Impact of ACE2 deficiency and oxidative stress on cerebrovascular function with aging

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Impact of ACE2 deficiency and oxidative stress on cerebrovascular function with aging is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1161/STROKEAHA.112.667063
P932PMC publication ID3529166
P698PubMed publication ID23160880

P50authorJosef PenningerQ1674391
Ricardo Pena SilvaQ43122518
Frank M FaraciQ86046795
P2093author name stringYi Chu
Jordan D Miller
Donald D Heistad
Ian J Mitchell
P2860cites workDisruption of the Ang II type 1 receptor promotes longevity in miceQ24647615
Angiotensin-(1-7) is an endogenous ligand for the G protein-coupled receptor MasQ24680069
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ACEH/ACE2 is a novel mammalian metallocarboxypeptidase and a homologue of angiotensin-converting enzyme insensitive to ACE inhibitorsQ28218830
Angiotensin II impairs neurovascular coupling in neocortex through NADPH oxidase-derived radicalsQ28511880
Age-related alterations in reactivity of cerebral arterioles: role of oxidative stressQ28584121
Heart disease and stroke statistics--2012 update: a report from the American Heart AssociationQ29547909
Angiotensin II attenuates endothelium-dependent responses in the cerebral microcirculation through nox-2-derived radicalsQ33232591
Cerebrovascular nitrosative stress mediates neurovascular and endothelial dysfunction induced by angiotensin II.Q33265176
Nox2-derived reactive oxygen species mediate neurovascular dysregulation in the aging mouse brainQ33281864
Decreased glomerular and tubular expression of ACE2 in patients with type 2 diabetes and kidney diseaseQ33387233
Angiotensin-(1-7)-angiotensin-converting enzyme 2 attenuates reactive oxygen species formation to angiotensin II within the cell nucleusQ33652507
The cerebrovascular dysfunction induced by slow pressor doses of angiotensin II precedes the development of hypertensionQ33726694
Sex differences in protection against angiotensin II-induced endothelial dysfunction by manganese superoxide dismutase in the cerebral circulationQ33835991
Severe acute respiratory syndrome, Beijing, 2003Q34973792
Protecting against vascular disease in brainQ34979773
Age-associated vascular oxidative stress, Nrf2 dysfunction, and NF-{kappa}B activation in the nonhuman primate Macaca mulatta.Q35142935
Angiotensin-converting enzyme 2 deficiency is associated with impaired gestational weight gain and fetal growth restrictionQ35587023
Neurovascular coupling in the normal brain and in hypertension, stroke, and Alzheimer diseaseQ36343094
Neurovascular unit dysfunction: a vascular component of Alzheimer disease?Q36821841
Loss of angiotensin-converting enzyme-2 exacerbates diabetic cardiovascular complications and leads to systolic and vascular dysfunction: a critical role of the angiotensin II/AT1 receptor axisQ37101896
Angiotensin-converting enzyme 2 gene targeting studies in mice: mixed messagesQ37122931
Role of oxidative stress and AT1 receptors in cerebral vascular dysfunction with agingQ37276197
Angiotensin II blockade: a strategy to slow ageing by protecting mitochondria?Q37785713
Regulator of calcineurin 1 mediates pathological vascular wall remodelingQ38583217
Angiotensin-Converting Enzyme Inhibitor Use Is Associated With Reduced Plasma Concentration of C-Reactive Protein in Patients With First-Ever Ischemic StrokeQ40551007
Evidence that prolyl endopeptidase participates in the processing of brain angiotensinQ41974935
Angiotensin-(1-7) counterregulates angiotensin II signaling in human endothelial cells.Q42521222
Relationship of angiotensin-converting enzyme 2 gene polymorphism with the prognosis of hypertensive stroke patientsQ43179505
Coronary endothelial dysfunction is associated with an increased risk of cerebrovascular eventsQ44456357
Markers of endothelial dysfunction in older subjects with late onset Alzheimer's disease or vascular dementia.Q45959996
ACE2 gene polymorphism and essential hypertension: an updated meta-analysis involving 11,051 subjectsQ46273463
Regulation of vascular function by RCAN1 (ADAPT78).Q46738087
Age- and gender-related difference of ACE2 expression in rat lungQ47686945
In vivo metabolism of angiotensin I by neutral endopeptidase (EC 3.4.24.11) in spontaneously hypertensive ratsQ48478548
No association of angiotensin-converting enzyme 2 gene (ACE2) polymorphisms with essential hypertension.Q51995128
Angiotensin converting enzyme-2 confers endothelial protection and attenuates atherosclerosis.Q53463683
Endothelial Function in Resistance and Conduit Arteries and 5-Year Risk of Cardiovascular DiseaseQ61442738
Angiotensin-(1-7) causes endothelium-dependent relaxation in canine middle cerebral arteryQ74071611
Ageing alters aortic antioxidant enzyme activities in Fischer-344 ratsQ78195923
Modulation of dilator responses of cerebral arterioles by extracellular superoxide dismutaseQ79157022
Polymorphisms of ACE2 gene are associated with essential hypertension and antihypertensive effects of Captopril in womenQ80251093
Cerebral vascular dysfunction during hypercholesterolemiaQ80382250
Advanced age is associated with endothelial dysfunction in healthy elderly subjectsQ81164809
SIRT-1 and vascular endothelial dysfunction with ageing in mice and humansQ84539908
P433issue12
P407language of work or nameEnglishQ1860
P304page(s)3358-3363
P577publication date2012-11-15
P1433published inStroke JournalQ7624282
P1476titleImpact of ACE2 deficiency and oxidative stress on cerebrovascular function with aging
P478volume43

Reverse relations

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Q94571148COVID-19, Angiotensin Receptor Blockers, and the Brain
Q26751153Cerebral Small Vessel Disease: Targeting Oxidative Stress as a Novel Therapeutic Strategy?
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