Protein kinase C delta negatively modulates canonical Wnt pathway and cell proliferation in colon tumor cell lines

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Protein kinase C delta negatively modulates canonical Wnt pathway and cell proliferation in colon tumor cell lines is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode2013PLoSO...858540H
P356DOI10.1371/JOURNAL.PONE.0058540
P932PMC publication ID3592802
P698PubMed publication ID23520519
P5875ResearchGate publication ID236072435

P2093author name stringM Cristina Castañeda-Patlán
Paula Santoyo-Ramos
Martha Robles-Flores
José G Hernández-Maqueda
Luis Bernardo Luna-Ulloa
P2860cites workExpression of an ATP binding mutant of PKC-delta inhibits Sis-induced transformation of NIH3T3 cells.Q38354090
Nuclear export of the APC tumour suppressor controls beta-catenin function in transcriptionQ39735654
Plasma membrane recruitment of dephosphorylated beta-catenin upon activation of the Wnt pathway.Q39984947
The APC tumor suppressor counteracts beta-catenin activation and H3K4 methylation at Wnt target genesQ40309718
Protein kinase C (PKC) betaII induces cell invasion through a Ras/Mek-, PKC iota/Rac 1-dependent signaling pathwayQ40575136
PKCdelta acts as a growth and tumor suppressor in rat colonic epithelial cellsQ40972626
Roles of specific isoforms of protein kinase C in the transcriptional control of cyclin D1 and related genesQ42800956
Elevated protein kinase C betaII is an early promotive event in colon carcinogenesis.Q53400706
Protein kinase C ζ is a positive modulator of canonical Wnt signaling pathway in tumoral colon cell lines.Q54352733
Phosphorylation of the tumor suppressor adenomatous polyposis coli (APC) by the cyclin-dependent kinase p34.Q54559631
The ubiquitin-proteasome pathway and serine kinase activity modulate adenomatous polyposis coli protein-mediated regulation of beta-catenin-lymphocyte enhancer-binding factor signalingQ77808311
Mouse model of colonic adenoma-carcinoma progression based on somatic Apc inactivationQ81454513
GSK-3beta-dependent phosphorylation of adenomatous polyposis coli gene product can be modulated by beta-catenin and protein phosphatase 2A complexed with AxinQ22253256
Mechanism of phosphorylation-dependent binding of APC to beta-catenin and its role in beta-catenin degradationQ24301873
Crystal structure of a beta-catenin/APC complex reveals a critical role for APC phosphorylation in APC functionQ24301888
The Wnt signaling pathway in development and diseaseQ27861019
Axin-dependent phosphorylation of the adenomatous polyposis coli protein mediated by casein kinase 1epsilonQ28211035
The third 20 amino acid repeat is the tightest binding site of APC for beta-cateninQ28244270
beta-catenin destruction complex: insights and questions from a structural perspectiveQ28276987
Beta-catenin degradation mediated by the CID domain of APC provides a model for the selection of APC mutations in colorectal, desmoid and duodenal tumoursQ28296898
Specificity and mechanism of action of some commonly used protein kinase inhibitorsQ28344791
Protein kinase C alpha signaling inhibits cyclin D1 translation in intestinal epithelial cellsQ28566892
Stabilization of beta-catenin by genetic defects in melanoma cell linesQ29620190
Mutations in the human naked cuticle homolog NKD1 found in colorectal cancer alter Wnt/Dvl/beta-catenin signalingQ30945376
Protein kinase C-mediated regulation of the cell cycleQ33890432
Deconstructing the ßcatenin destruction complex: mechanistic roles for the tumor suppressor APC in regulating Wnt signalingQ35011212
Phosphorylation near nuclear localization signal regulates nuclear import of adenomatous polyposis coli proteinQ35818475
Signaling pathways in intestinal development and cancerQ35912854
Self-renewal and cancer of the gut: two sides of a coin.Q36080124
The role of protein kinase C isoforms in modulating injury and repair of the intestinal barrierQ36185928
Drosophila APC2 is a cytoskeletally-associated protein that regulates wingless signaling in the embryonic epidermisQ36301446
Genetic testing in colorectal cancer: who, when, how and why.Q36773324
Protein kinase Cdelta selectively regulates protein kinase D-dependent activation of NF-kappaB in oxidative stress signalingQ37011824
APC shuttling to the membrane, nucleus and beyondQ37291638
New perspectives on APC control of cell fate and proliferation in colorectal cancerQ37549825
Protein kinase C delta inhibits Caco-2 cell proliferation by selective changes in cell cycle and cell death regulators.Q38316461
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue3
P407language of work or nameEnglishQ1860
P304page(s)e58540
P577publication date2013-01-01
P1433published inPLOS OneQ564954
P1476titleProtein kinase C delta negatively modulates canonical Wnt pathway and cell proliferation in colon tumor cell lines
P478volume8

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cites work (P2860)
Q35037676Cancer-associated protein kinase C mutations reveal kinase's role as tumor suppressor
Q39340632Clinicopathological characteristics of KIT and protein kinase C-δ expression in adenoid cystic carcinoma: comparison with chromophobe renal cell carcinoma and gastrointestinal stromal tumour.
Q49951378Discovery of a small-molecule protein kinase Cδ-selective activator with promising application in colon cancer therapy.
Q40557243Global Gene Expression Analysis in PKCα-/- Mouse Skin Reveals Structural Changes in the Dermis and Defective Wound Granulation Tissue
Q50949314Inhibitory effect of a standardized pomegranate fruit extract on Wnt signalling in 1, 2-dimethylhydrazine induced rat colon carcinogenesis.
Q38834586Multifunctional roles of PKCδ: Opportunities for targeted therapy in human disease
Q35742107Neurokinin-2 receptor polymorphism predicts lymph node metastasis in colorectal cancer patients
Q36782617PKCδ activated by c-MET enhances infiltration of human glioblastoma cells through NOTCH2 signaling
Q38902920PKCδ maintains phenotypes of tumor initiating cells through cytokine-mediated autocrine loop with positive feedback
Q38702391Protein kinase C ϵ stabilizes β-catenin and regulates its subcellular localization in podocytes
Q47591912Scutellaria barbata D. Don inhibits colorectal cancer growth via suppression of Wnt/β-catenin signaling pathway
Q39026588Self-renewal molecular mechanisms of colorectal cancer stem cells
Q49312207Stabilization of Sur8 via PKCα/δ degradation promotes transformation and migration of colorectal cancer cells
Q58781156Tumor suppressive role for kinases phosphorylating p53 in DNA damage-induced apoptosis
Q35043217Tumour suppressor TRIM33 targets nuclear β-catenin degradation

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