Increased platelet sensitivity to ADP in mice lacking platelet-type 12-lipoxygenase

scientific journal article

Increased platelet sensitivity to ADP in mice lacking platelet-type 12-lipoxygenase is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode1998PNAS...95.3100J
P356DOI10.1073/PNAS.95.6.3100
P932PMC publication ID19701
P698PubMed publication ID9501222
P5875ResearchGate publication ID51298937

P2093author name stringC. D. Funk
L. F. Brass
E. N. Johnson
P2860cites workMolecular cloning, primary structure, and expression of the human platelet/erythroleukemia cell 12-lipoxygenaseQ24295267
Cloning of the cDNA for human 12-lipoxygenaseQ24299952
Purification and characterization of recombinant histidine-tagged human platelet 12-lipoxygenase expressed in a baculovirus/insect cell systemQ24308744
Aggressiveness, hypoalgesia and high blood pressure in mice lacking the adenosine A2a receptorQ24323906
Prostaglandin endoperoxides. Novel transformations of arachidonic acid in human plateletsQ24564188
12-HETE inhibits the binding of PGH2/TxA2 receptor ligands in human plateletsQ28274475
The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase CQ28327651
Disruption of 12/15-lipoxygenase expression in peritoneal macrophages. Enhanced utilization of the 5-lipoxygenase pathway and diminished oxidation of low density lipoproteinQ28505058
Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogeneQ28512170
Functional expression and cellular localization of a mouse epidermal lipoxygenaseQ28513319
Immunocytochemical localization of platelet-type arachidonate 12-lipoxygenase in mouse blood cellsQ28593560
cDNA cloning, expression, mutagenesis of C-terminal isoleucine, genomic structure, and chromosomal localizations of murine 12-lipoxygenasesQ28594638
The endothelial cell ecto-ADPase responsible for inhibition of platelet function is CD39.Q30448825
Native and mutant 5-lipoxygenase expression in a baculovirus/insect cell systemQ33849757
Downregulation of human platelet reactivity by neutrophils. Participation of lipoxygenase derivatives and adhesive proteinsQ33902134
Mice deficient in cellular glutathione peroxidase develop normally and show no increased sensitivity to hyperoxiaQ34430043
Mammalian lipoxygenases: molecular structures and functionsQ35460975
Prostaglandins and thromboxanesQ37802829
Factors responsible for ADP-induced release reaction of human plateletsQ39340022
Regulation of arachidonate metabolism via lipoxygenase and cyclo-oxygenase by 12-HPETE, the product of human platelet lipoxygenaseQ39692740
A review of possible roles of the platelet 12-lipoxygenaseQ39860140
Occurrence of lipoxygenase products in membranes of rabbit reticulocytes. Evidence for a role of the reticulocyte lipoxygenase in the maturation of red cellsQ41193209
The molecular biology of mammalian lipoxygenases and the quest for eicosanoid functions using lipoxygenase-deficient miceQ41245074
Lipoxin generation by human megakaryocyte-induced 12-lipoxygenaseQ41643855
Platelet lipoxygenase inhibitors attenuate thrombin- and thromboxane mimetic-induced intracellular calcium mobilization and platelet aggregationQ44988917
Role of leukotrienes revealed by targeted disruption of the 5-lipoxygenase gene.Q52512619
Role of the thrombin receptor in development and evidence for a second receptor.Q52519548
Sandy: a new mouse model for platelet storage pool deficiencyQ68038207
12 -Hydroxyeicosatetraenoic acid plays a central role in the regulation of platelet activationQ68251774
Platelet aggregation and release of ADP, serotonin and histamine associated with phagocytosis of antigen-antibody complexesQ70061806
Altered lipoxygenase metabolism and decreased glutathione peroxidase activity in platelets from selenium-deficient ratsQ71494164
Deficiency of platelet lipoxygenase activity in myeloproliferative disordersQ71586555
Mouse antithrombotic assay: a simple method for the evaluation of antithrombotic agents in vivo. Potentiation of antithrombotic activity by ethyl alcoholQ71690422
In vivo antithrombotic effect of triflavin, an Arg-Gly-Asp containing peptide on platelet plug formation in mesenteric microvessels of miceQ72600793
P433issue6
P407language of work or nameEnglishQ1860
P921main subjectArachidonate 12-lipoxygenaseQ21494714
P304page(s)3100–3105
P577publication date1998-03-17
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleIncreased platelet sensitivity to ADP in mice lacking platelet-type 12-lipoxygenase
P478volume95

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cites work (P2860)
Q4191719112-hydroxyeicosatetraenoic acid is associated with variability in aspirin-induced platelet inhibition.
Q5089312512-lipoxygenase activity plays an important role in PAR4 and GPVI-mediated platelet reactivity.
Q3420768712-lipoxygenase: a potential target for novel anti-platelet therapeutics
Q9242351012/15 Lipoxygenase as a Therapeutic Target in Brain Disorders
Q36777936A guide to murine platelet structure, function, assays, and genetic alterations.
Q92955441ALOX12 is required for p53-mediated tumour suppression through a distinct ferroptosis pathway
Q34796480ATP antagonizes thrombin-induced signal transduction through 12(S)-HETE and cAMP
Q27014988Advances in Our Understanding of Oxylipins Derived from Dietary PUFAs
Q47308552An ALOX12-12-HETE-GPR31 signaling axis is a key mediator of hepatic ischemia-reperfusion injury
Q77360947Anandamide activates human platelets through a pathway independent of the arachidonate cascade
Q35550212Antiplatelet therapy: in search of the 'magic bullet'.
Q34159100Arachidonate 12-lipoxygenases
Q92257954Arachidonic Acid Metabolism and Kidney Inflammation
Q28252674Biosynthesis, biological effects, and receptors of hydroxyeicosatetraenoic acids (HETEs) and oxoeicosatetraenoic acids (oxo-ETEs) derived from arachidonic acid
Q24531388Determinants of the cellular specificity of acetaminophen as an inhibitor of prostaglandin H(2) synthases.
Q48157381Dietary modulation of oxylipins in cardiovascular disease and aging
Q40628307Differential behavior of mesangial cells derived from 12/15-lipoxygenase knockout mice relative to control mice11See Editorial by Kasinath, p. 1918
Q36370888Discrete role for cytosolic phospholipase A(2)alpha in platelets: studies using single and double mutant mice of cytosolic and group IIA secretory phospholipase A(2).
Q33676724Effects of nonsteroidal anti-inflammatory therapy on platelets
Q87985046Eicosanoids in platelets and the effect of their modulation by aspirin in the cardiovascular system (and beyond)
Q93345082Emerging role of 12/15-Lipoxygenase (ALOX15) in human pathologies
Q37142660Evolutionary alteration of ALOX15 specificity optimizes the biosynthesis of antiinflammatory and proresolving lipoxins
Q38272869Evolutionary aspects of lipoxygenases and genetic diversity of human leukotriene signaling.
Q38642400First Selective 12-LOX Inhibitor, ML355, Impairs Thrombus Formation and Vessel Occlusion In Vivo With Minimal Effects on Hemostasis
Q47358955Flipping the cyclooxygenase (Ptgs) genes reveals isoform-specific compensatory functions
Q48832499Genetic ablation and short-duration inhibition of lipoxygenase results in increased macroautophagy
Q35330471Group VIB calcium-independent phospholipase A2 (iPLA2γ) regulates platelet activation, hemostasis and thrombosis in mice
Q28586401Increased thrombin responsiveness in platelets from mice lacking glycoprotein V
Q33791854Insight into prostaglandin, leukotriene, and other eicosanoid functions using mice with targeted gene disruptions
Q37416809Interactions between α-tocopherol, polyunsaturated fatty acids, and lipoxygenases during embryogenesis
Q39021950Is arachidonic acid stimulation really a test for the response to aspirin? Time to think again?
Q34997977Lipoxygenase genes and their targeted disruption
Q28709175Lipoxygenase pathways in Homo neanderthalensis: functional comparison with Homo sapiens isoforms
Q28249730Mammalian lipoxygenases and their biological relevance
Q46252434Networks of enzymatically oxidized membrane lipids support calcium-dependent coagulation factor binding to maintain hemostasis.
Q39147112New Concepts and Mechanisms of Platelet Activation Signaling
Q33416935Platelet 12-LOX is essential for FcγRIIa-mediated platelet activation
Q35213593Platelet activation attracts a subpopulation of effector monocytes to sites of Leishmania major infection
Q26998976Platelet lipidomics: modern day perspective on lipid discovery and characterization in platelets
Q35845952Platelet microparticles are internalized in neutrophils via the concerted activity of 12-lipoxygenase and secreted phospholipase A2-IIA
Q33375459Platelet particle formation by anti GPIIIa49-66 Ab, Ca2+ ionophore A23187, and phorbol myristate acetate is induced by reactive oxygen species and inhibited by dexamethasone blockade of platelet phospholipase A2, 12-lipoxygenase, and NADPH oxidase
Q34560219Protease-activated receptor signaling in platelets activates cytosolic phospholipase A2α differently for cyclooxygenase-1 and 12-lipoxygenase catalysis
Q33388380RUNX1/core binding factor A2 regulates platelet 12-lipoxygenase gene (ALOX12): studies in human RUNX1 haplodeficiency
Q31808197Role of 'platelet-type' 12-lipoxygenase in skin carcinogenesis
Q28349952Role of ETB and B2 receptors in the ex vivo platelet inhibitory properties of endothelin and bradykinin in the mouse
Q50336029Targeted disruption of cd39/ATP diphosphohydrolase results in disordered hemostasis and thromboregulation
Q35651297Targeted knock-down of a structurally atypical zebrafish 12S-lipoxygenase leads to severe impairment of embryonic development
Q26823893The emerging role of oxylipins in thrombosis and diabetes
Q39320449The expansive role of oxylipins on platelet biology.
Q26795652The role of lipoxygenases in pathophysiology; new insights and future perspectives
Q33330294Transforming growth factor beta1 enhances platelet aggregation through a non-transcriptional effect on the fibrinogen receptor
Q47983293cDNA cloning of 15-lipoxygenase type 2 and 12-lipoxygenases of bovine corneal epithelium

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