Dynamics of HIV-1 quasispecies during antiviral treatment dissected using ultra-deep pyrosequencing

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Dynamics of HIV-1 quasispecies during antiviral treatment dissected using ultra-deep pyrosequencing is …
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scholarly articleQ13442814

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P819ADS bibcode2010PLoSO...511345H
P356DOI10.1371/JOURNAL.PONE.0011345
P932PMC publication ID2898805
P698PubMed publication ID20628644
P5875ResearchGate publication ID45185882

P50authorJan AlbertQ39183357
Bjorn AnderssonQ54965417
Thomas LeitnerQ84143742
Charlotte HedskogQ92719374
Göran BrattQ117462810
P2093author name stringJoakim Lundeberg
Ellen Sherwood
Mattias Mild
Johanna Jernberg
P2860cites workGenome sequencing in microfabricated high-density picolitre reactorsQ24544260
Residual human immunodeficiency virus type 1 viremia in some patients on antiretroviral therapy is dominated by a small number of invariant clones rarely found in circulating CD4+ T cellsQ24548940
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Simple PCR assays improve the sensitivity of HIV-1 subtype B drug resistance testing and allow linking of resistance mutationsQ28469253
Recombination rate and selection strength in HIV intra-patient evolutionQ28472689
Minority HIV-1 drug resistance mutations are present in antiretroviral treatment-naïve populations and associate with reduced treatment efficacyQ28473296
Low-abundance HIV drug-resistant viral variants in treatment-experienced persons correlate with historical antiretroviral useQ28475651
HIV-1 dynamics in vivo: virion clearance rate, infected cell life-span, and viral generation timeQ29547822
Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infectionQ29547852
Viral dynamics in human immunodeficiency virus type 1 infectionQ29547908
The hypercycle. A principle of natural self-organization. Part A: Emergence of the hypercycleQ29616074
HIV population dynamics in vivo: implications for genetic variation, pathogenesis, and therapyQ29616404
Lower in vivo mutation rate of human immunodeficiency virus type 1 than that predicted from the fidelity of purified reverse transcriptaseQ29619994
Quantitative deep sequencing reveals dynamic HIV-1 escape and large population shifts during CCR5 antagonist therapy in vivoQ33455862
Minority variants associated with transmitted and acquired HIV-1 nonnucleoside reverse transcriptase inhibitor resistance: implications for the use of second-generation nonnucleoside reverse transcriptase inhibitorsQ33601530
A novel assay allows genotyping of the latent reservoir for human immunodeficiency virus type 1 in the resting CD4+ T cells of viremic patientsQ33724247
Antiretroviral resistance during successful therapy of HIV type 1 infection.Q33919308
Generation of hybrid human immunodeficiency virus by homologous recombinationQ34298463
Persistence and fitness of multidrug-resistant human immunodeficiency virus type 1 acquired in primary infectionQ34330667
Molecular impact of the M184V mutation in human immunodeficiency virus type 1 reverse transcriptaseQ35566910
Treatment of antiretroviral-drug-resistant HIV-1 infectionQ35610798
The fitness cost of mutations associated with human immunodeficiency virus type 1 drug resistance is modulated by mutational interactionsQ35784897
Reduced replication of 3TC-resistant HIV-1 variants in primary cells due to a processivity defect of the reverse transcriptase enzyme.Q35905947
Characterization of mutation spectra with ultra-deep pyrosequencing: application to HIV-1 drug resistanceQ35914785
DNA bar coding and pyrosequencing to identify rare HIV drug resistance mutationsQ35916998
Few infected CD4+ T cells but a high proportion of replication-competent provirus copies in asymptomatic human immunodeficiency virus type 1 infectionQ36684367
Update of the drug resistance mutations in HIV-1: 2007.Q36919747
Minority human immunodeficiency virus type 1 variants in antiretroviral-naive persons with reverse transcriptase codon 215 revertant mutations.Q36949610
HIV rebounds from latently infected cells, rather than from continuing low-level replicationQ36954950
In vivo fitness cost of the M184V mutation in multidrug-resistant human immunodeficiency virus type 1 in the absence of lamivudineQ37099813
Treatment intensification does not reduce residual HIV-1 viremia in patients on highly active antiretroviral therapyQ37200979
Update of the Drug Resistance Mutations in HIV-1.Q37357605
Continued evolution in gp41 after interruption of enfuvirtide in subjects with advanced HIV type 1 diseaseQ38434624
Evolution of lamivudine resistance in human immunodeficiency virus type 1-infected individuals: the relative roles of drift and selectionQ39591902
Initial appearance of the 184Ile variant in lamivudine-treated patients is caused by the mutational bias of human immunodeficiency virus type 1 reverse transcriptaseQ39879230
Analysis of human immunodeficiency virus type 1 viremia and provirus in resting CD4+ T cells reveals a novel source of residual viremia in patients on antiretroviral therapyQ41876448
Low-abundance drug-resistant HIV-1 variants: finding significance in an era of abundant diagnostic and therapeutic optionsQ42586120
Low-abundance drug-resistant viral variants in chronically HIV-infected, antiretroviral treatment-naive patients significantly impact treatment outcomesQ43889383
Relationship between adherence and the development of resistance in antiretroviral-naive, HIV-1-infected patients receiving lopinavir/ritonavir or nelfinavirQ46494163
Development of HIV-1 resistance to (-)2'-deoxy-3'-thiacytidine in patients with AIDS or advanced AIDS-related complex.Q54177270
Persistence of lamivudine-sensitive HIV-1 quasispecies in the presence of lamivudine in vitro and in vivo.Q54563531
Fidelity of HIV-1 reverse transcriptase copying a hypervariable region of the HIV-1 env geneQ56903994
The clinical implications of reduced viral fitnessQ57207415
Temporal fluctuations in HIV quasispecies in vivo are not reflected by sequential HIV isolationsQ69355758
Reverse transcriptase fidelity and HIV-1 variationQ71984125
HIV-1 transmission cluster with M41L 'singleton' mutation and decreased transmission of resistance in newly diagnosed Swedish homosexual menQ79779078
Sensitive mutation detection in heterogeneous cancer specimens by massively parallel picoliter reactor sequencingQ79787202
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue7
P407language of work or nameEnglishQ1860
P921main subjectpyrosequencingQ2342248
viral quasispeciesQ104765291
P304page(s)e11345
P577publication date2010-07-07
P1433published inPLOS OneQ564954
P1476titleDynamics of HIV-1 quasispecies during antiviral treatment dissected using ultra-deep pyrosequencing
P478volume5

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