Obesity and diabetes as comorbidities for COVID-19: Underlying mechanisms and the role of viral-bacterial interactions

scientific article published on 15 September 2020

Obesity and diabetes as comorbidities for COVID-19: Underlying mechanisms and the role of viral-bacterial interactions is …
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scholarly articleQ13442814

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P356DOI10.7554/ELIFE.61330
P932PMC publication ID7492082
P698PubMed publication ID32930095

P50authorManasi ShahQ99544125
Philipp E. SchererQ60572448
Ilja L KruglikovQ89677053
P2860cites workBinding and internalization of lipopolysaccharide by Cla-1, a human orthologue of rodent scavenger receptor B1Q24298291
Age-associated increase in cytokine production during systemic inflammation: adipose tissue as a major source of IL-6Q24616666
Human nutrition, the gut microbiome and the immune systemQ24620449
The role of respiratory viruses in the etiology of bacterial pneumonia: An ecological perspectiveQ26765407
Metabolic endotoxemia: a molecular link between obesity and cardiovascular riskQ27023488
A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus-induced lung injuryQ28260798
Both systemic and local lipopolysaccharide (LPS) burden are associated with knee OA severity and inflammationQ28389532
Is adipose tissue a place for Mycobacterium tuberculosis persistence?Q28469097
Metabolic endotoxemia initiates obesity and insulin resistanceQ29547720
Lung microbiome and disease progression in idiopathic pulmonary fibrosis: an analysis of the COMET studyQ30384494
A novel risk factor for a novel virus: obesity and 2009 pandemic influenza A (H1N1).Q30398268
Obesity and respiratory hospitalizations during influenza seasons in Ontario, Canada: a cohort studyQ30405999
Obesity and the risk and outcome of infectionQ30416191
Adipose tissue serves as a reservoir for recrudescent Rickettsia prowazekii infection in a mouse model.Q33521906
The role of adipocytes and adipocyte-like cells in the severity of COVID-19 infectionsQ93256597
Cardiovascular Disease, Drug Therapy, and Mortality in Covid-19Q94478168
Obesity could shift severe COVID-19 disease to younger agesQ94538338
Is diabetes mellitus associated with mortality and severity of COVID-19? A meta-analysisQ94680716
Clinical Characteristics and Outcomes of Patients With Diabetes and COVID-19 in Association With Glucose-Lowering MedicationQ94685427
Obesity and COVID-19 Severity in a Designated Hospital in Shenzhen, ChinaQ94685447
COVID-19 in diabetic patients: related risks and specifics of managementQ94938940
Exploring Diseases/Traits and Blood Proteins Causally Related to Expression of ACE2, the Putative Receptor of SARS-CoV-2: A Mendelian Randomization Analysis Highlights Tentative Relevance of Diabetes-Related TraitsQ95272307
The cytokine storm in COVID-19: An overview of the involvement of the chemokine/chemokine-receptor systemQ95645944
Factors associated with hospital admission and critical illness among 5279 people with coronavirus disease 2019 in New York City: prospective cohort studyQ95659103
ACE-inhibitors and Angiotensin-2 Receptor Blockers are not associated with severe SARS-COVID19 infection in a multi-site UK acute Hospital TrustQ96109911
Alterations of the Gut Microbiota in Patients with COVID-19 or H1N1 InfluenzaQ96122174
Relationship between COVID-19 and obesityQ96160937
Greater risk of severe COVID-19 in Black, Asian and Minority Ethnic populations is not explained by cardiometabolic, socioeconomic or behavioural factors, or by 25(OH)-vitamin D status: study of 1326 cases from the UK BiobankQ96579884
Thrombosis and COVID-19 pneumonia: the clot thickens!Q96590044
COVID-19 revisiting inflammatory pathways of arthritisQ96610156
The Lung Tissue Microbiota Features of 20 Deceased Patients with COVID-19Q96649399
In-Hospital Use of Statins Is Associated with a Reduced Risk of Mortality among Individuals with COVID-19Q96768496
Fasting blood glucose at admission is an independent predictor for 28-day mortality in patients with COVID-19 without previous diagnosis of diabetes: a multi-centre retrospective studyQ97546781
Aging, Male Sex, Obesity, and Metabolic Inflammation Create the Perfect Storm for COVID-19Q97567103
SARS-CoV-2 Infections and ACE2: Clinical Outcomes Linked With Increased Morbidity and Mortality in Individuals With DiabetesQ97567111
COVID-19 in people with diabetes: understanding the reasons for worse outcomesQ97597390
Type 2 diabetes influences bacterial tissue compartmentalisation in human obesityQ97643685
Managing Hyperglycemia in the COVID-19 Inflammatory StormQ98302547
Association of high level gene expression of ACE2 in adipose tissue with mortality of COVID-19 infection in obese patientsQ98657383
Coronavirus (COVID-19) Pandemic and Health Workers of an Ethnic Group-A Slant on a Shocking ReportQ98663307
Effect of porcine respiratory coronavirus infection on lipopolysaccharide recognition proteins and haptoglobin levels in the lungsQ49084254
Matrix metalloproteinase-14 triggers an anti-inflammatory proteolytic cascade in endotoxemia.Q50218199
Effect of diabetes mellitus on endotoxin-induced lung injury.Q50515229
Short-Term Versus Long-Term Effects of Adipocyte Toll-Like Receptor 4 Activation on Insulin Resistance in Male Mice.Q50785259
Increased levels of acute-phase serum proteins in diabetes.Q51618740
ADAM17-Mediated Ectodomain Shedding of Toll-Like Receptor 4 as a Negative Feedback Regulation in Lipopolysaccharide-Activated Aortic Endothelial Cells.Q51743843
Gut-dependent microbial translocation induces inflammation and cardiovascular events after ST-elevation myocardial infarction.Q52609376
Angiotensin-(1-9) ameliorates pulmonary arterial hypertension via angiotensin type II receptor.Q55360608
Hepatocyte toll-like receptor 4 deficiency protects against alcohol-induced fatty liver disease.Q55506426
Pioglitazone upregulates angiotensin converting enzyme 2 expression in insulin-sensitive tissues in rats with high-fat diet-induced nonalcoholic steatohepatitis.Q55641730
Correlative Light-Electron Microscopy detects lipopolysaccharide and its association with fibrin fibres in Parkinson's Disease, Alzheimer's Disease and Type 2 Diabetes MellitusQ59127020
The endotoxin-induced pulmonary inflammatory response is enhanced during the acute phase of influenza infectionQ59357539
Toll-like receptor 4 in acute viral infection: Too much of a good thingQ60945182
Prognostic Value of Nutritional Status in Chronic Obstructive Pulmonary DiseaseQ61875242
Reactivation of antigen-induced arthritis in mice by oral administration of lipopolysaccharideQ81063980
Role of gut microbiota in type 2 diabetes pathophysiologyQ92416693
High Fructose Intake and AdipogenesisQ92635321
Critical Role of Matrix Metalloproteinase 14 in Adipose Tissue Remodeling during ObesityQ92976697
Presenting Characteristics, Comorbidities, and Outcomes Among 5700 Patients Hospitalized With COVID-19 in the New York City AreaQ93147595
The pivotal link between ACE2 deficiency and SARS-CoV-2 infectionQ93237239
Persistence of Coxiella burnetii, the agent of Q fever, in murine adipose tissueQ33623657
Hepatocyte Toll-like receptor 4 regulates obesity-induced inflammation and insulin resistanceQ33840644
Lipid-induced insulin resistance mediated by the proinflammatory receptor TLR4 requires saturated fatty acid-induced ceramide biosynthesis in miceQ34178121
Elevated muscle TLR4 expression and metabolic endotoxemia in human agingQ35029353
CD14 modulates inflammation-driven insulin resistanceQ35123567
Gut dysbiosis and detection of "live gut bacteria" in blood of Japanese patients with type 2 diabetes.Q35167982
ACE2 and Microbiota: Emerging Targets for Cardiopulmonary Disease TherapyQ35760437
The Gut-Lung Axis in Respiratory DiseaseQ35848701
Emerging pathogenic links between microbiota and the gut-lung axis.Q36150861
ACE2 Deficiency Worsens Epicardial Adipose Tissue Inflammation and Cardiac Dysfunction in Response to Diet-Induced ObesityQ36392875
Modulation of TNF-alpha-converting enzyme by the spike protein of SARS-CoV and ACE2 induces TNF-alpha production and facilitates viral entryQ36693984
Developmental cell/molecular biologic approach to the etiology and treatment of bronchopulmonary dysplasiaQ36827804
ACE2 is expressed in mouse adipocytes and regulated by a high-fat diet.Q36877738
Loss of angiotensin-converting enzyme-2 exacerbates diabetic cardiovascular complications and leads to systolic and vascular dysfunction: a critical role of the angiotensin II/AT1 receptor axisQ37101896
Changes in endotoxin levels in T2DM subjects on anti-diabetic therapiesQ37172453
Rosiglitazone, a peroxisome proliferator-activated receptor-γ agonist, restores alveolar and pulmonary vascular development in a rat model of bronchopulmonary dysplasiaQ37418778
Diabetes, insulin, and development of acute lung injuryQ37521491
Initial viral load and the outcomes of SARS.Q37610938
Characterization of ACE and ACE2 Expression within Different Organs of the NOD MouseQ37729150
Polymicrobial respiratory disease in pigsQ37966069
Beneficial effects of probiotics in upper respiratory tract infections and their mechanical actions to antagonize pathogensQ38025737
Review: Viral infections and mechanisms of thrombosis and bleedingQ38038832
Angiotensin-(1-7) and angiotensin-(1-9): function in cardiac and vascular remodellingQ38193206
Obesity paradox: does fat alter outcomes in chronic obstructive pulmonary disease?Q38221515
Relation Between Obesity and Survival in Patients Hospitalized for Pulmonary Arterial Hypertension (from a Nationwide Inpatient Sample Database 2003 to 2011).Q38732550
Pathogenic mechanisms of intracellular bacteriaQ38992307
Importance of cholesterol for infection of cells by transmissible gastroenteritis virusQ39947080
Tumor necrosis factor-alpha convertase (ADAM17) mediates regulated ectodomain shedding of the severe-acute respiratory syndrome-coronavirus (SARS-CoV) receptor, angiotensin-converting enzyme-2 (ACE2).Q40404194
Lung endothelial ADAM17 regulates the acute inflammatory response to lipopolysaccharideQ41847844
High Glucose Up-regulates ADAM17 through HIF-1α in Mesangial CellsQ41849322
Leptin resistance protects mice from hyperoxia-induced acute lung injuryQ42738508
High sucrose intake in rats is associated with increased ACE2 and angiotensin-(1-7) levels in the adipose tissue.Q43117155
Diet-induced obese mice have increased mortality and altered immune responses when infected with influenza virusQ45404876
Ethnic and sex differences in circulating endotoxin levels: A novel marker of atherosclerotic and cardiovascular risk in a British multi-ethnic populationQ46160524
Loss of angiotensin-converting enzyme 2 exacerbates myocardial injury via activation of the CTGF-fractalkine signaling pathwayQ46207876
Haptoglobin and the inflammatory and oxidative status in experimental diabetic rats: antioxidant role of haptoglobinQ46379099
Mendelian randomization analysis to assess a causal effect of haptoglobin on macroangiopathy in Chinese type 2 diabetes patientsQ48233021
A potential role for tumour necrosis factor-alpha in synergy between porcine respiratory coronavirus and bacterial lipopolysaccharide in the induction of respiratory disease in pigsQ49075141
Structural basis for human coronavirus attachment to sialic acid receptorsQ84315449
Membrane Cholesterol Modulates Oligomeric Status and Peptide-Membrane Interaction of Severe Acute Respiratory Syndrome Coronavirus Fusion PeptideQ84316079
Virus interactions with bacteria: Partners in the infectious danceQ89655622
It's the fiber, not the fat: significant effects of dietary challenge on the gut microbiomeQ89662478
Clinical and biochemical indexes from 2019-nCoV infected patients linked to viral loads and lung injuryQ89670059
Endothelial Dysfunction in Obesity-Induced Inflammation: Molecular Mechanisms and Clinical ImplicationsQ89761305
SARS-CoV-2 Viral Load in Upper Respiratory Specimens of Infected PatientsQ89779929
Comorbid diabetes results in immune dysregulation and enhanced disease severity following MERS-CoV infectionQ90255332
Survival Benefit of Obese Patients With Pulmonary EmbolismQ90488625
Viral dynamics in mild and severe cases of COVID-19Q90564410
Bone Marrow-Derived Cells Restore Functional Integrity of the Gut Epithelial and Vascular Barriers in a Model of Diabetes and ACE2 DeficiencyQ90698406
COVID-19 Pandemic, Corona Viruses, and Diabetes MellitusQ90758519
Diabetes is a risk factor for the progression and prognosis of COVID-19Q90788181
Aging progression of human gut microbiotaQ90983597
Potential harmful effects of discontinuing ACE-inhibitors and ARBs in COVID-19 patientsQ91586974
Angiotensin Converting Enzyme 2: SARS-CoV-2 Receptor and Regulator of the Renin-Angiotensin SystemQ91703665
ACE2 exhibits protective effects against LPS-induced acute lung injury in mice by inhibiting the LPS-TLR4 pathwayQ91723901
Incidence of thrombotic complications in critically ill ICU patients with COVID-19Q91931008
ADAM17 inhibition may exert a protective effect on COVID-19Q91934668
Coronavirus infections and type 2 diabetes-shared pathways with therapeutic implicationsQ91956201
Adipose tissue derived bacteria are associated with inflammation in obesity and type 2 diabetesQ92128732
LPS-Binding Protein Modulates Acute Renal Fibrosis by Inducing Pericyte-to-Myofibroblast Trans-Differentiation through TLR-4 SignalingQ92257857
P921main subjectcomorbidityQ1414874
COVID-19Q84263196
P577publication date2020-09-15
P1433published ineLifeQ2000008
P1476titleObesity and diabetes as comorbidities for COVID-19: Underlying mechanisms and the role of viral-bacterial interactions
P478volume9

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Q101214896miR-98 Regulates TMPRSS2 Expression in Human Endothelial Cells: Key Implications for COVID-19cites workP2860

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