The lack of anti-idiotypic antibodies, not the presence of the corresponding autoantibodies to glutamate decarboxylase, defines type 1 diabetes

scholarly article

The lack of anti-idiotypic antibodies, not the presence of the corresponding autoantibodies to glutamate decarboxylase, defines type 1 diabetes is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode2008PNAS..105.5471O
P356DOI10.1073/PNAS.0800578105
P932PMC publication ID2291139
P698PubMed publication ID18367670
P5875ResearchGate publication ID5484203

P50authorLisa K GilliamQ114431955
Christiane S HampeQ44927527
Mona Landin-OlssonQ46942445
Ingrid KockumQ55446225
P2093author name stringMerrill J Rowley
J Paul Banga
Michael R Christie
Shilpa Oak
Carina Törn
Christina R Pennington
P2860cites workRecombinant anti-idiotypic antibodies inhibit human natural anti-glycoprotein (GP)IIb/IIIa autoantibodiesQ31040277
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Immunomodulation of autoimmune and inflammatory diseases with intravenous immune globulinQ34362734
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Development of type 1 diabetes despite severe hereditary B-cell deficiencyQ74593633
The idiotypic network in autoimmunity: antibodies that bind antibodies that bind antibodiesQ75217669
Autoantibodies associated with Type I diabetes mellitus persist after diagnosis in childrenQ77619587
Recombinant Fabs of human monoclonal antibodies specific to the middle epitope of GAD65 inhibit type 1 diabetes-specific GAD65AbsQ79207765
Multiplicity of the antibody response to GAD65 in Type I diabetesQ80892738
Dynamic changes of GAD65 autoantibody epitope specificities in individuals at risk of developing type 1 diabetesQ81657563
Identification of the 64K autoantigen in insulin-dependent diabetes as the GABA-synthesizing enzyme glutamic acid decarboxylaseQ34566310
Autoantibodies in autoimmune polyendocrine syndrome type II.Q34715410
Newborn humans manifest autoantibodies to defined self molecules detected by antigen microarray informaticsQ35649417
Antibody-enhanced cross-presentation of self antigen breaks T cell toleranceQ35745247
Diabetes-related antibodies in adult diabetic patientsQ36096638
Facing the enigma of immunomodulatory effects of intravenous immunoglobulinQ36359673
Physiological β Cell Death Triggers Priming of Self-reactive T Cells by Dendritic Cells in a Type-1 Diabetes ModelQ36371477
Autoimmunity to glutamic acid decarboxylase (GAD) in stiffman syndrome and insulin-dependent diabetes mellitusQ36708258
Immunoglobulin E blockade in the treatment of asthmaQ36951998
Anti-idiotypic antibodies prevent the serologic detection of antiribosomal P autoantibodies in healthy adultsQ37387240
Modulation of antigen presentation by autoreactive B cell clones specific for GAD65 from a type I diabetic patientQ40607014
Suppressive effect of glutamic acid decarboxylase 65-specific autoimmune B lymphocytes on processing of T cell determinants located within the antibody epitopeQ40720812
Human B cells secreting immunoglobulin G to glutamic acid decarboxylase-65 from a nondiabetic patient with multiple autoantibodies and Graves' disease: a comparison with those present in type 1 diabetesQ44191950
IgG auto-anti-idiotype antibodies against antibody to insulin in insulin-dependent (type 1) diabetes mellitus. Detection by capture enzyme linked immunosorbent assay (ELISA) and relationship with anti-insulin antibody levelsQ44489482
GAD65-specific autoantibodies enhance the presentation of an immunodominant T-cell epitope from GAD65.Q44876645
Prediction of IDDM in the general population: strategies based on combinations of autoantibody markersQ45087522
Analysis of GAD65 autoantibodies in Stiff-Person syndrome patientsQ46815045
A 12-year prospective study of the relationship between islet antibodies and beta-cell function at and after the diagnosis in patients with adult-onset diabetes.Q51542822
Mouse antibodies to the insulin receptor developing spontaneously as anti-idiotypes. II. Effects on glucose homeostasis and the insulin receptor.Q51642495
Dynamics of beta-cell mass in the growing rat pancreas. Estimation with a simple mathematical model.Q52348002
Unmasking of anti-ribosomal P autoantibodies in healthy individualsQ52509111
COOH-Terminal Clustering of Autoantibody and T-Cell Determinants on the Structure of GAD65 Provide Insights Into the Molecular Basis of AutoreactivityQ57079408
Beta-cell proliferation and apoptosis in the developing normal human pancreas and in hyperinsulinism of infancyQ57499724
Naturally occurring anti-idiotypic antibodies in myasthenia gravis patientsQ59071320
Modulation of diabetes in NOD mice by GAD65-specific monoclonal antibodies is epitope specific and accompanied by anti-idiotypic antibodiesQ59829524
Idiotypic-antiidiotypic interactions in manQ67285035
Insulin-mimicking anti-idiotypic antibodies in development of spontaneous autoimmune diabetes in BB/E ratsQ68611947
Characterization of anti-Fab' antibodies in human sera: identification of soluble immune complexes that contain hidden anti-KLH and blocking anti-immunoglobulins following immunization with keyhole limpet haemocyaninQ70991907
Auto-anti-anti-DNA antibodies from SLE patients and normalsQ71010766
Prediction of type I diabetes in first-degree relatives using a combination of insulin, GAD, and ICA512bdc/IA-2 autoantibodiesQ71150178
Receptor-like activity of a monoclonal anti-idiotypic antibody against an anti-acetylcholine receptor antibodyQ71372296
Idiotype-anti-idiotype circuit in non-autoimmune mice after immunization with the epitope and complementary epitope 289-308aa of La/SSB: implications for the maintenance and perpetuation of the anti-La/SSB responseQ73738496
High frequency of persisting or increasing islet-specific autoantibody levels after diagnosis of type 1 diabetes presenting before 40 years of age. The Belgian Diabetes RegistryQ73857667
The presence of masked antiribosomal P autoantibodies in healthy childrenQ74060189
Anti-idiotypic antibodies to anti-PDC-E2 in primary biliary cirrhosis and normal subjectsQ74529894
P433issue14
P407language of work or nameEnglishQ1860
P921main subjectantibodyQ79460
autoantibodyQ785022
type-1 diabetesQ124407
P304page(s)5471-5476
P577publication date2008-03-26
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleThe lack of anti-idiotypic antibodies, not the presence of the corresponding autoantibodies to glutamate decarboxylase, defines type 1 diabetes
P478volume105

Reverse relations

cites work (P2860)
Q34182775Anti-idiotypic antibody specific to GAD65 autoantibody prevents type 1 diabetes in the NOD mouse
Q34347058Anti-idiotypic monobodies for immune response profiling
Q41751849Association of TCF7L2 variation with single islet autoantibody expression in children with type 1 diabetes
Q36551060Association of the idiotype:antiidiotype antibody ratio with the efficacy of intravenous immunoglobulin treatment for the prevention of recurrent autoimmune-associated congenital heart block.
Q82269020Autoimmunity: increasing suspects in the CD4+ T cell lineup
Q33593017B-CD8+ T Cell Interactions in the Anti-Idiotypic Response against a Self-Antibody.
Q33750667Banting Lecture 2009: An unfinished journey: molecular pathogenesis to prevention of type 1A diabetes
Q34262463Changes in GAD65Ab-specific antiidiotypic antibody levels correlate with changes in C-peptide levels and progression to islet cell autoimmunity
Q37482636Comparison of three assays for the detection of GAD65Ab-specific anti-idiotypic antibodies
Q40070247DPD epitope-specific glutamic acid decarboxylase (GAD)65 autoantibodies in children with Type 1 diabetes
Q34778635Decline in titers of anti-idiotypic antibodies specific to autoantibodies to GAD65 (GAD65Ab) precedes development of GAD65Ab and type 1 diabetes
Q33358948Distinct clinical and laboratory characteristics of latent autoimmune diabetes in adults in relation to type 1 and type 2 diabetes mellitus
Q45820463Failure to detect anti-idiotypic antibodies in the autoimmune response to IA-2 in Type 1 diabetes.
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Q90401543Immune Response Regulation by Antigen Receptors' Clone-Specific Nonself Parts
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Q38156224Immunology of stiff person syndrome and other GAD-associated neurological disorders
Q34630695Kinetics of the post-onset decline in zinc transporter 8 autoantibodies in type 1 diabetic human subjects
Q33682376Masked and overt autoantibodies specific to the DPD epitope of 65-kDa glutamate decarboxylase (GAD65-DPD) are associated with preserved β-cell functional reserve in ketosis-prone diabetes
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Q38132851The preventive role of type 2 NKT cells in the development of type 1 diabetes
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Q37520312ZnT8 autoantibody titers in type 1 diabetes patients decline rapidly after clinical onset

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