| scholarly article | Q13442814 |
| P50 | author | Daniel S. Greenspan | Q37377606 |
| P2093 | author name string | Koichi Kobayashi | |
| Yue Zhang | |||
| Andreas Kispert | |||
| Gaoxiang Ge | |||
| Min Luo | |||
| Thomas N Sato | |||
| Craig T Basson | |||
| David C Wilkes | |||
| Guorui Huang | |||
| Thomas Grieskamp | |||
| Ting-Chun Liu | |||
| Chikaomi Yamada | |||
| P2860 | cites work | SHH-N upregulates Sfrp2 to mediate its competitive interaction with WNT1 and WNT4 in the somitic mesoderm | Q22011181 |
| Secreted Frizzled-related proteins inhibit motility and promote growth of human malignant glioma cells | Q24290219 | ||
| Wnt signaling inhibitors regulate the transcriptional response to morphogenetic Shh-Gli signaling in the neural tube | Q24301422 | ||
| Type I procollagen COOH-terminal proteinase enhancer protein: identification, primary structure, and chromosomal localization of the cognate human gene (PCOLCE) | Q24306207 | ||
| Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action | Q24311356 | ||
| SARPs: a family of secreted apoptosis-related proteins | Q24311564 | ||
| Deletion of Epidermal Growth Factor-like Domains Converts Mammalian Tolloid into a Chordinase and Effective Procollagen C-proteinase | Q59491714 | ||
| Determination of 3- and 4-hydroxyproline | Q70353114 | ||
| Antisera and cDNA probes to human and certain animal model bone matrix noncollagenous proteins | Q70879887 | ||
| The infarcted myocardium: simply dead tissue, or a lively target for therapeutic interventions | Q73482816 | ||
| Molecular mechanisms of myocardial remodeling | Q77918078 | ||
| The determination of hydroxyproline in tissue and protein samples containing small proportions of this imino acid | Q79111319 | ||
| A family of secreted proteins contains homology to the cysteine-rich ligand-binding domain of frizzled receptors | Q24569584 | ||
| Mammalian BMP-1/Tolloid-related metalloproteinases, including novel family member mammalian Tolloid-like 2, have differential enzymatic activities and distributions of expression relevant to patterning and skeletogenesis | Q27876216 | ||
| Autocrine/paracrine secreted Frizzled-related protein 2 induces cellular resistance to apoptosis: a possible mechanism of mammary tumorigenesis | Q28237570 | ||
| Epigenetic inactivation of SFRP genes allows constitutive WNT signaling in colorectal cancer | Q28251800 | ||
| The Wnt antagonist secreted frizzled-related protein-1 is a negative regulator of trabecular bone formation in adult mice | Q28508070 | ||
| Sfrp1 and Sfrp2 regulate anteroposterior axis elongation and somite segmentation during mouse embryogenesis | Q28511470 | ||
| Fritz: a secreted frizzled-related protein that inhibits Wnt activity | Q28586530 | ||
| Secreted frizzled related protein 2 (Sfrp2) is the key Akt-mesenchymal stem cell-released paracrine factor mediating myocardial survival and repair | Q28587325 | ||
| The stomach mesenchymal transcription factor Barx1 specifies gastric epithelial identity through inhibition of transient Wnt signaling | Q28587498 | ||
| Mechanisms of Wnt signaling in development | Q29547537 | ||
| Secreted antagonists of the Wnt signalling pathway | Q29615521 | ||
| Bone morphogenetic protein 1 processes prolactin to a 17-kDa antiangiogenic factor | Q33286692 | ||
| Infarct scar: a dynamic tissue | Q33895480 | ||
| Embryonic dorsal-ventral signaling: secreted frizzled-related proteins as inhibitors of tolloid proteinases | Q34484724 | ||
| Mammalian tolloid-like 1 binds procollagen C-proteinase enhancer protein 1 and differs from bone morphogenetic protein 1 in the functional roles of homologous protein domains | Q34498298 | ||
| Type I procollagen C-proteinase from mouse fibroblasts. Purification and demonstration of a 55-kDa enhancer glycoprotein | Q34514736 | ||
| Molecular genetics of axis formation in zebrafish | Q34562575 | ||
| Remodeling of the myocardium and potential targets in the collagen degradation and synthesis pathways | Q35137466 | ||
| Use of Bmp1/Tll1 doubly homozygous null mice and proteomics to identify and validate in vivo substrates of bone morphogenetic protein 1/tolloid-like metalloproteinases | Q35150332 | ||
| Ventricular remodeling after infarction and the extracellular collagen matrix: when is enough enough? | Q35219500 | ||
| Dorsal-ventral patterning and neural induction in Xenopus embryos | Q35912796 | ||
| BMP1 controls TGFbeta1 activation via cleavage of latent TGFbeta-binding protein | Q36118959 | ||
| The bone morphogenetic protein 1/Tolloid-like metalloproteinases | Q36846125 | ||
| Sizzled controls dorso-ventral polarity by repressing cleavage of the Chordin protein | Q38315245 | ||
| Expression of Frzb/secreted Frizzled-related protein 3, a secreted Wnt antagonist, in human androgen-independent prostate cancer PC-3 cells suppresses tumor growth and cellular invasiveness | Q40355353 | ||
| Substrate-specific modulation of a multisubstrate proteinase. C-terminal processing of fibrillar procollagens is the only BMP-1-dependent activity to be enhanced by PCPE-1. | Q40434283 | ||
| FrzA, a secreted frizzled related protein, induced angiogenic response | Q40684521 | ||
| The ventralized ogon mutant phenotype is caused by a mutation in the zebrafish homologue of Sizzled, a secreted Frizzled-related protein | Q42604498 | ||
| The NTR module: domains of netrins, secreted frizzled related proteins, and type I procollagen C-proteinase enhancer protein are homologous with tissue inhibitors of metalloproteases | Q42608136 | ||
| Pax-6 regulates expression of SFRP-2 and Wnt-7b in the developing CNS. | Q45971109 | ||
| Myeloma cells suppress bone formation by secreting a soluble Wnt inhibitor, sFRP-2. | Q46283393 | ||
| Aberrant methylation of secreted frizzled-related protein genes in esophageal adenocarcinoma and Barrett's esophagus | Q46433748 | ||
| Reduction of infarct size and prevention of cardiac rupture in transgenic mice overexpressing FrzA. | Q47438866 | ||
| Wnt signaling induces the myogenic specification of resident CD45+ adult stem cells during muscle regeneration. | Q47789558 | ||
| Ogon/Secreted Frizzled functions as a negative feedback regulator of Bmp signaling | Q47927424 | ||
| Sizzled: a secreted Xwnt8 antagonist expressed in the ventral marginal zone of Xenopus embryos. | Q48041125 | ||
| Involvement of FrzA/sFRP-1 and the Wnt/frizzled pathway in ischemic preconditioning. | Q52564453 | ||
| P433 | issue | 1 | |
| P921 | main subject | myocardial infarction | Q12152 |
| Bone morphogenetic protein 1 | Q14903765 | ||
| Secreted frizzled-related protein 2 | Q21989148 | ||
| P304 | page(s) | 46-55 | |
| P577 | publication date | 2008-12-14 | |
| P1433 | published in | Nature Cell Biology | Q1574111 |
| P1476 | title | Secreted Frizzled-related protein 2 is a procollagen C proteinase enhancer with a role in fibrosis associated with myocardial infarction | |
| P478 | volume | 11 |
| Q28585445 | A critical role for sFRP proteins in maintaining caudal neural tube closure in mice via inhibition of BMP signaling |
| Q34044380 | Active Wnt signaling in response to cardiac injury |
| Q34989584 | Additional sex combs-like 2 is required for polycomb repressive complex 2 binding at select targets |
| Q45977362 | Age-related external anal sphincter muscle dysfunction and fibrosis: possible role of Wnt/β-catenin signaling pathways. |
| Q37096257 | Aging and the cardiac collagen matrix: Novel mediators of fibrotic remodelling |
| Q38896053 | Agonists and Antagonists of TGF-β Family Ligands |
| Q41335502 | Akt-dependent Girdin phosphorylation regulates repair processes after acute myocardial infarction |
| Q28534797 | An anthelmintic drug, pyrvinium pamoate, thwarts fibrosis and ameliorates myocardial contractile dysfunction in a mouse model of myocardial infarction |
| Q38977493 | Biomarkers to Predict Reverse Remodeling and Myocardial Recovery in Heart Failure |
| Q35309820 | Bone morphogenetic protein-1 processes insulin-like growth factor-binding protein 3 |
| Q38215191 | Building and repairing the heart: what can we learn from embryonic development? |
| Q38846401 | Can heart function lost to disease be regenerated by therapeutic targeting of cardiac scar tissue? |
| Q38692353 | Canonical Wnt signaling in systemic sclerosis |
| Q38151902 | Canonical Wnt signalling as a key regulator of fibrogenesis - implications for targeted therapies? |
| Q38542448 | Cardiac Physiology of Aging: Extracellular Considerations. |
| Q37986552 | Cardiac cell therapy: boosting mesenchymal stem cells effects |
| Q33663946 | Cardiac extracellular matrix remodeling: fibrillar collagens and Secreted Protein Acidic and Rich in Cysteine (SPARC) |
| Q38040163 | Cardiac fibroblasts, fibrosis and extracellular matrix remodeling in heart disease |
| Q37076096 | Cardiac-Secreted Factors as Peripheral Metabolic Regulators and Potential Disease Biomarkers. |
| Q63446874 | Cardiovascular function and structure are preserved despite induced ablation of BMP1-related proteinases |
| Q37707161 | Cell-cell interaction in the heart via Wnt/β-catenin pathway after cardiac injury |
| Q36699619 | Cellular mechanisms of tissue fibrosis. 2. Contributory pathways leading to myocardial fibrosis: moving beyond collagen expression |
| Q34726861 | Circulating bone morphogenetic protein 1-3 isoform increases renal fibrosis |
| Q42576585 | Complex and dynamic patterns of Wnt pathway gene expression in the developing chick forebrain |
| Q39485853 | Continuous antagonism by Dkk1 counter activates canonical Wnt signaling and promotes cardiomyocyte differentiation of embryonic stem cells |
| Q40307101 | Dentin sialophosphoprotein (DSPP) is cleaved into its two natural dentin matrix products by three isoforms of bone morphogenetic protein-1 (BMP1). |
| Q42131909 | Dorsal-ventral patterning: Crescent is a dorsally secreted Frizzled-related protein that competitively inhibits Tolloid proteases |
| Q36115526 | Effects of the absence of procollagen C-endopeptidase enhancer-2 on myocardial collagen accumulation in chronic pressure overload |
| Q36920724 | Emerging Concepts in Paracrine Mechanisms in Regenerative Cardiovascular Medicine and Biology |
| Q41414327 | Epigenetic reprogramming converts human Wharton's jelly mesenchymal stem cells into functional cardiomyocytes by differential regulation of Wnt mediators |
| Q41486920 | Estrogen-inducible sFRP5 inhibits early B-lymphopoiesis in vivo, but not during pregnancy. |
| Q34397290 | Exogenously administered secreted frizzled related protein 2 (Sfrp2) reduces fibrosis and improves cardiac function in a rat model of myocardial infarction |
| Q42775592 | Experimental myocardial infarction triggers canonical Wnt signaling and endothelial-to-mesenchymal transition |
| Q38423857 | Extracellular matrix communication and turnover in cardiac physiology and pathology |
| Q37377705 | Fibronectin binds and enhances the activity of bone morphogenetic protein 1. |
| Q33926642 | First evidence of bone morphogenetic protein 1 expression and activity in sheep ovarian follicles. |
| Q47907554 | Frizzled-5: a high affinity receptor for secreted frizzled-related protein-2 activation of nuclear factor of activated T-cells c3 signaling to promote angiogenesis. |
| Q64988590 | GSK3β inhibition and canonical Wnt signaling in mice hearts after myocardial ischemic damage. |
| Q39875402 | Genomic phenotype of non-cultured pulmonary fibroblasts in idiopathic pulmonary fibrosis |
| Q45977256 | Growth and differentiation of the retina and the optic tectum in the medaka fish requires olSfrp5. |
| Q28587480 | Hydroureternephrosis due to loss of Sox9-regulated smooth muscle cell differentiation of the ureteric mesenchyme |
| Q37998444 | Importance of myocyte-nonmyocyte interactions in cardiac development and disease |
| Q36819462 | Inhibition of Wnt6 by Sfrp2 regulates adult cardiac progenitor cell differentiation by differential modulation of Wnt pathways |
| Q35126269 | Integrative computational and experimental approaches to establish a post-myocardial infarction knowledge map. |
| Q38042490 | Interventions in Wnt signaling as a novel therapeutic approach to improve myocardial infarct healing |
| Q47927759 | Left ventricle transcriptomic analysis reveals connective tissue accumulation associates with initial age-dependent decline in V̇o2peak from its lifetime apex |
| Q30277999 | Making better scar: Emerging approaches for modifying mechanical and electrical properties following infarction and ablation |
| Q26743437 | Mammalian tolloid proteinases: role in growth factor signalling |
| Q28481719 | Mapping genetic variants associated with beta-adrenergic responses in inbred mice |
| Q39356113 | Matricellular proteins in cancer: a focus on secreted Frizzled-related proteins |
| Q37801803 | Mechanisms driving neural crest induction and migration in the zebrafish and Xenopus laevis |
| Q52591110 | Mechanisms of Cardiac Repair and Regeneration. |
| Q35604976 | Metalloproteinases in Drosophila to humans that are central players in developmental processes. |
| Q38499043 | Microarray profiling of diaphyseal bone of rats suffering from hypervitaminosis A. |
| Q34315290 | Morphogen pathways as molecular targets for the treatment of fibrosis in systemic sclerosis |
| Q38071976 | Morphogen pathways in systemic sclerosis |
| Q89768088 | Multiple Roles of sFRP2 in Cardiac Development and Cardiovascular Disease |
| Q24313457 | Novel genetic variants contributing to left ventricular hypertrophy: the HyperGEN study |
| Q42813557 | Osteogenesis induced by frizzled-related protein (FRZB) is linked to the netrin-like domain |
| Q36777369 | Peroxisome proliferator-activated receptor pathway gene polymorphism associated with extent of coronary artery disease in patients with type 2 diabetes in the bypass angioplasty revascularization investigation 2 diabetes trial |
| Q39469580 | Procollagen C-proteinase enhancer stimulates procollagen processing by binding to the C-propeptide region only |
| Q38423146 | Proteolytic control of TGF-β co-receptor activity by BMP-1/tolloid-like proteases revealed by quantitative iTRAQ proteomics |
| Q89736925 | Role of Sfrps in cardiovascular disease |
| Q38064702 | Role of the Wnt-Frizzled system in cardiac pathophysiology: a rapidly developing, poorly understood area with enormous potential. |
| Q33855167 | Role of the netrin-like domain of procollagen C-proteinase enhancer-1 in the control of metalloproteinase activity |
| Q34506485 | SFRP2 and slug contribute to cellular resistance to apoptosis in hypertrophic scars |
| Q51768583 | SFRPs act as negative modulators of ADAM10 to regulate retinal neurogenesis. |
| Q95856530 | Secreted Frizzled-Related Protein 2 and Extracellular Volume Fraction in Patients with Heart Failure |
| Q37629036 | Secreted Frizzled-related protein 2 as a target in antifibrotic therapeutic intervention |
| Q28115695 | Secreted Frizzled-related protein potentiation versus inhibition of Wnt3a/β-catenin signaling |
| Q42158760 | Secreted frizzled related protein 4 reduces fibrosis scar size and ameliorates cardiac function after ischemic injury |
| Q48273047 | Secreted frizzled related proteins modulate pathfinding and fasciculation of mouse retina ganglion cell axons by direct and indirect mechanisms. |
| Q37707814 | Sfrp5 identifies murine cardiac progenitors for all myocardial structures except for the right ventricle. |
| Q34701562 | Sfrp5 modulates both Wnt and BMP signaling and regulates gastrointestinal organogenesis [corrected] in the zebrafish, Danio rerio. |
| Q92750770 | Sfrp5/Wnt Pathway: A Protective Regulatory System in Atherosclerotic Cardiovascular Disease |
| Q26782820 | Signaling in Fibrosis: TGF-β, WNT, and YAP/TAZ Converge |
| Q42532115 | Sizzled is unique among secreted frizzled-related proteins for its ability to specifically inhibit bone morphogenetic protein-1 (BMP-1)/tolloid-like proteinases |
| Q39556581 | Sizzled-tolloid interactions maintain foregut progenitors by regulating fibronectin-dependent BMP signaling |
| Q39791753 | Strong cooperativity and loose geometry between CUB domains are the basis for procollagen c-proteinase enhancer activity |
| Q41494116 | Synthetic enzyme-substrate tethering obviates the Tolloid-ECM interaction during Drosophila BMP gradient formation. |
| Q38733048 | TGF-β Family Signaling in Early Vertebrate Development |
| Q35916732 | TNAP: a new player in cardiac fibrosis? Focus on "Tissue-nonspecific alkaline phosphatase as a target of sFRP2 in cardiac fibroblasts". |
| Q43702481 | Telemetric ambulatory arterial stiffness index, a predictor of cardio-cerebro-vascular mortality, is associated with aortic stiffness-determining factors. |
| Q53115057 | Tenotomy immobilization as a model to investigate skeletal muscle fibrosis (with emphasis on Secreted frizzled-related protein 2). |
| Q39618277 | The atypical cadherin Celsr1 functions non-cell autonomously to block rostral migration of facial branchiomotor neurons in mice. |
| Q56974209 | The cardiokine secreted Frizzled-related protein 3, a modulator of Wnt signalling, in clinical and experimental heart failure |
| Q37949269 | The complex roles of Wnt antagonists in RCC. |
| Q36764483 | The plasma membrane calcium ATPase 4 signalling in cardiac fibroblasts mediates cardiomyocyte hypertrophy |
| Q35916722 | Tissue-nonspecific alkaline phosphatase as a target of sFRP2 in cardiac fibroblasts |
| Q38878307 | Transforming growth factor-β-dependent Wnt secretion controls myofibroblast formation and myocardial fibrosis progression in experimental autoimmune myocarditis. |
| Q26770160 | View from the heart: cardiac fibroblasts in development, scarring and regeneration |
| Q47299786 | WNT Signaling in Cardiac and Vascular Disease. |
| Q35080930 | WNT signaling pathway gene polymorphisms and risk of hepatic fibrosis and inflammation in HCV-infected patients |
| Q38542451 | Wnt Signaling in Cardiac Disease |
| Q52815224 | Wnt Signaling in Cardiac Remodeling and Heart Failure. |
| Q33681070 | Wnt-β Catenin Signaling Pathway: A Major Player in the Injury Induced Fibrosis and Dysfunction of the External Anal Sphincter |
| Q90419301 | Wnt/β-catenin in ischemic myocardium: interactions and signaling pathways as a therapeutic target |
| Q41694294 | Wnt/β-catenin pathway in arrhythmogenic cardiomyopathy |
| Q38544289 | Wnt/β-catenin signaling in heart regeneration. |
| Q34232889 | Wnt1/βcatenin injury response activates the epicardium and cardiac fibroblasts to promote cardiac repair. |
| Q36144944 | Wnt10b Gain-of-Function Improves Cardiac Repair by Arteriole Formation and Attenuation of Fibrosis. |
| Q36587736 | Wnt11 Gene Therapy with Adeno-associated Virus 9 Improves Recovery from Myocardial Infarction by Modulating the Inflammatory Response |
| Q41319987 | Wnt11 gene therapy with adeno-associated virus 9 improves the survival of mice with myocarditis induced by coxsackievirus B3 through the suppression of the inflammatory reaction |
| Q34181982 | Wnt5a is strongly expressed at the leading edge in non-melanoma skin cancer, forming active gradients, while canonical Wnt signalling is repressed |
| Q42784361 | sFRP2 activates Wnt/β-catenin signaling in cardiac fibroblasts: differential roles in cell growth, energy metabolism, and extracellular matrix remodeling |
| Q83144925 | sFRPs: a declaration of (Wnt) independence |
| Q30581923 | sfrp1 promotes cardiomyocyte differentiation in Xenopus via negative-feedback regulation of Wnt signalling. |
| Q83348217 | shRNA targeting SFRP2 promotes the apoptosis of hypertrophic scar fibroblast |
| Q42158082 | sizzled function and secreted factor network dynamics |
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