Rational design of a fibroblast growth factor 21-based clinical candidate, LY2405319

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Rational design of a fibroblast growth factor 21-based clinical candidate, LY2405319 is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode2013PLoSO...858575K
P356DOI10.1371/JOURNAL.PONE.0058575
P3181OpenCitations bibliographic resource ID4523976
P932PMC publication ID3594191
P698PubMed publication ID23536797
P5875ResearchGate publication ID235922710

P2093author name stringAlexei Kharitonenkov
James D Dunbar
Radmila Micanovic
Shun Li
Christine C Cheng
David E Moller
Tamer Coskun
Anja Koester
Christopher C Frye
Beth A Strifler
John M Beals
Victor J Wroblewski
Thomas F Bumol
Amy M Ford
Radhakrishnan Rathnachalam
P2860cites workLong-acting FGF21 has enhanced efficacy in diet-induced obese mice and in obese rhesus monkeysQ46844955
Effects of pH, temperature, and sucrose on benzyl alcohol-induced aggregation of recombinant human granulocyte colony stimulating factorQ48694793
Yeast polypeptide fusion surface display levels predict thermal stability and soluble secretion efficiencyQ56902099
Solvent effects on the solubility and physical stability of human insulin-like growth factor IQ73371162
Interleukin-1 receptor (IL-1R) liquid formulation development using differential scanning calorimetryQ74383152
Restoration of leptin responsiveness in diet-induced obese mice using an optimized leptin analog in combination with exendin-4 or FGF21Q84079985
[Optimization and characterization of a novel FGF21 mutant]Q85001479
Identification of a novel FGF, FGF-21, preferentially expressed in the liverQ22254289
betaKlotho is required for fibroblast growth factor (FGF) 21 signaling through FGF receptor (FGFR) 1c and FGFR3cQ24306279
Different roles of N- and C- termini in the functional activity of FGF21Q24312210
FGF21 N- and C-termini play different roles in receptor interaction and activationQ24322074
FGF-21 as a novel metabolic regulatorQ24523933
Lessons from the lysozyme of phage T4Q24623930
BetaKlotho is required for metabolic activity of fibroblast growth factor 21Q24681531
Klotho converts canonical FGF receptor into a specific receptor for FGF23Q28272505
FGF21 requires βklotho to act in vivoQ28485347
Fundamentals of FGF19 & FGF21 action in vitro and in vivoQ28729024
Applications of yeast in biotechnology: protein production and genetic analysisQ33744864
The metabolic state of diabetic monkeys is regulated by fibroblast growth factor-21.Q34577053
Fibroblast growth factor 21 corrects obesity in miceQ34805555
Growth hormone induces hepatic production of fibroblast growth factor 21 through a mechanism dependent on lipolysis in adipocytesQ35266423
Recombinant expression systems in the pharmaceutical industryQ35916340
Peroxisomal targeting, import, and assembly of alcohol oxidase in Pichia pastorisQ36254940
Hormone-like (endocrine) Fgfs: their evolutionary history and roles in development, metabolism, and diseaseQ37781747
Immunogenicity of protein aggregates--concerns and realitiesQ38006563
Metabolic disease drug discovery- "hitting the target" is easier said than doneQ39666960
FGF21 reloaded: challenges of a rapidly growing fieldQ39798117
FGF21 analogs of sustained action enabled by orthogonal biosynthesis demonstrate enhanced antidiabetic pharmacology in rodentsQ40667176
The breadth of FGF21's metabolic actions are governed by FGFR1 in adipose tissueQ41912342
FGF-21/FGF-21 receptor interaction and activation is determined by betaKlothoQ42819634
Molecular determinants of FGF-21 activity-synergy and cross-talk with PPARgamma signalingQ42834234
Fibroblast growth factor 21 reverses hepatic steatosis, increases energy expenditure, and improves insulin sensitivity in diet-induced obese miceQ43224118
Introduction to Pichia pastorisQ45888519
The effect of benzyl alcohol on recombinant human interferon-gammaQ46186532
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue3
P407language of work or nameEnglishQ1860
P304page(s)e58575
P577publication date2013-01-01
P1433published inPLOS OneQ564954
P1476titleRational design of a fibroblast growth factor 21-based clinical candidate, LY2405319
P478volume8

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cites work (P2860)
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