scholarly article | Q13442814 |
P2093 | author name string | Alexei Kharitonenkov | |
James D Dunbar | |||
Radmila Micanovic | |||
Shun Li | |||
Christine C Cheng | |||
David E Moller | |||
Tamer Coskun | |||
Anja Koester | |||
Christopher C Frye | |||
Beth A Strifler | |||
John M Beals | |||
Victor J Wroblewski | |||
Thomas F Bumol | |||
Amy M Ford | |||
Radhakrishnan Rathnachalam | |||
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FGF21 N- and C-termini play different roles in receptor interaction and activation | Q24322074 | ||
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The metabolic state of diabetic monkeys is regulated by fibroblast growth factor-21. | Q34577053 | ||
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Growth hormone induces hepatic production of fibroblast growth factor 21 through a mechanism dependent on lipolysis in adipocytes | Q35266423 | ||
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Peroxisomal targeting, import, and assembly of alcohol oxidase in Pichia pastoris | Q36254940 | ||
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Immunogenicity of protein aggregates--concerns and realities | Q38006563 | ||
Metabolic disease drug discovery- "hitting the target" is easier said than done | Q39666960 | ||
FGF21 reloaded: challenges of a rapidly growing field | Q39798117 | ||
FGF21 analogs of sustained action enabled by orthogonal biosynthesis demonstrate enhanced antidiabetic pharmacology in rodents | Q40667176 | ||
The breadth of FGF21's metabolic actions are governed by FGFR1 in adipose tissue | Q41912342 | ||
FGF-21/FGF-21 receptor interaction and activation is determined by betaKlotho | Q42819634 | ||
Molecular determinants of FGF-21 activity-synergy and cross-talk with PPARgamma signaling | Q42834234 | ||
Fibroblast growth factor 21 reverses hepatic steatosis, increases energy expenditure, and improves insulin sensitivity in diet-induced obese mice | Q43224118 | ||
Introduction to Pichia pastoris | Q45888519 | ||
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P275 | copyright license | Creative Commons Attribution 4.0 International | Q20007257 |
P6216 | copyright status | copyrighted | Q50423863 |
P433 | issue | 3 | |
P407 | language of work or name | English | Q1860 |
P304 | page(s) | e58575 | |
P577 | publication date | 2013-01-01 | |
P1433 | published in | PLOS One | Q564954 |
P1476 | title | Rational design of a fibroblast growth factor 21-based clinical candidate, LY2405319 | |
P478 | volume | 8 |
Q38707493 | A Comprehensive Review of Novel Drug-Disease Models in Diabetes Drug Development |
Q102144619 | AKR-001, an Fc-FGF21 Analog, Showed Sustained Pharmacodynamic Effects on Insulin Sensitivity and Lipid Metabolism in Type 2 Diabetes Patients |
Q37448127 | An engineered FGF21 variant, LY2405319, can prevent non-alcoholic steatohepatitis by enhancing hepatic mitochondrial function |
Q34247340 | Autophagy and non-alcoholic fatty liver disease. |
Q36611366 | Circulating FGF21 proteolytic processing mediated by fibroblast activation protein |
Q33808884 | Discovery of Novel Insulin Sensitizers: Promising Approaches and Targets. |
Q104073661 | Discovery of a novel fibroblast activation protein (FAP) inhibitor, BR103354, with anti-diabetic and anti-steatotic effects |
Q43639041 | Effects of fibroblast growth factor 21 on cell damage in vitro and atherosclerosis in vivo |
Q50858150 | FAP finds FGF21 easy to digest. |
Q98906651 | FGF/FGFR signaling in health and disease |
Q35830589 | FGF21 does not require interscapular brown adipose tissue and improves liver metabolic profile in animal models of obesity and insulin-resistance |
Q37485018 | FGF21 is not required for glucose homeostasis, ketosis or tumour suppression associated with ketogenic diets in mice |
Q37211913 | FGF21 mimetic shows therapeutic promise. |
Q36674741 | Fibroblast Activation Protein Cleaves and Inactivates Fibroblast Growth Factor 21 |
Q38794405 | Fibroblast Growth Factor 21 As an Emerging Therapeutic Target for Type 2 Diabetes Mellitus |
Q39325845 | Fibroblast Growth Factor 21 Mimetics for Treating Atherosclerosis. |
Q26772751 | Fibroblast Growth Factor Signaling in Metabolic Regulation |
Q41166927 | Fibroblast activation protein (FAP) as a novel metabolic target |
Q35387801 | Fibroblast growth factor 21 improves insulin sensitivity and synergizes with insulin in human adipose stem cell-derived (hASC) adipocytes |
Q64889156 | Fibroblast growth factor 21 in chronic kidney disease. |
Q35784028 | Fibroblast growth factor 21 is elevated in metabolically unhealthy obesity and affects lipid deposition, adipogenesis, and adipokine secretion of human abdominal subcutaneous adipocytes |
Q39017842 | Fibroblast growth factor 21 night watch: advances and uncertainties in the field |
Q64973345 | Fibroblast growth factors 19 and 21 in acute liver damage. |
Q52649955 | Fusion of fibroblast growth factor 21 to a thermally responsive biopolymer forms an injectable depot with sustained anti-diabetic action. |
Q51730495 | Glyco-engineered Long Acting FGF21 Variant with Optimal Pharmaceutical and Pharmacokinetic Properties to Enable Weekly to Twice Monthly Subcutaneous Dosing. |
Q92707454 | Hepatic posttranscriptional network comprised of CCR4-NOT deadenylase and FGF21 maintains systemic metabolic homeostasis |
Q61443294 | High-efficiency expression and secretion of human FGF21 in Bacillus subtilis by intercalation of a mini-cistron cassette and combinatorial optimization of cell regulatory components |
Q28550659 | Human FGF-21 Is a Substrate of Fibroblast Activation Protein |
Q64111598 | Inducible Loss of the Aryl Hydrocarbon Receptor Activates Perigonadal White Fat Respiration and Brown Fat Thermogenesis via Fibroblast Growth Factor 21 |
Q53807997 | Insulin sensitizes FGF21 in glucose and lipid metabolisms via activating common AKT pathway. |
Q26823319 | Inventing new medicines: The FGF21 story |
Q34792753 | LY2405319, an Engineered FGF21 Variant, Improves the Metabolic Status of Diabetic Monkeys |
Q50000450 | LY2405319, an analog of fibroblast growth factor 21 ameliorates α-smooth muscle actin production through inhibition of the succinate-G-protein couple receptor 91 (GPR91) pathway in mice |
Q38475978 | Latest approaches for the treatment of obesity. |
Q26781427 | Metabolic Effects of FGF-21: Thermoregulation and Beyond |
Q33685319 | Metabolic role of fibroblast growth factor 21 in liver, adipose and nervous system tissues |
Q36107291 | Minireview: Roles of Fibroblast Growth Factors 19 and 21 in Metabolic Regulation and Chronic Diseases |
Q38397340 | New perspectives on the development of antiobesity drugs |
Q47209022 | Once-weekly administration of a long-acting fibroblast growth factor 21 analogue modulates lipids, bone turnover markers, blood pressure and body weight differently in obese people with hypertriglyceridaemia and in non-human primates. |
Q37112476 | PF-05231023, a long-acting FGF21 analogue, decreases body weight by reduction of food intake in non-human primates. |
Q35581474 | Pharmacokinetics (PK), pharmacodynamics (PD) and integrated PK/PD modeling of a novel long acting FGF21 clinical candidate PF-05231023 in diet-induced obese and leptin-deficient obese mice |
Q47742925 | Process development of a FGF21 protein-antibody conjugate. |
Q47151186 | Prokaryotic soluble expression and purification of bioactive human fibroblast growth factor 21 using maltose-binding protein. |
Q33835303 | Reduced adiposity attenuates FGF21 mediated metabolic improvements in the Siberian hamster. |
Q89497203 | Role of Hepatokines in Non-alcoholic Fatty Liver Disease |
Q50001768 | Structures of β-klotho reveal a 'zip code'-like mechanism for endocrine FGF signalling |
Q38852204 | Targeting adipose tissue in the treatment of obesity-associated diabetes |
Q30234616 | The Role and Potential Therapeutic Implications of the Fibroblast Growth Factors in Energy Balance and Type 2 Diabetes |
Q98238156 | The therapeutic potential of FGF21 in metabolic diseases: from bench to clinic |
Q38633258 | Therapeutic potential of the endocrine fibroblast growth factors FGF19, FGF21 and FGF23. |
Q91753933 | YIPF6 controls sorting of FGF21 into COPII vesicles and promotes obesity |
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