Metallothionein-1G facilitates sorafenib resistance through inhibition of ferroptosis

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Metallothionein-1G facilitates sorafenib resistance through inhibition of ferroptosis is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1002/HEP.28574
P8608Fatcat IDrelease_vluznv4edbhstgkblvlcwo3xve
P3181OpenCitations bibliographic resource ID3765234
P932PMC publication ID4956496
P698PubMed publication ID27015352

P2093author name stringDaolin Tang
Rui Kang
De Chen
Xiaofang Sun
Xiaohua Niu
Wenyin He
Ruochan Chen
P2860cites workRole of Nrf2 in oxidative stress and toxicityQ23919669
Sorafenib in advanced hepatocellular carcinomaQ27861075
HSPB1 as a novel regulator of ferroptotic cancer cell deathQ28258033
Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in miceQ28396141
Activation of the p62-Keap1-NRF2 pathway protects against ferroptosis in hepatocellular carcinoma cellsQ28397198
Cancer statistics, 2016Q29547383
Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: a phase III randomised, double-blind, placebo-controlled trialQ29547903
Hepatocellular carcinomaQ29615765
Pharmacological inhibition of cystine-glutamate exchange induces endoplasmic reticulum stress and ferroptosisQ33745283
Regulation of ferroptotic cancer cell death by GPX4Q33826380
PKM2 regulates the Warburg effect and promotes HMGB1 release in sepsisQ33926167
Ferroptosis: an iron-dependent form of nonapoptotic cell deathQ34032093
The role of iron and reactive oxygen species in cell deathQ34039363
Sorafenib induces ferroptosis in human cancer cell lines originating from different solid tumors.Q34042349
Ferroptosis as a p53-mediated activity during tumour suppressionQ34043533
T cell lipid peroxidation induces ferroptosis and prevents immunity to infection.Q34043611
Loss of cysteinyl-tRNA synthetase (CARS) induces the transsulfuration pathway and inhibits ferroptosis induced by cystine deprivationQ34044497
Ferroptosis: Death by Lipid PeroxidationQ34045575
Ferroptosis: process and functionQ34045909
Isolation and culture of primary hepatocytes from resected human liver tissueQ34127014
Synchronized renal tubular cell death involves ferroptosis.Q34447203
Brusatol enhances the efficacy of chemotherapy by inhibiting the Nrf2-mediated defense mechanismQ34534013
Metallothioneins and cancerQ34610906
Metallothionein: the multipurpose proteinQ34648045
Sorafenib inhibits proliferation and invasion of human hepatocellular carcinoma cells via up-regulation of p53 and suppressing FoxM1.Q35080145
The nuclear function of p53 is required for PUMA-mediated apoptosis induced by DNA damageQ35676779
High-mobility group box 1 is essential for mitochondrial quality controlQ35800479
High-mobility group box 1 activates caspase-1 and promotes hepatocellular carcinoma invasiveness and metastasesQ36175681
Identification of retinoic acid as an inhibitor of transcription factor Nrf2 through activation of retinoic acid receptor alphaQ36288735
Metallothionein expression is suppressed in primary human hepatocellular carcinomas and is mediated through inactivation of CCAAT/enhancer binding protein alpha by phosphatidylinositol 3-kinase signaling cascadeQ36512697
The role of metallothioneins in anticancer drug resistanceQ36546717
Sorafenib: where do we go from here?Q36708741
Metallothionein - immunohistochemical cancer biomarker: a meta-analysisQ37453240
The role of metallothionein in oxidative stressQ38090395
Toward clinical application of the Keap1-Nrf2 pathwayQ38105775
New biological perspectives for the improvement of the efficacy of sorafenib in hepatocellular carcinomaQ38174980
Regulated necrosis: disease relevance and therapeutic opportunitiesQ38699324
Iron-dependent cell death of hepatocellular carcinoma cells exposed to sorafenibQ39179266
Hypoxia-mediated sorafenib resistance can be overcome by EF24 through Von Hippel-Lindau tumor suppressor-dependent HIF-1α inhibition in hepatocellular carcinoma.Q39214063
Inhibition of the Nrf2 transcription factor by the alkaloid trigonelline renders pancreatic cancer cells more susceptible to apoptosis through decreased proteasomal gene expression and proteasome activityQ39251887
High-yield preparation of isolated rat liver parenchymal cells: a biochemical and fine structural studyQ41115222
Loss of metallothionein predisposes mice to diethylnitrosamine-induced hepatocarcinogenesis by activating NF-kappaB target genesQ42699492
Increased expression of metallothionein is associated with irinotecan resistance in gastric cancerQ44980763
Identification and Successful Negotiation of a Metabolic Checkpoint in Direct Neuronal ReprogrammingQ49020427
Detection of metallothionein 1G as a methylated tumor suppressor gene in human hepatocellular carcinoma using a novel method of double combination array analysis.Q51564639
Inhibition of glutathione synthesis with propargylglycine enhances N-acetylmethionine protection and methylation in bromobenzene-treated Syrian hamstersQ74615654
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectferroptosisQ24466962
P304page(s)488-500
P577publication date2016-08-01
P1433published inHepatologyQ15724398
P1476titleMetallothionein-1G facilitates sorafenib resistance through inhibition of ferroptosis
P478volume64

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