Rapid identification of the hepatic cytochrome P450 2C19 activity using a novel and noninvasive [13C]pantoprazole breath test

scientific article published on 09 January 2009

Rapid identification of the hepatic cytochrome P450 2C19 activity using a novel and noninvasive [13C]pantoprazole breath test is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1124/JPET.108.147751
P932PMC publication ID2670589
P698PubMed publication ID19136640
P5875ResearchGate publication ID23770912

P50authorDavid FlockhartQ23563106
Zeruesenay DestaQ87723626
P2093author name stringLang Li
Phuong D Nguyen
Anil Modak
Yasuhisa Kurogi
Suzanne M Lemler
P2860cites workClinical significance of the cytochrome P450 2C19 genetic polymorphismQ28201086
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Stereoselective pharmacokinetics of pantoprazole, a proton pump inhibitor, in extensive and poor metabolizers of S-mephenytoinQ32156812
Influence of omeprazole on the antiplatelet action of clopidogrel associated with aspirin: the randomized, double-blind OCLA (Omeprazole CLopidogrel Aspirin) studyQ34009506
Influence of CYP2C19 pharmacogenetic polymorphism on proton pump inhibitor-based therapiesQ34430052
Thalidomide metabolism by the CYP2C subfamily.Q34523961
CYP2C19 pharmacogenomics associated with therapy of Helicobacter pylori infection and gastro-esophageal reflux diseases with a proton pump inhibitorQ34583603
Allele and genotype frequencies of polymorphic cytochromes P450 (CYP2C9, CYP2C19, CYP2E1) and dihydropyrimidine dehydrogenase (DPYD) in the Egyptian populationQ35803786
Review article: immediate-release proton-pump inhibitor therapy--potential advantagesQ36319531
Limited frequency of the CYP2C19*17 allele and its minor role in a Japanese populationQ36535932
Evaluation of a [13C]-dextromethorphan breath test to assess CYP2D6 phenotypeQ36684887
Stereoselective disposition of proton pump inhibitorsQ37136970
Pharmacokinetics, metabolism and interactions of acid pump inhibitors. Focus on omeprazole, lansoprazole and pantoprazoleQ41128197
A common novel CYP2C19 gene variant causes ultrarapid drug metabolism relevant for the drug response to proton pump inhibitors and antidepressantsQ42168063
Identification and functional characterization of new potentially defective alleles of human CYP2C19.Q44237764
Oral bioavailability of pantoprazole suspended in sodium bicarbonate solutionQ44538625
Pregnancy and use of oral contraceptives reduces the biotransformation of proguanil to cycloguanilQ44573290
Rapid identification of dihydropyrimidine dehydrogenase deficiency by using a novel 2-13C-uracil breath testQ44854701
Omeprazole as a CYP2C19 marker in Chinese subjects: assessment of its gene-dose effect and intrasubject variabilityQ44897887
Cytochrome P450 pharmacogenetics as a predictor of toxicity and clinical response to pulse cyclophosphamide in lupus nephritisQ44973876
Frequencies of the defective CYP2C19 alleles responsible for the mephenytoin poor metabolizer phenotype in various Oriental, Caucasian, Saudi Arabian and American black populationsQ46141212
The effect of aging on the relationship between the cytochrome P450 2C19 genotype and omeprazole pharmacokineticsQ46758734
The CYP2D6 activity score: translating genotype information into a qualitative measure of phenotypeQ46922848
Impact of the ultrarapid CYP2C19*17 allele on serum concentration of escitalopram in psychiatric patients.Q51901597
Cytochrome P450 2C19 loss-of-function polymorphism is a major determinant of clopidogrel responsiveness in healthy subjectsQ60018974
Effect of CYP2C19*17 gene variant on Helicobacter pylori eradication in peptic ulcer patientsQ61945694
Direct determination of pantoprazole enantiomers in human serum by reversed-phase high-performance liquid chromatography using a cellulose-based chiral stationary phase and column-switching system as a sample cleanup procedureQ71553628
Isolation and characterization of human liver cytochrome P450 2C19: correlation between 2C19 and S-mephenytoin 4'-hydroxylationQ72545136
Differential stereoselective pharmacokinetics of pantoprazole, a proton pump inhibitor in extensive and poor metabolizers of pantoprazole--a preliminary studyQ73204570
Allelic, genotypic and phenotypic distributions of S-mephenytoin 4'-hydroxylase (CYP2C19) in healthy Caucasian populations of European descent throughout the worldQ73257076
Metabolic disposition of pantoprazole, a proton pump inhibitor, in relation to S-mephenytoin 4'-hydroxylation phenotype and genotypeQ74058615
Effect of genetic differences in omeprazole metabolism on cure rates for Helicobacter pylori infection and peptic ulcerQ77732655
CYP2C19 genotype status and effect of omeprazole on intragastric pH in humansQ77788807
Liver disease selectively modulates cytochrome P450--mediated metabolismQ80212249
Polymorphisms of CYP2C19 gene are associated with the efficacy of thalidomide based regimens in multiple myelomaQ80709728
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectbreathingQ9530
P304page(s)297-305
P577publication date2009-01-09
P1433published inJournal of Pharmacology and Experimental TherapeuticsQ1500272
P1476titleRapid identification of the hepatic cytochrome P450 2C19 activity using a novel and noninvasive [13C]pantoprazole breath test
P478volume329

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cites work (P2860)
Q37628680(13)C breath tests in personalized medicine: fiction or reality?
Q36808111A rapid non invasive L-DOPA-¹³C breath test for optimally suppressing extracerebral AADC enzyme activity - toward individualizing carbidopa therapy in Parkinson’s disease
Q35023701Addressing phenoconversion: the Achilles' heel of personalized medicine
Q38560254Alternative Sampling Strategies for Cytochrome P450 Phenotyping.
Q38122635Breath tests to phenotype drug disposition in oncology
Q96588883Effect of High-Dose Esomeprazole on CYP1A2, CYP2C19 and CYP3A4 Activities in Humans: Evidence for Substantial and Long-lasting Inhibition of CYP2C19
Q40471212Effects of Genetic Polymorphisms of Cytochrome P450 Enzymes and MDR1 Transporter on Pantoprazole Metabolism and Helicobacter pylori Eradication.
Q82468735Evaluation of lansoprazole as a probe for assessing cytochrome P450 2C19 activity and genotype-phenotype correlation in childhood
Q36653603Is (+)-[13C]-pantoprazole better than (±)-[13C]-pantoprazole for the breath test to evaluate CYP2C19 enzyme activity?
Q34093850Role of the ¹³C-methacetin breath test in the assessment of acute liver injury in a rat model
Q35537682Stereoselective pharmacokinetics of stable isotope (+/-)-[13C]-pantoprazole: Implications for a rapid screening phenotype test of CYP2C19 activity
Q43116214[13C]pantoprazole breath test as a predictor of the anti-platelet function of clopidogrel

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