A rapid non invasive L-DOPA-¹³C breath test for optimally suppressing extracerebral AADC enzyme activity - toward individualizing carbidopa therapy in Parkinson’s disease

scientific article published on January 2012

A rapid non invasive L-DOPA-¹³C breath test for optimally suppressing extracerebral AADC enzyme activity - toward individualizing carbidopa therapy in Parkinson’s disease is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.3233/JPD-012132
P932PMC publication ID3640795
P698PubMed publication ID23646099

P2093author name stringDavid Rosen
Raymon Durso
Anil Modak
Ephraim Josephs
P2860cites workThe effects of carbidopa administration on 6-[18F]fluoro-L-dopa kinetics in positron emission tomographyQ48446833
Idiopathic Parkinsonism Treated with an Extracerebral Decarboxylase Inhibitor in Combination with LevodopaQ55061662
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High-performance liquid chromatographic method for measuring homovanillic acid in cerebrospinal fluid using electrochemical detection with internal standardizationQ68014062
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Kinetics of homovanillic acid and determination of its production rate in humansQ70431184
Aromatic l-amino acid decarboxylase activity in central and peripheral tissues and serum of rats with l-dopa and l-5-hydroxytryptophan as substratesQ70899887
The effect of carbidopa and entacapone pretreatment on the L-dopa pharmacokinetics and metabolism in blood plasma and skeletal muscle in beagle dog: an in vivo microdialysis studyQ72335318
L-dopa dose and the duration and severity of dyskinesia in primed MPTP-treated primatesQ80188582
Decreased noradrenaline (norepinephrine) synthesis in familial dysautonomiaQ28364925
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Microdialysis with radiometric monitoring of L-[β-11C]DOPA to assess dopaminergic metabolism: effect of inhibitors of L-amino acid decarboxylase, monoamine oxidase, and catechol-O-methyltransferase on rat striatal dialysateQ34627496
Parkinson's disease: medical treatment of moderate to advanced diseaseQ34666449
Evaluation of a [13C]-dextromethorphan breath test to assess CYP2D6 phenotypeQ36684887
Are high doses of carbidopa a concern? A randomized, clinical trial in Parkinson's diseaseQ37001159
Point-of-care continuous (13)C-methacetin breath test improves decision making in acute liver disease: results of a pilot clinical trialQ37122442
Rapid identification of the hepatic cytochrome P450 2C19 activity using a novel and noninvasive [13C]pantoprazole breath testQ37162141
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Variable absorption of carbidopa affects both peripheral and central levodopa metabolismQ40753373
The response to levodopa in Parkinson's disease: imposing pharmacological law and orderQ40981288
Pharmacodynamics of benserazide assessed by its effects on endogenous and exogenous levodopa pharmacokineticsQ41883836
Entacapone improves the availability of L-dopa in plasma by decreasing its peripheral metabolism independent of L-dopa/carbidopa doseQ42099300
Rapid identification of dihydropyrimidine dehydrogenase deficiency by using a novel 2-13C-uracil breath testQ44854701
Motor fluctuations in Parkinson's disease: pathogenetic and therapeutic studiesQ45026726
Is there a difference in gastric emptying between Parkinson's disease patients under long-term L-dopa therapy with and without motor fluctuations? An analysis using the 13C-acetate breath test.Q45941262
Increased prevalence of dihydropyrimidine dehydrogenase deficiency in African-Americans compared with CaucasiansQ46402944
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The effect of carbidopa on the pharmacokinetics of intravenously administered levodopa: the mechanism of action in the treatment of parkinsonismQ48438376
P433issue4
P921main subject(S)-(−)-carbidopa monohydrateQ414225
breathingQ9530
P304page(s)349-356
P577publication date2012-01-01
P1433published inJournal of Parkinson's diseaseQ26842319
P1476titleA rapid non invasive L-DOPA-¹³C breath test for optimally suppressing extracerebral AADC enzyme activity - toward individualizing carbidopa therapy in Parkinson’s disease
P478volume2

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