Monoclonal antibody therapies against anthrax

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Monoclonal antibody therapies against anthrax is …
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scholarly articleQ13442814
review articleQ7318358

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P356DOI10.3390/TOXINS3081004
P8608Fatcat IDrelease_3du5qzvxgjdevg76vuthka4g3q
P3181OpenCitations bibliographic resource ID4748446
P932PMC publication ID3202866
P698PubMed publication ID22069754
P5875ResearchGate publication ID51785534

P50authorRobert H. PurcellQ2157414
Mahtab MoayeriQ62580112
P2093author name stringZhaochun Chen
P2860cites workHuman monoclonal antibodies that neutralize anthrax toxin by inhibiting heptamer assemblyQ81321290
Postexposure prophylaxis against experimental inhalation anthraxQ64051299
A deleted variant of Bacillus anthracis protective antigen is non-toxic and blocks anthrax toxin action in vivoQ69243931
Characterization of lethal factor binding and cell receptor binding domains of protective antigen of Bacillus anthracis using monoclonal antibodiesQ71679438
Structure-function analysis of Bacillus anthracis edema factor by using monoclonal antibodiesQ72310318
Comparative efficacy of experimental anthrax vaccine candidates against inhalation anthrax in rhesus macaquesQ74818408
A case of naturally acquired inhalation anthrax: clinical care and analyses of anti-protective antigen immunoglobulin G and lethal factorQ79890058
Induction of opsonic antibodies to the gamma-D-glutamic acid capsule of Bacillus anthracis by immunization with a synthetic peptide-carrier protein conjugateQ44810979
Genetic immunization against anthraxQ44833567
Protection of mice against tetanus toxin by combination of two human monoclonal antibodies recognizing distinct epitopes on the toxin moleculeQ44840200
Selection of Bacillus anthracis isolates resistant to antibioticsQ44942836
Potent neutralization of primary human immunodeficiency virus clade C isolates with a synergistic combination of human monoclonal antibodies raised against clade B.Q45736635
Synergistic neutralization of a chimeric SIV/HIV type 1 virus with combinations of human anti-HIV type 1 envelope monoclonal antibodies or hyperimmune globulinsQ45762836
A phase 1 study of PAmAb, a fully human monoclonal antibody against Bacillus anthracis protective antigen, in healthy volunteersQ46529537
Quantitative analysis of the effect of cell type and cellular differentiation on protective antigen binding to human target cells.Q51806044
Binding stoichiometry and kinetics of the interaction of a human anthrax toxin receptor, CMG2, with protective antigenQ24320977
Susceptibility of mitogen-activated protein kinase kinase family members to proteolysis by anthrax lethal factorQ24532224
Contribution of individual toxin components to virulence of Bacillus anthracisQ24652917
Bacillus anthracisQ24672893
Human monoclonal antibodies against anthrax lethal factor and protective antigen act independently to protect against Bacillus anthracis infection and enhance endogenous immunity to anthraxQ24682011
Investigation of bioterrorism-related anthrax, United States, 2001: epidemiologic findingsQ24718884
Human anti-anthrax protective antigen neutralizing monoclonal antibodies derived from donors vaccinated with anthrax vaccine adsorbedQ24806902
The Sverdlovsk anthrax outbreak of 1979Q28241641
Raxibacumab for the treatment of inhalational anthraxQ28251284
Proteolytic inactivation of MAP-kinase-kinase by anthrax lethal factorQ28269030
In vitro and in vivo characterization of anthrax anti-protective antigen and anti-lethal factor monoclonal antibodies after passive transfer in a mouse lethal toxin challenge model to define correlates of immunityQ28383065
Conference report on public health and clinical guidelines for anthraxQ28386084
Isolation and chimerization of a highly neutralizing antibody conferring passive protection against lethal Bacillus anthracis infectionQ28389813
Anthrax postexposure prophylaxis in postal workers, Connecticut, 2001Q28390531
A high-affinity monoclonal antibody to anthrax protective antigen passively protects rabbits before and after aerosolized Bacillus anthracis spore challengeQ28398021
Anthrax toxin edema factor: a bacterial adenylate cyclase that increases cyclic AMP concentrations of eukaryotic cellsQ28609196
Anthrax as a biological weapon, 2002: updated recommendations for managementQ29615587
Passive transfer of protection against Bacillus anthracis infection in a murine modelQ30696618
Defining a serological correlate of protection in rabbits for a recombinant anthrax vaccineQ33195848
Neutralizing monoclonal antibody against anthrax lethal factor inhibits intoxication in a mouse modelQ33203095
Immunogenicity and protective efficacy of Bacillus anthracis poly-gamma-D-glutamic acid capsule covalently coupled to a protein carrier using a novel triazine-based conjugation strategyQ33227409
Efficient neutralization of anthrax toxin by chimpanzee monoclonal antibodies against protective antigenQ33232901
Protective and immunochemical activities of monoclonal antibodies reactive with the Bacillus anthracis polypeptide capsuleQ33261310
Capsule synthesis by Bacillus anthracis is required for dissemination in murine inhalation anthraxQ33739694
Study of immunization against anthrax with the purified recombinant protective antigen of Bacillus anthracisQ33756961
Neutralizing monoclonal antibody to edema toxin and its effect on murine anthraxQ33877222
Antimicrobial postexposure prophylaxis for anthrax: adverse events and adherenceQ33962064
Search for correlates of protective immunity conferred by anthrax vaccineQ34007168
Protection against anthrax lethal toxin challenge by genetic immunization with a plasmid encoding the lethal factor proteinQ34008307
An anthrax lethal factor-neutralizing monoclonal antibody protects rats before and after challenge with anthrax toxinQ34033505
Potent neutralization of botulinum neurotoxin by recombinant oligoclonal antibodyQ34038244
Anthrax toxin-neutralizing antibody reconfigures the protective antigen heptamer into a supercomplexQ34069693
Efficiency of protection of guinea pigs against infection with Bacillus anthracis spores by passive immunizationQ34117219
Comparative safety and efficacy against Bacillus anthracis of protective antigen and live vaccines in miceQ34167973
Vaccination of rhesus macaques with the anthrax vaccine adsorbed vaccine produces a serum antibody response that effectively neutralizes receptor-bound protective antigen in vitroQ34289924
Human monoclonal anti-protective antigen antibody completely protects rabbits and is synergistic with ciprofloxacin in protecting mice and guinea pigs against inhalation anthraxQ34334451
Pre- and postexposure protection against virulent anthrax infection in mice by humanized monoclonal antibodies to Bacillus anthracis capsuleQ34490786
Anthrax toxin targeting of myeloid cells through the CMG2 receptor is essential for establishment of Bacillus anthracis infections in miceQ34545842
Receptors of anthrax toxin and cell entry.Q34659076
Passive antibody administration (immediate immunity) as a specific defense against biological weaponsQ34762095
Prophylaxis and therapy of inhalational anthrax by a novel monoclonal antibody to protective antigen that mimics vaccine-induced immunityQ35073821
Poly(gamma-D-glutamic acid) protein conjugates induce IgG antibodies in mice to the capsule of Bacillus anthracis: a potential addition to the anthrax vaccineQ35171265
Protective immunity induced by Bacillus anthracis toxin-deficient strains.Q35400677
Passive protection by polyclonal antibodies against Bacillus anthracis infection in guinea pigsQ35560377
The roles of anthrax toxin in pathogenesisQ35702957
A dually active anthrax vaccine that confers protection against both bacilli and toxinsQ35978682
Human antibodies from transgenic animalsQ36252986
Delayed treatment with W1-mAb, a chimpanzee-derived monoclonal antibody against protective antigen, reduces mortality from challenges with anthrax edema or lethal toxin in rats and with anthrax spores in miceQ36469606
Poly-gamma-glutamate in bacteriaQ36475462
Characterization of the interaction between anthrax toxin and its cellular receptorsQ36761999
Production and characterization of monoclonal antibodies against the lethal factor component of Bacillus anthracis lethal toxinQ36982457
Immunization studies with attenuated strains of Bacillus anthracisQ37029061
Potent neutralization of anthrax edema toxin by a humanized monoclonal antibody that competes with calmodulin for edema factor bindingQ37304034
Novel chimpanzee/human monoclonal antibodies that neutralize anthrax lethal factor, and evidence for possible synergy with anti-protective antigen antibodyQ37333457
mAbs to Bacillus anthracis capsular antigen for immunoprotection in anthrax and detection of antigenemiaQ37416012
Cellular and systemic effects of anthrax lethal toxin and edema toxinQ37441837
The human immune response to Dengue virus is dominated by highly cross-reactive antibodies endowed with neutralizing and enhancing activityQ37448171
The capsule of Bacillus anthracis behaves as a thymus-independent type 2 antigenQ37521734
In vitro selection and characterization of Bacillus anthracis mutants with high-level resistance to ciprofloxacinQ39776135
Neutralizing activity of vaccine-induced antibodies to two Bacillus anthracis toxin components, lethal factor and edema factorQ40046283
Functional analysis of Bacillus anthracis protective antigen by using neutralizing monoclonal antibodiesQ40204434
Alanine-scanning mutations in domain 4 of anthrax toxin protective antigen reveal residues important for binding to the cellular receptor and to a neutralizing monoclonal antibodyQ40644450
In-vitro characterisation of the phagocytosis and fate of anthrax spores in macrophages and the effects of anti-PA antibody.Q40689685
The synergistic neutralization of Rift Valley fever virus by monoclonal antibodies to the envelope glycoproteinsQ40738802
Development of novel vaccines against anthrax in man.Q41039399
Human monoclonal antibody AVP-21D9 to protective antigen reduces dissemination of the Bacillus anthracis Ames strain from the lungs in a rabbit modelQ41869569
Efficacy of a human anthrax vaccine in guinea pigs, rabbits, and rhesus macaques against challenge by Bacillus anthracis isolates of diverse geographical originQ43581522
The role of antibodies to Bacillus anthracis and anthrax toxin components in inhibiting the early stages of infection by anthrax spores.Q43629044
In vitro correlate of immunity in a rabbit model of inhalational anthraxQ43727746
Protection against anthrax toxin by recombinant antibody fragments correlates with antigen affinityQ44013452
Treatment of anthrax infection with combination of ciprofloxacin and antibodies to protective antigen of Bacillus anthracisQ44735551
P275copyright licenseCreative Commons Attribution 3.0 UnportedQ14947546
P6216copyright statuscopyrightedQ50423863
P433issue8
P407language of work or nameEnglishQ1860
P921main subjectantibodyQ79460
ANTRAXQ129104
globulinsQ321710
monoclonal antibodyQ422248
blood proteinsQ425056
immunotherapyQ1427096
bacterial antigensQ65983976
P5008on focus list of Wikimedia projectScienceSourceQ55439927
P304page(s)1004-19
P577publication date2011-08-01
P1433published inToxinsQ15724569
P1476titleMonoclonal antibody therapies against anthrax
P478volume3

Reverse relations

cites work (P2860)
Q40570352A Diverse Set of Single-domain Antibodies (VHHs) against the Anthrax Toxin Lethal and Edema Factors Provides a Basis for Construction of a Bispecific Agent That Protects against Anthrax Infection
Q35808793A Novel Chimeric Anti-PA Neutralizing Antibody for Postexposure Prophylaxis and Treatment of Anthrax
Q35173029A heterodimer of a VHH (variable domains of camelid heavy chain-only) antibody that inhibits anthrax toxin cell binding linked to a VHH antibody that blocks oligomer formation is highly protective in an anthrax spore challenge model
Q36665638Adenoviral Expression of a Bispecific VHH-Based Neutralizing Agent That Targets Protective Antigen Provides Prophylactic Protection from Anthrax in Mice
Q28075453Alternative pre-approved and novel therapies for the treatment of anthrax
Q26852034Anthrax lethal and edema toxins in anthrax pathogenesis
Q26781366Anthrax prophylaxis: recent advances and future directions
Q38760476Anti-virulence Strategies to Target Bacterial Infections
Q30201937Approval of Raxibacumab for the Treatment of Inhalation Anthrax Under the US Food and Drug Administration "Animal Rule".
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Q36911369Combinations of monoclonal antibodies to anthrax toxin manifest new properties in neutralization assays
Q37065380Controlled release of an anthrax toxin-neutralizing antibody from hydrolytically degradable polyethylene glycol hydrogels
Q35018313Designing inhibitors of anthrax toxin
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