| scholarly article | Q13442814 |
| P50 | author | Claus Oxvig | Q56430506 |
| P2093 | author name string | Claus Oxvig | |
| P2860 | cites work | A growth-deficiency phenotype in heterozygous mice carrying an insulin-like growth factor II gene disrupted by targeting. | Q52241373 |
| Targeted disruption of the pregnancy-associated plasma protein-A gene is associated with diminished smooth muscle cell response to insulin-like growth factor-I and resistance to neointimal hyperplasia after vascular injury. | Q52573422 | ||
| A perfusion study of the effect of stanniectomy on the net influx of calcium 45 across an isolated eel gill | Q54206408 | ||
| Involvement of pregnancy-associated plasma protein-A2 in insulin-like growth factor (IGF) binding protein-5 proteolysis during pregnancy: a potential mechanism for increasing IGF bioavailability. | Q54696377 | ||
| Molecular characterization of pregnancy-associated plasma protein-A by electrophoresis | Q67655837 | ||
| A sensitive enzyme immunoassay for pregnancy-associated plasma protein A (PAPP-A): a possible first trimester method of screening for Down syndrome and other trisomies | Q71598362 | ||
| Isolation and characterization of circulating complex between human pregnancy-associated plasma protein-A and proform of eosinophil major basic protein | Q71664937 | ||
| Evidence that the insulin-like growth factor binding protein-4 protease in human ovarian follicular fluid is pregnancy associated plasma protein-A | Q73276486 | ||
| Insulin-like growth factor binding protein-4 protease produced by smooth muscle cells increases in the coronary artery after angioplasty | Q73570841 | ||
| Pregnancy-associated plasma protein-a is the insulin-like growth factor binding protein-4 protease secreted by human ovarian granulosa cells and is a marker of dominant follicle selection and the corpus luteum | Q73794006 | ||
| Double-monoclonal immunofluorometric assays for pregnancy-associated plasma protein A/proeosinophil major basic protein (PAPP-A/proMBP) complex in first-trimester maternal serum screening for Down syndrome | Q74078655 | ||
| Pregnancy-associated plasma protein-A is involved in insulin-like growth factor binding protein-2 (IGFBP-2) proteolytic degradation in bovine and porcine preovulatory follicles: identification of cleavage site and characterization of IGFBP-2 degrada | Q78694188 | ||
| Characterization of the common fragile site FRA9E and its potential role in ovarian cancer | Q78851113 | ||
| Cell surface detachment of pregnancy-associated plasma protein-A requires the formation of intermolecular proteinase-inhibitor disulfide bonds and glycosaminoglycan covalently bound to the inhibitor | Q79404961 | ||
| Quantification of proteolytically active pregnancy-associated plasma protein-A with an assay based on quenched fluorescence | Q79960898 | ||
| Genetic deletion of pregnancy-associated plasma protein-A is associated with resistance to atherosclerotic lesion development in apolipoprotein E-deficient mice challenged with a high-fat diet | Q80352362 | ||
| Loss of pregnancy-associated plasma protein A extends lifespan in mice | Q80753534 | ||
| Tumor dormancy: elevated expression of stanniocalcins in late relapsing breast cancer | Q80923776 | ||
| The insulin-like growth factor (IGF)-dependent IGF binding protein-4 protease secreted by human fibroblasts is pregnancy-associated plasma protein-A | Q22009032 | ||
| Expression of recombinant human pregnancy-associated plasma protein-A and identification of the proform of eosinophil major basic protein as its physiological inhibitor | Q22254673 | ||
| Pregnancy-associated plasma protein-A2 (PAPP-A2), a novel insulin-like growth factor-binding protein-5 proteinase | Q24290962 | ||
| Amino acid sequence of human pregnancy-associated plasma protein-A derived from cloned cDNA | Q28115174 | ||
| Mutational analysis of the proteolytic domain of pregnancy-associated plasma protein-A (PAPP-A): classification as a metzincin | Q28119163 | ||
| Messenger ribonucleic acid levels of pregnancy-associated plasma protein-A and the proform of eosinophil major basic protein: expression in human reproductive and nonreproductive tissues | Q28144716 | ||
| Mammalian stanniocalcins and cancer | Q28204297 | ||
| Bikunin target genes in ovarian cancer cells identified by microarray analysis | Q28207799 | ||
| Complex of pregnancy-associated plasma protein-A and the proform of eosinophil major basic protein. Disulfide structure and carbohydrate attachment | Q28214228 | ||
| Cellular actions of the insulin-like growth factor binding proteins | Q28216659 | ||
| IGF binding proteins in cancer: mechanistic and clinical insights | Q28237971 | ||
| Location and nature of carbohydrate groups in proform of human major basic protein isolated from pregnancy serum | Q28286985 | ||
| Localization of pregnancy-associated plasma protein-A and colocalization of pregnancy-associated plasma protein-A messenger ribonucleic acid and eosinophil granule major basic protein messenger ribonucleic acid in placenta | Q28287076 | ||
| Circulating human pregnancy-associated plasma protein-A is disulfide-bridged to the proform of eosinophil major basic protein | Q28298024 | ||
| The murine stanniocalcin 2 gene is a negative regulator of postnatal growth | Q28505295 | ||
| Diminished growth and enhanced glucose metabolism in triple knockout mice containing mutations of insulin-like growth factor binding protein-3, -4, and -5 | Q28506469 | ||
| Expression of recombinant murine pregnancy-associated plasma protein-A (PAPP-A) and a novel variant (PAPP-Ai) with differential proteolytic activity | Q28510464 | ||
| Pregnancy-associated plasma protein-A (PAPP-A) cleaves insulin-like growth factor binding protein (IGFBP)-5 independent of IGF: implications for the mechanism of IGFBP-4 proteolysis by PAPP-A | Q28616725 | ||
| Structure and function of matrix metalloproteinases and TIMPs | Q30014818 | ||
| Insulin-like growth factor binding proteins: a structural perspective | Q30417447 | ||
| Definition, expression, and characterization of a protein domain in the N-terminus of pregnancy-associated plasma protein-A distantly related to the family of laminin G-like modules | Q30810642 | ||
| Molecular analysis of ulilysin, the structural prototype of a new family of metzincin metalloproteases | Q33240511 | ||
| Inhibition of the proteolytic activity of pregnancy-associated plasma protein-A by targeting substrate exosite binding | Q33330587 | ||
| Indirect targeting of IGF receptor signaling in vivo by substrate-selective inhibition of PAPP-A proteolytic activity | Q33572235 | ||
| Whole-genome reconstruction and mutational signatures in gastric cancer. | Q33751188 | ||
| The GH/IGF-1 axis in ageing and longevity | Q33817029 | ||
| Expression of haptoglobin-related protein and its potential role as a tumor antigen | Q33837149 | ||
| Longevity and age-related pathology of mice deficient in pregnancy-associated plasma protein-A. | Q33849416 | ||
| Lack of functional pregnancy-associated plasma protein-A (PAPPA) compromises mouse ovarian steroidogenesis and female fertility | Q33868844 | ||
| Skp2B overexpression alters a prohibitin-p53 axis and the transcription of PAPP-A, the protease of insulin-like growth factor binding protein 4 | Q33988397 | ||
| Pregnancy-associated plasma protein-A increases osteoblast proliferation in vitro and bone formation in vivo | Q33996924 | ||
| BRCA1 transcriptionally regulates genes involved in breast tumorigenesis | Q34064538 | ||
| Purification, characterization, and bioassay of teleocalcin, a glycoprotein from salmon corpuscles of Stannius | Q34183704 | ||
| Evolution and roles of stanniocalcin | Q34235837 | ||
| Human stanniocalcin-2 exhibits potent growth-suppressive properties in transgenic mice independently of growth hormone and IGFs | Q34348245 | ||
| Measurement of pregnancy-associated plasma proteins during human gestation | Q34466219 | ||
| Protein secretion is required for pregnancy-associated plasma protein-A to promote lung cancer growth in vivo | Q34477488 | ||
| The stanniocalcin family of proteins | Q34556479 | ||
| Stanniocalcin1 (STC1) Inhibits Cell Proliferation and Invasion of Cervical Cancer Cells | Q34575305 | ||
| Pregnancy-associated plasma protein-A expression in human breast cancer | Q35019711 | ||
| Stanniocalcin-2 inhibits mammalian growth by proteolytic inhibition of the insulin-like growth factor axis | Q35055523 | ||
| Insulin-like growth factor binding protein proteolysis | Q35114599 | ||
| First trimester concentrations of pregnancy associated plasma protein A and placental protein 14 in Down's syndrome | Q35822399 | ||
| Pregnancy-associated plasma protein A. A clinically significant predictor of early recurrence in stage I breast carcinoma is independent of estrogen receptor status | Q35835472 | ||
| Key questions and answers about pregnancy-associated plasma protein-A. | Q35947007 | ||
| Liver-derived insulin-like growth factor I (IGF-I) is the principal source of IGF-I in blood but is not required for postnatal body growth in mice | Q36392687 | ||
| Normal growth and development in the absence of hepatic insulin-like growth factor I | Q36394699 | ||
| The role of the IGF system in cancer growth and metastasis: overview and recent insights | Q36576678 | ||
| Insulin-like growth factor (IGF) binding protein-4 is both a positive and negative regulator of IGF activity in vivo | Q36629279 | ||
| Pregnancy-associated plasma protein A (PAPP-A) modulates the early developmental rate in zebrafish independently of its proteolytic activity | Q36742290 | ||
| Insulin-like growth factor receptor inhibitors: baby or the bathwater? | Q36790586 | ||
| Identification of pregnancy-associated plasma protein A as a migration-promoting gene in malignant pleural mesothelioma cells: a potential therapeutic target | Q37207654 | ||
| Resistance to age-dependent thymic atrophy in long-lived mice that are deficient in pregnancy-associated plasma protein A. | Q37237012 | ||
| Pregnancy-associated plasma protein-A (PAPP-A) and cardiovascular risk | Q37267887 | ||
| Mice deficient in PAPP-A show resistance to the development of diabetic nephropathy | Q37286585 | ||
| Expression of a protease-resistant insulin-like growth factor-binding protein-4 inhibits tumour growth in a murine model of breast cancer | Q37287447 | ||
| Preferential impact of pregnancy-associated plasma protein-A deficiency on visceral fat in mice on high-fat diet | Q37341957 | ||
| Inducible reduction in pregnancy-associated plasma protein-A gene expression inhibits established atherosclerotic plaque progression in mice | Q37648054 | ||
| Biology of pregnancy-associated plasma protein-A in relation to prenatal diagnostics: an overview. | Q37784027 | ||
| Targeting the insulin-like growth factor network in cancer therapy | Q37839580 | ||
| The insulin and insulin-like growth factor receptor family in neoplasia: an update | Q37984217 | ||
| PAPP-A in cardiac and non-cardiac conditions | Q38069408 | ||
| Architecture and function of metallopeptidase catalytic domains | Q38193464 | ||
| Genetic downregulation of pregnancy-associated plasma protein-A (PAPP-A) by bikunin reduces IGF-I-dependent Akt and ERK1/2 activation and subsequently reduces ovarian cancer cell growth, invasion and metastasis | Q38344803 | ||
| Differential regulation of pregnancy associated plasma protein-A in human coronary artery endothelial cells and smooth muscle cells | Q38624847 | ||
| Pregnancy-associated plasma protein A regulates mitosis and is epigenetically silenced in breast cancer | Q38984536 | ||
| miRNA-214 is related to invasiveness of human non-small cell lung cancer and directly regulates alpha protein kinase 2 expression | Q39113137 | ||
| Overexpression of pregnancy-associated plasma protein-A in ovarian cancer cells promotes tumor growth in vivo | Q39595849 | ||
| Transgenic overexpression of pregnancy-associated plasma protein-A increases the somatic growth and skeletal muscle mass in mice. | Q40075011 | ||
| A substrate specificity-determining unit of three Lin12-Notch repeat modules is formed in trans within the pappalysin-1 dimer and requires a sequence stretch C-terminal to the third module | Q40168513 | ||
| Regulation of insulin-like growth factor (IGF) bioactivity by sequential proteolytic cleavage of IGF binding protein-4 and -5. | Q40168727 | ||
| Proteinase inhibition by proform of eosinophil major basic protein (pro-MBP) is a multistep process of intra- and intermolecular disulfide rearrangements. | Q40472377 | ||
| The Lin12-notch repeats of pregnancy-associated plasma protein-A bind calcium and determine its proteolytic specificity | Q40533687 | ||
| Pregnancy-associated plasma protein-A (PAPP-A) expression and insulin-like growth factor binding protein-4 protease activity in normal and malignant ovarian surface epithelial cells. | Q40555419 | ||
| Cell surface adhesion of pregnancy-associated plasma protein-A is mediated by four clusters of basic residues located in its third and fourth CCP module | Q40569861 | ||
| Inhibition of proteolysis by the proform of eosinophil major basic protein (proMBP) requires covalent binding to its target proteinase | Q40585039 | ||
| Cell surface targeting of pregnancy-associated plasma protein A proteolytic activity. Reversible adhesion is mediated by two neighboring short consensus repeats. | Q40699143 | ||
| Substrate specificity of the metalloproteinase pregnancy-associated plasma protein-A (PAPP-A) assessed by mutagenesis and analysis of synthetic peptides: substrate residues distant from the scissile bond are critical for proteolysis | Q40702779 | ||
| Evidence that the interaction between insulin-like growth factor (IGF)-II and IGF binding protein (IGFBP)-4 is essential for the action of the IGF-II-dependent IGFBP-4 protease | Q41748050 | ||
| Pregnancy-associated plasma protein A associates with cardiovascular events in diabetic hemodialysis patients | Q42202543 | ||
| Cytokine stimulation of pregnancy-associated plasma protein A expression in human coronary artery smooth muscle cells: inhibition by resveratrol. | Q42487658 | ||
| Identification and characterization of renal cell carcinoma gene markers. | Q43137048 | ||
| Systemic administration of insulin-like growth factor (IGF)-binding protein-4 (IGFBP-4) increases bone formation parameters in mice by increasing IGF bioavailability via an IGFBP-4 protease-dependent mechanism | Q43610678 | ||
| Antiserum to pregnancy-associated plasma protein A (PAPP-A) recognizes human haptoglobin | Q43655776 | ||
| Pregnancy-associated plasma protein A as a marker of acute coronary syndromes | Q43756514 | ||
| Identification and regulation of the IGFBP-4 protease and its physiological inhibitor in human trophoblasts and endometrial stroma: evidence for paracrine regulation of IGF-II bioavailability in the placental bed during human implantation. | Q43982505 | ||
| Transforming growth factor-beta regulation of the insulin-like growth factor binding protein-4 protease system in cultured human osteoblasts | Q44484952 | ||
| Regulation of pregnancy-associated plasma protein-A expression in cultured human osteoblasts | Q44764098 | ||
| IGF dependent modulation of IGF binding protein (IGFBP) proteolysis by pregnancy-associated plasma protein-A (PAPP-A): multiple PAPP-A-IGFBP interaction sites. | Q45358184 | ||
| Papp-a2 modulates development of cranial cartilage and angiogenesis in zebrafish embryos | Q47073155 | ||
| Early-pregnancy origins of low birth weight | Q47182924 | ||
| Pregnancy-associated plasma protein a gene expression as a target of inflammatory cytokines. | Q47340920 | ||
| Localization and regulation of pregnancy-associated plasma protein a expression in healing human skin. | Q47630415 | ||
| Regulation and processing of a precursor form of eosinophil granule major basic protein (ProMBP) in differentiating eosinophils | Q47869673 | ||
| Relationship between pregnancy-associated plasma protein-A and lung cancer | Q48011420 | ||
| Quantitative analysis of insulin-like growth factor-modulated proteolysis of insulin-like growth factor binding protein-4 and -5 by pregnancy-associated plasma protein-A. | Q50336373 | ||
| Metalloproteinase pregnancy-associated plasma protein A is a critical growth regulatory factor during fetal development. | Q51028952 | ||
| Disruption of insulin-like growth factor-II imprinting during embryonic development rescues the dwarf phenotype of mice null for pregnancy-associated plasma protein-A. | Q52042509 | ||
| P433 | issue | 2 | |
| P1104 | number of pages | 11 | |
| P304 | page(s) | 177-187 | |
| P577 | publication date | 2015-01-25 | |
| P1433 | published in | Journal of Cell Communication and Signaling | Q26841964 |
| P1476 | title | The role of PAPP-A in the IGF system: location, location, location | |
| P478 | volume | 9 |
| Q90100849 | A common variant of the pregnancy-associated plasma protein-A (PAPPA) gene encodes a protein with reduced proteolytic activity towards IGF-binding proteins |
| Q98463541 | Aberrant pregnancy-associated plasma protein-A expression in breast cancers prognosticates clinical outcomes |
| Q40282656 | Early Pregnancy-Associated Plasma Protein A Concentrations Are Associated With Third Trimester Insulin Sensitivity |
| Q92407078 | Epigenetics meets proteomics in an epigenome-wide association study with circulating blood plasma protein traits |
| Q48108034 | First trimester PAPP-A2, PAPP-A and hCGβ in small-for-gestational-age pregnancies. |
| Q47546157 | First-Trimester Inflammatory Markers for Risk Evaluation of Pregnancy Hypertension. |
| Q49444774 | Hallmarks of Human Small Antral Follicle Development: Implications for Regulation of Ovarian Steroidogenesis and Selection of the Dominant Follicle |
| Q55259134 | IGF-Binding Proteins: Why Do They Exist and Why Are There So Many? |
| Q55430419 | Increased Concentrations of Insulin-Like Growth Factor Binding Protein (IGFBP)-2, IGFBP-3, and IGFBP-4 Are Associated With Fetal Mortality in Pregnant Cows. |
| Q40988757 | Inducible knockdown of pregnancy-associated plasma protein-A gene expression in adult female mice extends life span |
| Q90479283 | Insulin-Like Growth Factor Binding Protein-5 in Physiology and Disease |
| Q36759471 | Lactation opposes pappalysin-1-driven pregnancy-associated breast cancer. |
| Q54238174 | Leptospira interrogans Secreted Proteases Degrade Extracellular Matrix and Plasma Proteins From the Host. |
| Q92994179 | Metalloproteinase PAPP-A regulation of IGF-1 contributes to polycystic kidney disease pathogenesis |
| Q36759492 | Mutations in pregnancy-associated plasma protein A2 cause short stature due to low IGF-I availability |
| Q53764548 | Myocardial and Peripheral Ischemia Causes an Increase in Circulating Pregnancy-Associated Plasma Protein-A in Non-atherosclerotic, Non-heparinized Pigs. |
| Q89469001 | Netazepide Inhibits Expression of Pappalysin 2 in Type 1 Gastric Neuroendocrine Tumors |
| Q91846314 | Nonclassical GH Insensitivity: Characterization of Mild Abnormalities of GH Action |
| Q47252219 | Novel Modulators of the Growth Hormone - Insulin-Like Growth Factor Axis: Pregnancy-Associated Plasma Protein-A2 and Stanniocalcin-2. |
| Q42288349 | One level up: abnormal proteolytic regulation of IGF activity plays a role in human pathophysiology |
| Q90093908 | PAPP-A and the IGF system in atherosclerosis: what's up, what's down? |
| Q36544836 | PAPP-A proteolytic activity enhances IGF bioactivity in ascites from women with ovarian carcinoma |
| Q37678178 | PAPP-A: a promising therapeutic target for healthy longevity. |
| Q64070308 | Parity predisposes breasts to the oncogenic action of PAPP-A and activation of the collagen receptor DDR2 |
| Q47656807 | Pharmacokinetics of IGF-1 in PAPP-A2-Deficient Patients, Growth Response, and Effects on Glucose and Bone Density. |
| Q92394724 | Plausible Links Between Metabolic Networks, Stem Cells, and Longevity |
| Q92814047 | Pregnancy Associated Plasma Protein-A as a Cardiovascular Risk Marker in Patients with Stable Coronary Heart Disease During 10 Years Follow-Up-A CLARICOR Trial Sub-Study |
| Q90468746 | Pregnancy-Associated Plasma Protein A Induces Inflammatory Cytokine Expression by Activating IGF-I/PI3K/Akt Pathways |
| Q40056700 | Pregnancy-Associated Plasma Protein-A2 and Anthropometry, Lifestyle, and Biochemical Factors in a Human Adult Population |
| Q88608525 | Pregnancy-Associated Plasma Protein-aa Regulates Photoreceptor Synaptic Development to Mediate Visually Guided Behavior |
| Q47324073 | Pregnancy-associated plasma protein-A (PAPP-A) levels in patients with severe allergic asthma are reduced by omalizumab. |
| Q55418368 | Prognostic relevance and performance characteristics of serum IGFBP-2 and PAPP-A in women with breast cancer: a long-term Danish cohort study. |
| Q55014471 | Prognostic value of the Stanniocalcin-2/PAPP-A/IGFBP-4 axis in ST-segment elevation myocardial infarction. |
| Q90447988 | Role of stanniocalcin-1 in breast cancer |
| Q90166528 | Screening circulating proteins to identify biomarkers of fetal macrosomia |
| Q35701645 | Stanniocalcin-1 Potently Inhibits the Proteolytic Activity of the Metalloproteinase Pregnancy-associated Plasma Protein-A. |
| Q50895246 | Targeted Inhibition of Pregnancy-Associated Plasma Protein-A Activity Reduces Atherosclerotic Plaque Burden in Mice. |
| Q64887461 | The IGF system in patients with inflammatory bowel disease treated with prednisolone or infliximab: potential role of the stanniocalcin-2 / PAPP-A / IGFBP-4 axis. |
| Q90539086 | The insulin-like growth factor-1 system in the adult mammalian brain and its implications in central maternal adaptation |
| Q91951608 | The metalloproteinase Papp-aa controls epithelial cell quiescence-proliferation transition |
| Q91997571 | The potential role of pregnancy-associated plasma protein-A2 in angiogenesis and development of preeclampsia |
| Q38908472 | The proteolytic activity of pregnancy-associated plasma protein-A is potentially regulated by stanniocalcin-1 and -2 during human ovarian follicle development |
| Q92405753 | Transcription profile of the insulin-like growth factor signaling pathway during human ovarian follicular development |
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