Open-label comparative clinical study of chlorproguanil-dapsone fixed dose combination (Lapdap) alone or with three different doses of artesunate for uncomplicated Plasmodium falciparum malaria

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Open-label comparative clinical study of chlorproguanil-dapsone fixed dose combination (Lapdap) alone or with three different doses of artesunate for uncomplicated Plasmodium falciparum malaria is …
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scholarly articleQ13442814

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P819ADS bibcode2008PLoSO...3.1779W
P356DOI10.1371/JOURNAL.PONE.0001779
P3181OpenCitations bibliographic resource ID3083139
P932PMC publication ID2258152
P698PubMed publication ID18320064
P5875ResearchGate publication ID5532346

P50authorSteve WardQ55112735
Makandwe NyirendaQ56856504
Hannah BlencoweQ58226589
Giancarlo BiaginiQ41938978
P2093author name stringStephan Duparc
Malcolm Molyneux
Peter A Winstanley
Hyginus Opara
Daniel G Wootton
Colin Neate
Mary Woessner
Sam Dunyo
Paula L Kirby
Maxwell K Kanjala
Queen Dube-Mbeye
Thomas Kanyok
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Molecular evidence of greater selective pressure for drug resistance exerted by the long-acting antifolate Pyrimethamine/Sulfadoxine compared with the shorter-acting chlorproguanil/dapsone on Kenyan Plasmodium falciparumQ31389858
Adverse effects in patients with acute falciparum malaria treated with artemisinin derivativesQ33646966
Artemether-lumefantrine for the treatment of multidrug-resistant falciparum malariaQ33929311
Oral artesunate dose-response relationship in acute falciparum malariaQ34113505
Short-course artesunate treatment of uncomplicated Plasmodium falciparum malaria in GabonQ34734703
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Combination therapy counteracts the enhanced transmission of drug-resistant malaria parasites to mosquitoesQ37568641
Comparison of chlorproguanil-dapsone with sulfadoxine-pyrimethamine for the treatment of uncomplicated falciparum malaria in young African children: double-blind randomised controlled trialQ38870092
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Chlorproguanil-dapsone (LAPDAP) for uncomplicated falciparum malariaQ43796087
Artemisinin (qinghaosu)--a new gametocytocidal drug for malariaQ44147893
Moderate effect of artemisinin-based combination therapy on transmission of Plasmodium falciparumQ44167789
Chlorproguanil-dapsone versus sulfadoxine-pyrimethamine for sequential episodes of uncomplicated falciparum malaria in Kenya and Malawi: a randomised clinical trialQ44185167
5-day nonobserved artesunate monotherapy for treating uncomplicated Falciparum malaria in young Gabonese children.Q46545290
Parasite viability during treatment of severe falciparum malaria: differential effects of artemether and quinine.Q46597626
Effects of artemisinin derivatives on malaria transmissibilityQ48027455
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectmalariaQ12156
Plasmodium falciparumQ311383
artesunateQ707939
Plasmodium falciparum malariaQ18554672
P304page(s)e1779
P577publication date2008-03-05
P1433published inPLOS OneQ564954
P1476titleOpen-label comparative clinical study of chlorproguanil-dapsone fixed dose combination (Lapdap) alone or with three different doses of artesunate for uncomplicated Plasmodium falciparum malaria
P478volume3