PI3Kα-regulated gelsolin activity is a critical determinant of cardiac cytoskeletal remodeling and heart disease

scientific article published in Nature Communications

PI3Kα-regulated gelsolin activity is a critical determinant of cardiac cytoskeletal remodeling and heart disease is …
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scholarly articleQ13442814

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P819ADS bibcode2018NatCo...9.5390P
P356DOI10.1038/S41467-018-07812-8
P932PMC publication ID6300608
P698PubMed publication ID30568254

P50authorVaibhav B. PatelQ42402068
Dong FanQ90648110
Mousumi HazraQ90648112
Pavel ZhabyeyevQ60321267
Bart VanhaesebroeckQ64481959
Christopher MccullochQ88585534
P2093author name stringPu Zhang
Gavin Y Oudit
W Glen Pyle
Ratnadeep Basu
Zamaneh Kassiri
John F Dawson
Faqi Wang
Manish Paul
Xueyi Chen
Saumya Shah
Saugata Hazra
Brent A McLean
P2860cites workNebulette Mutations Are Associated With Dilated Cardiomyopathy and Endocardial FibroelastosisQ24303466
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PI3Ks maintain the structural integrity of T-tubules in cardiac myocytesQ27321455
Ca2+ binding by domain 2 plays a critical role in the activation and stabilization of gelsolinQ27656937
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Intercellular adhesion, signalling and the cytoskeletonQ28214252
Hemostatic, inflammatory, and fibroblast responses are blunted in mice lacking gelsolinQ28300043
Induced deletion of the N-cadherin gene in the heart leads to dissolution of the intercalated disc structureQ28303455
Actin-depolymerizing factor and cofilin-1 play overlapping roles in promoting rapid F-actin depolymerization in mammalian nonmuscle cellsQ28506999
Loss of PI3Kγ enhances cAMP-dependent MMP remodeling of the myocardial N-cadherin adhesion complexes and extracellular matrix in response to early biomechanical stressQ28590326
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Membrane cytoskeleton: PIP(2) pulls the strings.Q33912799
Class IA phosphoinositide 3-kinase regulates heart size and physiological cardiac hypertrophyQ34097448
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Activation of moesin, a protein that links actin cytoskeleton to the plasma membrane, occurs by phosphatidylinositol 4,5-bisphosphate (PIP2) binding sequentially to two sites and releasing an autoinhibitory linkerQ35956572
The conserved phosphoinositide 3-kinase pathway determines heart size in miceQ36246110
ACE2 Deficiency Worsens Epicardial Adipose Tissue Inflammation and Cardiac Dysfunction in Response to Diet-Induced ObesityQ36392875
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2-Deoxyadenosine triphosphate restores the contractile function of cardiac myofibril from adult dogs with naturally occurring dilated cardiomyopathyQ36699259
The p110beta isoform of phosphoinositide 3-kinase signals downstream of G protein-coupled receptors and is functionally redundant with p110gamma.Q36751486
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Loss of angiotensin-converting enzyme-2 exacerbates diabetic cardiovascular complications and leads to systolic and vascular dysfunction: a critical role of the angiotensin II/AT1 receptor axisQ37101896
Loss of Apelin exacerbates myocardial infarction adverse remodeling and ischemia-reperfusion injury: therapeutic potential of synthetic Apelin analogues.Q37310459
Uncoupling between enhanced excitation-contraction coupling and the response to heart disease: lessons from the PI3Kγ knockout murine model.Q37833231
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Multifunctional roles of gelsolin in health and diseasesQ38034125
Mechanisms and Functions of Vinculin Interactions with Phospholipids at Cell Adhesion SitesQ38265394
Identification of a phosphatidylinositol 4,5-bisphosphate-binding site in chicken skeletal muscle alpha-actininQ38361897
Molecules in medicine mini-review: isoforms of PI3K in biology and diseaseQ38666875
Regulation of myocardial contractility and cell size by distinct PI3K-PTEN signaling pathwaysQ39750571
Regulation of intercellular adhesion strength in fibroblastsQ40537082
Isoform-selective induction of human p110δ PI3K expression by TNFα: identification of a new and inducible PIK3CD promoterQ41789259
Angiogenesis selectively requires the p110alpha isoform of PI3K to control endothelial cell migration.Q41791633
MinActionPath: maximum likelihood trajectory for large-scale structural transitions in a coarse-grained locally harmonic energy landscapeQ41808112
Phosphoinositide 3-kinase gamma-deficient mice are protected from isoproterenol-induced heart failure.Q42447268
FAK, PIP5KIgamma and gelsolin cooperatively mediate force-induced expression of alpha-smooth muscle actinQ42795993
Comparative molecular dynamics simulation studies for determining factors contributing to the thermostability of chemotaxis protein "CheY".Q43018766
Cadherins mediate intercellular mechanical signaling in fibroblasts by activation of stretch-sensitive calcium-permeable channelsQ43683616
The progression from hypertension to congestive heart failureQ43812016
Focal adhesion kinase is activated and mediates the early hypertrophic response to stretch in cardiac myocytesQ44477120
Phosphoinositide 3-kinase p110α is a master regulator of exercise-induced cardioprotection and PI3K gene therapy rescues cardiac dysfunctionQ45879808
Protein misfolding and amyloid formation for the peptide GNNQQNY from yeast prion protein Sup35: simulation by reaction path annealingQ46492576
Loss of p47phox subunit enhances susceptibility to biomechanical stress and heart failure because of dysregulation of cortactin and actin filaments.Q46983155
Gelsolin and cardiac myocyte apoptosis: a new target in the treatment of postinfarction remodelingQ48024113
Advanced heart failure treated with continuous-flow left ventricular assist deviceQ48952442
Cardiac improvement during mechanical circulatory support: a prospective multicenter study of the LVAD Working Group.Q51010198
PI3Kα is essential for the recovery from Cre/tamoxifen cardiotoxicity and in myocardial insulin signalling but is not required for normal myocardial contractility in the adult heart.Q51308924
Angiotensin-converting enzyme 2 suppresses pathological hypertrophy, myocardial fibrosis, and cardiac dysfunction.Q51772425
On the convergence of the conformational coordinates basis set obtained by the essential dynamics analysis of proteins' molecular dynamics simulations.Q52206949
Cardioprotective effects mediated by angiotensin II type 1 receptor blockade and enhancing angiotensin 1-7 in experimental heart failure in angiotensin-converting enzyme 2-null mice.Q53173814
Novel Dominant-Negative Mutation in Cardiac Troponin I Causes Severe Restrictive Cardiomyopathy.Q53520024
Exogenous gelsolin binds to sarcomeric thin filaments without severingQ54187969
Loss of PTEN attenuates the development of pathological hypertrophy and heart failure in response to biomechanical stressQ57184516
Combination of Tumor Necrosis Factor-α Ablation and Matrix Metalloproteinase Inhibition Prevents Heart Failure After Pressure Overload in Tissue Inhibitor of Metalloproteinase-3 Knock-Out MiceQ58211733
Control of cytoplasmic actin gel–sol transformation by gelsolin, a calcium-dependent regulatory proteinQ59064148
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Dependence of fibroblast migration on actin severing activity of gelsolinQ71246159
Early activation of the multicomponent signaling complex associated with focal adhesion kinase induced by pressure overload in the rat heartQ73015364
Gelsolin binding to phosphatidylinositol 4,5-bisphosphate is modulated by calcium and pHQ73575375
The insulin-like growth factor 1 receptor induces physiological heart growth via the phosphoinositide 3-kinase(p110alpha) pathwayQ79248092
A high-throughput assay shows that DNase-I binds actin monomers and polymers with similar affinityQ80070026
ADP-Ribosylation of Cross-Linked Actin Generates Barbed-End Polymerization-Deficient F-Actin OligomersQ84959303
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P4510describes a project that usesImageJQ1659584
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectcytoskeletonQ154626
P304page(s)5390
P577publication date2018-12-19
P1433published inNature CommunicationsQ573880
P1476titlePI3Kα-regulated gelsolin activity is a critical determinant of cardiac cytoskeletal remodeling and heart disease
P478volume9

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cites work (P2860)
Q91660243Impaired branched chain amino acid oxidation contributes to cardiac insulin resistance in heart failure
Q90124031Nicotinic acid affects cytoskeleton remodeling via increasing the activity of gelsolin
Q89459605PI3K inhibitors in thrombosis and cardiovascular disease
Q64075558PI3Kα Pathway Inhibition With Doxorubicin Treatment Results in Distinct Biventricular Atrophy and Remodeling With Right Ventricular Dysfunction
Q91606069PI3Kα in cardioprotection: Cytoskeleton, late Na+ current, and mechanism of arrhythmias

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