Advances in the structural biology, design and clinical development of Bcr-Abl kinase inhibitors for the treatment of chronic myeloid leukaemia

scientific article

Advances in the structural biology, design and clinical development of Bcr-Abl kinase inhibitors for the treatment of chronic myeloid leukaemia is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

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P356DOI10.1016/J.BBAPAP.2005.07.040
P698PubMed publication ID16172030
P5875ResearchGate publication ID7591832

P2093author name stringJürgen Mestan
Sandra W Cowan-Jacob
Paul William Manley
P433issue1-2
P407language of work or nameEnglishQ1860
P921main subjectleukemiaQ29496
structural biologyQ908902
P304page(s)3-13
P577publication date2005-12-30
P1433published inBiochimica et Biophysica ActaQ864239
P1476titleAdvances in the structural biology, design and clinical development of Bcr-Abl kinase inhibitors for the treatment of chronic myeloid leukaemia
P478volume1754

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cites work (P2860)
Q36892617A critical appraisal of conventional and investigational drug therapy in patients with hypereosinophilic syndrome and clonal eosinophilia
Q33817421A phase I study of single-agent nilotinib or in combination with imatinib in patients with imatinib-resistant gastrointestinal stromal tumors
Q39235281An overview of quinoline as a privileged scaffold in cancer drug discovery
Q41980844BCR-ABL1 compound mutations combining key kinase domain positions confer clinical resistance to ponatinib in Ph chromosome-positive leukemia
Q42222524Bcr-Abl tyrosine kinase inhibitors- current status
Q38133575Changes in molecular biology of chronic myeloid leukemia in tyrosine kinase inhibitor era.
Q39516382Choosing the best second-line tyrosine kinase inhibitor in imatinib-resistant chronic myeloid leukemia patients harboring Bcr-Abl kinase domain mutations: how reliable is the IC₅₀?
Q36731265Chronic Myeloid Leukaemia in The 21st Century
Q37163550Chronic myeloid leukemia: an update of concepts and management recommendations of European LeukemiaNet
Q37498272Class effects of tyrosine kinase inhibitors in the treatment of chronic myeloid leukemia
Q83834361Clone wars in CML
Q81241473Comparison of nilotinib and imatinib inhibition of FMS receptor signaling, macrophage production and osteoclastogenesis
Q36801573Discoidin domain receptor-1 and periostin: new players in chronic kidney disease
Q30489704Discovery and structural analysis of Eph receptor tyrosine kinase inhibitors
Q53054357Effect of nilotinib on airway remodeling in a murine model of chronic asthma.
Q54365521Effect of nilotinib on bleomycin-induced acute lung injury and pulmonary fibrosis in mice.
Q36445910Effective and selective inhibition of chronic myeloid leukemia primitive hematopoietic progenitors by the dual Src/Abl kinase inhibitor SKI-606.
Q92631070Emerging Developments in Targeting Proteotoxicity in Neurodegenerative Diseases
Q39657684Expanding the Diversity of Allosteric Bcr-Abl Inhibitors
Q33285468Imatinib mesylate and nilotinib (AMN107) exhibit high-affinity interaction with ABCG2 on primitive hematopoietic stem cells.
Q46079038In silico profiling of tyrosine kinases binding specificity and drug resistance using Monte Carlo simulations with the ensembles of protein kinase crystal structures.
Q35071010Inhibition of PI3K/mTOR overcomes nilotinib resistance in BCR-ABL1 positive leukemia cells through translational down-regulation of MDM2.
Q36997348Ligand binding site identification by higher dimension molecular dynamics
Q38081983Management of gastrointestinal stromal tumors
Q46703844Molecular basis explanation for imatinib resistance of BCR-ABL due to T315I and P-loop mutations from molecular dynamics simulations
Q38166071Molecular basis of cancer-therapy-induced cardiotoxicity: introducing microRNA biomarkers for early assessment of subclinical myocardial injury
Q42015762Nilotinib attenuates renal injury and prolongs survival in chronic kidney disease
Q34130343Nilotinib for the treatment of chronic myeloid leukemia: An evidence-based review
Q90190658Nilotinib, an approved leukemia drug, inhibits smoothened signaling in Hedgehog-dependent medulloblastoma
Q36906387Nilotinib-Induced Keratosis Pilaris
Q39768989Novel imatinib derivatives with altered specificity between Bcr-Abl and FMS, KIT, and PDGF receptors
Q37763106Optimizing outcomes in patients with chronic myeloid leukemia in chronic phase: comparative safety profiles of newer agents
Q48168059Pathological role of a point mutation (T315I) in BCR-ABL1 protein-A computational insight.
Q40252880Plasma inhibitory activity (PIA): a pharmacodynamic assay reveals insights into the basis for cytotoxic response to FLT3 inhibitors
Q38957115Pneumatosis intestinalis during chemotherapy with nilotinib in a patient with chronic myeloid leukemia who tested positive for anti-topoisomerase I antibodies
Q41130127Preclinical anticancer activity of the potent, oral Src inhibitor AZD0530
Q43213931Rapid synthesis of Abelson tyrosine kinase inhibitors using click chemistry
Q35242120Real-time analysis of imatinib- and dasatinib-induced effects on chronic myelogenous leukemia cell interaction with fibronectin
Q37118177Reengineering dendritic cell-based anti-cancer vaccines
Q38841623Ruxolitinib induces autophagy in chronic myeloid leukemia cells.
Q34622576Second generation inhibitors of BCR-ABL for the treatment of imatinib-resistant chronic myeloid leukaemia
Q41002630Selective Inhibition of Human Equilibrative and Concentrative Nucleoside Transporters by BCR-ABL Kinase Inhibitors: IDENTIFICATION OF KEY hENT1 AMINO ACID RESIDUES FOR INTERACTION WITH BCR-ABL KINASE INHIBITORS.
Q37235024Somatic pharmacogenomics in cancer
Q44296766Src kinase-induced phosphorylation of annexin A2 mediates glucocorticoid resistance in MLL-rearranged infant acute lymphoblastic leukemia.
Q27640723Structural biology contributions to the discovery of drugs to treat chronic myelogenous leukaemia
Q29547395Targeting cancer with small molecule kinase inhibitors
Q36983136Targeting epidermal growth factor receptor and SRC pathways in head and neck cancer
Q37896606The current role of high-dose imatinib in chronic myeloid leukemia patients, newly diagnosed or resistant to standard dose
Q94544586The effects of combination treatments on drug resistance in chronic myeloid leukaemia: an evaluation of the tyrosine kinase inhibitors axitinib and asciminib
Q37139171The role of mitochondrial DNA damage and repair in the resistance of BCR/ABL-expressing cells to tyrosine kinase inhibitors
Q36498802The second generation of BCR-ABL tyrosine kinase inhibitors
Q37406014Tumour antigen-targeted immunotherapy for chronic myeloid leukaemia: is it still viable?
Q52567954Tyrosine Kinase Inhibitors in the Treatment of Chronic-Phase CML: Strategies for Frontline Decision-making.
Q27478101c-Src protein kinase inhibitors block assembly and maturation of dengue virus

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