Potent spinal analgesia elicited through stimulation of NTS2 neurotensin receptors

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Potent spinal analgesia elicited through stimulation of NTS2 neurotensin receptors is …
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scholarly articleQ13442814

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P356DOI10.1523/JNEUROSCI.0810-05.2005
P932PMC publication ID6725526
P698PubMed publication ID16148226
P5875ResearchGate publication ID7614164

P50authorJean MartinezQ37369993
P2093author name stringAlain Beaudet
Amélie Perron
Michael J Esdaile
Philippe Sarret
Thomas Stroh
P2860cites workBiochemical and pharmacological profile of a potent and selective nonpeptide antagonist of the neurotensin receptorQ24563882
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Alterations in nociception and body temperature after intracisternal administration of neurotensin, beta-endorphin, other endogenous peptides, and morphineQ34039450
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Specific gene blockade shows that peptide nucleic acids readily enter neuronal cells in vivoQ38339934
Localization of the antinociceptive and antianalgesic effects of neurotensin within the rostral ventromedial medullaQ39391387
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Neurotensin administered intracisternally inhibits responsiveness of mice to noxious stimuliQ40117383
Distribution of neurotensin and its receptor in the central nervous systemQ40134265
Identification and functional characterization of a 5-transmembrane domain variant isoform of the NTS2 neurotensin receptor in rat central nervous system.Q40473940
The effects of deleting the mouse neurotensin receptor NTR1 on central and peripheral responses to neurotensinQ40761616
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Biochemical and pharmacological activities of SR 142948A, a new potent neurotensin receptor antagonistQ41131367
Neurotensin: Antinocisponsive action in rodentsQ41445511
In vivo and in vitro structure-activity studies with peptide and pseudopeptide neurotensin analogs suggest the existence of distinct central neurotensin receptor subtypesQ41496282
Neurotensin-induced antinociception in mice: antagonism by thyrotropin-releasing hormoneQ41531796
The nonpeptide neurotensin antagonist, SR 48692, used as a tool to reveal putative neurotensin receptor subtypesQ41899918
Endogenous neurotensin facilitates visceral nociception and is required for stress-induced antinociception in mice and ratsQ42463419
Neurotensin excites periaqueductal gray neurons projecting to the rostral ventromedial medullaQ43565349
Neuropeptide receptors in developing and adult rat spinal cord: an in vitro quantitative autoradiography study of calcitonin gene-related peptide, neurokinins, mu-opioid, galanin, somatostatin, neurotensin and vasoactive intestinal polypeptide recepQ44335230
Immunohistochemical distribution of NTS2 neurotensin receptors in the rat central nervous systemQ44441072
Comparison of mice deficient in the high- or low-affinity neurotensin receptors, Ntsr1 or Ntsr2, reveals a novel function for Ntsr2 in thermal nociceptionQ44730144
Peripheral nerve injury induces trans-synaptic modification of channels, receptors and signal pathways in rat dorsal spinal cordQ44791905
Localization of neurotensin-immunoreactivity in the spinal cord and peripheral nervous system of the guinea pig.Q46706994
Tissue distribution and cellular localization of the levocabastine-sensitive neurotensin receptor mRNA in adult rat brainQ47798016
Identification of the receptor subtype involved in the analgesic effect of neurotensinQ48319054
Regional and cellular distribution of low affinity neurotensin receptor mRNA in adult and developing mouse brainQ48473610
A mechanism for the analgesic effect of neurotensin as revealed by behavioral and electrophysiological techniquesQ48589742
Structure-antinociceptive activity of neurotensin and some novel analogues in the periaqueductal gray region of the brainstemQ48670799
Neurotensin: topographical distribution of brain sites involved in hypothermia and antinociceptionQ48895799
Neurotensin: topographical distribution in rat brain by immunohistochemistryQ48895831
Antinociception after microinjection of neurotensin into the central amygdaloid nucleus of the rat.Q48921836
Differences in the pharmacological actions of intrathecally administered neurotensin and morphineQ49011080
Antinocisponsive effects of neurotensin and neurotensin-related peptidesQ49078139
Effect of dorsal rhizotomy on the autoradiographic distribution of opiate and neurotensin receptors and neurotensin-like immunoreactivity within the rat spinal cordQ49129426
Neurotensin receptors in the human spinal cord: A quantitative autoradiographic studyQ60513783
Ultrastructural localization of immunoreactive neurotensin in the monkey superficial dorsal hornQ63608737
Heterogeneous distribution of neurotensin-like immunoreactive neurons and fibers in the midbrain periaqueductal gray of the ratQ68172751
Distinguishable effects of intrathecal dynorphins, somatostatin, neurotensin and s-calcitonin on nociception and motor function in the ratQ69928173
Neurotensin immunoreactivity in the superficial laminae of the dorsal horn of the rat: I. Light microscopic studies of cell bodies and proximal dendritesQ70226047
Low doses of neurotensin in the preoptic area produce hyperthermia. Comparison with other brain sites and with neurotensin-induced analgesiaQ71252303
Different mechanisms are involved in the respiratory depression and analgesia induced by neurotensin in ratsQ71324330
Ultrastructural studies on peptides in the dorsal horn of the spinal cord--I. Co-existence of galanin with other peptides in primary afferents in normal ratsQ71611940
Complementary distribution of receptors for neurotensin and NPY in small neurons in rat lumbar DRGs and regulation of the receptors and peptides after peripheral axotomyQ71689221
The distribution of nine peptides in rat spinal cord with special emphasis on the substantia gelatinosa and on the area around the central canal (laminaX)Q72644545
An immunohistochemical study of neuronal populations containing neuropeptides or gamma-aminobutyrate within the superficial layers of the rat dorsal hornQ72650621
Pharmacological studies on the application, disposition, and release of neurotensin in the spinal cordQ72694432
Antinociceptive action of intrathecal neurotensin in miceQ72718895
P433issue36
P407language of work or nameEnglishQ1860
P304page(s)8188-8196
P577publication date2005-09-07
P1433published inJournal of NeuroscienceQ1709864
P1476titlePotent spinal analgesia elicited through stimulation of NTS2 neurotensin receptors
P478volume25

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