Sequence analysis of heparan sulfate epitopes with graded affinities for fibroblast growth factors 1 and 2.

scientific article published on 13 June 2001

Sequence analysis of heparan sulfate epitopes with graded affinities for fibroblast growth factors 1 and 2. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M102628200
P698PubMed publication ID11406624

P50authorUlf LindahlQ5953253
P2093author name stringSturiale L
Giménez-Gallego G
Salmivirta M
Kreuger J
P2860cites workCrystal structure of a ternary FGF-FGFR-heparin complex reveals a dual role for heparin in FGFR binding and dimerizationQ24290400
Crystal structure of fibroblast growth factor receptor ectodomain bound to ligand and heparinQ24290496
Heparin structure and interactions with basic fibroblast growth factorQ27732601
Structure of a heparin-linked biologically active dimer of fibroblast growth factorQ27760195
Regulated diversity of heparan sulfateQ28282444
Requirement of heparan sulfate for bFGF-mediated fibroblast growth and myoblast differentiationQ28296150
Cell surface, heparin-like molecules are required for binding of basic fibroblast growth factor to its high affinity receptorQ29616189
Functions of cell surface heparan sulfate proteoglycansQ29618521
Sequencing complex polysaccharidesQ30791276
Heparan sulfate oligosaccharides require 6-O-sulfation for promotion of basic fibroblast growth factor mitogenic activityQ32030968
Generation and application of type-specific anti-heparan sulfate antibodies using phage display technology. Further evidence for heparan sulfate heterogeneity in the kidneyQ32064386
A strategy for rapid sequencing of heparan sulfate and heparin saccharidesQ35059120
Structural requirements in heparin for binding and activation of FGF-1 and FGF-4 are different from that for FGF-2.Q38302156
Binding of heparin/heparan sulfate to fibroblast growth factor receptor 4.Q38302571
Structural features in heparin which modulate specific biological activities mediated by basic fibroblast growth factorQ38305985
Structure of a heparan sulphate oligosaccharide that binds to basic fibroblast growth factorQ38327052
Age-dependent modulation of heparan sulfate structure and functionQ38337039
Interaction of heparan sulfate from mammary cells with acidic fibroblast growth factor (FGF) and basic FGF. Regulation of the activity of basic FGF by high and low affinity binding sites in heparan sulfateQ38338357
Glycosaminoglycans and the regulation of blood coagulationQ40851193
Structural diversity of N-sulfated heparan sulfate domains: distinct modes of glucuronyl C5 epimerization, iduronic acid 2-O-sulfation, and glucosamine 6-O-sulfationQ40856219
Structure of heparan sulphate from human brain, with special regard to Alzheimer's diseaseQ42160698
Further characterization of the antithrombin-binding sequence in heparinQ42263887
Domain structure of heparan sulfates from bovine organsQ42555942
Highly sensitive sequencing of the sulfated domains of heparan sulfate.Q42814375
High-level synthesis in Escherichia coli of shortened and full-length human acidic fibroblast growth factor and purification in a form stable in aqueous solutionsQ42820125
New method for quantitative determination of uronic acidsQ43736049
Proteoglycans: master regulators of molecular encounter?Q46076112
Developmental Regulation of Neural Response to FGF-1 and FGF-2 by Heparan Sulfate ProteoglycanQ52225676
Engineering of an FGF-proteoglycan fusion protein with heparin-independent, mitogenic activity.Q54049715
Presence of N-unsubstituted glucosamine units in native heparan sulfate revealed by a monoclonal antibody.Q54598050
Bio-specific sequences and domains in heparan sulphate and the regulation of cell growth and adhesionQ64146688
Amyloid-specific heparan sulfate from human liver and spleenQ73797107
The proliferative and migratory activities of breast cancer cells can be differentially regulated by heparan sulfatesQ73914306
Characterization of fibroblast growth factor 1 binding heparan sulfate domainQ77856163
P433issue33
P407language of work or nameEnglishQ1860
P304page(s)30744-30752
P577publication date2001-06-13
P1433published inJournal of Biological ChemistryQ867727
P1476titleSequence analysis of heparan sulfate epitopes with graded affinities for fibroblast growth factors 1 and 2.
P478volume276

Reverse relations

cites work (P2860)
Q332301923-O-sulfated oligosaccharide structures are recognized by anti-heparan sulfate antibody HS4C3.
Q28473002A computational approach for deciphering the organization of glycosaminoglycans
Q44816865A new model for the domain structure of heparan sulfate based on the novel specificity of K5 lyase.
Q30386218A synergistic approach to protein crystallization: combination of a fixed-arm carrier with surface entropy reduction.
Q37216313Biological implications of glycosaminoglycan interactions with haemopoietic cytokines.
Q31074211Biosynthetic oligosaccharide libraries for identification of protein-binding heparan sulfate motifs. Exploring the structural diversity by screening for fibroblast growth factor (FGF)1 and FGF2 binding
Q63362963Characterization and Quantification of Highly Sulfated Glycosaminoglycan Isomers by Gated-Trapped Ion Mobility Spectrometry Negative Electron Transfer Dissociation MS/MS
Q33285352Characterization of anti-heparan sulfate phage display antibodies AO4B08 and HS4E4.
Q33806757Chemoenzymatic synthesis and structural characterization of 2-O-sulfated glucuronic acid-containing heparan sulfate hexasaccharides
Q47265732Chondroitin sulfate chains on syndecan-1 and syndecan-4 from normal murine mammary gland epithelial cells are structurally and functionally distinct and cooperate with heparan sulfate chains to bind growth factors. A novel function to control bindin
Q33480621Compositional analysis of heparin/heparan sulfate interacting with fibroblast growth factor.fibroblast growth factor receptor complexes
Q42820482Covalently attached FGF-2 to three-dimensional polyamide nanofibrillar surfaces demonstrates enhanced biological stability and activity
Q51556332Deciphering functional glycosaminoglycan motifs in development.
Q33222215Demonstration of the pleiotrophin-binding oligosaccharide sequences isolated from chondroitin sulfate/dermatan sulfate hybrid chains of embryonic pig brains
Q37256534Differential sulfation remodelling of heparan sulfate by extracellular 6-O-sulfatases regulates fibroblast growth factor-induced boundary formation by glial cells: implications for glial cell transplantation.
Q36332838Endothelial heparan sulfate 6-O-sulfation levels regulate angiogenic responses of endothelial cells to fibroblast growth factor 2 and vascular endothelial growth factor.
Q90158049Evaluation of top-down mass spectrometry and ion-mobility spectroscopy as a means of mapping protein-binding motifs within heparin chains
Q33897755Extended N-sulfated domains reside at the nonreducing end of heparan sulfate chains.
Q33282863Extracellular sulfatases, elements of the Wnt signaling pathway, positively regulate growth and tumorigenicity of human pancreatic cancer cells
Q35082690FGF2 binding, signaling, and angiogenesis are modulated by heparanase in metastatic melanoma cells
Q30568524Fell-Muir Lecture: Heparan sulphate and the art of cell regulation: a polymer chain conducts the protein orchestra
Q58377532Fibroblast Growth Factor Receptors 1 and 2 Interact Differently with Heparin/Heparan Sulfate
Q31153852Fibroblast growth factors share binding sites in heparan sulphate
Q36923642Fibroblast growth factors, old kids on the new block
Q47148090Gas-Phase Analysis of the Complex of Fibroblast GrowthFactor 1 with Heparan Sulfate: A Traveling Wave Ion Mobility Spectrometry (TWIMS) and Molecular Modeling Study
Q33551154Generating heparan sulfate saccharide libraries for glycomics applications.
Q24541580HSulf-2, an extracellular endoglucosamine-6-sulfatase, selectively mobilizes heparin-bound growth factors and chemokines: effects on VEGF, FGF-1, and SDF-1.
Q35219652Heparan sulfate 2-O-sulfotransferase (Hs2st) and mouse development.
Q26796383Heparan sulfate and heparin interactions with proteins
Q38050077Heparan sulfate biosynthesis: regulation and variability
Q33615579Heparan sulfate domain organization and sulfation modulate FGF-induced cell signaling
Q42276329Heparan sulfate phage display antibodies identify distinct epitopes with complex binding characteristics: insights into protein binding specificities
Q35059448Heparan sulfate proteoglycans
Q38747421Heparan sulfate proteoglycans as key regulators of the mesenchymal niche of hematopoietic stem cells.
Q35780214Heparan sulfate sulfatase SULF2 regulates PDGFRα signaling and growth in human and mouse malignant glioma
Q38311931Heparan sulfate-related oligosaccharides in ternary complex formation with fibroblast growth factors 1 and 2 and their receptors
Q34328757Heparan sulfate: growth control with a restricted sequence menu
Q54888139Heparan sulphate proteoglycans in glia and in the normal and injured CNS: expression of sulphotransferases and changes in sulphation
Q41504553Heparanase Inhibitors Facilitate the Assembly of the Basement Membrane in Artificial Skin
Q47159791Heparin Mimetics: Their Therapeutic Potential.
Q44120939Heparin inhibits DNA synthesis and gene expression in alveolar type II cells
Q39111023Heparin modulates the mitogenic activity of fibroblast growth factor by inducing dimerization of its receptor. a 3D view by using NMR.
Q37736668Heparin-derived heparan sulfate mimics to modulate heparan sulfate-protein interaction in inflammation and cancer
Q92152542Heparinoid Complex-Based Heparin-Binding Cytokines and Cell Delivery Carriers
Q28213553Hereditary multiple exostoses and heparan sulfate polymerization
Q33864454Highly sulfated nonreducing end-derived heparan sulfate domains bind fibroblast growth factor-2 with high affinity and are enriched in biologically active fractions
Q39984528Hydrogen peroxide as a potential mediator of the transcriptional regulation of heparan sulphate biosynthesis in keratinocytes
Q36194268Inactivation of heparan sulfate 2-O-sulfotransferase accentuates neutrophil infiltration during acute inflammation in mice.
Q42491092Influence of heparan sulfate chains in proteoglycan at the dermal-epidermal junction on epidermal homeostasis
Q33542995Interaction of E2 glycoprotein with heparan sulfate is crucial for cellular infection of Sindbis virus
Q38312237Isolation and characterization of low sulfated heparan sulfate sequences with affinity for lipoprotein lipase
Q28278567Keratinocyte growth factor/fibroblast growth factor 7, a homeostatic factor with therapeutic potential for epithelial protection and repair
Q36964230LC-MS and LC-MS/MS studies of incorporation of 34SO3 into glycosaminoglycan chains by sulfotransferases
Q35945285Long-lived engineering of glycans to direct stem cell fate
Q34652072Mammalian heparanase: what is the message?
Q33819268Matrix regulators in neural stem cell functions
Q34310374Molecular diversity of heparan sulfate
Q33676686Molecular mechanism of substrate specificity for heparan sulfate 2-O-sulfotransferase
Q43197470Multimers of the fibroblast growth factor (FGF)-FGF receptor-saccharide complex are formed on long oligomers of heparin.
Q36851279Multivalent proteoglycan modulation of FGF mitogenic responses in perivascular cells.
Q34602695Mutational study of heparan sulfate 2-O-sulfotransferase and chondroitin sulfate 2-O-sulfotransferase.
Q56833662New tools for carbohydrate sulfation analysis: heparan sulfate 2--sulfotransferase (HS2ST) is a target for small-molecule protein kinase inhibitors
Q79210669Nitrocellulose Filter Binding to Assess Binding of Glycosaminoglycans to Proteins
Q46391304Novel heparan sulfate structures revealed by monoclonal antibodies
Q36071884Novel therapeutic targets in the brain tumor microenvironment
Q31139063Oligosaccharide Library-based Assessment of Heparan Sulfate 6-O-Sulfotransferase Substrate Specificity
Q36219228Podocyte-specific deletion of NDST1, a key enzyme in the sulfation of heparan sulfate glycosaminoglycans, leads to abnormalities in podocyte organization in vivo
Q38181492Post-Synthetic Regulation of HS Structure: The Yin and Yang of the Sulfs in Cancer
Q42120275Precocious initiation of spermatogenesis in a 19-month-old boy with Hurler syndrome
Q36182371Proteoglycan sequence
Q38680940Proteoglycans and axon guidance: a new relationship between old partners
Q36816444Proteoglycans and their roles in brain cancer
Q39155470Quantitative phosphoproteomics analysis reveals broad regulatory role of heparan sulfate on endothelial signaling
Q27652967Redirecting the substrate specificity of heparan sulfate 2-O-sulfotransferase by structurally guided mutagenesis
Q34361094Role of heparan sulfate domain organization in endostatin inhibition of endothelial cell function
Q34489556Role of heparan sulfate in fibroblast growth factor signalling: a structural view
Q34989564Role of heparan sulfate-2-O-sulfotransferase in the mouse.
Q34718195Roles of heparan-sulphate glycosaminoglycans in cancer
Q36324847Spatial and temporal expression of heparan sulfate in mouse development regulates FGF and FGF receptor assembly
Q42525353Spatiotemporal distribution of heparan sulfate epitopes during myogenesis and synaptogenesis: a study in developing mouse intercostal muscle
Q38334596Specific structural features of heparan sulfate proteoglycans potentiate neuregulin-1 signaling
Q55655141Stimulation of wound healing using bioinspired hydrogels with basic fibroblast growth factor (bFGF).
Q36822084Strategies in synthesis of heparin/heparan sulfate oligosaccharides: 2000-present
Q38974435Structural alteration of cell surface heparan sulfate through the stimulation of the signaling pathway for heparan sulfate 6-O-sulfotransferase-1 in mouse fibroblast cells.
Q40601795Structural determinants of heparan sulphate modulation of GDNF signalling
Q34805392Structural specificity of heparin binding in the fibroblast growth factor family of proteins
Q34523315Structure and biological interactions of heparin and heparan sulfate
Q50875019Structure-Activity Relationships of Bioengineered Heparin/Heparan Sulfates Produced in Different Bioreactors.
Q24550887Sulf-2, a proangiogenic heparan sulfate endosulfatase, is upregulated in breast cancer
Q40630770Sulfated Derivatives of Escherichia coli K5 Polysaccharides as Modulators of Fibroblast Growth Factor Signaling
Q33370024Sulfated oligosaccharides (heparin and fucoidan) binding and dimerization of stromal cell-derived factor-1 (SDF-1/CXCL 12) are coupled as evidenced by affinity CE-MS analysis
Q34943513Surface-templated hydrogel patterns prompt matrix-dependent migration of breast cancer cells towards chemokine-secreting cells
Q79230764Synthesis of heparin-like oligosaccharides on a soluble polymer support
Q80866631Synthesis of heparin-like oligosaccharides on polymer supports
Q38290246The "in and out" of glucosamine 6-O-sulfation: the 6th sense of heparan sulfate.
Q38100660The African Fusarium/maize disease
Q24306406The epidermal growth factor-like domains of the human EMR2 receptor mediate cell attachment through chondroitin sulfate glycosaminoglycans
Q34412830The heparan sulfate motif (GlcNS6S-IdoA2S)3, common in heparin, has a strict topography and is involved in cell behavior and disease.
Q40315779The morphogenic properties of oligomeric endostatin are dependent on cell surface heparan sulfate
Q34474956The specificity of interactions between proteins and sulfated polysaccharides
Q44368469The structural biology of growth factor receptor activation
Q37445949Therapeutically targeting protein-glycan interactions
Q27028136Understanding the substrate specificity of the heparan sulfate sulfotransferases by an integrated biosynthetic and crystallographic approach