Ferroptosis: past, present and future

scientific article published on 03 February 2020

Ferroptosis: past, present and future is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

External links are
P356DOI10.1038/S41419-020-2298-2
P932PMC publication ID6997353
P698PubMed publication ID32015325

P50authorJie LiQ89518299
P2093author name stringFeng Cao
Gang Wang
Ning Mao
Bei Sun
He-Liang Yin
Zhi-Tao Lin
Zi-Jian Huang
P2860cites workMolecular characterization of mitochondrial apoptosis-inducing factorQ22001452
AMID, an apoptosis-inducing factor-homologous mitochondrion-associated protein, induces caspase-independent apoptosisQ24295497
CD44 variant regulates redox status in cancer cells by stabilizing the xCT subunit of system xc(-) and thereby promotes tumor growthQ24296787
Dysregulation of glutathione homeostasis in neurodegenerative diseasesQ26822726
Characterization of mammalian selenoproteomes.Q27863319
HSPB1 as a novel regulator of ferroptotic cancer cell deathQ28258033
Metallothionein-1G facilitates sorafenib resistance through inhibition of ferroptosisQ28384683
Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in miceQ28396141
Activation of the p62-Keap1-NRF2 pathway protects against ferroptosis in hepatocellular carcinoma cellsQ28397198
Ultrasmall nanoparticles induce ferroptosis in nutrient-deprived cancer cells and suppress tumour growthQ30828545
Mitochondrial complex I inhibition triggers a mitophagy-dependent ROS increase leading to necroptosis and ferroptosis in melanoma cellsQ30844792
Iron accumulation in deep cortical layers accounts for MRI signal abnormalities in ALS: correlating 7 tesla MRI and pathology.Q31058247
Synthetic lethal screening identifies compounds activating iron-dependent, nonapoptotic cell death in oncogenic-RAS-harboring cancer cellsQ33324778
Regulation of ferroptotic cancer cell death by GPX4Q33826380
Oxidized arachidonic and adrenic PEs navigate cells to ferroptosisQ33897013
Ferroptosis: an iron-dependent form of nonapoptotic cell deathQ34032093
Ferroptosis as a p53-mediated activity during tumour suppressionQ34043533
Glutaminolysis and Transferrin Regulate FerroptosisQ34044434
Ferroptosis: Death by Lipid PeroxidationQ34045575
Ferroptosis: process and functionQ34045909
Ferrostatins inhibit oxidative lipid damage and cell death in diverse disease modelsQ34408158
Synchronized renal tubular cell death involves ferroptosis.Q34447203
RAS-RAF-MEK-dependent oxidative cell death involving voltage-dependent anion channelsQ34618715
Iron accumulates in Huntington's disease neurons: protection by deferoxamineQ35023030
Iron-induced damage in cardiomyopathy: oxidative-dependent and independent mechanisms.Q35296244
Heme oxygenase-1 accelerates erastin-induced ferroptotic cell deathQ36414474
Regulators of Iron Homeostasis: New Players in Metabolism, Cell Death, and DiseaseQ36665139
Dynamic roles of p53-mediated metabolic activities in ROS-induced stress responsesQ36780705
The ferroptosis inducer erastin enhances sensitivity of acute myeloid leukemia cells to chemotherapeutic agentsQ36997966
Functional interactions of the cystine/glutamate antiporter, CD44v and MUC1-C oncoprotein in triple-negative breast cancer cellsQ37022006
Autophagy promotes ferroptosis by degradation of ferritinQ37141766
Intranasal deferoxamine provides increased brain exposure and significant protection in rat ischemic strokeQ37312849
The Role of Reactive Oxygen Species and Ferroptosis in Heme-Mediated Activation of Human PlateletsQ88993613
CISD2 inhibition overcomes resistance to sulfasalazine-induced ferroptotic cell death in head and neck cancerQ89179081
Cell Death Pathways Drive Necroinflammation during Acute Kidney InjuryQ89365807
Sigma-1 receptor protects against ferroptosis in hepatocellular carcinoma cellsQ90048390
Recent Progress in Ferroptosis Inducers for Cancer TherapyQ90601782
Exquisite sensitivity of adrenocortical carcinomas to induction of ferroptosisQ90702153
FSP1 is a glutathione-independent ferroptosis suppressorQ90850050
The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosisQ90850055
Role of ferroptosis in hepatocellular carcinomaQ91243890
Chaperone-mediated autophagy is involved in the execution of ferroptosisQ91340147
Glutathione peroxidase 4 participates in secondary brain injury through mediating ferroptosis in a rat model of intracerebral hemorrhageQ91386173
Ferroptotic cell death and TLR4/Trif signaling initiate neutrophil recruitment after heart transplantationQ92109247
Activation of SAT1 engages polyamine metabolism with p53-mediated ferroptotic responsesQ37398094
Nrf2 inhibition reverses the resistance of cisplatin-resistant head and neck cancer cells to artesunate-induced ferroptosisQ37543809
The transsulfuration pathway: a source of cysteine for glutathione in astrocytesQ37849215
The regulation of iron transport.Q38153305
Ferroptosis, but Not Necroptosis, Is Important in Nephrotoxic Folic Acid-Induced AKI.Q39648552
Contribution of reactive oxygen species to ovarian cancer cell growth arrest and killing by the anti-malarial drug artesunateQ39996069
Identification of genotype-selective antitumor agents using synthetic lethal chemical screening in engineered human tumor cellsQ40658370
Iron addiction: a novel therapeutic target in ovarian cancerQ41211121
Nigral iron elevation is an invariable feature of Parkinson's disease and is a sufficient cause of neurodegenerationQ41825693
Ablation of ferroptosis regulator glutathione peroxidase 4 in forebrain neurons promotes cognitive impairment and neurodegenerationQ42321081
Identification of artesunate as a specific activator of ferroptosis in pancreatic cancer cellsQ42430876
Increased iron levels and decreased tissue integrity in hippocampus of Alzheimer's disease detected in vivo with magnetic resonance imagingQ43509556
Oxidative stress parameters in plasma of Huntington's disease patients, asymptomatic Huntington's disease gene carriers and healthy subjects : a cross-sectional studyQ45306906
Potentiation of glutathione loss and nerve cell death by the transition metals iron and copper: Implications for age-related neurodegenerative diseasesQ46255147
Cysteine Dioxygenase 1 Mediates Erastin-Induced Ferroptosis in Human Gastric Cancer CellsQ46260326
Sesamin attenuates neurotoxicity in mouse model of ischemic brain stroke.Q46269921
Haloperidol, a sigma receptor 1 antagonist, promotes ferroptosis in hepatocellular carcinoma cellsQ46328831
The Impact of DIDS-Induced Inhibition of Voltage-Dependent Anion Channels (VDAC) on Cellular Response of Lymphoblastoid Cells to Ionizing Radiation.Q46380063
Friedreich ataxia-induced pluripotent stem cell-derived neurons show a cellular phenotype that is corrected by a benzamide HDAC inhibitorQ46421445
Iron accumulation in the basal ganglia following severe ischemic-anoxic insults in childrenQ46557394
The retinoblastoma (Rb) protein regulates ferroptosis induced by sorafenib in human hepatocellular carcinoma cellsQ46807686
NFS1 undergoes positive selection in lung tumours and protects cells from ferroptosisQ47371292
CHAC1 degradation of glutathione enhances cystine-starvation-induced necroptosis and ferroptosis in human triple negative breast cancer cells via the GCN2-eIF2α-ATF4 pathway.Q47642087
The Tumor Suppressor p53 Limits Ferroptosis by Blocking DPP4 ActivityQ47945423
miR-137 regulates ferroptosis by targeting glutamine transporter SLC1A5 in melanoma.Q48214977
p53 Suppresses Metabolic Stress-Induced Ferroptosis in Cancer CellsQ49200611
Piperlongumine rapidly induces the death of human pancreatic cancer cells mainly through the induction of ferroptosisQ49379289
Low-density lipoprotein docosahexaenoic acid nanoparticles induce ferroptotic cell death in hepatocellular carcinomaQ50147318
Heme Oxygenase-1 Mitigates Ferroptosis in Renal Proximal Tubule Cells.Q50640125
Ferroptosis: A Novel Anti-Tumor Action for Cisplatin.Q51008237
CISD1 inhibits ferroptosis by protection against mitochondrial lipid peroxidation.Q51579570
Ferroptosis, a newly characterized form of cell death in Parkinson's disease that is regulated by PKC.Q53085614
Oxytosis/Ferroptosis-(Re-) Emerging Roles for Oxidative Stress-Dependent Non-apoptotic Cell Death in Diseases of the Central Nervous System.Q54946045
Ferroptosis-inducing agents compromise in vitro human islet viability and function.Q55025225
Glutathione depletion induces ferroptosis, autophagy, and premature cell senescence in retinal pigment epithelial cells.Q55527156
N-acetylcysteine targets 5 lipoxygenase-derived, toxic lipids and can synergize with PGE to inhibit ferroptosis and improve outcomes following hemorrhagic stroke in miceQ57182391
P53-dependent induction of ferroptosis is required for artemether to alleviate carbon tetrachloride-induced liver fibrosis and hepatic stellate cell activationQ57463249
The glutathione redox system is essential to prevent ferroptosis caused by impaired lipid metabolism in clear cell renal cell carcinomaQ57903458
Nrf2 inhibition reverses resistance to GPX4 inhibitor-induced ferroptosis in head and neck cancerQ58553382
Activation of Glutathione Peroxidase 4 as a Novel Anti-inflammatory StrategyQ58585327
Selenium unmasks protective iron armor: A possible defense against cutaneous inflammation and cancerQ61203483
Ferroptosis as a target for protection against cardiomyopathyQ61808556
Inhibition of ferroptosis attenuates tissue damage and improves long-term outcomes after traumatic brain injury in mice.Q64883818
Inhibition of selenoprotein synthesis by selenocysteine tRNA[Ser]Sec lacking isopentenyladenosineQ73815535
Brain mitochondrial iron accumulates in Huntington's disease, mediates mitochondrial dysfunction, and can be removed pharmacologicallyQ88292931
Iron and Alzheimer's Disease: An Update on Emerging MechanismsQ88978904
P275copyright licenseCreative Commons AttributionQ6905323
P433issue2
P921main subjectpharmacologyQ128406
molecular biologyQ7202
FerroptosisQ55446273
P304page(s)88
P577publication date2020-02-03
P1433published inCell Death and DiseaseQ2197222
P1476titleFerroptosis: past, present and future
P478volume11

Reverse relations

cites work (P2860)
Q98502789Circular RNA cIARS regulates ferroptosis in HCC cells through interacting with RNA binding protein ALKBH5
Q100332922Crosstalk Between Autophagy and Ferroptosis and Its Putative Role in Ischemic Stroke
Q98226249Ferroptosis in Acute Central Nervous System Injuries: The Future Direction?
Q91813228Iron overload contributes to general anaesthesia-induced neurotoxicity and cognitive deficits
Q97593160Molecular Mechanisms of Ferroptosis and Its Role in Pulmonary Disease
Q101455784Neuronal cell life, death, and axonal degeneration as regulated by the BCL-2 family proteins
Q103728445SARS-CoV-2 infection: can ferroptosis be a potential treatment target for multiple organ involvement?
Q99616624Together we stand, apart we fall: how cell-to-cell contact/interplay provides resistance to ferroptosis
Q99548916mRNA Post-Transcriptional Regulation by AU-Rich Element-Binding Proteins in Liver Inflammation and Cancer
Q94671691p53: 800 million years of evolution and 40 years of discovery

Search more.