Expression of recombinant murine pregnancy-associated plasma protein-A (PAPP-A) and a novel variant (PAPP-Ai) with differential proteolytic activity

scientific journal article

Expression of recombinant murine pregnancy-associated plasma protein-A (PAPP-A) and a novel variant (PAPP-Ai) with differential proteolytic activity is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1046/J.1432-1033.2002.02883.X
P698PubMed publication ID11985604
P5875ResearchGate publication ID11383566

P50authorMichael Toft OvergaardQ47805032
Claus OxvigQ56430506
Lisbeth S LaursenQ64681314
Linda GiudiceQ91869487
P2093author name stringCheryl A Conover
Lars Sottrup-Jensen
Inger M Olsen
Anni R Thomsen
Jesper Haaning
Rikke Søe
P2860cites workThe insulin-like growth factor (IGF)-dependent IGF binding protein-4 protease secreted by human fibroblasts is pregnancy-associated plasma protein-AQ22009032
Expression of recombinant human pregnancy-associated plasma protein-A and identification of the proform of eosinophil major basic protein as its physiological inhibitorQ22254673
Pregnancy-associated plasma protein-A2 (PAPP-A2), a novel insulin-like growth factor-binding protein-5 proteinaseQ24290962
Analysis of mutation in human cells by using an Epstein-Barr virus shuttle systemQ24628961
The metzincins — Topological and sequential relations between the astacins, adamalysins, serralysins, and matrixins (collagenases) define a super family of zinc‐peptidasesQ24675153
Site-directed mutagenesis by overlap extension using the polymerase chain reactionQ27860503
Amino acid sequence of human pregnancy-associated plasma protein-A derived from cloned cDNAQ28115174
The insulin-like growth factor-binding protein (IGFBP) superfamilyQ28140850
Messenger ribonucleic acid levels of pregnancy-associated plasma protein-A and the proform of eosinophil major basic protein: expression in human reproductive and nonreproductive tissuesQ28144716
Identification of angiotensinogen and complement C3dg as novel proteins binding the proform of eosinophil major basic protein in human pregnancy serum and plasmaQ28287991
Comparative mapping of 50 human chromosome 9 loci in the laboratory mouseQ28302750
Pregnancy-associated plasma protein-A (PAPP-A) cleaves insulin-like growth factor binding protein (IGFBP)-5 independent of IGF: implications for the mechanism of IGFBP-4 proteolysis by PAPP-AQ28616725
Production of high-titer helper-free retroviruses by transient transfectionQ29547802
Characterization of Insulin-Like Growth Factor Binding Proteins (IGFBPs) during Gestation in Mice: Effects of Hypophysectomy and an IGFBP-Specific Serum Protease Activity*Q30826665
Predicting internal exons by oligonucleotide composition and discriminant analysis of spliceable open reading framesQ35873486
Proteolytic cleavage of insulin-like growth factor binding protein 4 (IGFBP-4). Localization of cleavage site to non-homologous region of native IGFBP-4.Q38295427
Insulin-like growth factors I and II. Peptide, messenger ribonucleic acid and gene structures, serum, and tissue concentrationsQ38667678
Structural features of a superfamily of zinc-endopeptidases: the metzincinsQ40428339
Studies on the role of human insulin-like growth factor-II (IGF-II)-dependent IGF binding protein (hIGFBP)-4 protease in human osteoblasts using protease-resistant IGFBP-4 analogsQ40908680
Heparin-binding, highly basic regions within the thyroglobulin type-1 repeat of insulin-like growth factor (IGF)-binding proteins (IGFBPs) -3, -5, and -6 inhibit IGFBP-4 degradationQ42800345
Insulin-like growth factor (IGF)-binding protein-3 (IGFBP-3) functions as an IGF-reversible inhibitor of IGFBP-4 proteolysisQ42820555
Pregnancy-associated plasma protein A as a marker of acute coronary syndromesQ43756514
Insulin-Like Growth Factor Binding Proteins in Maternal Serum Throughout Gestation and in the Puerperium: Effects of a Pregnancy-Associated Serum Protease Activity*Q46189339
Insulinlike growth factor-binding protein proteolysis an emerging paradigm in insulinlike growth factor physiology.Q53484761
P433issue8
P407language of work or nameEnglishQ1860
P921main subjectproteolysisQ33123
Pregnancy-associated plasma protein AQ14913990
P304page(s)2247-2256
P577publication date2002-04-01
P1433published inFEBS JournalQ1388041
P1476titleExpression of recombinant murine pregnancy-associated plasma protein-A (PAPP-A) and a novel variant (PAPP-Ai) with differential proteolytic activity
P478volume269

Reverse relations

cites work (P2860)
Q34036198Altered placental expression of PAPPA2 does not affect birth weight in mice
Q33572235Indirect targeting of IGF receptor signaling in vivo by substrate-selective inhibition of PAPP-A proteolytic activity
Q33330587Inhibition of the proteolytic activity of pregnancy-associated plasma protein-A by targeting substrate exosite binding
Q52728979Insulin- like Growth Factor-Binding Protein Action in Bone Tissue: A Key Role for Pregnancy- Associated Plasma Protein-A.
Q36417183Insulin-like growth factor-binding protein-5 (IGFBP-5): a critical member of the IGF axis
Q35947007Key questions and answers about pregnancy-associated plasma protein-A.
Q33868844Lack of functional pregnancy-associated plasma protein-A (PAPPA) compromises mouse ovarian steroidogenesis and female fertility
Q36953356Molecular interactions in the insulin-like growth factor (IGF) axis: a surface plasmon resonance (SPR) based biosensor study
Q37678178PAPP-A: a promising therapeutic target for healthy longevity.
Q37832610Placental regulation of peptide hormone and growth factor activity by proMBP.
Q36742290Pregnancy-associated plasma protein A (PAPP-A) modulates the early developmental rate in zebrafish independently of its proteolytic activity
Q35055523Stanniocalcin-2 inhibits mammalian growth by proteolytic inhibition of the insulin-like growth factor axis
Q35690633The role of PAPP-A in the IGF system: location, location, location.
Q34092815Transgenic overexpression of pregnancy-associated plasma protein-A in murine arterial smooth muscle accelerates atherosclerotic lesion development

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