Heparan sulfate phage display antibodies identify distinct epitopes with complex binding characteristics: insights into protein binding specificities

scientific article published on December 2009

Heparan sulfate phage display antibodies identify distinct epitopes with complex binding characteristics: insights into protein binding specificities is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M109.009712
P932PMC publication ID2790993
P698PubMed publication ID19837661

P50authorPaul D LostyQ89944464
David G. FernigQ37379493
P2093author name stringToin H van Kuppevelt
Els M A van de Westerlo
Jeremy E Turnbull
Edwin C Jesudason
Sophie M Thompson
P2860cites workConformational transitions induced in heparin octasaccharides by binding with antithrombin III.Q38312109
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Identification of an extended N-acetylated sequence adjacent to the protein-linkage region of fibroblast heparan sulphateQ42855547
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Sequence analysis of heparan sulfate epitopes with graded affinities for fibroblast growth factors 1 and 2.Q43640409
Immunochemical characterization and ultrastructural localization of chondroitin sulfates and keratan sulfate in embryonic chick bone marrowQ44237672
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Influence of substitution pattern and cation binding on conformation and activity in heparin derivatives.Q50975134
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1H and 13C NMR spectral assignments of the major sequences of twelve systematically modified heparin derivativesQ56833717
Heparan sulphate epitope-expression is associated with the inflammatory response in metastatic malignant melanomaQ56895314
Large, tissue-regulated domain diversity of heparan sulfates demonstrated by phage display antibodiesQ56895736
Chondroitin sulphate proteoglycans in extracellular matrices: sulphation specificity in relation to cellular differentiationQ57540008
Mapping by monoclonal antibody detection of glycosaminoglycans in connective tissuesQ57540011
Identification of a monoclonal antibody that specifically recognizes corneal and skeletal keratan sulfate. Monoclonal antibodies to cartilage proteoglycanQ57540014
Liver heparan sulfate structure. A novel molecular designQ64146700
A monoclonal antibody against GBM heparan sulfate induces an acute selective proteinuria in ratsQ68136806
Endothelial heparan sulphate: compositional analysis and comparison of chains from different proteoglycan populationsQ68407274
Energetic characterization of the basic fibroblast growth factor-heparin interaction: identification of the heparin binding domainQ72326632
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Structural differences and the presence of unsubstituted amino groups in heparan sulphates from different tissues and speciesQ24530061
The heparanome and regulation of cell function: structures, functions and challengesQ28281711
Conformer populations of L-iduronic acid residues in glycosaminoglycan sequencesQ28283247
Conformation of heparin pentasaccharide bound to antithrombin IIIQ28360842
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Human single chain antibodies against heparin: selection, characterization, and effect on coagulationQ30827306
Heparan sulfate heterogeneity in skeletal muscle basal lamina: demonstration by phage display-derived antibodies.Q30872188
Highly diverse heparan sulfate analogue libraries: providing access to expanded areas of sequence space for bioactivity screeningQ31034506
Generation and application of type-specific anti-heparan sulfate antibodies using phage display technology. Further evidence for heparan sulfate heterogeneity in the kidneyQ32064386
Fibroblast growth factor receptor signalling is dictated by specific heparan sulphate saccharidesQ33179207
Sequencing of 3-O sulfate containing heparin decasaccharides with a partial antithrombin III binding siteQ33181061
Localization and functional characterization of glycosaminoglycan domains in the normal human kidney as revealed by phage display-derived single chain antibodies.Q33213182
3-O-sulfated oligosaccharide structures are recognized by anti-heparan sulfate antibody HS4C3.Q33230192
Novel 'phage display antibodies identify distinct heparan sulfate domains in developing mammalian lungQ33268875
Characterization of anti-heparan sulfate phage display antibodies AO4B08 and HS4E4.Q33285352
Using an enzymatic combinatorial approach to identify anticoagulant heparan sulfate structuresQ33299802
Saccharide microarrays for high-throughput interrogation of glycan-protein binding interactionsQ33416890
Conformation and dynamics of heparin and heparan sulfateQ34087654
Computer modeling of electrostatic steering and orientational effects in antibody-antigen associationQ34128635
A strategy for rapid sequencing of heparan sulfate and heparin saccharidesQ35059120
Interactions of heparin/heparan sulfate with proteins: appraisal of structural factors and experimental approachesQ35626646
Heparan sulfates in skeletal muscle development and physiologyQ36180874
Evaluation of critical groups required for the binding of heparin to antithrombinQ36248809
Spatial and temporal expression of heparan sulfate in mouse development regulates FGF and FGF receptor assemblyQ36324847
Multiprotein signalling complexes: regional assembly on heparan sulphateQ36482130
Developmental changes in heparan sulfate expression: in situ detection with mAbsQ36532134
Interactions between heparan sulfate and proteins: the concept of specificityQ36552851
Structure of the antithrombin-binding site in heparinQ37335850
Antithrombin-binding octasaccharides and role of extensions of the active pentasaccharide sequence in the specificity and strength of interaction. Evidence for very high affinity induced by an unusual glucuronic acid residueQ38289147
High affinity interaction between a synthetic, highly negatively charged pentasaccharide and alpha- or beta-antithrombin is predominantly due to nonionic interactions.Q38304327
P433issue51
P407language of work or nameEnglishQ1860
P921main subjectphage displayQ896217
antibodyQ79460
P304page(s)35621-35631
P577publication date2009-12-01
P1433published inJournal of Biological ChemistryQ867727
P1476titleHeparan sulfate phage display antibodies identify distinct epitopes with complex binding characteristics: insights into protein binding specificities
P478volume284

Reverse relations

cites work (P2860)
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Q35036977Glycobiology and the growth plate: current concepts in multiple hereditary exostoses
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Q35624698Heparan sulfate phage display antibodies recognise epitopes defined by a combination of sugar sequence and cation binding.
Q37151121Heparan sulfate proteoglycans containing a glypican 5 core and 2-O-sulfo-iduronic acid function as Sonic Hedgehog co-receptors to promote proliferation
Q37698254Heparin sensing: blue-chip binding
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Q36176861Poly(ethylene glycol acrylate)-functionalized hydrogels for heparan sulfate oligosaccharide recognition
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Q28550135Sulf1 and Sulf2 Differentially Modulate Heparan Sulfate Proteoglycan Sulfation during Postnatal Cerebellum Development: Evidence for Neuroprotective and Neurite Outgrowth Promoting Functions
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Q34412830The heparan sulfate motif (GlcNS6S-IdoA2S)3, common in heparin, has a strict topography and is involved in cell behavior and disease.

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