Structure and biological interactions of heparin and heparan sulfate

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Structure and biological interactions of heparin and heparan sulfate is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

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P356DOI10.1016/S0065-2318(01)57017-1
P698PubMed publication ID11836942

P2093author name stringB Casu
U Lindahl
P2860cites workRequirement for anticoagulant heparan sulfate in the fibroblast growth factor receptor complexQ78037697
Negative ion fast-atom bombardment tandem mass spectrometry to determine sulfate and linkage position in glycosaminoglycan-derived disaccharidesQ86746086
A force-field study of the conformational characteristics of the iduronate ringQ89354825
High-performance liquid chromatographic separation of heparin-derived oligosaccharidesQ93681630
Human heparanase. Purification, characterization, cloning, and expressionQ22003728
Mammalian heparanase: gene cloning, expression and function in tumor progression and metastasisQ22010222
Crystal structure of a ternary FGF-FGFR-heparin complex reveals a dual role for heparin in FGFR binding and dimerizationQ24290400
Crystal structure of fibroblast growth factor receptor ectodomain bound to ligand and heparinQ24290496
Molecular cloning and expression of human UDP-d-Xylose:proteoglycan core protein beta-d-xylosyltransferase and its first isoform XT-IIQ24290566
The putative tumour suppressor EXT1 alters the expression of cell-surface heparan sulfateQ24323532
The EXT1/EXT2 tumor suppressors: catalytic activities and role in heparan sulfate biosynthesisQ24522477
N.m.r. and molecular-modelling studies of the solution conformation of heparinQ24528140
Molecular distinctions between heparan sulphate and heparin. Analysis of sulphation patterns indicates that heparan sulphate and heparin are separate families of N-sulphated polysaccharidesQ24529894
Structural basis and potential role of heparin/heparan sulfate binding to the angiogenesis inhibitor endostatinQ24529922
Structural differences and the presence of unsubstituted amino groups in heparan sulphates from different tissues and speciesQ24530061
cDNA cloning, genomic organization and chromosomal localization of human heparan glucosaminyl N-deacetylase/N-sulphotransferase-2Q24530865
Expression of heparan sulphate L-iduronyl 2-O-sulphotransferase in human kidney 293 cells results in increased D-glucuronyl 2-O-sulphationQ24531959
The intact and cleaved human antithrombin III complex as a model for serpin–proteinase interactionsQ27729838
Biological implications of a 3 A structure of dimeric antithrombinQ27730918
Heparin structure and interactions with basic fibroblast growth factorQ27732601
Structure of a heparin-linked biologically active dimer of fibroblast growth factorQ27760195
Molecular cloning and expression of a third member of the heparan sulfate/heparin GlcNAc N-deacetylase/ N-sulfotransferase familyQ28118805
Cloning of mammalian heparanase, an important enzyme in tumor invasion and metastasisQ28138868
Heparan sulfate D-glucosaminyl 3-O-sulfotransferase-3A sulfates N-unsubstituted glucosamine residuesQ28141121
A novel role for 3-O-sulfated heparan sulfate in herpes simplex virus 1 entryQ28145858
Multivalent Ligand-Receptor Binding Interactions in the Fibroblast Growth Factor System Produce a Cooperative Growth Factor and Heparin Mechanism for Receptor DimerizationQ71642294
Polydispersity in sulfation profile of oligosaccharide alditols isolated from the protein-linkage region and the repeating disaccharide region of chondroitin 4-sulfate of bovine nasal septal cartilageQ71652972
Rational design of synthetic heparin analogues with tailor-made coagulation factor inhibitory activityQ71727041
Perlecan: a gem of a proteoglycanQ28238298
Integral membrane heparan sulfate proteoglycansQ28262453
Substrate specificity of heparanases from human hepatoma and plateletsQ28276774
Regulated diversity of heparan sulfateQ28282444
Conformer populations of L-iduronic acid residues in glycosaminoglycan sequencesQ28283247
The putative tumor suppressors EXT1 and EXT2 are glycosyltransferases required for the biosynthesis of heparan sulfateQ28284035
Requirement of heparan sulfate for bFGF-mediated fibroblast growth and myoblast differentiationQ28296150
Conformation of heparin pentasaccharide bound to antithrombin IIIQ28360842
Common binding sites for beta-amyloid fibrils and fibroblast growth factor-2 in heparan sulfate from human cerebral cortexQ28374326
Specificities of heparan sulphate proteoglycans in developmental processesQ28377841
Abnormal mast cells in mice deficient in a heparin-synthesizing enzymeQ28586968
Targeted disruption of NDST-1 gene leads to pulmonary hypoplasia and neonatal respiratory distress in miceQ28589567
Multiple isozymes of heparan sulfate/heparin GlcNAc N-deacetylase/GlcN N-sulfotransferase. Structure and activity of the fourth member, NDST4Q28591320
The occurrence of three isoforms of heparan sulfate 6-O-sulfotransferase having different specificities for hexuronic acid adjacent to the targeted N-sulfoglucosamineQ28594700
Cell surface, heparin-like molecules are required for binding of basic fibroblast growth factor to its high affinity receptorQ29616189
Dengue virus infectivity depends on envelope protein binding to target cell heparan sulfateQ29618060
Functions of cell surface heparan sulfate proteoglycansQ29618521
Angiogenic factorsQ29620582
Synthesis of thrombin-inhibiting heparin mimetics without side effectsQ30573078
Sequencing complex polysaccharidesQ30791276
Structure of heparin-derived tetrasaccharide complexed to the plasma protein antithrombin derived from NOEs, J-couplings and chemical shiftsQ31271143
Mass spectrometric evidence for the enzymatic mechanism of the depolymerization of heparin-like glycosaminoglycans by heparinase II.Q32000531
Heparan sulfate oligosaccharides require 6-O-sulfation for promotion of basic fibroblast growth factor mitogenic activityQ32030968
Generation and application of type-specific anti-heparan sulfate antibodies using phage display technology. Further evidence for heparan sulfate heterogeneity in the kidneyQ32064386
Direct evidence for a predominantly exolytic processive mechanism for depolymerization of heparin-like glycosaminoglycans by heparinase I.Q32068517
Ion-spray mass spectrometric analysis of glycosaminoglycan oligosaccharides.Q33429751
Pharmacokinetic and pharmacodynamic properties of oral anticoagulants, especially phenprocoumonQ33635030
Heparin in inflammation: potential therapeutic applications beyond anticoagulation.Q33637649
The elusive functions of proteoglycans: in vivo veritasQ33825069
Overexpression of different isoforms of glucosaminyl N-deacetylase/N-sulfotransferase results in distinct heparan sulfate N-sulfation patternsQ33897548
Selectively desulfated heparin inhibits fibroblast growth factor-induced mitogenicity and angiogenesisQ33902258
Heparin and heparan sulfate: biosynthesis, structure and functionQ33927046
Molecular structure of the carbohydrate-protein linkage region fragments from connective-tissue proteoglycansQ34064621
Conformation and dynamics of heparin and heparan sulfateQ34087654
Signal transduction by allosteric receptor oligomerizationQ34165171
Isolation and characterization of hexasaccharides derived from heparin. Analysis by HPLC and elucidation of structure by 1H NMRQ72112565
Preparation and structural characterization of large heparin-derived oligosaccharidesQ72292508
Energetic characterization of the basic fibroblast growth factor-heparin interaction: identification of the heparin binding domainQ72326632
The effect of variation of substitution on the solution conformation of heparin: a spectroscopic and molecular modelling studyQ72414841
Structural studies on the oligosaccharides isolated from bovine kidney heparan sulphate and characterization of bacterial heparitinases used as substratesQ72423520
Substrate specificity of the heparin lyases from Flavobacterium heparinumQ72545221
"Fast moving" and "slow moving" heparins, dermatan sulfate, and chondroitin sulfate: qualitative and quantitative analysis by agarose-gel electrophoresisQ72559654
Structure of heparan sulfate from the fresh water mollusc Anomantidae sp: sequencing of its disaccharide unitsQ72565706
Characterization of the chemical structure of sulphated glycosaminoglycans after enzymatic digestion. Application of liquid chromatography-mass spectrometry with an atmospheric pressure interfaceQ72572617
Thermodynamics of charged oligopeptide-heparin interactionsQ72638505
Separation of glycosaminoglycan-derived oligosaccharides by capillary electrophoresis using reverse polarityQ72870539
FABMS/derivatisation strategies for the analysis of heparin-derived oligosaccharidesQ72873336
Sulfated Oligosaccharides Isolated from the Deamination Products of Heparins1Q72908972
New insights on the specificity of heparin and heparan sulfate lyases from Flavobacterium heparinum revealed by the use of synthetic derivatives of K5 polysaccharide from E. coli and 2-O-desulfated heparinQ73223170
Preparation and structure of heparin lyase-derived heparan sulfate oligosaccharidesQ73304927
Direct isolation and sequencing of specific protein-binding glycosaminoglycansQ73339920
Specific binding of the chemokine platelet factor 4 to heparan sulfateQ73575394
Partial purification and substrate specificity of heparan sulfate alpha-N-acetylglucosaminyltransferase I: synthesis, NMR spectroscopic characterization and in vitro assays of two aryl tetrasaccharidesQ73579678
Role of arginine 129 in heparin binding and activation of antithrombinQ73675879
Amyloid-specific heparan sulfate from human liver and spleenQ73797107
Preparation of completely 6-O-desulfated heparin and its ability to enhance activity of basic fibroblast growth factorQ73850106
Fibroblast growth factors and their receptorsQ74584667
Characterization of heparin oligosaccharide mixtures as ammonium salts using electrospray mass spectrometryQ74604046
Determination of the structure of oligosaccharides prepared from acharan sulfateQ74801759
The putative heparin-specific N-acetylglucosaminyl N-Deacetylase/N-sulfotransferase also occurs in non-heparin-producing cellsQ77126990
Conversion of N-sulfated glucosamine to N-sulfated mannosamine in an unsaturated heparin disaccharide by non-enzymatic, base-catalyzed C-2 epimerization during enzymatic oligosaccharide preparationQ77317037
Microanalysis of glycosaminoglycan-derived oligosaccharides labeled with a fluorophore 2-aminobenzamide by high-performance liquid chromatography: application to disaccharide composition analysis and exosequencing of oligosaccharidesQ77380362
Characterization of fibroblast growth factor 1 binding heparan sulfate domainQ77856163
Combined NMR and molecular modeling study of an iduronic acid-containing trisaccharide related to antithrombotic heparin fragmentsQ38344398
Endothelial cell heparanase modulation of lipoprotein lipase activity. Evidence that heparan sulfate oligosaccharide is an extracellular chaperoneQ38344887
Glycosaminoglycans can influence fibroblast growth factor-2 mitogenicity without significant growth factor bindingQ38344902
Properly oriented heparin-decasaccharide-induced dimers are the biologically active form of basic fibroblast growth factor.Q38346690
Characterization of heparin and heparan sulfate domains binding to the long splice variant of platelet-derived growth factor A chainQ38348282
Conformation of the pentasaccharide corresponding to the binding site of heparin to antithrombin-III.Q38349007
Enzymatic preparation of heparin oligosaccharides containing antithrombin III binding sitesQ38350614
Domain structure of proteoheparan sulphate from confluent cultures of human embryonic skin fibroblastsQ38351842
Sequence variation in heparin octasaccharides with high affinity for antithrombin III.Q38353259
An animal cell mutant defective in heparan sulfate hexuronic acid 2-O-sulfationQ38355072
Structure and biological activity of finback-whale (Balaenoptera physalus L.) heparin octasaccharide. Chemical, carbon-13 nuclear-magnetic-resonance, enzymic and biological studiesQ38355332
Structures of five sulfated hexasaccharides prepared from porcine intestinal heparin using bacterial heparinase. Structural variants with apparent biosynthetic precursor-product relationships for the antithrombin III-binding siteQ38358031
Conformational flexibility: a new concept for explaining binding and biological properties of iduronic acid-containing glycosaminoglycansQ39579344
Polysaccharide lyasesQ39735604
Structure and biological activity of heparin.Q39841200
More to "heparin" than anticoagulationQ40695910
Substrate specificity of the heparan sulfate hexuronic acid 2-O-sulfotransferaseQ40809157
Glycosaminoglycans and the regulation of blood coagulationQ40851193
Regulation of growth factor activation by proteoglycans: what is the role of the low affinity receptors?Q40922726
Involvement of the core protein in the first beta-N-acetylgalactosamine transfer to the glycosaminoglycan-protein linkage-region tetrasaccharide and in the subsequent polymerization: the critical determining step for chondroitin sulphate biosynthesiQ40953551
Monomer complexes of basic fibroblast growth factor and heparan sulfate oligosaccharides are the minimal functional unit for cell activationQ40957417
Heparan sulphate and protein recognition. Binding specificities and activation mechanisms.Q40967487
Heparan sulfate: a piece of informationQ41135360
Alternatively spliced juxtamembrane domain of a tyrosine kinase receptor is a multifunctional regulatory site. Deletion alters cellular tyrosine phosphorylation pattern and facilitates binding of phosphatidylinositol-3-OH kinase to the hepatocyte grQ41380865
Biosynthesis of heparin. Use of Escherichia coli K5 capsular polysaccharide as a model substrate in enzymic polymer-modification reactionsQ41814747
Very-high-field n.m.r. studies of bovine lung heparan sulphate tetrasaccharides produced by nitrous acid deaminative cleavage. Determination of saccharide sequence, uronate composition and degrees of sulphationQ41816735
Binding of the G domains of laminin alpha1 and alpha2 chains and perlecan to heparin, sulfatides, alpha-dystroglycan and several extracellular matrix proteinsQ42001102
Biosynthesis of heparin. Relationship between the polymerization and sulphation processesQ42005884
Fractionation of heparin-derived oligosaccharides by gradient polyacrylamide-gel electrophoresisQ42047718
Structure of heparan sulphate from human brain, with special regard to Alzheimer's diseaseQ42160698
Distribution of iduronate 2-sulphate residues in heparan sulphate. Evidence for an ordered polymeric structureQ42161980
Further characterization of the antithrombin-binding sequence in heparinQ42263887
Heparan sulfate degradation: relation to tumor invasive and metastatic properties of mouse B16 melanoma sublinesQ42450178
Human platelet heparanase: purification, characterization and catalytic activityQ42451905
Domain structure of heparan sulfates from bovine organsQ42555942
Structure of heparin-derived tetrasaccharidesQ42670467
A major common trisulfated hexasaccharide core sequence, hexuronic acid(2-sulfate)-glucosamine(N-sulfate)-iduronic acid-N-acetylglucosamine-glucuronic acid-glucosamine(N-sulfate), isolated from the low sulfated irregular region of porcine intestinalQ42671353
Human glucosamine-6-sulphatase deficiency. Diagnostic enzymology towards heparin-derived trisaccharide substratesQ42792998
Mitogenic activity of acidic fibroblast growth factor is enhanced by highly sulfated oligosaccharides derived from heparin and heparan sulfateQ42807954
Highly sensitive sequencing of the sulfated domains of heparan sulfate.Q42814375
Distinct role of 2-O-, N-, and 6-O-sulfate groups of heparin in the formation of the ternary complex with basic fibroblast growth factor and soluble FGF receptor-1.Q42834483
Conformational equilibria of alpha-L-iduronate residues in disaccharides derived from heparinQ42855754
The disaccharide composition of heparins and heparan sulfatesQ43545252
Sequence analysis of heparan sulfate epitopes with graded affinities for fibroblast growth factors 1 and 2.Q43640409
Disaccharide compositional analysis of heparin and heparan sulfate using capillary zone electrophoresisQ43833849
The disaccharide repeating-units of heparan sulfateQ44177045
Sulfation of some chemically-modified heparins. Formation of a 3-sulfate analog of heparinQ44577321
One- and two-dimensional 1H-NMR characterization of two series of sulfated disaccharides prepared from chondroitin sulfate and heparan sulfate/heparin by bacterial eliminase digestionQ44661049
1H-N.m.r. spectral assignments for two series of heparin-derived oligosaccharides.Q45908212
Defining the interleukin-8-binding domain of heparan sulfateQ38336349
Age-dependent modulation of heparan sulfate structure and functionQ38337039
Structural modification of fibroblast growth factor-binding heparan sulfate at a determinative stage of neural developmentQ38339362
Oligosaccharide mapping of low molecular weight heparins: structure and activity differencesQ38340683
Interaction of fibroblast growth factor-1 and related peptides with heparan sulfate and its oligosaccharidesQ38342270
Structural requirement of heparan sulfate for interaction with herpes simplex virus type 1 virions and isolated glycoprotein C.Q38342862
Chemical sulfonation and anticoagulant activity of acharan sulfateQ46417968
Endothelial heparan sulfate proteoglycans that bind to L-selectin have glucosamine residues with unsubstituted amino groupsQ46519756
Turnover of heparan sulfate depends on 2-O-sulfation of uronic acidsQ46699156
"Supersulfated" heparin fragments, a new type of low-molecular weight heparin. Physico-chemical and pharmacological propertiesQ47194633
Assessment through chemical synthesis of the size of the heparin sequence involved in thrombin inhibitionQ47258600
Molecular profiling and weight determination of heparins and depolymerized heparinsQ47353379
Physiochemical characterization of low molecular weight heparinQ47359027
Molecular weight of low molecular weight heparins by 13C nuclear magnetic resonance spectroscopyQ47378087
Gradient polyacrylamide gel electrophoresis for determination of molecular weights of heparin preparations and low-molecular-weight heparin derivativesQ47409124
Importance of size and sulfation of heparin in release of basic fibroblast growth factor from the vascular endothelium and extracellular matrixQ47416115
FGF signaling in skeletal development.Q47768464
New insights into heparin-induced FGF oligomerizationQ47842142
Identification and expression in mouse of two heparan sulfate glucosaminyl N-deacetylase/N-sulfotransferase genesQ48037516
Biosynthesis of heparin/heparan sulfate. cDNA cloning and expression of D-glucuronyl C5-epimerase from bovine lungQ48043443
Reg1ulatory role and molecular interactions of a cell-surface heparan sulfate proteoglycan (N-syndecan) in hippocampal long-term potentiation.Q48287519
Heparin-induced conformational change and activation of mucus proteinase inhibitor.Q50790111
Isolation and recovery of acidic oligosaccharides from polyacrylamide gels by semi-dry electrotransferQ50884304
Flavobacterium heparinum 2-O-sulphatase for 2-O-sulphato-delta 4,5-glycuronate-terminated oligosaccharides from heparin.Q50919485
Developmental Regulation of Neural Response to FGF-1 and FGF-2 by Heparan Sulfate ProteoglycanQ52225676
FKBP-12 recognition is dispensable for signal generation by type I transforming growth factor-beta receptors.Q52521102
Motional properties of E. coli polysaccharide K5 in aqueous solution analyzed by NMR relaxation measurements.Q54566015
Presence of N-unsubstituted glucosamine units in native heparan sulfate revealed by a monoclonal antibody.Q54598050
Heparin-like compounds prepared by chemical modification of capsular polysaccharide from E. coli K5.Q54625741
Low-sulphated oligosaccharides derived from heparan sulphate inhibit normal angiogenesis.Q54647861
Effect of substitution pattern on 1 H, 13 C NMR chemical shifts and 1 J CH coupling constants in heparin derivativesQ56833711
Evidence for a heparin derivative containing an N-sulfated aziridine ring that retains high anti-factor Xa activityQ56833712
Modifications under basic conditions of the minor sequences of heparin containing 2,3 or 2,3,6 sulfatedd-glucosamine residuesQ56833714
Combined Quantitative 1H and 13C Nuclear Magnetic Resonance Spectroscopy for Characterization of Heparin PreparationsQ57563823
Conformational analysis of heparin epoxide in aqueous solution. An NMR relaxation studyQ57563854
Synthesis of a N′-Alkylamine Anticoagulant Active Low-Molecular-Mass Heparin for Radioactive and Fluorescent LabelingQ57563874
Conformation of the Unsaturated Uronic Acid Residues of Glycosamtnoglycan DisaccharidesQ57563878
Purification and characterization of fetal bovine serum beta-N-acetyl-D-galactosaminyltransferase and beta-D-glucuronyltransferase involved in chondroitin sulfate biosynthesisQ58831352
Synthesis and Characterization of Highly Sensitive Heparin Probes for Detection of Heparin-Binding ProteinsQ63944754
High-performance liquid chromatographic-mass spectrometric analysis of oligosaccharides from enzymatic digestion of glycosaminoglycans. Application to human samplesQ68171518
Heparin-derived oligosaccharides: affinity for acidic fibroblast growth factor and effect on its growth-promoting activity for human endothelial cellsQ69355994
Sequence analysis of highly sulfated, heparin-derived oligosaccharides using fast atom bombardment mass spectrometryQ69715083
Study of structurally defined oligosaccharide substrates of heparin and heparan monosulfate lyasesQ69777421
N.m.r. spectroscopic observations related to the function of sulfate groups in heparin. Calcium binding vs. biological activityQ70027267
Marked stereoselectivity in the binding of copper ions by heparin. Contrasts with the binding of gadolinium and calcium ionsQ70244333
A relationship between 13C-chemical-shift displacements and counterion-condensation theory, in the binding of calcium ion by heparinQ70373222
Isolation and characterization of heparan sulfate from crude porcine intestinal mucosal peptidoglycan heparinQ70823083
A method for rapid quantitation and preparation of antithrombin III--high-affinity heparin fractionsQ71027130
Structure-activity relationship in heparin: a synthetic pentasaccharide with high affinity for antithrombin III and eliciting high anti-factor Xa activityQ71137899
A new glycosaminoglycan from the giant African snail Achatina fulicaQ71142713
Strategy for the sequence analysis of heparinQ71291258
Chemical modifications of heparin that diminish its anticoagulant but preserve its heparanase-inhibitory, angiostatic, anti-tumor and anti-metastatic propertiesQ71303804
Structural studies on heparin. Tetrasaccharides obtained by heparinase degradationQ71321960
Divalent cations and heparin/heparan sulfate cooperate to control assembly and activity of the fibroblast growth factor receptor complexQ71574049
???Q22009535
Isolation and characterization of human heparinQ34279022
Toward a biotechnological heparin through combined chemical and enzymatic modification of the Escherichia coli K5 polysaccharideQ34415381
A strategy for rapid sequencing of heparan sulfate and heparin saccharidesQ35059120
Isolation and expression in Escherichia coli of hepB and hepC, genes coding for the glycosaminoglycan-degrading enzymes heparinase II and heparinase III, respectively, from Flavobacterium heparinumQ35192351
Cell surface receptors for herpes simplex virus are heparan sulfate proteoglycansQ36531041
Expression in Escherichia coli, purification and characterization of heparinase I from Flavobacterium heparinumQ36797422
Molecular cloning and expression of Chinese hamster ovary cell heparan-sulfate 2-sulfotransferaseQ36861170
NMR solution conformation of heparin-derived hexasaccharideQ36889781
Proteoglycans: structures and interactionsQ37285263
Genetic analysis of proteoglycan structure, function and metabolismQ37421925
The heparin-binding (fibroblast) growth factor family of proteinsQ38286731
Molecular organization of the interferon γ-binding domain in heparan sulphateQ38292110
The activation of fibroblast growth factors by heparin: synthesis, structure, and biological activity of heparin-like oligosaccharides.Q38292324
Structural and functional properties of heparin analogues obtained by chemical sulphation of Escherichia coli K5 capsular polysaccharideQ38293432
FGF binding and FGF receptor activation by synthetic heparan-derived di- and trisaccharides.Q38296447
Structure of heparin fragments with high affinity for lipoprotein lipase and inhibition of lipoprotein lipase binding to alpha 2-macroglobulin-receptor/low-density-lipoprotein-receptor-related protein by heparin fragmentsQ38297068
Enzymatic degradation of glycosaminoglycansQ38300252
Structural requirements in heparin for binding and activation of FGF-1 and FGF-4 are different from that for FGF-2.Q38302156
Binding of heparin/heparan sulfate to fibroblast growth factor receptor 4.Q38302571
Structural features in heparin which modulate specific biological activities mediated by basic fibroblast growth factorQ38305985
Structural studies on the tri- and tetrasaccharides isolated from porcine intestinal heparin and characterization of heparinase/heparitinases using them as substratesQ38311533
Elucidation of the structural features of heparan sulfate important for interaction with the Hep-2 domain of fibronectin.Q38315553
A novel strategy to generate biologically active neo-glycosaminoglycan conjugates.Q38318456
Nature of the interaction of heparin with acidic fibroblast growth factorQ38319104
Oligosaccharides corresponding to the regular sequence of heparin: chemical synthesis and interaction with FGF-2.Q38319215
A synthetic heparan sulfate pentasaccharide, exclusively containing L-iduronic acid, displays higher affinity for FGF-2 than its D-glucuronic acid-containing isomersQ38320742
Identification of a hexasaccharide sequence able to inhibit thrombin and suitable for 'polymerisation'.Q38321135
Sequence analysis of heparan sulphate and heparin oligosaccharidesQ38325522
Structural studies of octasaccharides derived from the low-sulfated repeating disaccharide region and octasaccharide serines derived from the protein linkage region of porcine intestinal heparinQ38329461
Diversity does make a difference: fibroblast growth factor-heparin interactionsQ38331346
Heparin is required for cell-free binding of basic fibroblast growth factor to a soluble receptor and for mitogenesis in whole cellsQ38331586
Heparinase II from Flavobacterium heparinum. HPLC analysis of the saccharides generated from chemically modified heparinsQ38331863
Mechanism of heparin activation of antithrombin: evidence for an induced-fit model of allosteric activation involving two interaction subsitesQ38333380
P407language of work or nameEnglishQ1860
P921main subjectheparinQ190016
P304page(s)159-206
P577publication date2001-01-01
P1433published inAdvances in Carbohydrate Chemistry and BiochemistryQ15749696
P1476titleStructure and biological interactions of heparin and heparan sulfate
P478volume57

Reverse relations

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Q34351342Hexuronyl C5-epimerases in alginate and glycosaminoglycan biosynthesis
Q37388669Identification of candidate cancer-causing genes in mouse brain tumors by retroviral tagging
Q37543699Interactions between heparan sulfate and proteins-design and functional implications
Q64060489Introduction to the Molecules Special Edition Entitled '': Some Outstanding Questions in Heparan Sulfate and Heparin Research
Q57563789Investigating Glycol-Split-Heparin-Derived Inhibitors of Heparanase: A Study of Synthetic Trisaccharides
Q40602026Involvement of glycosylphosphatidylinositol-linked ceruloplasmin in the copper/zinc-nitric oxide-dependent degradation of glypican-1 heparan sulfate in rat C6 glioma cells
Q39146814Ion exchange chromatographic separation and isolation of oligosaccharides of intact low-molecular-weight heparin for the determination of their anticoagulant and anti-inflammatory properties
Q34289321Irreversible glucuronyl C5-epimerization in the biosynthesis of heparan sulfate
Q90948634Is host heparanase required for the rapid spread of heparan sulfate binding viruses?
Q38312237Isolation and characterization of low sulfated heparan sulfate sequences with affinity for lipoprotein lipase
Q34068498Kinetic studies on the interactions of heparin and complement proteins using surface plasmon resonance
Q37257393Lack of L-iduronic acid in heparan sulfate affects interaction with growth factors and cell signaling
Q38362109Location of N-unsubstituted glucosamine residues in heparan sulfate
Q95271959MASP-2 Is a Heparin-Binding Protease; Identification of Blocking Oligosaccharides
Q36270533Mechanical fibrinogen-depletion supports heparin-free mesenchymal stem cell propagation in human platelet lysate
Q35181635Mechanisms of glycosaminoglycan activation of the serpins in hemostasis
Q33994681Microscale isolation and analysis of heparin from plasma using an anion-exchange spin column
Q45221614Modulation of the heparanase-inhibiting activity of heparin through selective desulfation, graded N-acetylation, and glycol splitting
Q38152204Molecular engineering of glycosaminoglycan chemistry for biomolecule delivery
Q51568879Molecular modeling of the interaction between heparan sulfate and cellular growth factors: bringing pieces together.
Q41002514NDST2 (N-Deacetylase/N-Sulfotransferase-2) Enzyme Regulates Heparan Sulfate Chain Length
Q79210669Nitrocellulose Filter Binding to Assess Binding of Glycosaminoglycans to Proteins
Q38175433Non-anticoagulant derivatives of heparin for the management of asthma: distant dream or close reality?
Q37379726Non-anticoagulant heparins and inhibition of cancer
Q38855728Old and new applications of non-anticoagulant heparin
Q79372181Oligosaccharide microarrays to map interactions of carbohydrates in biological systems
Q35147247Opposing effects of low molecular weight heparins on the release of inflammatory cytokines from peripheral blood mononuclear cells of asthmatics
Q37359606Orthogonal analytical approaches to detect potential contaminants in heparin
Q26823840Pathophysiology of heparan sulphate: many diseases, few drugs
Q34452632Platelet factor 4 inhibits thrombomodulin-dependent activation of thrombin-activatable fibrinolysis inhibitor (TAFI) by thrombin
Q89977542Potential Mechanisms of Cancer-Related Hypercoagulability
Q35746811Preparation and characterization of heparin hexasaccharide library with N-unsubstituted glucosamine residues
Q73929097Preparation and utility of neoproteoglycan probes in analyses of interaction with glycosaminoglycan-binding proteins
Q38331584Preparation of heparin/heparan sulfate oligosaccharides with internal N-unsubstituted glucosamine residues for functional studies
Q38319635Profiling glycol-split heparins by high-performance liquid chromatography/mass spectrometry analysis of their heparinase-generated oligosaccharides
Q30838810Profiling heparin-chemokine interactions using synthetic tools
Q38303432Profiling sulfation/epimerization pattern of full-length heparan sulfate by NMR following cell culture 13C-glucose metabolic labeling
Q42577323Residual dipolar coupling investigation of a heparin tetrasaccharide confirms the limited effect of flexibility of the iduronic acid on the molecular shape of heparin
Q34361094Role of heparan sulfate domain organization in endostatin inhibition of endothelial cell function
Q109525076SARS-CoV-2 spike protein causes blood coagulation and thrombosis by competitive binding to heparan sulfate
Q35656129SPECT imaging of peripheral amyloid in mice by targeting hyper-sulfated heparan sulfate proteoglycans with specific scFv antibodies.
Q36556537Significance of the 2-O-sulfo group of L-iduronic acid residues in heparin on the growth inhibition of bovine pulmonary artery smooth muscle cells
Q59813809Solution Conformation of Heparin Tetrasaccharide. DFT Analysis of Structure and Spin⁻Spin Coupling Constants
Q38324768Specific interaction of the envelope glycoproteins E1 and E2 with liver heparan sulfate involved in the tissue tropismatic infection by hepatitis C virus
Q38559646Stem Cells on Biomaterials for Synthetic Grafts to Promote Vascular Healing
Q36822084Strategies in synthesis of heparin/heparan sulfate oligosaccharides: 2000-present
Q24306149Structural recognition by recombinant human heparanase that plays critical roles in tumor metastasis. Hierarchical sulfate groups with different effects and the essential target disulfated trisaccharide sequence
Q51806250Structural requirements for heparin/heparan sulfate binding to type V collagen.
Q34805392Structural specificity of heparin binding in the fibroblast growth factor family of proteins
Q92370403Substrate binding mode and catalytic mechanism of human heparan sulfate d-glucuronyl C5 epimerase
Q38357174Substrate specificities of mouse heparan sulphate glucosaminyl 6-O-sulphotransferases
Q30482247Sugar Chips immobilized with synthetic sulfated disaccharides of heparin/heparan sulfate partial structure
Q34625346Susceptibility of enoxaparin reducing end amino sugars to periodate oxidation
Q35783198Synergistic Binding of Vascular Endothelial Growth Factor-A and Its Receptors to Heparin Selectively Modulates Complex Affinity
Q39590858Synthesis and evaluation of xylopyranoside derivatives as "decoy acceptors" of human β-1,4-galactosyltransferase 7.
Q34276825Synthesis of a heparan sulfate mimetic library targeting FGF and VEGF via click chemistry on a monosaccharide template
Q79230764Synthesis of heparin-like oligosaccharides on a soluble polymer support
Q80866631Synthesis of heparin-like oligosaccharides on polymer supports
Q39399937Targeting heparin and heparan sulfate protein interactions.
Q28072373The Endothelial Glycocalyx: New Diagnostic and Therapeutic Approaches in Sepsis
Q40103047The glycosaminoglycan chain of decorin plays an important role in collagen fibril formation at the early stages of fibrillogenesis
Q24300738The human D-glucuronyl C5-epimerase gene is transcriptionally activated through the beta-catenin-TCF4 pathway
Q53634101The stereoselectivities of tributyltin hydride-mediated reductions of 5-bromo-D-glucuronides to L-iduronides are dependent on the anomeric substituent: syntheses and DFT calculations.
Q33579043Towards the assembly of heparin and heparan sulfate oligosaccharide libraries: efficient synthesis of uronic acid and disaccharide building blocks
Q81474966Transgenic or tumor-induced expression of heparanase upregulates sulfation of heparan sulfate
Q40447314Two heparanase splicing variants with distinct properties are necessary in early Xenopus development.
Q45331274Two promoters with distinct activities in different tissues drive the expression of heparanase in Xenopus
Q35853992Unfractionated heparin attenuates intestinal injury in mouse model of sepsis by inhibiting heparanase

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