Targeting the IL-6 dependent phenotype can identify novel therapies for cholangiocarcinoma

scientific article

Targeting the IL-6 dependent phenotype can identify novel therapies for cholangiocarcinoma is …
instance of (P31):
scholarly articleQ13442814

External links are
P819ADS bibcode2010PLoSO...515195B
P356DOI10.1371/JOURNAL.PONE.0015195
P932PMC publication ID3002961
P698PubMed publication ID21179572
P5875ResearchGate publication ID49703552

P2093author name stringChiara Braconi
Nianyuan Huang
Takayuki Kogure
Tushar Patel
Erica Swenson
P2860cites workCancer risk in users of calcium channel blockers.Q50956016
Translational regulation by p38 mitogen-activated protein kinase signaling during human cholangiocarcinoma growth.Q53378279
Potentiation of kinesin spindle protein inhibitor-induced cell death by modulation of mitochondrial and death receptor apoptotic pathways.Q53578688
Marked elevation of serum interleukin-6 in patients with cholangiocarcinoma: validation of utility as a clinical markerQ74397599
Antihypertensive medication and their impact on cancer incidence: a mixed treatment comparison meta-analysis of randomized controlled trialsQ80837639
CholangiocarcinomaQ82195092
Worldwide trends in mortality from biliary tract malignanciesQ21093310
Cancer statistics, 2007Q29547293
Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitorsQ29547463
The Connectivity Map: using gene-expression signatures to connect small molecules, genes, and diseaseQ29547614
Gender disparity in liver cancer due to sex differences in MyD88-dependent IL-6 productionQ29614596
Dietary and genetic obesity promote liver inflammation and tumorigenesis by enhancing IL-6 and TNF expressionQ29615766
Oral capecitabine for the treatment of hepatocellular carcinoma, cholangiocarcinoma, and gallbladder carcinomaQ33361810
Increasing incidence and mortality of primary intrahepatic cholangiocarcinoma in the United StatesQ33949931
Changing international trends in mortality rates for liver, biliary and pancreatic tumoursQ33962674
Phase II study of erlotinib in patients with advanced biliary cancerQ33997258
Epigenetic regulation of microRNA-370 by interleukin-6 in malignant human cholangiocytesQ34648030
IL-6 activates serum and glucocorticoid kinase via p38alpha mitogen-activated protein kinase pathwayQ34804514
Over-expression of interleukin-6 enhances cell survival and transformed cell growth in human malignant cholangiocytesQ34881846
Interleukin-6 decreases senescence and increases telomerase activity in malignant human cholangiocytesQ34882042
Inverse association between prostate cancer and the use of calcium channel blockersQ35671014
Advances in the diagnosis, evaluation and management of cholangiocarcinomaQ36426732
Treatment of children with acute promyelocytic leukemia: results of the first North American Intergroup trial INT0129Q36430103
Calcium and cancer: targeting Ca2+ transportQ36856463
Cholangiocarcinoma and its managementQ36999338
The wolf in sheep's clothing: the role of interleukin-6 in immunity, inflammation and cancerQ37080407
L-type calcium channel blockers reverse docetaxel and vincristine-induced multidrug resistance independent of ABCB1 expression in human lung cancer cell linesQ38348538
Diagnostic utility of interleukin-6 (IL-6) for primary bile duct cancer and changes in serum IL-6 levels following photodynamic therapyQ38505216
Candidate therapeutic agents for hepatocellular cancer can be identified from phenotype-associated gene expression signatures.Q39840008
Histone deacetylase inhibitor MS-275 alone or combined with bortezomib or sorafenib exhibits strong antiproliferative action in human cholangiocarcinoma cellsQ40088575
Interleukin-6 contributes to growth in cholangiocarcinoma cells by aberrant promoter methylation and gene expressionQ40213105
Sorafenib alone or as combination therapy for growth control of cholangiocarcinomaQ40246733
Involvement of p38 mitogen-activated protein kinase signaling in transformed growth of a cholangiocarcinoma cell lineQ40836231
Relationship between interleukin-6 and proliferation and differentiation in cholangiocarcinomaQ41004779
Induction of apoptosis by monastrol, an inhibitor of the mitotic kinesin Eg5, is independent of the spindle checkpointQ46080289
Diagnostic role of serum interleukin 6 and CA 19-9 in patients with cholangiocarcinoma.Q47975129
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue12
P407language of work or nameEnglishQ1860
P921main subjectphenotypeQ104053
cholangiocarcinomaQ124292
P304page(s)e15195
P577publication date2010-12-16
P1433published inPLOS OneQ564954
P1476titleTargeting the IL-6 dependent phenotype can identify novel therapies for cholangiocarcinoma
P478volume5

Reverse relations

cites work (P2860)
Q35620650A combination of serum leucine-rich α-2-glycoprotein 1, CA19-9 and interleukin-6 differentiate biliary tract cancer from benign biliary strictures.
Q46243039Characterisation of the immune-related transcriptome in resected biliary tract cancers
Q28547244Chemical Library Screening and Structure-Function Relationship Studies Identify Bisacodyl as a Potent and Selective Cytotoxic Agent Towards Quiescent Human Glioblastoma Tumor Stem-Like Cells
Q50025185Clinical Significance of Soluble Intercellular Adhesion Molecule-1 and Interleukin-6 in Patients with Extrahepatic Cholangiocarcinoma
Q53090136Gankyrin promotes tumor growth and metastasis through activation of IL-6/STAT3 signaling in human cholangiocarcinoma.
Q38183539Hydrodynamic transfection for generation of novel mouse models for liver cancer research
Q37028411Liver carcinogenesis: rodent models of hepatocarcinoma and cholangiocarcinoma
Q47320115LncRNA LINC00880 promotes cell proliferation, migration and invasion while inhibiting apoptosis by targeting CACNG5 through the MAPK signaling pathway in spinal cord ependymoma.
Q47429093MIR21 drives resistance to Heat Shock Protein 90 inhibition in cholangiocarcinoma
Q37621790New insights into the molecular pathogenesis of intrahepatic cholangiocarcinoma
Q92730412Phosphatidylcholine Passes by Paracellular Transport to the Apical Side of the Polarized Biliary Tumor Cell Line Mz-ChA-1
Q55021190Suppression of IL-6 Gene by shRNA Augments Gemcitabine Chemosensitization in Pancreatic Adenocarcinoma Cells.
Q38734433TG2 and NF-κB Signaling Coordinates the Survival of Mantle Cell Lymphoma Cells via IL6-Mediated Autophagy
Q55513254Translational Bioinformatics for Cholangiocarcinoma: Opportunities and Challenges.
Q34811043Tumour cell-derived extracellular vesicles interact with mesenchymal stem cells to modulate the microenvironment and enhance cholangiocarcinoma growth

Search more.