiesQ34198545
Perisynaptic localization of delta subunit-containing GABA(A) receptors and their activation by GABA spillover in the mouse dentate gyrus.Q34277867
Blockade of the discriminative stimulus effects of gamma-hydroxybutyric acid (GHB) by the GHB receptor antagonist NCS-382.Q34373780
Novel cyclic gamma-hydroxybutyrate (GHB) analogs with high affinity and stereoselectivity of binding to GHB sites in rat brain.Q34433571
Anti-sedative and anti-cataleptic properties of NCS-382, a γ-hydroxybutyrate receptor antagonistQ34669699
Novel high-affinity and selective biaromatic 4-substituted gamma-hydroxybutyric acid (GHB) analogues as GHB ligands: design, synthesis, and binding studies.Q34894062
Salicylidene salicylhydrazide, a selective inhibitor of beta 1-containing GABAA receptorsQ35047079
Effect of gene dosage on single-cell hippocampal electrophysiology in a murine model of SSADH deficiency (gamma-hydroxybutyric aciduria).Q35162336
Molecular basis for the high THIP/gaboxadol sensitivity of extrasynaptic GABA(A) receptorsQ35326774
Attenuated sensitivity to neuroactive steroids in gamma-aminobutyrate type A receptor delta subunit knockout mice.Q36562979
Gamma-hydroxybutyrate--a drug of abuseQ36566720
Mechanisms of sleep induction by GABA(A) receptor agonists.Q36835775
Progesterone withdrawal-evoked plasticity of neural function in the female periaqueductal grey matter.Q36995284
Extrasynaptic GABAA receptors: form, pharmacology, and functionQ37442515
Reconstructing stimuli from the spike times of leaky integrate and fire neuronsQ37851359
Subunit Compensation and Plasticity of Synaptic GABA(A) Receptors Induced by Ethanol in α4 Subunit Knockout MiceQ38547376
GABA(A) receptors: immunocytochemical distribution of 13 subunits in the adult rat brain.Q42497057
GABA(A) receptor beta 2 Tyr97 and Leu99 line the GABA-binding site. Insights into mechanisms of agonist and antagonist actionsQ42664010
Design, synthesis, and in vitro pharmacology of new radiolabeled gamma-hydroxybutyric acid analogues including photolabile analogues with irreversible binding to the high-affinity gamma-hydroxybutyric acid binding sitesQ42935195
Novel radioiodinated {gamma}-hydroxybutyric acid analogues for radiolabeling and Photolinking of high-affinity {gamma}-hydroxybutyric acid binding sitesQ42942203
γ-Hydroxybutyrate and the GABAergic footprint: a metabolomic approach to unpicking the actions of GHB.Q42948090
Binding characteristics of the gamma-hydroxybutyric acid receptor antagonist [(3)H](2E)-(5-hydroxy-5,7,8,9-tetrahydro-6H-benzo[a][7]annulen-6-ylidene) ethanoic acid in the rat brainQ43803870
gamma-Hydroxybutyric acid binding sites: evidence for coupling to a chloride anion channelQ43863754
Gamma-hydroxybutyric acid and diazepam antagonize a rapid increase in GABA(A) receptors alpha(4) subunit mRNA abundance induced by ethanol withdrawal in cerebellar granule cells.Q44367239
Specific gamma-hydroxybutyrate-binding sites but loss of pharmacological effects of gamma-hydroxybutyrate in GABA(B)(1)-deficient miceQ44680394
Phenylacetic acids and the structurally related non-steroidal anti-inflammatory drug diclofenac bind to specific gamma-hydroxybutyric acid sites in rat brain.Q45914894
The distribution of gamma-hydroxybutyrate-induced Fos expression in rat brain: comparison with baclofenQ46256545
Novel gamma-hydroxybutyric acid (GHB) analogs share some, but not all, of the behavioral effects of GHB and GABAB receptor agonistsQ46381195
Discriminative stimulus effects of gamma-hydroxybutyrate (GHB) in rats discriminating GHB from baclofen and diazepamQ46387409
Gamma-aminobutyric acidB (GABAB)-receptor mediation of different in vivo effects of gamma-butyrolactoneQ46757395
3-Hydroxy-2'-methoxy-6-methylflavone: a potent anxiolytic with a unique selectivity profile at GABA(A) receptor subtypesQ48230306
GABAA receptors involved in sleep and anaesthesia: β1- versus β3-containing assembliesQ48249252
γ-Hydroxybutyrate hyperpolarizes hippocampal neurones by activating GABAB receptorsQ48510585
Low nanomolar GABA effects at extrasynaptic α4β1/β3δ GABA(A) receptor subtypes indicate a different binding mode for GABA at these receptorsQ48647712
High affinity binding sites for gamma-hydroxybutyric acid in rat brain.Q48966115
Changes in GABA(A) receptor subunit expression in the midbrain during the oestrous cycle in Wistar rats.Q49053852
Intravenous self-administration of gamma-hydroxybutyric acid in drug-naive mice.Q52179980
Cooperative modulation of [3H]MK-801 binding to the N-methyl-D-aspartate receptor-ion channel complex by L-glutamate, glycine, and polyaminesQ69036827
Gamma-hydroxybutyric acid: an endogenous neuromodulator with abuse potential?Q77735770
P4510describes a project that usesImageJQ1659584
P433issue33
P407language of work or nameEnglishQ1860
P304page(s)13404-9
P577publication date2012-08-14
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleα4βδ GABA(A) receptors are high-affinity targets for γ-hydroxybutyric acid (GHB)
P478volume109

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Q28535012γ-Hydroxybutyric acid (GHB) is not an agonist of extrasynaptic GABAA receptors

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