Influence of major structural features of tocopherols and tocotrienols on their omega-oxidation by tocopherol-omega-hydroxylase

scientific article

Influence of major structural features of tocopherols and tocotrienols on their omega-oxidation by tocopherol-omega-hydroxylase is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1194/JLR.M600514-JLR200
P698PubMed publication ID17284776

P2093author name stringRobert S Parker
Timothy J Sontag
P2860cites workRole of human CYP4F2 in hepatic catabolism of the proinflammatory agent leukotriene B4Q22004251
Expression and molecular cloning of human liver leukotriene B4 omega-hydroxylase (CYP4F2) geneQ22010557
Cloning and expression of a novel form of leukotriene B4 omega-hydroxylase from human liverQ24313469
Molecular basis of vitamin E action. Tocotrienol potently inhibits glutamate-induced pp60(c-Src) kinase activation and death of HT4 neuronal cellsQ28142722
Induction of apoptosis in human breast cancer cells by tocopherols and tocotrienolsQ28142959
Comparative study on the action of tocopherols and tocotrienols as antioxidant: chemical and physical effectsQ28183114
Cholesterol is superior to 7-ketocholesterol or 7 alpha-hydroxycholesterol as an allosteric activator for acyl-coenzyme A:cholesterol acyltransferase 1Q28203844
Ligand specificity in the CRAL-TRIO protein familyQ28206484
The chemistry and antioxidant properties of tocopherols and tocotrienolsQ28291396
Free radical recycling and intramembrane mobility in the antioxidant properties of alpha-tocopherol and alpha-tocotrienolQ28298967
Increased atherosclerosis in hyperlipidemic mice deficient in alpha -tocopherol transfer protein and vitamin EQ28344980
Characterization of human liver leukotriene B(4) omega-hydroxylase P450 (CYP4F2).Q31389061
Alpha- and gamma-tocotrienols are metabolized to carboxyethyl-hydroxychroman derivatives and excreted in human urineQ32051277
d-alpha-tocopherol inhibition of vascular smooth muscle cell proliferation occurs at physiological concentrations, correlates with protein kinase C inhibition, and is independent of its antioxidant propertiesQ33654586
Allosteric phenomena in cytochrome P450-catalyzed monooxygenationsQ34370833
gamma-tocopherol and its major metabolite, in contrast to alpha-tocopherol, inhibit cyclooxygenase activity in macrophages and epithelial cellsQ35307368
Analysis of human cytochrome P450 3A4 cooperativity: construction and characterization of a site-directed mutant that displays hyperbolic steroid hydroxylation kineticsQ36481303
A new endogenous natriuretic factor: LLU-alphaQ37567918
Tocopherols are metabolized in HepG2 cells by side chain omega-oxidation and consecutive beta-oxidationQ40794302
omega-hydroxylation activity toward leukotriene B(4) and polyunsaturated fatty acids in the human hepatoblastoma cell line, HepG2, and human lung adenocarcinoma cell line, A549.Q40845440
Alpha-tocopherol affects the urinary and biliary excretion of 2,7,8-trimethyl-2 (2'-carboxyethyl)-6-hydroxychroman, gamma-tocopherol metabolite, in ratsQ43658026
The nitration product 5-nitro-gamma-tocopherol is increased in the Alzheimer brainQ43915384
Cytochrome P450 omega-hydroxylase pathway of tocopherol catabolism. Novel mechanism of regulation of vitamin E statusQ43984576
Measurement of vitamin E metabolites by high-performance liquid chromatography during high-dose administration of alpha-tocopherolQ44355787
Cell death caused by selenium deficiency and protective effect of antioxidantsQ44530918
Selective accumulation of alpha-tocopherol in Drosophila is associated with cytochrome P450 tocopherol-omega-hydroxylase activity but not alpha-tocopherol transfer proteinQ46804639
Model for the interaction of membrane-bound substrates and enzymes. Hydrolysis of ganglioside GD1a by sialidase of neuronal membranes isolated from calf brainQ48888942
Activation of CYP3A4: evidence for the simultaneous binding of two substrates in a cytochrome P450 active siteQ50120037
P433issue5
P407language of work or nameEnglishQ1860
P304page(s)1090-8
P577publication date2007-05-01
P1433published inJournal of Lipid ResearchQ6295449
P1476titleInfluence of major structural features of tocopherols and tocotrienols on their omega-oxidation by tocopherol-omega-hydroxylase
P478volume48

Reverse relations

cites work (P2860)
Q38062748A history of vitamin E.
Q45985321A novel mechanism of natural vitamin E tocotrienol activity: involvement of ERbeta signal transduction.
Q46161655Activation of autophagy and AMPK by gamma-tocotrienol suppresses the adipogenesis in human adipose derived stem cells
Q41872448Alpha-tocopherol beta-oxidation localized to rat liver mitochondria.
Q37289028Alpha-tocopherol modulates genes involved in hepatic xenobiotic pathways in mice
Q35067280Altered vitamin E status in Niemann-Pick type C disease
Q24322624CYP4F2 is a vitamin K1 oxidase: An explanation for altered warfarin dose in carriers of the V433M variant
Q33814811Cancer-preventive activities of tocopherols and tocotrienols
Q43451894Chain length of dietary alkylresorcinols affects their in vivo elimination kinetics in rats
Q24300669Common Variants of Cytochrome P450 4F2 Exhibit Altered Vitamin E-Ω-Hydroxylase Specific Activity
Q46592423Comparison of different vehicles to study the effect of tocopherols on gene expression in intestinal cells
Q28068513Complexity of vitamin E metabolism
Q36573346Cytochrome P450 regulation by α-tocopherol in Pxr-null and PXR-humanized mice
Q80371911Cytochrome P450-dependent metabolism of vitamin E isoforms is a critical determinant of their tissue concentrations in rats
Q34282367Deuterium-labeled phylloquinone fed to α-tocopherol-injected rats demonstrates sensitivity of low phylloquinone-containing tissues to menaquinone-4 depletion
Q36387257Disruption of P450-mediated vitamin E hydroxylase activities alters vitamin E status in tocopherol supplemented mice and reveals extra-hepatic vitamin E metabolism
Q36122179Disruption of mouse cytochrome p450 4f14 (Cyp4f14 gene) causes severe perturbations in vitamin E metabolism
Q46002895Effect of bilayer phospholipid composition and curvature on ligand transfer by the alpha-tocopherol transfer protein.
Q54399979Effects of Delta-tocotrienol Supplementation on Liver Enzymes, Inflammation, Oxidative stress and Hepatic Steatosis in Patients with Nonalcoholic Fatty Liver Disease.
Q36197858Enhancement of lipid peroxidation and its amelioration by vitamin E in a subject with mutations in the SBP2 gene
Q38715276Essential Dietary Bioactive Lipids in Neuroinflammatory Diseases
Q37109910Expression of CYP4F2 in human liver and kidney: assessment using targeted peptide antibodies
Q39871182Gamma-tocotrienol and gamma-tocopherol are primarily metabolized to conjugated 2-(beta-carboxyethyl)-6-hydroxy-2,7,8-trimethylchroman and sulfated long-chain carboxychromanols in rats.
Q36929610Human cytochrome p450 family 4 enzymes: function, genetic variation and regulation
Q34493004Increased vitamin E intake is associated with higher alpha-tocopherol concentration in the maternal circulation but higher alpha-carboxyethyl hydroxychroman concentration in the fetal circulation.
Q27000172Intracellular transport of fat-soluble vitamins A and E
Q37068624Long-chain carboxychromanols, metabolites of vitamin E, are potent inhibitors of cyclooxygenases
Q37076463Mechanisms for the prevention of vitamin E excess
Q48362689Metabolic syndrome increases dietary α-tocopherol requirements as assessed using urinary and plasma vitamin E catabolites: a double-blind, crossover clinical trial.
Q33998131Natural forms of vitamin E: metabolism, antioxidant, and anti-inflammatory activities and their role in disease prevention and therapy
Q42084725Nonlinear absorption kinetics of self-emulsifying drug delivery systems (SEDDS) containing tocotrienols as lipophilic molecules: in vivo and in vitro studies
Q36231628Novel metabolites and roles for α-tocopherol in humans and mice discovered by mass spectrometry-based metabolomics
Q34539068Nutrigenomics of extra-virgin olive oil: A review.
Q38078754Optimal dosing of warfarin and other coumarin anticoagulants: the role of genetic polymorphisms
Q59485938Phytochemical contents and oxidative stability of oils from non-traditional sources
Q35639232Promotion of plasma membrane repair by vitamin E.
Q26765469Regulation of Obesity and Metabolic Complications by Gamma and Delta Tocotrienols
Q90656773Rifampicin, not vitamin E, suppresses parenteral nutrition-associated liver disease development through the pregnane X receptor pathway in piglets
Q36580534Role of Cytochrome P450 Hydroxylase in the Decreased Accumulation of Vitamin E in Muscle from Turkeys Compared to that from Chickens.
Q47157084Scientific Opinion on Dietary Reference Values for vitamin E as α-tocopherol
Q37399991Sex differences in the inhibition of gamma-tocopherol metabolism by a single dose of dietary sesame oil in healthy subjects.
Q37682791So many options but one choice: the human body prefers alpha-tocopherol. A matter of stereochemistry
Q30392836Structural control of cytochrome P450-catalyzed ω-hydroxylation
Q53053971Structure-Function Relationship Studies In Vitro Reveal Distinct and Specific Effects of Long-Chain Metabolites of Vitamin E.
Q38742088The long chain α-tocopherol metabolite α-13'-COOH and γ-tocotrienol induce P-glycoprotein expression and activity by activation of the pregnane X receptor in the intestinal cell line LS 180.
Q60934196The relationship between vitamin C status, the gut-liver axis, and metabolic syndrome
Q82284608Tissue distribution of α- and γ-tocotrienol and γ-tocopherol in rats and interference with their accumulation by α-tocopherol
Q51803670Tocopherol and annatto tocotrienols distribution in laying-hen body.
Q36231625Urinary α-carboxyethyl hydroxychroman can be used as a predictor of α-tocopherol adequacy, as demonstrated in the Energetics Study
Q58320258Vitamin E
Q39411586Vitamin E and Alzheimer's Disease-Is It Time for Personalized Medicine?
Q38764248Vitamin E and Phosphoinositides Regulate the Intracellular Localization of the Hepatic α-Tocopherol Transfer Protein
Q89525397Vitamin E and cancer prevention: Studies with different forms of tocopherols and tocotrienols
Q26796303Vitamin E function and requirements in relation to PUFA
Q37618797Vitamin E is essential for Purkinje neuron integrity
Q33939835Vitamin E status and metabolism in adult and aged aryl hydrocarbon receptor null mice.
Q24197764Vitamin E supplementation for preventing recurrent stroke and other vascular events in patients with stroke or transient ischaemic attack
Q24676043Vitamin E, antioxidant and nothing more
Q35648953Why tocotrienols work better: insights into the in vitro anti-cancer mechanism of vitamin E.
Q42549132gamma-Tocotrienol ameliorates intestinal radiation injury and reduces vascular oxidative stress after total-body irradiation by an HMG-CoA reductase-dependent mechanism
Q50968871α-Tocopherol does not accelerate depletion of γ-tocopherol and tocotrienol or excretion of their metabolites in rats.
Q35529243α-Tocopherol injections in rats up-regulate hepatic ABC transporters, but not cytochrome P450 enzymes
Q58800216α-Tocopherol transfer protein does not regulate the cellular uptake and intracellular distribution of α- and γ-tocopherols and -tocotrienols in cultured liver cells
Q36408016δ-Tocopherol reduces lipid accumulation in Niemann-Pick type C1 and Wolman cholesterol storage disorders
Q37324706ω-Hydroxylation of phylloquinone by CYP4F2 is not increased by α-tocopherol.

Search more.