Oncogenic Smad3 signaling induced by chronic inflammation is an early event in ulcerative colitis-associated carcinogenesis

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Oncogenic Smad3 signaling induced by chronic inflammation is an early event in ulcerative colitis-associated carcinogenesis is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1002/IBD.21395
P698PubMed publication ID20602465
P5875ResearchGate publication ID45093542

P50authorToshifumi HibiQ91933653
P2093author name stringKatsuyoshi Matsuoka
Yasushi Iwao
Kazuichi Okazaki
Koichi Matsuzaki
Miki Murata
Toshihito Seki
Seiji Kawamata
P2860cites workTGF-beta signal transductionQ22003891
Nuclear CDKs drive Smad transcriptional activation and turnover in BMP and TGF-beta pathwaysQ24317164
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Smad-dependent and Smad-independent pathways in TGF-beta family signallingQ28208250
Reversible Smad-dependent signaling between tumor suppression and oncogenesisQ28564212
Pin1 promotes transforming growth factor-beta-induced migration and invasionQ33581891
Regulation of Smad activityQ33830190
Role of cytokines in the pathogenesis of inflammatory bowel diseaseQ33896046
Effect of 5-aminosalicylate use on colorectal cancer and dysplasia risk: a systematic review and metaanalysis of observational studiesQ33987498
Serum concentrations of tumour necrosis factor alpha in childhood chronic inflammatory bowel diseaseQ34394083
Increased expression of c-myc proto-oncogene in biopsies of ulcerative colitis and Crohn's colitisQ34395290
A cytokine-mediated link between innate immunity, inflammation, and cancerQ34625152
Ulcerative colitis and colorectal cancer. A population-based studyQ34634203
A mechanism of repression of TGFbeta/ Smad signaling by oncogenic RasQ35193411
Genomic instability is an early event during the progression pathway of ulcerative-colitis-related neoplasiaQ35787099
Inflammation and cancer IV. Colorectal cancer in inflammatory bowel disease: the role of inflammationQ35803526
Smad3 reduces susceptibility to hepatocarcinoma by sensitizing hepatocytes to apoptosis through downregulation of Bcl-2.Q37257648
Signaling cross-talk between TGF-beta/BMP and other pathwaysQ37323342
A negative feedback control of transforming growth factor-beta signaling by glycogen synthase kinase 3-mediated Smad3 linker phosphorylation at Ser-204.Q37338950
Phospho-control of TGF-beta superfamily signalingQ37359953
Transforming growth factor-{beta}-inducible phosphorylation of Smad3Q39883712
Dysplasia and Malignancy in Inflammatory Bowel DiseaseQ40177007
TGF-beta and HGF transmit the signals through JNK-dependent Smad2/3 phosphorylation at the linker regionsQ40522842
Severity of inflammation is a risk factor for colorectal neoplasia in ulcerative colitis.Q44755672
Hepatitis B virus X protein shifts human hepatic transforming growth factor (TGF)-beta signaling from tumor suppression to oncogenesis in early chronic hepatitis B.Q45386179
Inhibition of c-Jun NH2-terminal kinase switches Smad3 signaling from oncogenesis to tumor- suppression in rat hepatocellular carcinoma.Q46024086
5-aminosalicylic acid given in the remission stage of colitis suppresses colitis-associated cancer in a mouse colitis modelQ46920668
Cyclin-dependent kinases regulate the antiproliferative function of SmadsQ47229633
Dysplasia in inflammatory bowel disease: standardized classification with provisional clinical applications.Q50714369
Smad2 and Smad3 phosphorylated at both linker and COOH-terminal regions transmit malignant TGF-beta signal in later stages of human colorectal cancer.Q53389037
Comparative analysis of histology, DNA content, p53 and Ki-ras mutations in colectomy specimens with long-standing ulcerative colitis.Q53435738
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectinflammationQ101991
carcinogenesisQ1637543
P304page(s)683-95
P577publication date2011-03-01
P1433published inInflammatory Bowel DiseasesQ15749161
P1476titleOncogenic Smad3 signaling induced by chronic inflammation is an early event in ulcerative colitis-associated carcinogenesis
P478volume17

Reverse relations

cites work (P2860)
Q53234120Aberrant expression of p-Smad3 in oral carcinogenesis.
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Q37998023Differential Regulation of TGF-β/Smad Signaling in Hepatic Stellate Cells between Acute and Chronic Liver Injuries
Q37709089IL-37 suppresses hepatocellular carcinoma growth by converting pSmad3 signaling from JNK/pSmad3L/c-Myc oncogenic signaling to pSmad3C/P21 tumor-suppressive signaling
Q50662194Inactivation of JNK2 as carcinogenic factor in colitis-associated and sporadic colorectal carcinogenesis.
Q34662592Inflammatory colonic carcinogenesis: a review on pathogenesis and immunosurveillance mechanisms in ulcerative colitis
Q38266863Linker phosphorylation of Smad3 promotes fibro-carcinogenesis in chronic viral hepatitis of hepatocellular carcinoma
Q52351133Mitogen-activated protein kinase inhibitors reduce the nuclear accumulation of phosphorylated Smads by inhibiting Imp 7 or Imp 8 in HepG2 cells.
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