Coordinated defects in hepatic long chain fatty acid metabolism and triglyceride accumulation contribute to insulin resistance in non-human primates

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Coordinated defects in hepatic long chain fatty acid metabolism and triglyceride accumulation contribute to insulin resistance in non-human primates is …
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scholarly articleQ13442814

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P819ADS bibcode2011PLoSO...627617K
P356DOI10.1371/JOURNAL.PONE.0027617
P3181OpenCitations bibliographic resource ID1606582
P932PMC publication ID3220682
P698PubMed publication ID22125617
P5875ResearchGate publication ID51838498

P50authorFranco FolliQ57078092
Ralph A. DeFronzoQ58689309
Raul A BastarracheaQ61785527
Gary W ClineQ88551066
Anthony G ComuzzieQ114358626
Vicki MatternQ114358642
Amalia GastaldelliQ43294287
P2093author name stringDevjit Tripathy
Edward J Dick
Alberto O Chavez
Alberto M Davalli
Lilia M Jimenez-Ceja
Francesca Casiraghi
Glenn A Halff
Paul B Higgins
Rodolfo Guardado-Mendoza
Andrea Ricotti
Iram Pablo Rodriguez-Sanchez
Subhash Kamath
Gregory A Abrahamian
Ana Maria Paez
Mary E Tejero
P2860cites workHepatic lipid composition and stearoyl-coenzyme A desaturase 1 mRNA expression can be estimated from plasma VLDL fatty acid ratios.Q51413742
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Mitochondrial dysfunction precedes insulin resistance and hepatic steatosis and contributes to the natural history of non-alcoholic fatty liver disease in an obese rodent modelQ34021867
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Gene expression profiling of alcoholic liver disease in the baboon (Papio hamadryas) and human liverQ35843317
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Pancreatic islet amyloidosis, beta-cell apoptosis, and alpha-cell proliferation are determinants of islet remodeling in type-2 diabetic baboonsQ37310707
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Liver-specific loss of long chain acyl-CoA synthetase-1 decreases triacylglycerol synthesis and beta-oxidation and alters phospholipid fatty acid compositionQ37459831
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Lipids in the wrong place: visceral fat and nonalcoholic steatohepatitisQ37869703
Conjugated linoleic acid fails to worsen insulin resistance but induces hepatic steatosis in the presence of leptin in ob/ob miceQ38297728
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Competitive inhibition of leptin signaling results in amelioration of liver fibrosis through modulation of stellate cell function.Q38358299
Flavor preferences, food intake, and weight gain in baboons (Papio sp.).Q38578837
Nonalcoholic fatty liver disease is associated with low circulating levels of insulin-like growth factor-I.Q39494990
Relationships between hepatic stearoyl-CoA desaturase-1 activity and mRNA expression with liver fat content in humansQ39821210
Mechanism of hepatic insulin resistance in non-alcoholic fatty liver disease.Q42462295
Hepatic lipid partitioning and liver damage in nonalcoholic fatty liver disease: role of stearoyl-CoA desaturaseQ42563412
Effects of different fatty acids and dietary lipids on adiponectin gene expression in 3T3-L1 cells and C57BL/6J mice adipose tissue.Q42825313
Comparison of lipid and fatty acid composition of the liver, subcutaneous and intra-abdominal adipose tissue, and serumQ43637127
Nonalcoholic fatty liver, steatohepatitis, and the metabolic syndromeQ44385945
Habitual dietary intake of n-3 and n-6 fatty acids in relation to inflammatory markers among US men and womenQ44488009
Increase in long-chain polyunsaturated fatty acid n - 6/n - 3 ratio in relation to hepatic steatosis in patients with non-alcoholic fatty liver diseaseQ44726439
Insulin resistance in non-diabetic patients with non-alcoholic fatty liver disease: sites and mechanismsQ45300618
Physiological and molecular determinants of insulin action in the baboon.Q46823836
Increased intrahepatic triglyceride is associated with peripheral insulin resistance: in vivo MR imaging and spectroscopy studiesQ46970421
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P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue11
P407language of work or nameEnglishQ1860
P921main subjecttriglycerideQ186319
fatty acidQ61476
insulin resistanceQ1053470
preproinsulinQ7240673
P304page(s)e27617
P577publication date2011-01-01
P1433published inPLOS OneQ564954
P1476titleCoordinated defects in hepatic long chain fatty acid metabolism and triglyceride accumulation contribute to insulin resistance in non-human primates
P478volume6