Anti-oestrogen resistant human breast cancer cell lines are more sensitive towards treatment with the vitamin D analogue EB1089 than parent MCF-7 cells

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Anti-oestrogen resistant human breast cancer cell lines are more sensitive towards treatment with the vitamin D analogue EB1089 than parent MCF-7 cells is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1030959280
P356DOI10.1054/BJOC.2000.1646
P932PMC publication ID2363804
P698PubMed publication ID11237391
P5875ResearchGate publication ID12095299

P2093author name stringA E Lykkesfeldt
S S Larsen
I Heiberg
P2860cites workA phase I study of the vitamin D analogue EB 1089 in patients with advanced breast and colorectal cancerQ28368253
Seocalcitol (EB 1089): a vitamin D analogue of anti-cancer potential. Background, design, synthesis, pre-clinical and clinical evaluationQ33927758
17beta-estradiol inhibits apoptosis in MCF-7 cells, inducing bcl-2 expression via two estrogen-responsive elements present in the coding sequence.Q33962903
EB1089, a synthetic analogue of vitamin D, induces apoptosis in breast cancer cells in vivo and in vitroQ35028096
Indirect mechanism of oestradiol stimulation of cell proliferation of human breast cancer cell linesQ36027345
Differential regulation of specific genes in MCF-7 and the ICI 182780-resistant cell line MCF-7/182R-6.Q36618242
Mechanisms of transcriptional activation of bcl-2 gene expression by 17beta-estradiol in breast cancer cellsQ38318911
A role for insulin-like growth factor binding protein 5 in the antiproliferative action of the antiestrogen ICI 182780.Q38351774
Induction of apoptosis in breast cancer cells in response to vitamin D and antiestrogensQ40470534
1alpha,25-Dihydroxyvitamin D3 down-regulates estrogen receptor abundance and suppresses estrogen actions in MCF-7 human breast cancer cellsQ40859289
Reversal of hypercalcemia with the vitamin D analogue EB1089 in a human model of squamous cancer.Q40940280
Resistance of human breast-cancer cells to the pure steroidal anti-estrogen ICI 182,780 is not associated with a general loss of estrogen-receptor expression or lack of estrogen responsivenessQ41083185
Antiproliferative action of vitamin D-related compounds and insulin-like growth factor-binding protein 5 accumulationQ41110785
Estrogen receptor messenger RNA splice variants are not involved in antiestrogen resistance in sublines of MCF-7 human breast cancer cellsQ41127543
Antiestrogen potentiation of antiproliferative effects of vitamin D3 analogues in breast cancer cells.Q41191360
Human breast cancer cell lines resistant to pure anti-estrogens are sensitive to tamoxifen treatmentQ41345051
Altered expression of estrogen-regulated genes in a tamoxifen-resistant and ICI 164,384 and ICI 182,780 sensitive human breast cancer cell line, MCF-7/TAMR-1.Q41480629
Effect of estrogen and antiestrogens on cell proliferation and synthesis of secreted proteins in the human breast cancer cell line MCF-7 and a tamoxifen resistant variant subline, AL-1.Q41645493
Differential effects of 1,25-dihydroxyvitamin D3 and tetradecanoylphorbol acetate on cell cycle and apoptosis of MCF-7 cells and a vitamin D3-resistant variantQ42546942
MCF7/LCC9: an antiestrogen-resistant MCF-7 variant in which acquired resistance to the steroidal antiestrogen ICI 182,780 confers an early cross-resistance to the nonsteroidal antiestrogen tamoxifenQ42815735
Comparative effects of 1,25(OH)2D3 and EB1089 on cell cycle kinetics and apoptosis in MCF-7 breast cancer cells.Q52525004
Dissociation of vitamin D3 and anti-estrogen mediated growth regulation in MCF-7 breast cancer cells.Q52532663
Acquired antiestrogen resistance in MCF-7 human breast cancer sublines is not accomplished by altered expression of receptors in the ErbB-family.Q54065729
Comparison of the effects of a pure steroidal antiestrogen with those of tamoxifen in a model of human breast cancer.Q54172521
Type I IGF receptor and acquired tamoxifen resistance in oestrogen-responsive human breast cancer cells.Q54254361
Apoptosis induced by vitamin D compounds in breast cancer cells is inhibited by Bcl-2 but does not involve known caspases or p53Q59487853
Immunocytochemical localization of BCL-2 protein in human breast cancers and its relationship to a series of prognostic markers and response to endocrine therapyQ62690767
p53 and bcl-2 expression correlates with clinical outcome in a series of node-positive breast cancer patientsQ71059816
The value of estrogen and progesterone receptors in the treatment of breast cancerQ71432010
Apoptosis suppressing protein bcl-2 is expressed in well-differentiated breast carcinomas with favourable prognosisQ71512317
Checkpoints of dueling dimers foil death wishesQ72790765
Clinical significance of bcl-2 gene expression in human breast cancer tissuesQ73313971
bcl-2, p53, and response to tamoxifen in estrogen receptor-positive metastatic breast cancer: a Southwest Oncology Group studyQ73368662
Vitamin D analogues suppress IGF-I signalling and promote apoptosis in breast cancer cellsQ73446751
The expression of Ki-S1 and BCL-2 and the response to primary tamoxifen therapy in elderly patients with breast cancerQ73533098
Overexpression of BCL-x protein in primary breast cancer is associated with high tumor grade and nodal metastasesQ73603139
Vitamin D compounds as potential therapeutics for estrogen-independent breast cancerQ73844927
Vitamin D derivatives inhibit the mitogenic effects of IGF-I on MCF-7 human breast cancer cellsQ73900538
Growth inhibition of both MCF-7 and Hs578T human breast cancer cell lines by vitamin D analogues is associated with increased expression of insulin-like growth factor binding protein-3Q74346662
EB 1089, a novel vitamin D analogue, has strong antiproliferative and differentiation inducing effects on cancer cellsQ77609554
Apoptosis and Bcl-2 expression in relation to age, tumor characteristics and prognosis in breast cancer. South-East Sweden Breast Cancer GroupQ77982200
P433issue5
P407language of work or nameEnglishQ1860
P921main subjectvitamin DQ175621
P304page(s)686-90
P577publication date2001-03-02
P1433published inBritish Journal of CancerQ326309
P1476titleAnti-oestrogen resistant human breast cancer cell lines are more sensitive towards treatment with the vitamin D analogue EB1089 than parent MCF-7 cells
P478volume84

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cites work (P2860)
Q38943401A kinase inhibitor screen identifies Mcl-1 and Aurora kinase A as novel treatment targets in antiestrogen-resistant breast cancer cells.
Q40663105Characterization of mammary tumor cell lines from wild type and vitamin D3 receptor knockout mice
Q36452355Jostling for position: optimizing linker location in the design of estrogen receptor-targeting PROTACs
Q37097049Prognostic value of Bcl-2 in two independent populations of estrogen receptor positive breast cancer patients treated with adjuvant endocrine therapy
Q40522824Sequential versus combined treatment of human breast cancer cells with antiestrogens and the vitamin D analogue EB1089 and evaluation of predictive markers for vitamin D treatment

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