Loss of angiotensin-converting enzyme-2 exacerbates diabetic cardiovascular complications and leads to systolic and vascular dysfunction: a critical role of the angiotensin II/AT1 receptor axis

scientific article published on 03 April 2012

Loss of angiotensin-converting enzyme-2 exacerbates diabetic cardiovascular complications and leads to systolic and vascular dysfunction: a critical role of the angiotensin II/AT1 receptor axis is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1161/CIRCRESAHA.112.268029
P932PMC publication ID3746191
P698PubMed publication ID22474255
P5875ResearchGate publication ID223986713

P50authorSreedhar BodigaQ48259153
Maria B GrantQ88523403
Vaibhav B. PatelQ42402068
P2093author name stringJennifer Lo
Gavin Y Oudit
Zuocheng Wang
Ratnadeep Basu
Zamaneh Kassiri
Wang Wang
Subhash K Das
JiuChang Zhong
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Nonobese, insulin-deficient Ins2Akita mice develop type 2 diabetes phenotypes including insulin resistance and cardiac remodelingQ46970404
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Angiotensin-converting enzyme 2 suppresses pathological hypertrophy, myocardial fibrosis, and cardiac dysfunction.Q51772425
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Relationship Between Coronary Microvascular Dysfunction and Cardiac Energetics Impairment in Type 1 Diabetes MellitusQ62396995
Protein kinase C phosphorylation of cardiac troponin I or troponin T inhibits Ca2(+)-stimulated actomyosin MgATPase activityQ67898066
Crucial role of endothelium in the vasodilator response to increased flow in vivoQ70275801
Clinical and morphological features of human hypertensive-diabetic cardiomyopathyQ70523586
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TIMP2 deficiency accelerates adverse post-myocardial infarction remodeling because of enhanced MT1-MMP activity despite lack of MMP2 activationQ82430948
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Activation of protein kinase C isoforms and its impact on diabetic complicationsQ33881442
Early activation of matrix metalloproteinases underlies the exacerbated systolic and diastolic dysfunction in mice lacking TIMP3 following myocardial infarctionQ33976308
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Akt induces enhanced myocardial contractility and cell size in vivo in transgenic miceQ34156036
Flow activates an endothelial potassium channel to release an endogenous nitrovasodilatorQ34209959
Pathways of angiotensin-(1-7) metabolism in the kidneyQ34258999
Angiotensin II-mediated hypertension in the rat increases vascular superoxide production via membrane NADH/NADPH oxidase activation. Contribution to alterations of vasomotor toneQ34378188
Oxidative stress and cardiovascular injury: Part II: animal and human studiesQ34542841
Irbesartan in patients with heart failure and preserved ejection fractionQ34877640
Molecular understanding of hyperglycemia's adverse effects for diabetic complicationsQ35005662
The kallikrein-kinin and the renin-angiotensin systems have a multilayered interactionQ35148421
Enhanced susceptibility to biomechanical stress in ACE2 null mice is prevented by loss of the p47(phox) NADPH oxidase subunitQ35152116
Hydrogen peroxide differentially modulates cardiac myocyte nitric oxide synthesisQ35229424
Loss of angiotensin-converting enzyme-2 (Ace2) accelerates diabetic kidney injuryQ35916066
Retinal arteriolar narrowing and left ventricular remodeling: the multi-ethnic study of atherosclerosisQ35990801
The renin-angiotensin-aldosterone system, glucose metabolism and diabetesQ36088736
Diabetic cardiomyopathy: the search for a unifying hypothesisQ36423632
Angiotensin II cell signaling: physiological and pathological effects in the cardiovascular systemQ36548154
Diabetic cardiomyopathy revisitedQ36860318
Myocardial matrix remodeling and the matrix metalloproteinases: influence on cardiac form and functionQ36967674
Insulin signalling in the heartQ37129268
The development of heart failure in patients with diabetes mellitus and pre-clinical diastolic dysfunction a population-based study.Q37425444
Diabetic nephropathy is markedly enhanced in mice lacking the bradykinin B2 receptorQ37513098
Treatment of heart failure with normal ejection fraction: an inconvenient truth!Q37691647
Role of ACE2 in diastolic and systolic heart failure.Q37884450
Tissue inhibitor of metalloproteinases (TIMPs) in heart failureQ37895982
Protein kinase C activation and its role in the development of vascular complications in diabetes mellitusQ41700541
Angiotensin II impairs endothelial function via tyrosine phosphorylation of the endothelial nitric oxide synthaseQ42463456
Aldosterone and D-glucose stimulate the proliferation of human cardiac myofibroblasts in vitroQ42518792
Neprilysin, obesity and the metabolic syndromeQ42610866
Loss of angiotensin-converting enzyme 2 accelerates maladaptive left ventricular remodeling in response to myocardial infarctionQ43266255
P4510describes a project that usesImageQuantQ112270642
P433issue10
P921main subjectcirculatory systemQ11068
systoleQ496359
P304page(s)1322-1335
P577publication date2012-04-03
P1433published inCirculation ResearchQ2599020
P1476titleLoss of angiotensin-converting enzyme-2 exacerbates diabetic cardiovascular complications and leads to systolic and vascular dysfunction: a critical role of the angiotensin II/AT1 receptor axis
P478volume110

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