The immunological basis for treatment of stiff person syndrome

scientific article published on October 12, 2010

The immunological basis for treatment of stiff person syndrome is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.JNEUROIM.2010.09.014
P953full work available at URLhttps://api.elsevier.com/content/article/PII:S0165572810004339?httpAccept=text/plain
https://api.elsevier.com/content/article/PII:S0165572810004339?httpAccept=text/xml
P3181OpenCitations bibliographic resource ID4707494
P698PubMed publication ID20943276

P50authorChristian GeisQ89247282
Trygve HolmøyQ64539783
P2860cites workVulnerability of human neurons to T cell-mediated cytotoxicityQ73552887
Presynaptic impairment of cerebellar inhibitory synapses by an autoantibody to glutamate decarboxylaseQ73720580
Pathological evidence of encephalomyelitis in the stiff man syndrome with anti-GAD antibodiesQ74395832
T-cell reactivity to glutamic acid decarboxylase in stiff-man syndrome and cerebellar ataxia associated with polyendocrine autoimmunityQ74666138
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GAD65-Reactive T cells in a non-diabetic stiff-man syndrome patientQ77756392
Selective suppression of cerebellar GABAergic transmission by an autoantibody to glutamic acid decarboxylaseQ78115533
Specific antibody index in cerebrospinal fluid from patients with central and peripheral paraneoplastic neurological syndromesQ79577556
Analysis of multiple sclerosis cerebrospinal fluid reveals a continuum of clonally related antibody-secreting cells that are predominantly plasma blastsQ81588164
GAD65 IgG autoantibodies in stiff person syndrome: clonality, avidity and persistenceQ81661292
Successful treatment with rituximab in a patient with stiff-person syndrome complicated by dysthyroid ophthalmopathyQ82716989
Stiff person syndrome associated with lower motor neuron disease and infiltration of cytotoxic T cells in the spinal cordQ84251277
Monozygotic twins with stiff person syndrome and autoimmune thyroiditis: rituximab inefficacy in a double-blind, randomised, placebo controlled crossover studyQ84393835
Long-lived plasma cells and memory B cells produce pathogenic anti-GAD65 autoantibodies in Stiff Person SyndromeQ21136358
The synaptic vesicle-associated protein amphiphysin is the 128-kD autoantigen of Stiff-Man syndrome with breast cancerQ24680318
Autoimmunity to gephyrin in Stiff-Man syndromeQ28145724
Autoimmunity in stiff-Man syndrome with breast cancer is targeted to the C-terminal region of human amphiphysin, a protein similar to the yeast proteins, Rvs167 and Rvs161Q28247444
Decreased synaptic vesicle recycling efficiency and cognitive deficits in amphiphysin 1 knockout miceQ28510217
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Distinct antigenic features of linear epitopes at the N-terminus and C-terminus of 65 kDa glutamic acid decarboxylase (GAD65): implications for autoantigen modification during pathogenesisQ30854842
Autoimmunity to GABAA-receptor-associated protein in stiff-person syndromeQ33258079
Intra-cerebral injection of neuromyelitis optica immunoglobulin G and human complement produces neuromyelitis optica lesions in mice.Q33656297
The structural era of endocytosisQ33683033
The stiff man and stiff man plus syndromesQ33719054
Characterization of CD4+ T cells specific for glutamic acid decarboxylase (GAD65) and proinsulin in a patient with stiff-person syndrome but without type 1 diabetesQ33884262
Cellular immunity to a determinant common to glutamate decarboxylase and coxsackie virus in insulin-dependent diabetesQ34159440
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Demonstration of functional coupling between gamma -aminobutyric acid (GABA) synthesis and vesicular GABA transport into synaptic vesiclesQ34183366
Central nervous system destruction mediated by glutamic acid decarboxylase-specific CD4+ T cellsQ34338895
Control of glial immune function by neuronsQ34398649
The clinical spectrum of anti-GAD antibody-positive patients with stiff-person syndromeQ34512042
Identification of the 64K autoantigen in insulin-dependent diabetes as the GABA-synthesizing enzyme glutamic acid decarboxylaseQ34566310
Advances in the pathogenesis and treatment of patients with stiff person syndromeQ34589713
High definition profiling of autoantibodies to glutamic acid decarboxylases GAD65/GAD67 in stiff-person syndromeQ34719788
GAD treatment and insulin secretion in recent-onset type 1 diabetesQ34848774
Cytomegalovirus in autoimmunity: T cell crossreactivity to viral antigen and autoantigen glutamic acid decarboxylaseQ35049679
Intrathecal pathogenic anti-aquaporin-4 antibodies in early neuromyelitis opticaQ35234452
Presynaptic inhibition of cerebellar GABAergic transmission by glutamate decarboxylase autoantibodies in progressive cerebellar ataxiaQ35461004
Humoral and cellular immune parameters before and during immunosuppressive therapy of a patient with stiff-man syndrome and insulin dependent diabetes mellitus.Q36318504
Review of 23 patients affected by the stiff man syndrome: clinical subdivision into stiff trunk (man) syndrome, stiff limb syndrome, and progressive encephalomyelitis with rigidityQ36318955
Neuropathology and binding studies in anti-amphiphysin-associated stiff-person syndromeQ48248500
Transport of CSF antibodies to Galpha subunits across neural membranes requires binding to the target protein and protein kinase C activity.Q48270983
Mild experimental autoimmune encephalitis as a tool to induce blood-brain barrier dysfunctionQ48394980
Progressive encephalomyelitis with rigidityQ48400148
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Stiff-man syndrome: possible autoimmune etiology targeted against GABA-ergic cellsQ48664998
Stiff person syndrome: advances in pathogenesis and therapeutic interventionsQ48751128
Stiff-man syndrome and encephalomyelitis. Report of a caseQ48858727
Subacute encephalomyelitis presenting as stiff-person syndrome: clinical, polygraphic, and pathologic correlationsQ48880483
Neuronal damage in autoimmune neuroinflammation mediated by the death ligand TRAIL.Q48894792
Paraneoplastic stiff-person syndrome: passive transfer to rats by means of IgG antibodies to amphiphysinQ48924908
Short-lived plasma blasts are the main B cell effector subset during the course of multiple sclerosisQ48949365
Cerebellar ataxia with anti-glutamic acid decarboxylase antibodies: study of 14 patientsQ49029367
Spectrum of neurological syndromes associated with glutamic acid decarboxylase antibodies: diagnostic clues for this association.Q51689887
Idiotope-specific CD4(+) T cells induce apoptosis of human oligodendrocytes.Q51793479
Humoral and Cellular Autoimmune Responses in Stiff Person SyndromeQ52956428
Genetics of susceptibility and resistance to insulin-dependent diabetes in stiff-man syndrome.Q54193067
Immune reactivity to glutamic acid decarboxylase 65 in stiffman syndrome and type 1 diabetes mellitus.Q55034045
Stiff man syndrome: clinical and laboratory findings in eight patients.Q55065966
High-Dose Intravenous Immune Globulin for Stiff-Person SyndromeQ59649757
Psychological factors in the diagnosis and pathogenesis of stiff-man syndromeQ60639987
Constitutive endocytosis of GABAA receptors by an association with the adaptin AP2 complex modulates inhibitory synaptic currents in hippocampal neuronsQ73119677
Microglia induce myelin basic protein-specific T cell anergy or T cell activation, according to their state of activationQ73129199
Higher autoantibody levels and recognition of a linear NH2-terminal epitope in the autoantigen GAD65, distinguish stiff-man syndrome from insulin-dependent diabetes mellitus.Q36363509
Short-lived plasmablasts and long-lived plasma cells contribute to chronic humoral autoimmunity in NZB/W miceQ36399066
Sudden death and paroxysmal autonomic dysfunction in stiff-man syndromeQ36405363
B lineage cells in the inflammatory central nervous system environment: migration, maintenance, local antibody production, and therapeutic modulationQ36485715
The lack of anti-idiotypic antibodies, not the presence of the corresponding autoantibodies to glutamate decarboxylase, defines type 1 diabetesQ36535592
The role of the synthetic enzyme GAD65 in the control of neuronal gamma-aminobutyric acid releaseQ36563300
BAR, F-BAR (EFC) and ENTH/ANTH domains in the regulation of membrane-cytosol interfaces and membrane curvatureQ36580060
The stiff leg syndromeQ36900963
Stiff-man syndrome associated with nocturnal myoclonus and epilepsyQ37059507
Immunobiology of stiff-person syndromeQ37094697
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Protective long-term antibody memory by antigen-driven and T help-dependent differentiation of long-lived memory B cells to short-lived plasma cells independent of secondary lymphoid organsQ37290484
Antigen processing patterns determine GAD65-specific regulation vs. pathogenesisQ37409952
Tissue-mediated control of immunopathology in coeliac diseaseQ37638199
Amphiphysin I and regulation of synaptic vesicle endocytosisQ37662707
A patient with reflex myoclonus and muscle rigidity: "jerking stiff-man syndrome".Q39244168
A selective activity-dependent requirement for dynamin 1 in synaptic vesicle endocytosisQ39752213
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Cerebrospinal fluid T cell responses against glutamic acid decarboxylase 65 in patients with stiff person syndromeQ39913279
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Modulation of antigen presentation by autoreactive B cell clones specific for GAD65 from a type I diabetic patientQ40607014
IgG-immunostaining in the intact rabbit brain: variable but significant staining of hippocampal and cerebellar neurons with anti-IgG.Q40622375
Suppressive effect of glutamic acid decarboxylase 65-specific autoimmune B lymphocytes on processing of T cell determinants located within the antibody epitopeQ40720812
Autoantibodies to GABA-ergic neurons and pancreatic beta cells in stiff-man syndromeQ41196484
Cerebellar Purkinje cells incorporate immunoglobulins and immunotoxins in vitro: implications for human neurological disease and immunotherapeuticsQ41790064
Identification of a dominant epitope of glutamic acid decarboxylase (GAD-65) recognized by autoantibodies in stiff-man syndromeQ41994256
Unique luminal localization of VGAT-C terminus allows for selective labeling of active cortical GABAergic synapsesQ42605038
Stiff-person syndrome: persistent elevation of glutamic acid decarboxylase antibodies despite successful treatment with rituximabQ43006057
Antibodies to glutamic acid decarboxylase define a form of limbic encephalitisQ43076381
Stiff person syndrome: quantification, specificity, and intrathecal synthesis of GAD65 antibodiesQ43734068
Immunoglobulin Fc gamma receptor promotes immunoglobulin uptake, immunoglobulin-mediated calcium increase, and neurotransmitter release in motor neuronsQ44059830
Selective extraction of small and large molecules from the cerebrospinal fluid by Purkinje neuronsQ44333123
Dual impairment of GABAA- and GABAB-receptor-mediated synaptic responses by autoantibodies to glutamic acid decarboxylaseQ44363790
Myelin antigen reactive T cells in cerebrovascular diseasesQ44501927
Direct impact of T cells on neurons revealed by two-photon microscopy in living brain tissue.Q44795497
GAD65-specific autoantibodies enhance the presentation of an immunodominant T-cell epitope from GAD65.Q44876645
Amphiphysin autoimmunity: paraneoplastic accompanimentsQ45130801
Stiff person syndrome associated anti-amphiphysin antibodies reduce GABA associated [Ca(2+)]i rise in embryonic motoneurons.Q45920186
Reversibility of cerebellar GABAergic synapse impairment induced by anti-glutamic acid decarboxylase autoantibodiesQ46555940
Analysis of GAD65 autoantibodies in Stiff-Person syndrome patientsQ46815045
Serum antibodies in epilepsy and seizure-associated disordersQ46848031
Inhibition of gamma-aminobutyric acid synthesis by glutamic acid decarboxylase autoantibodies in stiff-man syndromeQ47671744
Effects of anti-glutamic acid decarboxylase antibodies associated with neurological diseasesQ48122020
Autoantigenic properties of native and denatured glutamic acid decarboxylase: evidence for a conformational epitopeQ48153660
P433issue1-2
P407language of work or nameEnglishQ1860
P921main subjectimmunologyQ101929
P304page(s)55-60
P577publication date2010-10-12
2011-02-01
P1433published inJournal of NeuroimmunologyQ15716691
P1476titleThe immunological basis for treatment of stiff person syndrome
P478volume231

Reverse relations

cites work (P2860)
Q44842014A complex case of anti-GAD antibody-related syndrome treated with Rituximab
Q37410906Anti-glutamic acid decarboxylase antibody positive neurological syndromes
Q26753841Clinical Spectrum of Stiff Person Syndrome: A Review of Recent Reports
Q37924701Conventional apheresis therapies: a review
Q41107258Evaluation of Treatment Outcomes in Patients with Stiff Person Syndrome with Rituximab vs. Standard of Care
Q48661821Human IgG directed against amphiphysin induces anxiety behavior in a rat model after intrathecal passive transfer
Q35729575Immune mediated diseases and immune modulation in the neurocritical care unit
Q89881773Improvement of stiff-person syndrome symptoms in pregnancy: Case series and literature review
Q42530496Interactions of Human Autoantibodies with Hippocampal GABAergic Synaptic Transmission - Analyzing Antibody-Induced Effects ex vivo
Q28072253Neuronal central nervous system syndromes probably mediated by autoantibodies
Q33734422Stiff-person syndrome: case series

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