Chlorproguanil-dapsone versus sulfadoxine-pyrimethamine for sequential episodes of uncomplicated falciparum malaria in Kenya and Malawi: a randomised clinical trial

scientific article published in October 2002

Chlorproguanil-dapsone versus sulfadoxine-pyrimethamine for sequential episodes of uncomplicated falciparum malaria in Kenya and Malawi: a randomised clinical trial is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/S0140-6736(02)11198-6
P698PubMed publication ID12387962

P50authorKevin MarshQ30102986
P2093author name stringC V Plowe
M E Molyneux
W M Watkins
J G Kublin
T E Taylor
P A Winstanley
P Chimpeni
J Hatcher
J Sulo
P2860cites workMolecular evidence of greater selective pressure for drug resistance exerted by the long-acting antifolate Pyrimethamine/Sulfadoxine compared with the shorter-acting chlorproguanil/dapsone on Kenyan Plasmodium falciparumQ31389858
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Amino acids in the dihydrofolate reductase-thymidylate synthase gene of Plasmodium falciparum involved in cycloguanil resistance differ from those involved in pyrimethamine resistanceQ37739332
Characterisation of the dihydrofolate reductase-thymidylate synthetase gene from human malaria parasites highly resistant to pyrimethamineQ38345011
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Insecticide-treated bednets reduce mortality and severe morbidity from malaria among children on the Kenyan coast.Q39113802
Kenyan Plasmodium falciparum field isolates: correlation between pyrimethamine and chlorcycloguanil activity in vitro and point mutations in the dihydrofolate reductase domain.Q39557015
In vitro activities of novel antifolate drug combinations against Plasmodium falciparum and human granulocyte CFUsQ39779567
The efficacy of antifolate antimalarial combinations in Africa: a predictive model based on pharmacodynamic and pharmacokinetic analysesQ41913682
Chlorproguanil-dapsone for treatment of drug-resistant falciparum malaria in TanzaniaQ41918630
Identification and analysis of dihydrofolate reductase alleles from Plasmodium falciparum present at low frequency in polyclonal patient samples.Q41923590
Sequence variation of the hydroxymethyldihydropterin pyrophosphokinase: dihydropteroate synthase gene in lines of the human malaria parasite, Plasmodium falciparum, with differing resistance to sulfadoxine.Q41934737
Molecular markers for failure of sulfadoxine-pyrimethamine and chlorproguanil-dapsone treatment of Plasmodium falciparum malariaQ43864384
Highly pyrimethamine-resistant alleles of dihydrofolate reductase in isolates of Plasmodium falciparum from TanzaniaQ43949629
Treatment of Plasmodium falciparum malaria with pyrimethamine-sulfadoxine: selective pressure for resistance is a function of long elimination half-lifeQ44012338
Chlorproguanil/dapsone for uncomplicated Plasmodium falciparum malaria in young children: pharmacokinetics and therapeutic rangeQ46154949
Mutations in Plasmodium falciparum dihydrofolate reductase and dihydropteroate synthase and epidemiologic patterns of pyrimethamine-sulfadoxine use and resistanceQ46878245
Cardiac effects of antimalarial treatment with halofantrineQ48013877
P433issue9340
P407language of work or nameEnglishQ1860
P921main subjectKenyaQ114
MalawiQ1020
malariaQ12156
Plasmodium falciparumQ311383
pyrimethamineQ421072
P304page(s)1136-1143
P577publication date2002-10-01
P1433published inThe LancetQ939416
P1476titleChlorproguanil-dapsone versus sulfadoxine-pyrimethamine for sequential episodes of uncomplicated falciparum malaria in Kenya and Malawi: a randomised clinical trial
P478volume360

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Q35824695Dapsone therapy for malaria during pregnancy: maternal and fetal outcomes
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