Development of Protective Immunity in New Zealand White Rabbits Challenged with Bacillus anthracis Spores and Treated with Antibiotics and Obiltoxaximab, a Monoclonal Antibody against Protective Antigen

scientific article published on 13 November 2017

Development of Protective Immunity in New Zealand White Rabbits Challenged with Bacillus anthracis Spores and Treated with Antibiotics and Obiltoxaximab, a Monoclonal Antibody against Protective Antigen is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1128/AAC.01590-17
P932PMC publication ID5786786
P698PubMed publication ID29133571

P2093author name stringGregory V Stark
Lisa N Henning
Natalya V Serbina
Sarah Carpenter
P2860cites workInvestigation of bioterrorism-related anthrax, United States, 2001: epidemiologic findingsQ24718884
Cellular and physiological effects of anthrax exotoxin and its relevance to diseaseQ27010363
Raxibacumab for the treatment of inhalational anthraxQ28251284
Efficacy Projection of Obiltoxaximab for Treatment of Inhalational Anthrax across a Range of Disease SeverityQ28390214
Lethal factor toxemia and anti-protective antigen antibody activity in naturally acquired cutaneous anthraxQ28392283
Monoclonal antibody therapies against anthraxQ28393072
A high-affinity monoclonal antibody to anthrax protective antigen passively protects rabbits before and after aerosolized Bacillus anthracis spore challengeQ28398021
Approval of Raxibacumab for the Treatment of Inhalation Anthrax Under the US Food and Drug Administration "Animal Rule".Q30201937
Anthrax vaccine-induced antibodies provide cross-species prediction of survival to aerosol challengeQ30540217
Threats in bioterrorism. I: CDC category A agentsQ34743491
Antibodies against anthrax: mechanisms of action and clinical applicationsQ35610439
Bacillus anthracis Capsular Conjugates Elicit Chimpanzee Polyclonal Antibodies That Protect Mice from Pulmonary AnthraxQ35652068
Natural cutaneous anthrax infection, but not vaccination, induces a CD4(+) T cell response involving diverse cytokinesQ35726627
Expression of either lethal toxin or edema toxin by Bacillus anthracis is sufficient for virulence in a rabbit model of inhalational anthraxQ36155940
Contribution of toxins to the pathogenesis of inhalational anthraxQ36708397
Evaluation of immunogenicity and efficacy of anthrax vaccine adsorbed for postexposure prophylaxisQ36970295
Obiltoxaximab Prevents Disseminated Bacillus anthracis Infection and Improves Survival during Pre- and Postexposure Prophylaxis in Animal Models of Inhalational AnthraxQ37287801
Method validation of protein biomarkers in support of drug development or clinical diagnosis/prognosisQ37336235
Animal-to-Human Dose Translation of Obiltoxaximab for Treatment of Inhalational Anthrax Under the US FDA Animal RuleQ37594165
Clinical Framework and Medical Countermeasure Use During an Anthrax Mass-Casualty IncidentQ38384713
Obiltoxaximab: Adding to the Treatment Arsenal for Bacillus anthracis InfectionQ38749263
Lethal factor antibodies contribute to lethal toxin neutralization in recipients of anthrax vaccine precipitatedQ40213025
Bridging non-human primate correlates of protection to reassess the Anthrax Vaccine Adsorbed booster schedule in humansQ40838287
Comprehensive analysis and selection of anthrax vaccine adsorbed immune correlates of protection in rhesus macaquesQ41755913
Human monoclonal antibody AVP-21D9 to protective antigen reduces dissemination of the Bacillus anthracis Ames strain from the lungs in a rabbit modelQ41869569
Centers for disease control and prevention expert panel meetings on prevention and treatment of anthrax in adultsQ42735019
The pathology of experimental anthrax in rabbits exposed by inhalation and subcutaneous inoculation.Q43662258
Impairment of dendritic cells and adaptive immunity by anthrax lethal toxinQ44389292
Immune responses to Bacillus anthracis protective antigen in patients with bioterrorism-related cutaneous or inhalation anthraxQ45043237
A cautionary note on exact unconditional inference for a difference between two independent binomial proportionsQ50493198
Postexposure prophylaxis against experimental inhalation anthraxQ64051299
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectNew ZealandQ664
antibioticQ12187
Bacillus anthracisQ614156
P577publication date2017-11-13
P1433published inAntimicrobial Agents and ChemotherapyQ578004
P1476titleDevelopment of Protective Immunity in New Zealand White Rabbits Challenged with Bacillus anthracis Spores and Treated with Antibiotics and Obiltoxaximab, a Monoclonal Antibody against Protective Antigen
P478volume62

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