| P50 | author | Alma L Burlingame | Q78114859 |
| | Poulomi Acharya | Q96065981 |
| | Maria Almira Correia | Q125174081 |
| P2093 | author name string | Yi Liu | |
| | Dennis R Koop | |
| | Mingxiang Liao | |
| | Shenheng Guan | |
| | YongQiang Wang | |
| P2860 | cites work | Evidence of proteasome-mediated cytochrome P-450 degradation | Q73201772 |
| | Identification of a ubiquitination-Target/Substrate-interaction domain of cytochrome P-450 (CYP) 2E1 | Q73367721 |
| | Pharmacokinetic consequences of induction of CYP2E1 by ligand stabilization | Q73756800 |
| | CYP2E1 degradation by in vitro reconstituted systems: role of the molecular chaperone hsp90 | Q74014138 |
| | CYP2E1 induced by ethanol causes oxidative stress, proteasome inhibition and cytokeratin aggresome (Mallory body-like) formation | Q79224474 |
| | The tumor autocrine motility factor receptor, gp78, is a ubiquitin protein ligase implicated in degradation from the endoplasmic reticulum | Q24291942 |
| | Human ethanol-inducible P450IIE1: complete gene sequence, promoter characterization, chromosome mapping, and cDNA-directed expression | Q24297484 |
| | Human HRD1 is an E3 ubiquitin ligase involved in degradation of proteins from the endoplasmic reticulum | Q24298901 |
| | CYP3A4 ubiquitination by gp78 (the tumor autocrine motility factor receptor, AMFR) and CHIP E3 ligases | Q24310116 |
| | Structures of human cytochrome P-450 2E1. Insights into the binding of inhibitors and both small molecular weight and fatty acid substrates | Q24316102 |
| | Involvement of valosin-containing protein, an ATPase Co-purified with IkappaBalpha and 26 S proteasome, in ubiquitin-proteasome-mediated degradation of IkappaBalpha | Q24329214 |
| | A conserved ubiquitin ligase of the nuclear envelope/endoplasmic reticulum that functions in both ER-associated and Matalpha2 repressor degradation | Q24600318 |
| | SCFCdc4 acts antagonistically to the PGC-1alpha transcriptional coactivator by targeting it for ubiquitin-mediated proteolysis | Q24677035 |
| | Ubiquitination of serine, threonine, or lysine residues on the cytoplasmic tail can induce ERAD of MHC-I by viral E3 ligase mK3 | Q24683139 |
| | Distinct machinery is required in Saccharomyces cerevisiae for the endoplasmic reticulum-associated degradation of a multispanning membrane protein and a soluble luminal protein | Q27938024 |
| | A complex of Cdc4p, Skp1p, and Cdc53p/cullin catalyzes ubiquitination of the phosphorylated CDK inhibitor Sic1p | Q27939049 |
| | CHIP-Hsc70 Complex Ubiquitinates Phosphorylated Tau and Enhances Cell Survival | Q28183470 |
| | A furanocoumarin-free grapefruit juice establishes furanocoumarins as the mediators of the grapefruit juice-felodipine interaction | Q28239213 |
| | Site-specific phosphorylation of IkappaBalpha by a novel ubiquitination-dependent protein kinase activity | Q28276063 |
| | Signal-induced site-specific phosphorylation targets I kappa B alpha to the ubiquitin-proteasome pathway | Q28615706 |
| | Tumor necrosis factor alpha-induced phosphorylation of I kappa B alpha is a signal for its degradation but not dissociation from NF-kappa B | Q28615800 |
| | A proteomics approach to understanding protein ubiquitination | Q29547312 |
| | Control of I kappa B-alpha proteolysis by site-specific, signal-induced phosphorylation | Q29614709 |
| | FBW7 ubiquitin ligase: a tumour suppressor at the crossroads of cell division, growth and differentiation | Q29616127 |
| | Phosphorylation of Sic1p by G1 Cdk required for its degradation and entry into S phase | Q29618007 |
| | Phosphoproteome analysis by mass spectrometry and its application to Saccharomyces cerevisiae | Q29618445 |
| | Cdc53 targets phosphorylated G1 cyclins for degradation by the ubiquitin proteolytic pathway | Q29620291 |
| | Role of accurate mass measurement (+/- 10 ppm) in protein identification strategies employing MS or MS/MS and database searching. | Q30744805 |
| | In-depth analysis of tandem mass spectrometry data from disparate instrument types | Q31165068 |
| | Comparative evaluation of tandem MS search algorithms using a target-decoy search strategy | Q33285992 |
| | A role for protein phosphorylation in cytochrome P450 3A4 ubiquitin-dependent proteasomal degradation | Q33394515 |
| | Hepatic heme-regulated inhibitor (HRI) eukaryotic initiation factor 2alpha kinase: a protagonist of heme-mediated translational control of CYP2B enzymes and a modulator of basal endoplasmic reticulum stress tone | Q33754847 |
| | Stable isotope-free relative and absolute quantitation of protein phosphorylation stoichiometry by MS | Q33926837 |
| | The regulation of protein function by multisite phosphorylation--a 25 year update | Q33928103 |
| | Relationship between cytochrome P450 catalytic cycling and stability: fast degradation of ethanol-inducible cytochrome P450 2E1 (CYP2E1) in hepatoma cells is abolished by inactivation of its electron donor NADPH-cytochrome P450 reductase | Q41898273 |
| | Prediction of human drug-drug interactions from time-dependent inactivation of CYP3A4 in primary hepatocytes using a population-based simulator | Q43272814 |
| | Phosphorylation of native and heme-modified CYP3A4 by protein kinase C: a mass spectrometric characterization of the phosphorylated peptides | Q43740005 |
| | Ethanol withdrawal induced CYP2E1 degradation in vivo, blocked by proteasomal inhibitor PS-341. | Q43832670 |
| | Native CYP2C11: heterologous expression in Saccharomyces cerevisiae reveals a role for vacuolar proteases rather than the proteasome system in the degradation of this endoplasmic reticulum protein | Q43964742 |
| | Degradation of cytochrome P450 2E1: Selective loss after labilization of the enzyme | Q44879642 |
| | Endoplasmic reticulum-associated degradation of cytochrome P450 CYP3A4 in Saccharomyces cerevisiae: further characterization of cellular participants and structural determinants | Q45006702 |
| | Degradation of rat liver cytochromes P450 3A after their inactivation by 3,5-dicarbethoxy-2,6-dimethyl-4-ethyl-1,4-dihydropyridine: characterization of the proteolytic system | Q45131823 |
| | Distinction between human cytochrome P450 (CYP) isoforms and identification of new phosphorylation sites by mass spectrometry | Q45803322 |
| | Degradation of rat hepatic cytochrome P-450 heme by 3,5-dicarbethoxy-2,6-dimethyl-4-ethyl-1,4-dihydropyridine to irreversibly bound protein adducts. | Q45996347 |
| | Vacuolar degradation of rat liver CYP2B1 in Saccharomyces cerevisiae: further validation of the yeast model and structural implications for the degradation of mammalian endoplasmic reticulum P450 proteins. | Q46001476 |
| | Alzheimer disease-specific conformation of hyperphosphorylated paired helical filament-Tau is polyubiquitinated through Lys-48, Lys-11, and Lys-6 ubiquitin conjugation. | Q46031118 |
| | Identification of the heme-modified peptides from cumene hydroperoxide-inactivated cytochrome P450 3A4. | Q46476314 |
| | Enhanced ubiquitylation and accelerated degradation of the dopamine transporter mediated by protein kinase C. | Q46658258 |
| | The E3 ubiquitin ligase CHIP binds the androgen receptor in a phosphorylation-dependent manner. | Q51585733 |
| | 30 Cytochrome P450 turnover | Q67842834 |
| | Post-translational reduction of cytochrome P450IIE by CCl4, its substrate | Q67961375 |
| | Hormone- and substrate-regulated intracellular degradation of cytochrome P450 (2E1) involving MgATP-activated rapid proteolysis in the endoplasmic reticulum membranes | Q68225983 |
| | Macrolide antibiotics inhibit the degradation of the glucocorticoid-responsive cytochrome P-450p in rat hepatocytes in vivo and in primary monolayer culture | Q68797020 |
| | Induction of rat hepatic N-nitrosodimethylamine demethylase by acetone is due to protein stabilization | Q69942868 |
| | Acetone-regulated synthesis and degradation of cytochrome P450E1 and cytochrome P4502B1 in rat liver [corrected] | Q70168617 |
| | Phosphorylation of cytochrome P4502E1 (CYP2E1) by calmodulin dependent protein kinase, protein kinase C and cAMP dependent protein kinase | Q70476861 |
| | Purification of liver microsomal cytochrome P-450 isozymes 3a and 6 from imidazole-treated rabbits. Evidence for the identity of isozyme 3a with the form obtained by ethanol treatment | Q70481320 |
| | Ethanol induces CYP2E1 by protein stabilization. Role of ubiquitin conjugation in the rapid degradation of CYP2E1 | Q70808553 |
| | Purification and characterization of two membrane bound serine proteinases from rat liver microsomes active in degradation of cytochrome P450 | Q72632885 |
| | Heterologous expression and kinetic characterization of human cytochromes P-450: validation of a pharmaceutical tool for drug metabolism research | Q73019169 |
| | Cytochrome p450 turnover: regulation of synthesis and degradation, methods for determining rates, and implications for the prediction of drug interactions | Q34012134 |
| | Serine residues in the cytosolic tail of the T-cell antigen receptor alpha-chain mediate ubiquitination and endoplasmic reticulum-associated degradation of the unassembled protein | Q34025425 |
| | Liver cytochrome P450 3A ubiquitination in vivo by gp78/autocrine motility factor receptor and C terminus of Hsp70-interacting protein (CHIP) E3 ubiquitin ligases: physiological and pharmacological relevance | Q34285339 |
| | Cytochrome P450 ubiquitination: branding for the proteolytic slaughter? | Q34410443 |
| | Ubiquitination on nonlysine residues by a viral E3 ubiquitin ligase | Q34430908 |
| | Liver cytochrome P450 3A endoplasmic reticulum-associated degradation: a major role for the p97 AAA ATPase in cytochrome P450 3A extraction into the cytosol | Q34537028 |
| | Kinase-active interleukin-1 receptor-associated kinases promote polyubiquitination and degradation of the Pellino family: direct evidence for PELLINO proteins being ubiquitin-protein isopeptide ligases | Q34659316 |
| | Hepatic cytochrome P450 degradation: mechanistic diversity of the cellular sanitation brigade | Q35213373 |
| | The high-affinity HSP90-CHIP complex recognizes and selectively degrades phosphorylated tau client proteins | Q35629026 |
| | SCF-mediated protein degradation and cell cycle control | Q36101758 |
| | Regulation of cytochrome P450 by posttranslational modification | Q36148819 |
| | Phosphorylation of cytochromes P450: first discovery of a posttranslational modification of a drug-metabolizing enzyme | Q36246901 |
| | Nitric oxide-dependent proteasomal degradation of cytochrome P450 2B proteins | Q36343293 |
| | Ubiquitin ligases, critical mediators of endoplasmic reticulum-associated degradation | Q36384570 |
| | The ubiquitin-proteasome pathway in cell cycle control. | Q36563160 |
| | Different phosphorylation states of the anaphase promoting complex in response to antimitotic drugs: a quantitative proteomic analysis. | Q36579320 |
| | Cellular proteolytic systems in P450 degradation: evolutionary conservation from Saccharomyces cerevisiae to mammalian liver | Q36725213 |
| | Primary hepatocytes: current understanding of the regulation of metabolic enzymes and transporter proteins, and pharmaceutical practice for the use of hepatocytes in metabolism, enzyme induction, transporter, clearance, and hepatotoxicity studies. | Q36761687 |
| | Mechanism-based inactivation of cytochrome P450 enzymes: chemical mechanisms, structure-activity relationships and relationship to clinical drug-drug interactions and idiosyncratic adverse drug reactions | Q36855287 |
| | Characterization of the physiological turnover of native and inactivated cytochromes P450 3A in cultured rat hepatocytes: a role for the cytosolic AAA ATPase p97? | Q36876654 |
| | Pathways of carbamazepine bioactivation in vitro. III. The role of human cytochrome P450 enzymes in the formation of 2,3-dihydroxycarbamazepine | Q36926122 |
| | Hepatic CYP3A suppression by high concentrations of proteasomal inhibitors: a consequence of endoplasmic reticulum (ER) stress induction, activation of RNA-dependent protein kinase-like ER-bound eukaryotic initiation factor 2alpha (eIF2alpha)-kinase | Q37314375 |
| | C terminus of Hsc70-interacting protein promotes smooth muscle cell proliferation and survival through ubiquitin-mediated degradation of FoxO1. | Q37339007 |
| | Grapefruit juice increases felodipine oral availability in humans by decreasing intestinal CYP3A protein expression | Q37367800 |
| | Role of 26S proteasome and HRD genes in the degradation of 3-hydroxy-3-methylglutaryl-CoA reductase, an integral endoplasmic reticulum membrane protein | Q37383994 |
| | Substrate-, hormone-, and cAMP-regulated cytochrome P450 degradation. | Q37746364 |
| | Yeast expression of animal and plant P450s in optimized redox environments | Q39429286 |
| | SCF(Fbxw7/hCdc4) targets cyclin E2 for ubiquitin-dependent proteolysis | Q39904875 |
| | Ability of CK2beta to selectively regulate cellular protein kinases. | Q39971416 |
| | Regulation of cytochrome P450 2E1 by heat shock protein 90-dependent stabilization and CHIP-dependent proteasomal degradation | Q40343022 |
| | Proteasome-dependent degradation of cytochromes P450 2E1 and 2B1 expressed in tetracycline-regulated HeLa cells. | Q40516169 |
| | Phosphorylation of hepatic phenobarbital-inducible cytochrome P-450. | Q40819583 |
| | NADPH-dependent microsomal electron transfer increases degradation of CYP2E1 by the proteasome complex: role of reactive oxygen species | Q40925051 |
| | Tightly regulated and inducible expression of rabbit CYP2E1 using a tetracycline-controlled expression system. | Q40963345 |
| | Regulating the yeast kinetochore by ubiquitin-dependent degradation and Skp1p-mediated phosphorylation | Q41077870 |
| | Characterization of cytochrome P4502E1 turnover in transfected HepG2 cells expressing human CYP2E1. | Q41113944 |
| | Evidence against a role for serine 129 in determining murine cytochrome P450 Cyp2e-1 protein levels | Q41428050 |
| | Cytochrome P-450 and NADPH-cytochrome P-450 reductase are degraded in the autolysosomes in rat liver | Q41516073 |
| | Proteolytic degradation of heme-modified hepatic cytochromes P450: A role for phosphorylation, ubiquitination, and the 26S proteasome? | Q41648845 |
| | Cytochrome P450 3A degradation in isolated rat hepatocytes: 26S proteasome inhibitors as probes | Q41648850 |
| P4510 | describes a project that uses | ImageJ | Q1659584 |
| P433 | issue | 11 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | phosphorylation | Q242736 |
| | protein ubiquitination | Q3547638 |
| | cell biology | Q7141 |
| P304 | page(s) | 9443-56 | |
| P577 | publication date | 2011-03-18 | |
| P1433 | published in | Journal of Biological Chemistry | Q867727 |
| P1476 | title | Ubiquitin-dependent proteasomal degradation of human liver cytochrome P450 2E1: identification of sites targeted for phosphorylation and ubiquitination | |
| P478 | volume | 286 | |