Pirfenidone controls the feedback loop of the AT1R/p38 MAPK/renin-angiotensin system axis by regulating liver X receptor-α in myocardial infarction-induced cardiac fibrosis

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Pirfenidone controls the feedback loop of the AT1R/p38 MAPK/renin-angiotensin system axis by regulating liver X receptor-α in myocardial infarction-induced cardiac fibrosis is …
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scholarly articleQ13442814

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P6179Dimensions Publication ID1003770227
P356DOI10.1038/SREP40523
P932PMC publication ID5238375
P698PubMed publication ID28091615

P2093author name stringChunmei Li
Jie He
Jianping Wang
Le Kang
Jingwei Tian
Yonglin Gao
Rui Han
Yanshen Li
P2860cites workAngiotensin II regulates ACE and ACE2 in neurons through p38 mitogen-activated protein kinase and extracellular signal-regulated kinase 1/2 signalingQ28592286
Renoprotective properties of pirfenidone in subtotally nephrectomized ratsQ34087790
Activation of liver X receptor improves viability of adipose-derived mesenchymal stem cells to attenuate myocardial ischemia injury through TLR4/NF-κB and Keap-1/Nrf-2 signaling pathwaysQ34579503
p38 mitogen-activated protein kinase and liver X receptor-α mediate the leptin effect on sterol regulatory element binding protein-1c expression in hepatic stellate cellsQ35718937
Improving vagal activity ameliorates cardiac fibrosis induced by angiotensin II: in vivo and in vitroQ36310106
Renal Denervation Findings on Cardiac and Renal Fibrosis in Rats with Isoproterenol Induced CardiomyopathyQ36392895
Angiotensin II up-regulates angiotensin I-converting enzyme (ACE), but down-regulates ACE2 via the AT1-ERK/p38 MAP kinase pathway.Q36579769
Loss of angiotensin-converting enzyme-2 exacerbates diabetic cardiovascular complications and leads to systolic and vascular dysfunction: a critical role of the angiotensin II/AT1 receptor axisQ37101896
Myocardial infarct size measurement in the mouse chronic infarction model: comparison of area- and length-based approachesQ37175653
Marked Improvement with Pirfenidone in a Patient with Idiopathic Pulmonary Fibrosis.Q51539353
Involvement of angiotensin II and reactive oxygen species in pancreatic fibrosis.Q53288278
The liver X receptor agonist AZ876 protects against pathological cardiac hypertrophy and fibrosis without lipogenic side effects.Q53615353
Pirfenidone exhibits cardioprotective effects by regulating myocardial fibrosis and vascular permeability in pressure-overloaded hearts.Q54266973
Long-term oral Asperosaponin VI attenuates cardiac dysfunction, myocardial fibrosis in a rat model of chronic myocardial infarctionQ83462639
Expression of liver X receptor correlates with intrahepatic inflammation and fibrosis in patients with nonalcoholic fatty liver diseaseQ87521640
Aldosterone and angiotensin: Role in diabetes and cardiovascular diseasesQ38049919
Angiotensin-(1-7): beyond the cardio-renal actions.Q38068237
Functional and structural impact of pirfenidone on the alterations of cardiac disease and diabetes mellitusQ38238448
Losartan: Comprehensive Profile.Q38519556
ACE inhibition, ACE2 and angiotensin-(1-7) axis in kidney and cardiac inflammation and fibrosisQ38781834
The effects of different angiotensin II type 1 receptor blockers on the regulation of the ACE-AngII-AT1 and ACE2-Ang(1-7)-Mas axes in pressure overload-induced cardiac remodeling in male miceQ39745759
Increased mortality and aggravation of heart failure in liver X receptor-α knockout mice after myocardial infarctionQ40986115
GW3965, a synthetic liver X receptor (LXR) agonist, reduces angiotensin II-mediated pressor responses in Sprague-Dawley ratsQ41586886
Activation of the cardiac proteasome promotes angiotension II-induced hypertrophy by down-regulation of ATRAP.Q41666649
Cardiac LXRα protects against pathological cardiac hypertrophy and dysfunction by enhancing glucose uptake and utilizationQ42583421
Efficient long-term survival of cell grafts after myocardial infarction with thick viable cardiac tissue entirely from pluripotent stem cellsQ42628650
Effect of pirfenidone on proliferation, TGF-β-induced myofibroblast differentiation and fibrogenic activity of primary human lung fibroblasts.Q42706428
Effects and mechanism of irbesartan on tubulointerstitial fibrosis in 5/6 nephrectomized ratsQ43162268
Activation of liver X receptor-alpha reduces activation of the renal and cardiac renin-angiotensin-aldosterone systemQ43177134
Activation of liver X receptors inhibits experimental fibrosis by interfering with interleukin-6 release from macrophagesQ45207632
Effect of angiotensin-converting enzyme inhibition and angiotensin II receptor blockers on cardiac angiotensin-converting enzyme 2.Q46493539
Cardiac overexpression of angiotensin converting enzyme 2 protects the heart from ischemia-induced pathophysiologyQ46771630
Angiotensin II type-1 receptor activation in the adult heart causes blood pressure-independent hypertrophy and cardiac dysfunctionQ47399226
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P407language of work or nameEnglishQ1860
P921main subjectmyocardial infarctionQ12152
P304page(s)40523
P577publication date2017-01-16
P1433published inScientific ReportsQ2261792
P1476titlePirfenidone controls the feedback loop of the AT1R/p38 MAPK/renin-angiotensin system axis by regulating liver X receptor-α in myocardial infarction-induced cardiac fibrosis
P478volume7

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cites work (P2860)
Q42316580CO-releasing molecules CORM2 attenuates angiotensin II-induced human aortic smooth muscle cell migration through inhibition of ROS/IL-6 generation and matrix metalloproteinases-9 expression
Q92548798Cardiovascular Risks, Bleeding Risks, and Clinical Events from 3 Phase III Trials of Pirfenidone in Patients with Idiopathic Pulmonary Fibrosis
Q92977808Danqi soft capsule prevents infarct border zone remodelling and reduces susceptibility to ventricular arrhythmias in post-myocardial infarction rats
Q60956756Long-Term Regulation of Excitation-Contraction Coupling and Oxidative Stress in Cardiac Myocytes by Pirfenidone
Q54937508MiR-33 promotes myocardial fibrosis by inhibiting MMP16 and stimulating p38 MAPK signaling.
Q89014006Modulation of subsets of cardiac B lymphocytes improves cardiac function after acute injury
Q51745535Pirfenidone reduces profibrotic responses in human dermal myofibroblasts, in vitro.
Q64235758Transcriptome network analysis identifies protective role of the LXR/SREBP-1c axis in murine pulmonary fibrosis

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