Src kinase-induced phosphorylation of annexin A2 mediates glucocorticoid resistance in MLL-rearranged infant acute lymphoblastic leukemia.

scientific article

Src kinase-induced phosphorylation of annexin A2 mediates glucocorticoid resistance in MLL-rearranged infant acute lymphoblastic leukemia. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/LEU.2012.372
P698PubMed publication ID23334362

P50authorSandra Sofia Mimoso PinhançosQ85925179
P2093author name stringP Schneider
R Pieters
J A P Spijkers-Hagelstein
R W Stam
P2860cites workEndothelial cell annexin A2 regulates polyubiquitination and degradation of its binding partner S100A10/p11Q24647711
Advances in the structural biology, design and clinical development of Bcr-Abl kinase inhibitors for the treatment of chronic myeloid leukaemiaQ28273146
Annexin 2 has a dual role as regulator and effector of v-Src in cell transformationQ28570986
Tyrosine 23 phosphorylation-dependent cell-surface localization of annexin A2 is required for invasion and metastases of pancreatic cancerQ28740545
GenePattern 2.0Q29614171
Discovery of a novel, potent, and Src family-selective tyrosine kinase inhibitor. Study of Lck- and FynT-dependent T cell activationQ29617586
Dasatinib: an anti-tumour agent via Src inhibitionQ33393621
Anxa2 plays a critical role in enhanced invasiveness of the multidrug resistant human breast cancer cellsQ33504768
Novel dual Src/Abl inhibitors for hematologic and solid malignanciesQ34121339
Phase II trial of saracatinib (AZD0530), an oral SRC-inhibitor for the treatment of patients with hormone receptor-negative metastatic breast cancerQ35569694
Tyrosine kinase inhibitors: a new approach for asthmaQ35692069
H3K79 methylation profiles define murine and human MLL-AF4 leukemiasQ36991857
Targeting FLT3 in primary MLL-gene-rearranged infant acute lymphoblastic leukemiaQ38324952
Overexpression of Annexin II affects the proliferation, apoptosis, invasion and production of proangiogenic factors in multiple myelomaQ39827635
Lyn is an important component of the signal transduction pathway specific to FLT3/ITD and can be a therapeutic target in the treatment of AML with FLT3/ITD.Q40182148
Design, synthesis, and structure-activity relationship exploration of 1-substituted 4-aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-one analogues as inhibitors of the annexin A2-S100A10 protein interaction.Q42032160
Mononuclear cells contaminating acute lymphoblastic leukaemic samples tested for cellular drug resistance using the methyl-thiazol-tetrazolium assayQ42032841
Gene expression profiling-based dissection of MLL translocated and MLL germline acute lymphoblastic leukemia in infantsQ42643970
Association of high-level MCL-1 expression with in vitro and in vivo prednisone resistance in MLL-rearranged infant acute lymphoblastic leukemiaQ43228851
Patient stratification based on prednisolone-vincristine-asparaginase resistance profiles in children with acute lymphoblastic leukemiaQ44567802
In vitro drug-resistance profile in infant acute lymphoblastic leukemia in relation to age, MLL rearrangements and immunophenotypeQ44719683
Requirement of Src kinases Lyn, Hck and Fgr for BCR-ABL1-induced B-lymphoblastic leukemia but not chronic myeloid leukemiaQ44851706
Polymeric nanoparticles for sustained down-regulation of annexin A2 inhibit prostate tumor growthQ47770884
A treatment protocol for infants younger than 1 year with acute lymphoblastic leukaemia (Interfant-99): an observational study and a multicentre randomised trial.Q53232081
Elevated S100A8/S100A9 expression causes glucocorticoid resistance in MLL-rearranged infant acute lymphoblastic leukemia.Q54327060
A phase II trial of the Src kinase inhibitor saracatinib (AZD0530) in patients with metastatic or locally advanced gastric or gastro esophageal junction (GEJ) adenocarcinoma: a trial of the PMH phase II consortium.Q54604759
A phase I/II study of the Src inhibitor saracatinib (AZD0530) in combination with gemcitabine in advanced pancreatic cancerQ61872222
Relation between age, immunophenotype and in vitro drug resistance in 395 children with acute lymphoblastic leukemia--implications for treatment of infantsQ77299310
Structural basis for selective inhibition of Src family kinases by PP1Q78192599
P433issue5
P921main subjectleukemiaQ29496
phosphorylationQ242736
glucocorticoid resistanceQ11798714
P304page(s)1063-1071
P577publication date2012-12-28
P1433published inLeukemiaQ6534498
P1476titleSrc kinase-induced phosphorylation of annexin A2 mediates glucocorticoid resistance in MLL-rearranged infant acute lymphoblastic leukemia
P478volume27

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cites work (P2860)
Q53627616A distinct set of long non-coding RNAs in childhood MLL-rearranged acute lymphoblastic leukemia: biology and epigenetic target.
Q37586765Annexin A2: its molecular regulation and cellular expression in cancer development
Q52652985Calcium channel α2δ1 subunit as a novel biomarker for diagnosis of hepatocellular carcinoma.
Q39108160Chemical genomic screening identifies LY294002 as a modulator of glucocorticoid resistance in MLL-rearranged infant ALL.
Q39377574Clinical and prognostic role of annexin A2 in adamantinomatous craniopharyngioma
Q92463707Crucial role of Anxa2 in cancer progression: highlights on its novel regulatory mechanism
Q92347954Differential network analysis and protein-protein interaction study reveals active protein modules in glucocorticoid resistance for infant acute lymphoblastic leukemia
Q35805960Disruption of Annexin II /p11 Interaction Suppresses Leukemia Cell Binding, Homing and Engraftment, and Sensitizes the Leukemia Cells to Chemotherapy
Q41712023Extracellular vesicles released from cells exposed to reactive oxygen species increase annexin A2 expression and survival of target cells exposed to the same conditions
Q47152778Heterogeneous Stromal Signaling within the Tumor Microenvironment Controls the Metastasis of Pancreatic Cancer.
Q38091585In focus: MLL-rearranged leukemia.
Q89873581Integrated bioinformatics analysis of the crucial candidate genes and pathways associated with glucocorticoid resistance in acute lymphoblastic leukemia
Q98947319Integrative genomic analyses reveal mechanisms of glucocorticoid resistance in acute lymphoblastic leukemia
Q35176372LCK over-expression drives STAT5 oncogenic signaling in PAX5 translocated BCP-ALL patients
Q104104744Mesoglycan exerts its fibrinolytic effect through the activation of annexin A2
Q53763092Network-based expression analysis reveals key genes related to glucocorticoid resistance in infant acute lymphoblastic leukemia.
Q37377476Rack1 Mediates the Interaction of P-Glycoprotein with Anxa2 and Regulates Migration and Invasion of Multidrug-Resistant Breast Cancer Cells
Q64275561Rack1 mediates tyrosine phosphorylation of Anxa2 by Src and promotes invasion and metastasis in drug-resistant breast cancer cells
Q41870703Reactive oxygen species exert opposite effects on Tyr23 phosphorylation of the nuclear and cortical pools of annexin A2
Q60947864S100A10 and Cancer Hallmarks: Structure, Functions, and its Emerging Role in Ovarian Cancer
Q38217719Src family kinases and their role in hematological malignancies
Q35942561The NIH-Industry New Therapeutic Uses Pilot Program: Demonstrating the Power of Crowdsourcing
Q37730023The evolution of clinical trials for infant acute lymphoblastic leukemia.
Q38423064The inflammatory actions of coagulant and fibrinolytic proteases in disease

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