Mycolactone: a polyketide toxin from Mycobacterium ulcerans required for virulence

scientific article

Mycolactone: a polyketide toxin from Mycobacterium ulcerans required for virulence is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1126/SCIENCE.283.5403.854
P3181OpenCitations bibliographic resource ID454332
P698PubMed publication ID9933171

P50authorRichard LeeQ16735186
P2093author name stringK M George
D Chatterjee
P L Small
J Hayman
G Gunawardana
D Welty
P433issue5403
P407language of work or nameEnglishQ1860
P921main subjectMycobacterium ulceransQ141154
virulenceQ1460232
P304page(s)854-7
P577publication date1999-02-05
P1433published inScienceQ192864
P1476titleMycolactone: a polyketide toxin from Mycobacterium ulcerans required for virulence
P478volume283

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cites work (P2860)
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Q36733497Mycolactone activation of Wiskott-Aldrich syndrome proteins underpins Buruli ulcer formation
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Q38695592Mycolactone cytotoxicity in Schwann cells could explain nerve damage in Buruli ulcer.
Q21090122Mycolactone diffuses from Mycobacterium ulcerans-infected tissues and targets mononuclear cells in peripheral blood and lymphoid organs
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Q47137536Mycolactone displays anti-inflammatory effects on the nervous system.
Q30914398Mycolactone gene expression is controlled by strong SigA-like promoters with utility in studies of Mycobacterium ulcerans and buruli ulcer
Q36594072Mycolactone is responsible for the painlessness of Mycobacterium ulcerans infection (buruli ulcer) in a murine study
Q38951193Mycolactone reveals the substrate-driven complexity of Sec61-dependent transmembrane protein biogenesis.
Q37500335Mycolactone subverts immunity by selectively blocking the Sec61 translocon.
Q27318699Mycolactone-Dependent Depletion of Endothelial Cell Thrombomodulin Is Strongly Associated with Fibrin Deposition in Buruli Ulcer Lesions
Q35949741Mycolactone-mediated inhibition of tumor necrosis factor production by macrophages infected with Mycobacterium ulcerans has implications for the control of infection
Q37115277Mycolactone-mediated neurite degeneration and functional effects in cultured human and rat DRG neurons: Mechanisms underlying hypoalgesia in Buruli ulcer
Q34266843Mycolactones and Mycobacterium ulcerans disease
Q37170768Mycolactones: immunosuppressive and cytotoxic polyketides produced by aquatic mycobacteria
Q36200942Natural products as mediators of disease.
Q87166461Natural products: Hunting microbial metabolites
Q55247742Naturally occurring a loss of a giant plasmid from Mycobacterium ulcerans subsp. shinshuense makes it non-pathogenic.
Q39516850Necrosis of lung epithelial cells during infection with Mycobacterium tuberculosis is preceded by cell permeation
Q34292327Necrotic death of Rhodococcus equi-infected macrophages is regulated by virulence-associated plasmids.
Q28267545Neglected tropical diseases
Q35088084Nerve damage in Mycobacterium ulcerans-infected mice: probable cause of painlessness in buruli ulcer
Q46585361New approaches towards the synthesis of the side-chain of mycolactones A and B.
Q40282605Nontuberculous mycobacteria
Q36219941Overexpression of a Mycobacterium ulcerans Ag85B-EsxH Fusion Protein in Recombinant BCG Improves Experimental Buruli Ulcer Vaccine Efficacy
Q38180374Pathogenesis of skin ulcers: lessons from the Mycobacterium ulcerans and Leishmania spp. pathogens
Q33511900Pathogenetic mechanisms of the intracellular parasite Mycobacterium ulcerans leading to Buruli ulcer
Q30484591Persistent association of Mycobacterium ulcerans with West African predaceous insects of the family belostomatidae
Q90398229Phage therapy as a renewed therapeutic approach to mycobacterial infections: a comprehensive review
Q34702499Phage therapy is effective against infection by Mycobacterium ulcerans in a murine footpad model
Q34108761Pharmacokinetics of rifampin and clarithromycin in patients treated for Mycobacterium ulcerans infection.
Q33409842Phase change material for thermotherapy of Buruli ulcer: a prospective observational single centre proof-of-principle trial
Q34238411Photodegradation of the Mycobacterium ulcerans toxin, mycolactones: considerations for handling and storage
Q38180777Pleiotropic molecular effects of the Mycobacterium ulcerans virulence factor mycolactone underlying the cell death and immunosuppression seen in Buruli ulcer
Q24792373Principles of microbial alchemy: insights from the Streptomyces coelicolor genome sequence
Q36295353Promising clinical efficacy of streptomycin-rifampin combination for treatment of buruli ulcer (Mycobacterium ulcerans disease)
Q34174558Prophylactic effect of mycobacterium bovis BCG vaccination against osteomyelitis in children with Mycobacterium ulcerans disease (Buruli Ulcer).
Q35623341Prospects for vaccine development against Buruli disease
Q28469147Protection against Mycobacterium ulcerans lesion development by exposure to aquatic insect saliva
Q39580405Protective effect of a dewaxed whole-cell vaccine against Mycobacterium ulcerans infection in mice
Q24548647Protective efficacy of a DNA vaccine encoding antigen 85A from Mycobacterium bovis BCG against Buruli ulcer
Q34016179Proteomic analysis of the action of the Mycobacterium ulcerans toxin mycolactone: targeting host cells cytoskeleton and collagen
Q58042832Proteomics Reveals Scope of Mycolactone-mediated Sec61 Blockade and Distinctive Stress Signature
Q28552925RNA Aptamer That Specifically Binds to Mycolactone and Serves as a Diagnostic Tool for Diagnosis of Buruli Ulcer
Q33962755Rapid assessment of antibacterial activity against Mycobacterium ulcerans by using recombinant luminescent strains
Q28537749Rapid, serial, non-invasive assessment of drug efficacy in mice with autoluminescent Mycobacterium ulcerans infection
Q38634493Recent advances: role of mycolactone in the pathogenesis and monitoring of Mycobacterium ulcerans infection/Buruli ulcer disease.
Q35782951Recombinant BCG Expressing Mycobacterium ulcerans Ag85A Imparts Enhanced Protection against Experimental Buruli ulcer.
Q28535119Regulation of mycolactone, the Mycobacterium ulcerans toxin, depends on nutrient source
Q51410365Regulation of the Cell Biology of Antigen Cross-Presentation.
Q38579126Revisiting Buruli ulcer
Q36033978Risk factors for Mycobacterium ulcerans infection, southeastern Australia
Q38258019Roles of bacterial membrane vesicles.
Q33715059Scalable and efficient synthesis of the mycolactone core
Q33871043Seasonal Pattern of Mycobacterium ulcerans, the Causative Agent of Buruli Ulcer, in the Environment in Ghana
Q38692382Sec61 blockade by mycolactone inhibits antigen cross-presentation independently of endosome-to-cytosol export
Q28487505Secondary Bacterial Infections of Buruli Ulcer Lesions Before and After Chemotherapy with Streptomycin and Rifampicin
Q33988898Secondary Buruli ulcer skin lesions emerging several months after completion of chemotherapy: paradoxical reaction or evidence for immune protection?
Q39162386Secondary bacterial isolates from previously untreated Buruli ulcer lesions and their antibiotic susceptibility patterns in Southern Nigeria
Q37103259Secondary necrosis in multicellular animals: an outcome of apoptosis with pathogenic implications.
Q36229394Selective suppression of dendritic cell functions by Mycobacterium ulcerans toxin mycolactone
Q33745230Serological evaluation of Mycobacterium ulcerans antigens identified by comparative genomics
Q35644283Shaping mycolactone for therapeutic use against inflammatory disorders
Q86055703Short Convergent Synthesis of the Mycolactone Core Through Lithiation-Borylation Homologations
Q90739257Signaling Natural Products from Human Pathogenic Bacteria
Q52647372Skin and Soft Tissue Infections Due to Nontuberculous Mycobacteria.
Q57080441Skin ulceration: what lies beneath
Q90057158Skin-specific antibodies neutralizing mycolactone toxin during the spontaneous healing of Mycobacterium ulcerans infection
Q35857386Spontaneous Healing of Mycobacterium ulcerans Lesions in the Guinea Pig Model
Q39746007Structural and functional cellular changes induced by Burkholderia pseudomallei rhamnolipid.
Q27684461Structure, Biochemistry, and Inhibition of Essential 4′-Phosphopantetheinyl Transferases from Two Species of Mycobacteria
Q34654293Structure-activity relationship studies on the macrolide exotoxin mycolactone of Mycobacterium ulcerans
Q105307675Studies toward Unique Mycolactone Macrolides from Mycobacterium ulcerans
Q37062702Subtractive hybridization reveals a type I polyketide synthase locus specific to Mycobacterium ulcerans
Q54244186Surgery for Buruli ulcer in the antibiotic era.
Q44682716Susceptibility of Mycobacterium ulcerans to a combination of amikacin/rifampicin.
Q46201652Susceptibility to Buruli ulcer is associated with the SLC11A1 (NRAMP1) D543N polymorphism.
Q42372966Susceptibility to Mycobacterium ulcerans Disease (Buruli ulcer) Is Associated with IFNG and iNOS Gene Polymorphisms
Q34084883Susceptibility to development of Mycobacterium ulcerans disease: review of possible risk factors
Q33733563Synthesis and structure assignment of the minor metabolite arising from the frog pathogen Mycobacterium liflandii
Q37395656Synthesis and structure of mycolactone E isolated from frog mycobacterium
Q58479648Synthesis of the Conjugated Tetraene Acid Side Chain of Mycolactone E by Suzuki-Miyaura Cross-Coupling Reaction of Alkenyl Boronates
Q57776726Synthetic strategies towards mycolactone A/B, an exotoxin secreted by Mycobacterium ulcerans
Q42906162Synthetic studies on the mycolactone core
Q36582845Targeting drug tolerance in mycobacteria: a perspective from mycobacterial biofilms
Q60020041Targeting the Mycobacterium ulcerans cytochrome bc:aa for the treatment of Buruli ulcer
Q38569307The Buruli Ulcer
Q57229660The Genus Mycobacterium--Medical
Q28534813The cell wall-associated mycolactone polyketide synthases are necessary but not sufficient for mycolactone biosynthesis
Q41469222The chemistry and biology of mycolactones.
Q61805401The compound TB47 is highly bactericidal against Mycobacterium ulcerans in a Buruli ulcer mouse model
Q36583785The evolving story of Mycobacterium tuberculosis clade members detected in fish
Q61813591The extracellular matrix of mycobacterial biofilms: could we shorten the treatment of mycobacterial infections?
Q89886649The immunology of other mycobacteria: M. ulcerans, M. leprae
Q44814557The local immune response in ulcerative lesions of Buruli disease.
Q28541949The pathogenic mechanism of the Mycobacterium ulcerans virulence factor, mycolactone, depends on blockade of protein translocation into the ER
Q28659329The phosphopantetheinyl transferases: catalysis of a post-translational modification crucial for life
Q48269589The potent effect of mycolactone on lipid membranes.
Q44738439Topical exposure to exogenous ultraviolet-irradiated urocanic acid enhances Mycobacterium ulcerans infection in a Crl:IAF(HA)-hrBR hairless guinea-pig model of Buruli ulcer disease
Q36076322Total Synthesis of Mycolactones A and B.
Q35625819Treating Mycobacterium ulcerans disease (Buruli ulcer): from surgery to antibiotics, is the pill mightier than the knife?
Q35533091Tropical Plant Extracts Modulating the Growth of Mycobacterium ulcerans
Q47159580Tuberculosis: Just the FAQs
Q78816691Ultraviolet radiation enhances both the nodular and ulcerative forms of Mycobacterium ulcerans infection in a Crl:IAF(HA)-hrBR hairless guinea pig model of Buruli ulcer disease
Q64958683Understanding the Significance of Biochemistry in the Storage, Handling, Purification, and Sampling of Amphiphilic Mycolactone.
Q44353323Uptake and cellular actions of mycolactone, a virulence determinant for Mycobacterium ulcerans
Q35746584Use of Recombinant Virus Replicon Particles for Vaccination against Mycobacterium ulcerans Disease.
Q38972659Use of the immunodominant 18-kilodalton small heat shock protein as a serological marker for exposure to mycobacterium ulcerans
Q34483614Using Bioluminescence To Monitor Treatment Response in Real Time in Mice with Mycobacterium ulcerans Infection
Q35915755Vaccination with the Surface Proteins MUL_2232 and MUL_3720 of Mycobacterium ulcerans Induces Antibodies but Fails to Provide Protection against Buruli Ulcer.
Q39407596What does detection of Mycobacterium ulcerans DNA in the margin of an excised Buruli ulcer lesion tell us?
Q35234856Whole Genome Comparisons Suggest Random Distribution of Mycobacterium ulcerans Genotypes in a Buruli Ulcer Endemic Region of Ghana

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