Platelet activation attracts a subpopulation of effector monocytes to sites of Leishmania major infection

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Platelet activation attracts a subpopulation of effector monocytes to sites of Leishmania major infection is …
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scholarly articleQ13442814

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P356DOI10.1084/JEM.20101751
P932PMC publication ID3173254
P698PubMed publication ID21606505
P5875ResearchGate publication ID51159965

P2093author name stringDavid M Mosser
Xia Zhang
Alain Debrabant
Ricardo Goncalves
Heather Cohen
P2860cites workPlatelet-derived hyaluronidase 2 cleaves hyaluronan into fragments that trigger monocyte-mediated production of proinflammatory cytokinesQ24310749
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CC chemokine receptor (CCR)2 is required for langerhans cell migration and localization of T helper cell type 1 (Th1)-inducing dendritic cells. Absence of CCR2 shifts the Leishmania major-resistant phenotype to a susceptible state dominated by Th2 cQ28588634
Blood monocytes consist of two principal subsets with distinct migratory propertiesQ29614286
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Monitoring of blood vessels and tissues by a population of monocytes with patrolling behaviorQ29616447
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Lipopolysaccharide stimulates platelet secretion and potentiates platelet aggregation via TLR4/MyD88 and the cGMP-dependent protein kinase pathwayQ33384817
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Leishmania-derived murine monocyte chemoattractant protein 1 enhances the recruitment of a restrictive population of CC chemokine receptor 2-positive macrophagesQ35689327
Secretion of monocyte chemotactic activity by cultured rat aortic smooth muscle cells in response to PDGF is due predominantly to the induction of JE/MCP-1.Q35782281
Cytokine-activated human endothelial cells synthesize and secrete a monocyte chemoattractant, MCP-1/JE.Q35811725
Inflammatory chemokine transport and presentation in HEV: a remote control mechanism for monocyte recruitment to lymph nodes in inflamed tissuesQ36376423
Leishmania promastigotes require opsonic complement to bind to the human leukocyte integrin Mac-1 (CD11b/CD18)Q36530759
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Monocyte subpopulations and their differentiation patterns during infectionQ36809545
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Metacyclogenesis is a major determinant of Leishmania promastigote virulence and attenuationQ37008099
Gr1(+) inflammatory monocytes are required for mucosal resistance to the pathogen Toxoplasma gondiiQ37020098
In vivo imaging reveals an essential role for neutrophils in leishmaniasis transmitted by sand flies.Q37021689
Activation of the MAPK, ERK, following Leishmania amazonensis infection of macrophagesQ37097916
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Gr1+ cells control growth of YopM-negative yersinia pestis during systemic plagueQ37333386
Monocyte chemoattractant protein-1 (MCP-1): an overviewQ37481208
The role of inflammation in regulating platelet production and function: Toll-like receptors in platelets and megakaryocytesQ37640684
Platelets and innate immunityQ37657202
Activation of platelets by Aspergillus fumigatus and potential role of platelets in the immunopathogenesis of AspergillosisQ39763541
Toll-like receptor 2 on inflammatory monocytes induces type I interferon in response to viral but not bacterial ligandsQ39791660
Antimicrobial peptide-induced apoptotic death of leishmania results from calcium-de pend ent, caspase-independent mitochondrial toxicityQ39862605
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Monocyte chemotactic protein gene expression by cytokine-treated human fibroblasts and endothelial cellsQ42033561
Platelet-derived growth factor stimulation of monocyte chemoattractant protein-1 gene expression is mediated by transient activation of the phosphoinositide 3-kinase signal transduction pathwayQ42809872
TNF/iNOS-producing dendritic cells mediate innate immune defense against bacterial infectionQ44308127
Rapid recruitment of inflammatory monocytes is independent of neutrophil migrationQ44353696
Hold on, the monocytes are coming!Q44524328
Monocyte-derived dendritic cells formed at the infection site control the induction of protective T helper 1 responses against LeishmaniaQ44920559
Demonstration of a specific C3a receptor on guinea pig platelets.Q45146363
The monoclonal antimonocyte antibody My4 stains B lymphocytes and two distinct monocyte subsets in human peripheral bloodQ45158585
Platelets kill intraerythrocytic malarial parasites and mediate survival to infectionQ46131528
Leishmania immune adherence reaction in vertebratesQ46443728
Migrating monocytes recruited to the spleen play an important role in control of blood stage malariaQ47916546
Platelet depletion by anti-CD41 (alphaIIb) mAb injection early but not late in the course of disease protects against Plasmodium berghei pathogenesis by altering the levels of pathogenic cytokinesQ47997717
The third component of complement (C3) is responsible for the intracellular survival of Leishmania majorQ59096916
Cytoskeletal proteins and platelet signalingQ74314920
P4510describes a project that usesImageJQ1659584
P433issue6
P407language of work or nameEnglishQ1860
P921main subjectLeishmania majorQ1950715
P304page(s)1253-1265
P577publication date2011-05-23
P1433published inJournal of Experimental MedicineQ3186912
P1476titlePlatelet activation attracts a subpopulation of effector monocytes to sites of Leishmania major infection
P478volume208