Specificities of heparan sulphate proteoglycans in developmental processes

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Specificities of heparan sulphate proteoglycans in developmental processes is …
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review articleQ7318358
scholarly articleQ13442814

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P6179Dimensions Publication ID1048795058
P356DOI10.1038/35008000
P3181OpenCitations bibliographic resource ID273949
P698PubMed publication ID10783877
P5875ResearchGate publication ID12532653

P50authorNorbert PerrimonQ38523404
P2093author name stringM Bernfield
P2860cites workMutations in GPC3, a glypican gene, cause the Simpson-Golabi-Behmel overgrowth syndromeQ24320198
The putative tumour suppressor EXT1 alters the expression of cell-surface heparan sulfateQ24323532
Heparan sulfate proteoglycans of the cardiovascular system. Specific structures emerge but how is synthesis regulated?Q24561731
Biology of the syndecans: a family of transmembrane heparan sulfate proteoglycansQ28213234
Physiological degradation converts the soluble syndecan-1 ectodomain from an inhibitor to a potent activator of FGF-2Q28273441
Regulated diversity of heparan sulfateQ28282444
The putative tumor suppressors EXT1 and EXT2 are glycosyltransferases required for the biosynthesis of heparan sulfateQ28284035
Matrix proteoglycans: from molecular design to cellular functionQ28284300
The EXT2 multiple exostoses gene defines a family of putative tumour suppressor genesQ28288396
Abnormal mast cells in mice deficient in a heparin-synthesizing enzymeQ28586968
???Q22009535
Renal agenesis in mice homozygous for a gene trap mutation in the gene encoding heparan sulfate 2-sulfotransferaseQ28589603
Heparin is essential for the storage of specific granule proteases in mast cellsQ28589787
Comparative genomics of the eukaryotesQ29547504
Functions of cell surface heparan sulfate proteoglycansQ29618521
The cell-surface proteoglycan Dally regulates Wingless signalling in DrosophilaQ33869131
Spatially restricted expression of pipe in the Drosophila egg chamber defines embryonic dorsal-ventral polarityQ34481268
OCI-5/GPC3, a glypican encoded by a gene that is mutated in the Simpson-Golabi-Behmel overgrowth syndrome, induces apoptosis in a cell line-specific manner.Q36255453
Shedding of syndecan-1 and -4 ectodomains is regulated by multiple signaling pathways and mediated by a TIMP-3-sensitive metalloproteinaseQ36316404
Regulated shedding of syndecan-1 and -4 ectodomains by thrombin and growth factor receptor activation.Q42439019
Wingless repression of Drosophila frizzled 2 expression shapes the Wingless morphogen gradient in the wingQ46769553
Dally cooperates with Drosophila Frizzled 2 to transduce Wingless signallingQ47070638
Structural analysis of glycosaminoglycans in Drosophila and Caenorhabditis elegans and demonstration that tout-velu, a Drosophila gene related to EXT tumor suppressors, affects heparan sulfate in vivoQ47070848
Hedgehog movement is regulated through tout velu-dependent synthesis of a heparan sulfate proteoglycanQ47071002
Tout-velu is a Drosophila homologue of the putative tumour suppressor EXT-1 and is needed for Hh diffusionQ47072416
Syndecans, heparan sulfate proteoglycans, maintain the proteolytic balance of acute wound fluids.Q52186911
Developmental Regulation of Neural Response to FGF-1 and FGF-2 by Heparan Sulfate ProteoglycanQ52225676
Bio-specific sequences and domains in heparan sulphate and the regulation of cell growth and adhesionQ64146688
Syndecan-1 is required for Wnt-1-induced mammary tumorigenesis in miceQ73977149
P433issue6779
P407language of work or nameEnglishQ1860
P304page(s)725-8
P577publication date2000-04-13
P1433published inNatureQ180445
P1476titleSpecificities of heparan sulphate proteoglycans in developmental processes
P478volume404

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Q34310368Heparan sulfate proteoglycans: intricate molecules with intriguing functions.
Q51889188Heparan sulfate sugar modifications mediate the functions of slits and other factors needed for mouse forebrain commissure development.
Q44462178Heparan sulfate-FGF10 interactions during lung morphogenesis
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Q28566524Identification of a novel nonlysosomal sulphatase expressed in the floor plate, choroid plexus and cartilage
Q35077801Identification of amino acid residues important for heparan sulfate proteoglycan interaction within variable region 3 of the feline immunodeficiency virus surface glycoprotein
Q50335972Identification of chondroitin sulfate glucuronyltransferase as chondroitin synthase-3 involved in chondroitin polymerization: chondroitin polymerization is achieved by multiple enzyme complexes consisting of chondroitin synthase family members
Q37462495Impact of Sulfatase-2 on cancer progression and prognosis in patients with renal cell carcinoma
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Q42931605Improved workup for glycosaminoglycan disaccharide analysis using CE with LIF detection
Q44542416In vitro heparan sulfate polymerization: crucial roles of core protein moieties of primer substrates in addition to the EXT1-EXT2 interaction
Q24314370In vitro polymerization of heparan sulfate backbone by the EXT proteins
Q40205392In vivo and in vitro degradation of heparan sulfate (HS) proteoglycans by HPR1 in pancreatic adenocarcinomas. Loss of cell surface HS suppresses fibroblast growth factor 2-mediated cell signaling and proliferation
Q44765740In vivo hyaluronan synthesis upon expression of the mammalian hyaluronan synthase gene in Drosophila
Q39304663Inhibition of human respiratory syncytial virus infectivity by a dendrimeric heparan sulfate-binding peptide.
Q42155968Involvement of chondroitin sulfate synthase-3 (chondroitin synthase-2) in chondroitin polymerization through its interaction with chondroitin synthase-1 or chondroitin-polymerizing factor
Q40602026Involvement of glycosylphosphatidylinositol-linked ceruloplasmin in the copper/zinc-nitric oxide-dependent degradation of glypican-1 heparan sulfate in rat C6 glioma cells
Q39253947Kidney development and perspectives for organ engineering
Q24290392LDL-receptor-related proteins in Wnt signal transduction
Q28469158LPS responsiveness and neutrophil chemotaxis in vivo require PMN MMP-8 activity
Q56895736Large, tissue-regulated domain diversity of heparan sulfates demonstrated by phage display antibodies
Q34219410Laser-capture microdissection and transcriptional profiling of the dorsomedial nucleus of the hypothalamus
Q33315465Loss of Endocan tumorigenic properties after alternative splicing of exon 2.
Q28587262Loss of glypican-3 function causes growth factor-dependent defects in cardiac and coronary vascular development
Q44520479Major glycosaminoglycan species in the developing retina: synthesis, tissue distribution and effects upon cell death
Q28588474Mammalian Brain Morphogenesis and Midline Axon Guidance Require Heparan Sulfate
Q28587947Mammary gland development requires syndecan-1 to create a beta-catenin/TCF-responsive mammary epithelial subpopulation
Q51848445Mapping candidate regions and genes for congenital anomalies of the kidneys and urinary tract (CAKUT) by array-based comparative genomic hybridization.
Q96222241Mature oligodendrocytes bordering lesions limit demyelination and favor myelin repair via heparan sulphate production
Q38186487Mesenchymal stem cells, neural lineage potential, heparan sulfate proteoglycans and the matrix.
Q91828805Metabolic and behavioral parameters of mice with reduced expression of Syndecan-1
Q37089817Method development and analysis of free HS and HS in proteoglycans from pre- and postmenopausal women: evidence for biosynthetic pathway changes in sulfotransferase and sulfatase enzymes
Q34170525Methylation-associated silencing of heparan sulfate D-glucosaminyl 3-O-sulfotransferase-2 (3-OST-2) in human breast, colon, lung and pancreatic cancers
Q38296018Microarray analysis detects novel Pax3 downstream target genes
Q50571168Modulating Glypican4 suppresses tumorigenicity of embryonic stem cells while preserving self-renewal and pluripotency.
Q31012211Modulations of glypican-1 heparan sulfate structure by inhibition of endogenous polyamine synthesis. Mapping of spermine-binding sites and heparanase, heparin lyase, and nitric oxide/nitrite cleavage sites
Q36611135Modulatory effects of heparin and short-length oligosaccharides of heparin on the metastasis and growth of LMD MDA-MB 231 breast cancer cells in vivo
Q24291588Molecular cloning and expression of a human chondroitin synthase
Q42688017Molecular cloning and expression of a second chondroitin N-acetylgalactosaminyltransferase involved in the initiation and elongation of chondroitin/dermatan sulfate
Q38293889Molecular regulation of urothelial renewal and host defenses during infection with uropathogenic Escherichia coli
Q57279432Morphogen diffusion: the case of the Wingless protein
Q21245330Mutations in many genes affect aggressive behavior in Drosophila melanogaster
Q40838438N-unsubstituted glucosamine in heparan sulfate of recycling glypican-1 from suramin-treated and nitrite-deprived endothelial cells. mapping of nitric oxide/nitrite-susceptible glucosamine residues to clustered sites near the core protein.
Q52777524NDST1 missense mutations in autosomal recessive intellectual disability.
Q40706633NG2 proteoglycan mediates beta1 integrin-independent cell adhesion and spreading on collagen VI.
Q28298433Netrin-1/DCC signaling in commissural axon guidance requires cell-autonomous expression of heparan sulfate
Q31109060Nitric oxide-dependent processing of heparan sulfate in recycling S-nitrosylated glypican-1 takes place in caveolin-1-containing endosomes.
Q52165281Notch signaling: Fringe really is a glycosyltransferase.
Q50573731Old gene, new phenotype: mutations in heparan sulfate synthesis enzyme, EXT2 leads to seizure and developmental disorder, no exostoses.
Q46050552On the role of glypicans in the process of morphogen gradient formation
Q37310377On-line separations combined with MS for analysis of glycosaminoglycans
Q40021244Opposing roles of syndecan-1 and syndecan-2 in polyethyleneimine-mediated gene delivery
Q37071636Optimized extraction of glycosaminoglycans from normal and osteoarthritic cartilage for glycomics profiling
Q37169432Organ-specific heparan sulfate structural phenotypes.
Q43748131Ovarian carcinoma cells synthesize both chondroitin sulfate and heparan sulfate cell surface proteoglycans that mediate cell adhesion to interstitial matrix
Q24291309Overexpression of camello, a member of a novel protein family, reduces blastomere adhesion and inhibits gastrulation in Xenopus laevis
Q37559582Overexpression of heparan sulfate 6-O-sulfotransferase-2 in colorectal cancer
Q92956166Pathophysiology of aged lymphatic vessels
Q34133514Perception of lipo-chitooligosaccharidic Nod factors in legumes
Q52115466Perlecan participates in proliferation activation of quiescent Drosophila neuroblasts.
Q34122102Perspectives on the evolutionary origin of tetrapod limbs.
Q37889211Position matters: variability in the spatial pattern of BMP modulators generates functional diversity
Q35746811Preparation and characterization of heparin hexasaccharide library with N-unsubstituted glucosamine residues
Q38331584Preparation of heparin/heparan sulfate oligosaccharides with internal N-unsubstituted glucosamine residues for functional studies
Q28277212Processing by convertases is not required for glypican-3-induced stimulation of hepatocellular carcinoma growth
Q44978511Production of N-sulfated polysaccharides using yeast-expressed N-deacetylase/N-sulfotransferase-1 (NDST-1).
Q38680940Proteoglycans and axon guidance: a new relationship between old partners
Q34179324Proteoglycans in the nervous system--the quest for functional roles in vivo
Q34362776Proteoglycans: pericellular and cell surface multireceptors that integrate external stimuli in the mammary gland
Q37745062Proteoglycomics: recent progress and future challenges
Q33237312Proteomic analysis of colorectal cancer reveals alterations in metabolic pathways: mechanism of tumorigenesis.
Q39572643Reactive oxygen species mediate high glucose-induced heparanase-1 production and heparan sulphate proteoglycan degradation in human and rat endothelial cells: a potential role in the pathogenesis of atherosclerosis
Q34271235Recent advances in the structural biology of chondroitin sulfate and dermatan sulfate
Q34066504Recent advances in the study of the biosynthesis and functions of sulfated glycosaminoglycans
Q24676527Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family
Q36722802Redefining the role of syndecans in C. elegans biology
Q24537749Regulation of Wnt/LRP signaling by distinct domains of Dickkopf proteins
Q35114376Regulation of cytoskeletal organization by syndecan transmembrane proteoglycans
Q47621324Regulation of glycosaminoglycan biogenesis is critical for sensitive-period-dependent vocal ontogeny.
Q28584264Regulation of pancreatic endocrine cell differentiation by sulphated proteoglycans
Q28582695Regulation of ureteric bud branching morphogenesis by sulfated proteoglycans in the developing kidney
Q38523590Relationship between sprouting axons, proteoglycans and glial cells following unilateral nigrostriatal axotomy in the adult rat.
Q36220338Role of glycosaminoglycans in infectious disease
Q36802608Role of heparan sulfate in ocular diseases.
Q34414667Role of heparan sulfate proteoglycans in cell signaling and cancer
Q34017795Role of heparan sulfate proteoglycans in cell-cell signaling in Drosophila
Q34989564Role of heparan sulfate-2-O-sulfotransferase in the mouse.
Q37784308Roles of heparan sulfate in mammalian brain development current views based on the findings from Ext1 conditional knockout studies
Q34718195Roles of heparan-sulphate glycosaminoglycans in cancer
Q35697283Secreted HHIP1 interacts with heparan sulfate and regulates Hedgehog ligand localization and function
Q21144445Secreted sulfatases Sulf1 and Sulf2 have overlapping yet essential roles in mouse neonatal survival
Q38031468Signaling mechanisms controlling cell fate and embryonic patterning
Q53060649Skeletal dysplasia, global developmental delay, and multiple congenital anomalies in a 5-year-old boy-report of the second family with B3GAT3 mutation and expansion of the phenotype.
Q30960842Slalom encodes an adenosine 3'-phosphate 5'-phosphosulfate transporter essential for development in Drosophila
Q57242324Software for Peak Finding and Elemental Composition Assignment for Glycosaminoglycan Tandem Mass Spectra
Q35804497Spatially restricted patterning cues provided by heparin-binding VEGF-A control blood vessel branching morphogenesis
Q28251561Spatiotemporal distribution of heparan sulfate epitopes during murine cartilage growth plate development
Q42525353Spatiotemporal distribution of heparan sulfate epitopes during myogenesis and synaptogenesis: a study in developing mouse intercostal muscle
Q33317125Specific heparan sulfate structures modulate FGF10-mediated submandibular gland epithelial morphogenesis and differentiation
Q34103547Specificities of N-acetylglucosamine-6-O-sulfotransferases in relation to L-selectin ligand synthesis and tumor-associated enzyme expression
Q48439743Stem cells that know their place
Q64252462Structural Biology of the FGF7 Subfamily
Q46135223Structural and functional changes of sulfated glycosaminoglycans in Xenopus laevis during embryogenesis
Q38336239Structural and functional characterization of oversulfated chondroitin sulfate/dermatan sulfate hybrid chains from the notochord of hagfish. Neuritogenic and binding activities for growth factors and neurotrophic factors
Q27673616Structural basis of heparan sulfate-specific degradation by heparinase III
Q40802141Structural characterization of heparan sulfate and chondroitin sulfate of syndecan-1 purified from normal murine mammary gland epithelial cells. Common phosphorylation of xylose and differential sulfation of galactose in the protein linkage region t
Q33275137Structural determination of novel sulfated octasaccharides isolated from chondroitin sulfate of shark cartilage and their application for characterizing monoclonal antibody epitopes
Q34523315Structure and biological interactions of heparin and heparan sulfate
Q48267335Structure and elasticity of bush and brush-like models of the endothelial glycocalyx
Q37533574Structure and response to flow of the glycocalyx layer
Q38666664Sulfated glycopeptide nanostructures for multipotent protein activation
Q42668609Sulfated is a negative feedback regulator of wingless in Drosophila
Q51837891Sulfated polysaccharides enhance the biological activities of bone morphogenetic proteins.
Q34944523Sulfotransferases and sulfated oligosaccharides
Q51626960Suppression of the biological activities of the epidermal growth factor (EGF)-like domain by the heparin-binding domain of heparin-binding EGF-like Growth Factor.
Q47881177Syndecan-1 limits the progression of liver injury and promotes liver repair in acetaminophen-induced liver injury in mice
Q34177237Syndecan-1-Dependent Suppression of PDK1/Akt/Bad Signaling by Docosahexaenoic Acid Induces Apoptosis in Prostate Cancer
Q37008599Syndecan-1: a dynamic regulator of the myeloma microenvironment
Q61918715Syndecan-2 downregulation impairs angiogenesis in human microvascular endothelial cells
Q34250621Syndecans and cell adhesion
Q35611355Syndecans: proteoglycan regulators of cell-surface microdomains?
Q37697058Synthesis of fluorophore-tagged xylosides that prime glycosaminoglycan chains
Q42825962Temporal and functional changes in glycosaminoglycan expression during osteogenesis.
Q34392836The Caenorhabditis elegans vulval morphogenesis gene sqv-4 encodes a UDP-glucose dehydrogenase that is temporally and spatially regulated
Q47224539The Components of Bone and What They Can Teach Us about Regeneration
Q37810999The Dynamic Glycome Microenvironment and Stem Cell Differentiation into Vasculature
Q28205615The SLC26 gene family of multifunctional anion exchangers
Q24540364The SQV-1 UDP-glucuronic acid decarboxylase and the SQV-7 nucleotide-sugar transporter may act in the Golgi apparatus to affect Caenorhabditis elegans vulval morphogenesis and embryonic development
Q22065842The Sequence of the Human Genome
Q52085901The Wingless morphogen gradient is established by the cooperative action of Frizzled and Heparan Sulfate Proteoglycan receptors.
Q37152815The chemical neurobiology of carbohydrates
Q38059785The complex world of WNT receptor signalling
Q37004231The design and synthesis of new synthetic low-molecular-weight heparins
Q34522475The detection of glycosaminoglycans in pancreatic islets and lymphoid tissues
Q28216354The donor substrate specificity of the human beta 1,3-glucuronosyltransferase I toward UDP-glucuronic acid is determined by two crucial histidine and arginine residues
Q33948367The effect of precursor structures on the action of glucosaminyl 3-O-sulfotransferase-1 and the biosynthesis of anticoagulant heparan sulfate
Q36719459The endothelial glycocalyx: composition, functions, and visualization
Q54532324The heparin/heparan sulfate 2-O-sulfatase from Flavobacterium heparinum. Molecular cloning, recombinant expression, and biochemical characterization.
Q24300738The human D-glucuronyl C5-epimerase gene is transcriptionally activated through the beta-catenin-TCF4 pathway
Q40668417The involvement of heparan sulfate (HS) in FGF1/HS/FGFR1 signaling complex
Q37171354The lens capsule
Q24671153The link between heparan sulfate and hereditary bone disease: finding a function for the EXT family of putative tumor suppressor proteins
Q28575434The loss of glypican-3 induces alterations in Wnt signaling
Q28513833The molecular phenotype of heparan sulfate in the Hs2st-/- mutant mouse
Q42390629The role of Wnt signaling in neuronal dysfunction in Alzheimer's Disease
Q60482229The solution structure of heparan sulfate differs from that of heparin: implications for function
Q35107450The solution structure of heparan sulfate differs from that of heparin: implications for function.
Q36332805The structural basis for a coordinated reaction catalyzed by a bifunctional glycosyltransferase in chondroitin biosynthesis
Q33199519The transforming activity of Wnt effectors correlates with their ability to induce the accumulation of mammary progenitor cells
Q43795211The zebrafish glypican knypek controls cell polarity during gastrulation movements of convergent extension
Q26743361Tissue- and Serum-Associated Biomarkers of Hepatocellular Carcinoma
Q24314953Two endoplasmic reticulum (ER)/ER Golgi intermediate compartment-based lysine acetyltransferases post-translationally regulate BACE1 levels
Q34411574Two-step mechanism that determines the donor binding specificity of human UDP-N-acetylhexosaminyltransferase
Q35219626Unlocking the secrets of syndecans: transgenic organisms as a potential key.
Q33824982Unraveling the specificity of heparanase utilizing synthetic substrates
Q35564095Utilization of lectin-histochemistry in forensic neuropathology: lectin staining provides useful information for postmortem diagnosis in forensic neuropathology
Q52644490Variations in the Peritrophic Matrix Composition of Heparan Sulphate from the Tsetse Fly, Glossina morsitans morsitans.
Q52165379Vascular developmental biology: getting nervous.
Q52128481Well developed: the SDB reaches 60. Society for Developmental Biology.
Q46018207Wnt/β-catenin signaling during early vertebrate neural development.
Q81232514[Comparison of the osteogenic activity of bone morphogenetic protein (BMP) mutants]
Q29618701arrow encodes an LDL-receptor-related protein essential for Wingless signalling
Q33928505rib-2, a Caenorhabditis elegans homolog of the human tumor suppressor EXT genes encodes a novel alpha1,4-N-acetylglucosaminyltransferase involved in the biosynthetic initiation and elongation of heparan sulfate
Q24292160Molecular cloning and expression of human chondroitin N-acetylgalactosaminyltransferase: the key enzyme for chain initiation and elongation of chondroitin/dermatan sulfate on the protein linkage region tetrasaccharide shared by heparin/heparan sulfa

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