The transcription factor Mrr1p controls expression of the MDR1 efflux pump and mediates multidrug resistance in Candida albicans

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The transcription factor Mrr1p controls expression of the MDR1 efflux pump and mediates multidrug resistance in Candida albicans is …
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scholarly articleQ13442814

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P356DOI10.1371/JOURNAL.PPAT.0030164
P3181OpenCitations bibliographic resource ID2874998
P932PMC publication ID2048531
P698PubMed publication ID17983269
P5875ResearchGate publication ID5863962

P50authorJoachim MorschhäuserQ89087588
Ramin HomayouniQ71582235
P2093author name stringKatherine S Barker
P David Rogers
Teresa T Liu
Julia BlaB-Warmuth
P2860cites workCaIPF7817 is involved in the regulation of redox homeostasis in Candida albicansQ80389170
Heterozygosity of genes on the sex chromosome regulates Candida albicans virulenceQ80445106
Cap1p is involved in multiple pathways of oxidative stress response in Candida albicansQ82871230
A common drug-responsive element mediates the upregulation of the Candida albicans ABC transporters CDR1 and CDR2, two genes involved in antifungal drug resistanceQ42673167
Overexpression of the MDR1 gene is sufficient to confer increased resistance to toxic compounds in Candida albicansQ43261180
Molecular aspects of fluconazole resistance development in Candida albicansQ43899356
A proteomic approach to understanding the development of multidrug-resistant Candida albicans strainsQ44870226
Sequential gene disruption in Candida albicans by FLP-mediated site-specific recombinationQ47965325
A family of oligopeptide transporters is required for growth of Candida albicans on proteinsQ48090969
The SAT1 flipper, an optimized tool for gene disruption in Candida albicansQ48168925
Targeted gene disruption in Candida albicans wild-type strains: the role of the MDR1 gene in fluconazole resistance of clinical Candida albicans isolates.Q52539522
Proteomic analysis of the oxidative stress response in Candida albicans.Q53572547
Identification of promoter elements responsible for the regulation of MDR1 from Candida albicans, a major facilitator transporter involved in azole resistance.Q53583658
Analysis of the oxidative stress regulation of the Candida albicans transcription factor, Cap1p.Q54049038
Protective effects of antioxidants against benomyl-induced lipid peroxidation and glutathione depletion in ratsQ73039998
Identification of polymorphic mutant alleles of CaMDR1, a major facilitator of Candida albicans which confers multidrug resistance, and its in vitro transcriptional activationQ77323771
PDR16-mediated azole resistance in Candida albicansQ79780176
A human-curated annotation of the Candida albicans genomeQ21145286
Involvement of yeast YOL151W/GRE2 in ergosterol metabolismQ27930740
Saccharomyces cerevisiae Hsp31p, a stress response protein conferring protection against reactive oxygen speciesQ27933701
Competitive promoter occupancy by two yeast paralogous transcription factors controlling the multidrug resistance phenomenon.Q27936528
A rapid and simple method for preparation of RNA from Saccharomyces cerevisiaeQ28131648
Molecular cloning and characterization of a novel gene of Candida albicans, CDR1, conferring multiple resistance to drugs and antifungalsQ28293585
MDR1-mediated drug resistance in Candida dubliniensisQ28364120
TAC1, transcriptional activator of CDR genes, is a new transcription factor involved in the regulation of Candida albicans ABC transporters CDR1 and CDR2.Q33559776
Analysis of a Candida albicans gene that encodes a novel mechanism for resistance to benomyl and methotrexateQ33630438
Amino acid substitutions in the cytochrome P-450 lanosterol 14alpha-demethylase (CYP51A1) from azole-resistant Candida albicans clinical isolates contribute to resistance to azole antifungal agentsQ33689421
Distinct patterns of gene expression associated with development of fluconazole resistance in serial candida albicans isolates from human immunodeficiency virus-infected patients with oropharyngeal candidiasisQ33701491
Clinical, cellular, and molecular factors that contribute to antifungal drug resistance.Q33721804
Drug-induced regulation of the MDR1 promoter in Candida albicansQ33883805
Prevalence of molecular mechanisms of resistance to azole antifungal agents in Candida albicans strains displaying high-level fluconazole resistance isolated from human immunodeficiency virus-infected patientsQ33983022
The bZip transcription factor Cap1p is involved in multidrug resistance and oxidative stress response in Candida albicansQ33991085
The genetic basis of fluconazole resistance development in Candida albicansQ34135429
Endogenous reactive oxygen species is an important mediator of miconazole antifungal effectQ34143941
Cloning of Candida albicans genes conferring resistance to azole antifungal agents: characterization of CDR2, a new multidrug ABC transporter gene.Q34417276
Chromosome loss followed by duplication is the major mechanism of spontaneous mating-type locus homozygosis in Candida albicansQ34572390
A mutation in Tac1p, a transcription factor regulating CDR1 and CDR2, is coupled with loss of heterozygosity at chromosome 5 to mediate antifungal resistance in Candida albicansQ34588684
Mechanisms of resistance to azole antifungal agents in Candida albicans isolates from AIDS patients involve specific multidrug transportersQ35120105
Susceptibilities of Candida albicans multidrug transporter mutants to various antifungal agents and other metabolic inhibitorsQ35127954
Increased mRNA levels of ERG16, CDR, and MDR1 correlate with increases in azole resistance in Candida albicans isolates from a patient infected with human immunodeficiency virusQ35137093
Transcriptional regulation of MDR1, encoding a drug efflux determinant, in fluconazole-resistant Candida albicans strains through an Mcm1p binding siteQ35216756
Emergence of fluconazole-resistant strains of Candida albicans in patients with recurrent oropharyngeal candidosis and human immunodeficiency virus infection.Q37091074
Fluconazole-resistant recurrent oral candidiasis in human immunodeficiency virus-positive patients: persistence of Candida albicans strains with the same genotype.Q37166301
Comparison of gene expression profiles of Candida albicans azole-resistant clinical isolates and laboratory strains exposed to drugs inducing multidrug transportersQ38338527
Activation of the multiple drug resistance gene MDR1 in fluconazole-resistant, clinical Candida albicans strains is caused by mutations in a trans-regulatory factorQ39498564
Isogenic strain construction and gene targeting in Candida dubliniensisQ39526406
Multiple molecular mechanisms contribute to a stepwise development of fluconazole resistance in clinical Candida albicans strains.Q39559578
Light-directed 5'-->3' synthesis of complex oligonucleotide microarraysQ39744529
The presence of an R467K amino acid substitution and loss of allelic variation correlate with an azole-resistant lanosterol 14alpha demethylase in Candida albicansQ39784510
Overexpression of a cloned IMP dehydrogenase gene of Candida albicans confers resistance to the specific inhibitor mycophenolic acidQ39845163
Multiple cis-acting sequences mediate upregulation of the MDR1 efflux pump in a fluconazole-resistant clinical Candida albicans isolateQ41473540
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue11
P407language of work or nameEnglishQ1860
P921main subjectCandida albicansQ310443
multiple drug resistanceQ643839
P304page(s)e164
P577publication date2007-11-01
P1433published inPLOS PathogensQ283209
P1476titleThe transcription factor Mrr1p controls expression of the MDR1 efflux pump and mediates multidrug resistance in Candida albicans
P478volume3

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