Clinical relevance of genetic polymorphisms in the human CYP2C subfamily

scientific article

Clinical relevance of genetic polymorphisms in the human CYP2C subfamily is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1046/J.0306-5251.2001.01499.X
P3181OpenCitations bibliographic resource ID679812
P932PMC publication ID2014584
P698PubMed publication ID11678778
P5875ResearchGate publication ID227797908

P2093author name stringJ A Goldstein
P2860cites workcDNA and amino acid sequences of two members of the human P450IIC gene subfamilyQ24631075
An additional defective allele, CYP2C19*5, contributes to the S-mephenytoin poor metabolizer phenotype in CaucasiansQ28137607
A novel transversion in the intron 5 donor splice junction of CYP2C19 and a sequence polymorphism in exon 3 contribute to the poor metabolizer phenotype for the anticonvulsant drug S-mephenytoinQ28140035
Identification of a new non-functional CYP2C18 allele in Japanese: substitution of T204 to A in exon2 generates a premature stop codonQ71625126
Comparison of the kinetic disposition and metabolism of E3810, a new proton pump inhibitor, and omeprazole in relation to S-mephenytoin 4′-hydroxylation statusQ71993387
Stereoselective disposition of hexobarbital and its metabolites: relationship to the S-mephenytoin polymorphism in Caucasian and Chinese subjectsQ71996229
Impaired (S)-warfarin metabolism catalysed by the R144C allelic variant of CYP2C9Q71996232
The hydroxylation of omeprazole correlates with S-mephenytoin metabolism: a population studyQ72313200
Single-dose kinetics of clomipramine: relationship to the sparteine and S-mephenytoin oxidation polymorphismsQ72415315
Selective biotransformation of taxol to 6 alpha-hydroxytaxol by human cytochrome P450 2C8Q72710440
Inhibition by omeprazole of proguanil metabolism: mechanism of the interaction in vitro and prediction of in vivo results from the in vitro experimentsQ73045816
Metabolic disposition of lansoprazole in relation to the S-mephenytoin 4'-hydroxylation phenotype statusQ73369049
CYP2C9 Ile359 and Leu359 variants: enzyme kinetic study with seven substratesQ73669215
Genetic polymorphism of the CYP2C subfamily and excessive serum phenytoin concentration with central nervous system intoxicationQ73697009
Torsemide metabolism by CYP2C9 variants and other human CYP2C subfamily enzymesQ73769600
Genetic association between sensitivity to warfarin and expression of CYP2C9*3Q73834859
Metabolic disposition of pantoprazole, a proton pump inhibitor, in relation to S-mephenytoin 4'-hydroxylation phenotype and genotypeQ74058615
The hydroxylation of omeprazole correlates with S-mephenytoin and proguanil metabolismQ74222561
No correlation between side-chain of propranolol oxidation and S-mephenytoin 4'-hydroxylase activityQ74596634
Phenotypic and genotypic investigations of a healthy volunteer deficient in the conversion of losartan to its active metabolite E-3174Q74649851
Effect of genetic differences in omeprazole metabolism on cure rates for Helicobacter pylori infection and peptic ulcerQ77732655
CYP2C19 genotype status and effect of omeprazole on intragastric pH in humansQ77788807
Stereoselective mephobarbital hydroxylation cosegregates with mephenytoin hydroxylationQ93613086
Identification of a new genetic defect responsible for the polymorphism of (S)-mephenytoin metabolism in JapaneseQ28241420
The major genetic defect responsible for the polymorphism of S-mephenytoin metabolism in humansQ28254348
A new genetic defect in human CYP2C19: mutation of the initiation codon is responsible for poor metabolism of S-mephenytoinQ28259441
Geographical/interracial differences in polymorphic drug oxidation. Current state of knowledge of cytochromes P450 (CYP) 2D6 and 2C19Q28270486
Identification of new human CYP2C19 alleles (CYP2C19*6 and CYP2C19*2B) in a Caucasian poor metabolizer of mephenytoinQ28281837
Biochemistry and molecular biology of the human CYP2C subfamilyQ28299258
Differences in the incidence of the CYP2C19 polymorphism affecting the S-mephenytoin phenotype in Chinese Han and Bai populations and identification of a new rare CYP2C19 mutant alleleQ28307602
Pharmacokinetics of chlorpheniramine, phenytoin, glipizide and nifedipine in an individual homozygous for the CYP2C9*3 alleleQ28373588
Complete nucleotide sequence of a methylcholanthrene-inducible cytochrome P-450 (P-450d) gene in the ratQ28575566
Review article: cytochrome P450 and the metabolism of proton pump inhibitors--emphasis on rabeprazoleQ33734852
Proguanil metabolism is determined by the mephenytoin oxidation polymorphism in Vietnamese living in DenmarkQ34345510
In vitro proguanil activation to cycloguanil by human liver microsomes is mediated by CYP3A isoforms as well as by S-mephenytoin hydroxylaseQ34346652
The activation of the biguanide antimalarial proguanil co-segregates with the mephenytoin oxidation polymorphism--a panel studyQ34358893
The role of the CYP2C9-Leu359 allelic variant in the tolbutamide polymorphismQ34735686
Oxygen concentration influences proton pump inhibitor activity against Helicobacter pylori in vitroQ35125188
Comparison of (S)-mephenytoin and proguanil oxidation in vitro: contribution of several CYP isoformsQ36053568
Proguanil metabolism in relation to S-mephenytoin oxidation in a Turkish populationQ36093868
The gastric H+,K+-ATPase: the site of action of omeprazoleQ38313573
Genetic polymorphism of S-mephenytoin hydroxylationQ38692055
High and variable frequencies of CYP2C19 mutations: medical consequences of poor drug metabolism in Vanuatu and other Pacific islands.Q39119071
Chloroguanide metabolism in relation to the efficacy in malaria prophylaxis and the S-mephenytoin oxidation in Tanzanians.Q41931375
The elimination of diazepam in Chinese subjects is dependent on the mephenytoin oxidation phenotypeQ42284719
Genetic polymorphism of the CYP2C subfamily and its effect on the pharmacokinetics of phenytoin in Japanese patients with epilepsyQ42547133
The R144C change in the CYP2C9*2 allele alters interaction of the cytochrome P450 with NADPH:cytochrome P450 oxidoreductaseQ42548432
Hydroxylation of warfarin by human cDNA-expressed cytochrome P-450: a role for P-4502C9 in the etiology of (S)-warfarin-drug interactionsQ44735365
Characterization of the selectivity and mechanism of human cytochrome P450 inhibition by the human immunodeficiency virus-protease inhibitor nelfinavir mesylateQ45754897
Genetic analysis of the cytochrome P-45OIIC18 (CYP2C18) gene and a novel member of the CYP2C subfamilyQ48064742
Effect of the gene dosage of CgammaP2C19 on diazepam metabolism in Chinese subjects.Q51426110
Genetic polymorphism of CYP2C9 and its effect on warfarin maintenance dose requirement in patients undergoing anticoagulation therapy.Q53459208
Relation between chloroguanide bioactivation to cycloguanil and the genetically determined metabolism of mephenytoin in humansQ57314135
Pharmacokinetics of citalopram in relation to the sparteine and the mephenytoin oxidation polymorphismsQ60678418
Association of polymorphisms in the cytochrome P450 CYP2C9 with warfarin dose requirement and risk of bleeding complicationsQ63241969
Validation of methods for CYP2C9 genotyping: frequencies of mutant alleles in a Swedish population.Q64923947
Pharmacogenetics of tolbutamide metabolism in humansQ67017361
Polymorphic hydroxylation of S-mephenytoin and omeprazole metabolism in Caucasian and Chinese subjectsQ67832154
The mephenytoin oxidation polymorphism is partially responsible for the N-demethylation of imipramineQ68183654
Amitriptyline pharmacokinetics and clinical response: II. Metabolic polymorphism assessed by hydroxylation of debrisoquine and mephenytoinQ68994545
Propranolol's metabolism is determined by both mephenytoin and debrisoquin hydroxylase activitiesQ69936283
P433issue4
P407language of work or nameEnglishQ1860
P304page(s)349-55
P577publication date2001-10-01
P1433published inBritish Journal of Clinical PharmacologyQ176044
P1476titleClinical relevance of genetic polymorphisms in the human CYP2C subfamily
P478volume52

Reverse relations

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Q35876022Technology platforms for pharmacogenomic diagnostic assays
Q43454795The CYP2C19 ultra-rapid metabolizer genotype influences the pharmacokinetics of voriconazole in healthy male volunteers
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Q35826352The cost-effectiveness of high-dose oral proton pump inhibition after endoscopy in the acute treatment of peptic ulcer bleeding
Q46758734The effect of aging on the relationship between the cytochrome P450 2C19 genotype and omeprazole pharmacokinetics
Q44649926The effect of genetic polymorphisms of cytochrome P450 CYP2C9, CYP2C19, and CYP2D6 on drug-resistant epilepsy in Turkish children
Q35827277The effect of the cytochrome P450 CYP2C8 polymorphism on the disposition of (R)-ibuprofen enantiomer in healthy subjects.
Q35827919The effects of human CYP2C8 genotype and fluvoxamine on the pharmacokinetics of rosiglitazone in healthy subjects
Q39282924The emergence of new psychoactive substance (NPS) benzodiazepines: A review.
Q35062482The expression of CYP2B6, CYP2C9 and CYP3A4 genes: a tangle of networks of nuclear and steroid receptors.
Q34574033The pharmacogenomics of HIV therapy.
Q35827129The role of CYP2C and CYP3A in the disposition of 3-keto-desogestrel after administration of desogestrel
Q36497088The role of genetic variability in drug metabolism pathways in breast cancer prognosis
Q33597311The transcriptional regulation of the human CYP2C genes
Q27009221Therapeutic drug monitoring for triazoles: A needs assessment review and recommendations from a Canadian perspective
Q35873687Toward individualized pharmaceutical care of East Asians: the value of genetic testing for polymorphisms in drug-metabolizing genes
Q37945308Triazole antifungal agents drug-drug interactions involving hepatic cytochrome P450.
Q44732685Unusual side-effects due to clobazam: a case report with genetic study of CYP2C19.
Q42696284Upregulation of human CYP2C9 expression by Bisphenol A via estrogen receptor alpha (ERα) and Med25.
Q35829133Using germ-line genetic variation to investigate and treat cancer
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Q48577491Voriconazole and fluconazole increase the exposure to oral diazepam
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Q37052185Xenobiotic sensor- and metabolism-related gene variants in environmental sensitivity-related illnesses: a survey on the Italian population.

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