| scholarly article | Q13442814 |
| P356 | DOI | 10.1074/JBC.M406406200 |
| P698 | PubMed publication ID | 15247248 |
| P50 | author | Bao-Liang Song | Q59691556 |
| P2093 | author name string | Peter C W Lee | |
| Russell A Debose-Boyd | |||
| Robert B Rawson | |||
| Navdar Sever | |||
| P2860 | cites work | The human LDL receptor: a cysteine-rich protein with multiple Alu sequences in its mRNA | Q24300736 |
| Crucial step in cholesterol homeostasis: sterols promote binding of SCAP to INSIG-1, a membrane protein that facilitates retention of SREBPs in ER | Q24305459 | ||
| Insig-2, a second endoplasmic reticulum protein that binds SCAP and blocks export of sterol regulatory element-binding proteins | Q24307390 | ||
| SREBP-1, a membrane-bound transcription factor released by sterol-regulated proteolysis | Q24310555 | ||
| Identification of complexes between the COOH-terminal domains of sterol regulatory element-binding proteins (SREBPs) and SREBP cleavage-activating protein | Q24320818 | ||
| Three mutations in sterol-sensing domain of SCAP block interaction with insig and render SREBP cleavage insensitive to sterols. | Q24543928 | ||
| Liver-specific mRNA for Insig-2 down-regulated by insulin: implications for fatty acid synthesis | Q24554492 | ||
| Replacement of serine-871 of hamster 3-hydroxy-3-methylglutaryl-CoA reductase prevents phosphorylation by AMP-activated kinase and blocks inhibition of sterol synthesis induced by ATP depletion | Q24564683 | ||
| A proteolytic pathway that controls the cholesterol content of membranes, cells, and blood | Q24614744 | ||
| Immunological evidence for eight spans in the membrane domain of 3-hydroxy-3-methylglutaryl coenzyme A reductase: implications for enzyme degradation in the endoplasmic reticulum | Q24643318 | ||
| In vivo action of the HRD ubiquitin ligase complex: mechanisms of endoplasmic reticulum quality control and sterol regulation | Q27929958 | ||
| HRD4/NPL4 is required for the proteasomal processing of ubiquitinated ER proteins | Q27939971 | ||
| Membrane topology of human insig-1, a protein regulator of lipid synthesis | Q28189898 | ||
| Accelerated degradation of HMG CoA reductase mediated by binding of insig-1 to its sterol-sensing domain | Q28204022 | ||
| The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor | Q28238069 | ||
| Sterol resistance in CHO cells traced to point mutation in SREBP cleavage-activating protein | Q28295187 | ||
| Regulation of the mevalonate pathway | Q29547763 | ||
| Regulated step in cholesterol feedback localized to budding of SCAP from ER membranes | Q33916842 | ||
| The sterol-sensing domain: multiple families, a unique role? | Q34121980 | ||
| Membrane-bound domain of HMG CoA reductase is required for sterol-enhanced degradation of the enzyme | Q34198309 | ||
| Mutant mammalian cells as tools to delineate the sterol regulatory element-binding protein pathway for feedback regulation of lipid synthesis | Q34497858 | ||
| Bisphosphonates and atherosclerosis | Q34581585 | ||
| Cdc48-Ufd1-Npl4: stuck in the middle with Ub. | Q34641420 | ||
| Proteolysis and sterol regulation | Q34762541 | ||
| Recurrent G-to-A substitution in a single codon of SREBP cleavage-activating protein causes sterol resistance in three mutant Chinese hamster ovary cell lines. | Q35925028 | ||
| Sterols regulate processing of carbohydrate chains of wild-type SREBP cleavage-activating protein (SCAP), but not sterol-resistant mutants Y298C or D443N. | Q36619009 | ||
| Role of 26S proteasome and HRD genes in the degradation of 3-hydroxy-3-methylglutaryl-CoA reductase, an integral endoplasmic reticulum membrane protein | Q37383994 | ||
| The novel cholesterol-lowering drug SR-12813 inhibits cholesterol synthesis via an increased degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase | Q41191925 | ||
| Three different rearrangements in a single intron truncate sterol regulatory element binding protein-2 and produce sterol-resistant phenotype in three cell lines. Role of introns in protein evolution | Q41344600 | ||
| Genetic analysis of hydroxymethylglutaryl-coenzyme A reductase regulated degradation | Q41749022 | ||
| Sterol-resistant transcription in CHO cells caused by gene rearrangement that truncates SREBP-2. | Q42806953 | ||
| Loss of transcriptional repression of three sterol-regulated genes in mutant hamster cells. | Q42815198 | ||
| Isolation of cholesterol-requiring mutant Chinese hamster ovary cells with defects in cleavage of sterol regulatory element-binding proteins at site 1. | Q42819162 | ||
| Diminished hepatic response to fasting/refeeding and liver X receptor agonists in mice with selective deficiency of sterol regulatory element-binding protein-1c | Q43848640 | ||
| Insig-dependent ubiquitination and degradation of mammalian 3-hydroxy-3-methylglutaryl-CoA reductase stimulated by sterols and geranylgeraniol | Q44620965 | ||
| Apomine, a novel hypocholesterolemic agent, accelerates degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase and stimulates low density lipoprotein receptor activity | Q44662103 | ||
| Topology of SREBP cleavage-activating protein, a polytopic membrane protein with a sterol-sensing domain | Q47921201 | ||
| Failure to cleave sterol regulatory element-binding proteins (SREBPs) causes cholesterol auxotrophy in Chinese hamster ovary cells with genetic absence of SREBP cleavage-activating protein. | Q53436589 | ||
| Transport-Dependent Proteolysis of SREBP | Q54231898 | ||
| P433 | issue | 41 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | SR12813 | Q27088861 |
| P304 | page(s) | 43136-43147 | |
| P577 | publication date | 2004-07-07 | |
| P1433 | published in | Journal of Biological Chemistry | Q867727 |
| P1476 | title | Isolation of mutant cells lacking Insig-1 through selection with SR-12813, an agent that stimulates degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase | |
| P478 | volume | 279 |
| Q37158312 | Alpha-tocopheryl succinate induces apoptosis by targeting ubiquinone-binding sites in mitochondrial respiratory complex II. |
| Q51796573 | Amplification of the gene for SCAP, coupled with Insig-1 deficiency, confers sterol resistance in mutant Chinese hamster ovary cells. |
| Q24652984 | Cholesterol feedback: from Schoenheimer's bottle to Scap's MELADL |
| Q34119006 | Control of cholesterol synthesis through regulated ER-associated degradation of HMG CoA reductase |
| Q46512348 | Degradation of HMG-CoA reductase in rat liver is cholesterol and ubiquitin independent |
| Q35931146 | Differential gene expression in the adrenals of normal and anencephalic fetuses and studies focused on the Fras-1-related extracellular matrix protein (FREM2) gene |
| Q26866577 | Dual functions of Insig proteins in cholesterol homeostasis |
| Q37173755 | Feedback regulation of cholesterol synthesis: sterol-accelerated ubiquitination and degradation of HMG CoA reductase |
| Q35451879 | Forward genetic screening for regulators involved in cholesterol synthesis using validation-based insertional mutagenesis |
| Q61810682 | Genetic and genomic analyses of testicular hypoplasia in Nellore cattle |
| Q37033150 | Geranylgeranyl-regulated transport of the prenyltransferase UBIAD1 between membranes of the ER and Golgi |
| Q24324257 | Gp78, a membrane-anchored ubiquitin ligase, associates with Insig-1 and couples sterol-regulated ubiquitination to degradation of HMG CoA reductase |
| Q51796054 | Hypoxia stimulates degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase through accumulation of lanosterol and hypoxia-inducible factor-mediated induction of insigs. |
| Q34411329 | Identification of Ubxd8 protein as a sensor for unsaturated fatty acids and regulator of triglyceride synthesis |
| Q24302444 | Insig required for sterol-mediated inhibition of Scap/SREBP binding to COPII proteins in vitro |
| Q28251165 | Insig-dependent ubiquitination and degradation of 3-hydroxy-3-methylglutaryl coenzyme a reductase stimulated by delta- and gamma-tocotrienols |
| Q37446808 | Insig-mediated, sterol-accelerated degradation of the membrane domain of hamster 3-hydroxy-3-methylglutaryl-coenzyme A reductase in insect cells |
| Q37463283 | Intramembrane glycine mediates multimerization of Insig-2, a requirement for sterol regulation in Chinese hamster ovary cells |
| Q40428087 | Isolation of sterol-resistant Chinese hamster ovary cells with genetic deficiencies in both Insig-1 and Insig-2. |
| Q36842225 | Lipid-regulated degradation of HMG-CoA reductase and Insig-1 through distinct mechanisms in insect cells. |
| Q51734264 | Manipulating Cholesterol Status Within Cells. |
| Q40210920 | Mutations within the membrane domain of HMG-CoA reductase confer resistance to sterol-accelerated degradation |
| Q24540515 | Proteasomal degradation of ubiquitinated Insig proteins is determined by serine residues flanking ubiquitinated lysines |
| Q37454290 | Regulated endoplasmic reticulum-associated degradation of a polytopic protein: p97 recruits proteasomes to Insig-1 before extraction from membranes |
| Q37866898 | Regulation of cholesterol and fatty acid synthesis |
| Q64998467 | SREBPs in Lipid Metabolism, Insulin Signaling, and Beyond. |
| Q28509016 | Schoenheimer effect explained--feedback regulation of cholesterol synthesis in mice mediated by Insig proteins |
| Q37270579 | Sterol-induced dislocation of 3-hydroxy-3-methylglutaryl coenzyme A reductase from membranes of permeabilized cells |
| Q46884435 | Sterol-regulated ubiquitination and degradation of Insig-1 creates a convergent mechanism for feedback control of cholesterol synthesis and uptake |
| Q60920750 | The Potential of Isoprenoids in Adjuvant Cancer Therapy to Reduce Adverse Effects of Statins |
| Q36466836 | The lifetime of UDP-galactose:ceramide galactosyltransferase is controlled by a distinct endoplasmic reticulum-associated degradation (ERAD) regulated by sigma-1 receptor chaperones |
| Q35218996 | The prenyltransferase UBIAD1 is the target of geranylgeraniol in degradation of HMG CoA reductase |
| Q47372629 | UbiA prenyltransferase domain-containing protein-1 modulates HMG-CoA reductase degradation to coordinate synthesis of sterol and nonsterol isoprenoids |
| Q47436128 | Underlying mechanisms for sterol-induced ubiquitination and ER-associated degradation of HMG CoA reductase. |
| Q24655209 | Unsaturated fatty acids inhibit proteasomal degradation of Insig-1 at a postubiquitination step |
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