Substrate specificity of the metalloproteinase pregnancy-associated plasma protein-A (PAPP-A) assessed by mutagenesis and analysis of synthetic peptides: substrate residues distant from the scissile bond are critical for proteolysis

scientific article published on October 2002

Substrate specificity of the metalloproteinase pregnancy-associated plasma protein-A (PAPP-A) assessed by mutagenesis and analysis of synthetic peptides: substrate residues distant from the scissile bond are critical for proteolysis is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1042/BJ20020831
P932PMC publication ID1222882
P698PubMed publication ID12241545
P5875ResearchGate publication ID11148595

P50authorLisbeth S LaursenQ64681314
Linda GiudiceQ91869487
Kathrin H HopmannQ38320547
Michael Toft OvergaardQ47805032
P2093author name stringCheryl A Conover
Claus Oxvig
Henning B Boldt
Lars Sottrup-Jensen
Claus G Nielsen
P2860cites workMetal Substitutions and Inhibition of Thermolysin: Spectra of the Cobalt EnzymeQ47851666
Pregnancy-Associated Plasma Protein-A (PAPP-A) in Ovine, Bovine, Porcine, and Equine Ovarian Follicles: Involvement in IGF Binding Protein-4 Proteolytic Degradation and mRNA Expression During Follicular DevelopmentQ58610890
Analysis of serum insulin-like growth factor binding proteins using western blotting: use of the method for titration of the binding proteins and competitive binding studiesQ68962393
Determination of halfcystine in proteins as cysteine from reducing hydrolyzatesQ70484549
Analysis of elements in the substrate required for processing by mitochondrial processing peptidaseQ70808758
19 AstacinQ72059218
A low-pH reverse-phase high-performance liquid chromatography system for analysis of the phenylthiohydantoins of S-carboxymethylcysteine and S-carboxyamidomethylcysteineQ72307018
Structural requirement for recognition of the precursor proteins by the mitochondrial processing peptidaseQ72724059
Arginine residues in the extension peptide are required for cleavage of a precursor by mitochondrial processing peptidase. Demonstration using synthetic peptide as a substrateQ72724076
Electrostatic recognition of matrix targeting signal by mitochondrial processing peptidaseQ73338261
Insulin-like growth factor binding protein-4 protease produced by smooth muscle cells increases in the coronary artery after angioplastyQ73570841
Pregnancy-associated plasma protein-a is the insulin-like growth factor binding protein-4 protease secreted by human ovarian granulosa cells and is a marker of dominant follicle selection and the corpus luteumQ73794006
Partial IGF affinity of circulating N- and C-terminal fragments of human insulin-like growth factor binding protein-4 (IGFBP-4) and the disulfide bonding pattern of the C-terminal IGFBP-4 domainQ73811571
A protease-resistant form of insulin-like growth factor (IGF) binding protein 4 inhibits IGF-1 actionsQ77342918
Insulin-like growth factor binding protein-4 proteolytic degradation in ovine preovulatory follicles: studies of underlying mechanismsQ78180942
The insulin-like growth factor (IGF)-dependent IGF binding protein-4 protease secreted by human fibroblasts is pregnancy-associated plasma protein-AQ22009032
Expression of recombinant human pregnancy-associated plasma protein-A and identification of the proform of eosinophil major basic protein as its physiological inhibitorQ22254673
Pregnancy-associated plasma protein-A2 (PAPP-A2), a novel insulin-like growth factor-binding protein-5 proteinaseQ24290962
The metzincins — Topological and sequential relations between the astacins, adamalysins, serralysins, and matrixins (collagenases) define a super family of zinc‐peptidasesQ24675153
Site-directed mutagenesis by overlap extension using the polymerase chain reactionQ27860503
Amino acid sequence of human pregnancy-associated plasma protein-A derived from cloned cDNAQ28115174
Mutational analysis of the proteolytic domain of pregnancy-associated plasma protein-A (PAPP-A): classification as a metzincinQ28119163
Inflammation dampened by gelatinase A cleavage of monocyte chemoattractant protein-3Q28144040
Messenger ribonucleic acid levels of pregnancy-associated plasma protein-A and the proform of eosinophil major basic protein: expression in human reproductive and nonreproductive tissuesQ28144716
A helping hand for collagenases: the haemopexin-like domainQ28275184
Localization of pregnancy-associated plasma protein-A and colocalization of pregnancy-associated plasma protein-A messenger ribonucleic acid and eosinophil granule major basic protein messenger ribonucleic acid in placentaQ28287076
Identification of angiotensinogen and complement C3dg as novel proteins binding the proform of eosinophil major basic protein in human pregnancy serum and plasmaQ28287991
Circulating human pregnancy-associated plasma protein-A is disulfide-bridged to the proform of eosinophil major basic proteinQ28298024
Insulin-like growth factors and their binding proteins: biological actionsQ28301853
Pregnancy-associated plasma protein-A (PAPP-A) cleaves insulin-like growth factor binding protein (IGFBP)-5 independent of IGF: implications for the mechanism of IGFBP-4 proteolysis by PAPP-AQ28616725
Determination of protease cleavage site motifs using mixture-based oriented peptide librariesQ30702360
A proposed common structure of substrates bound to mitochondrial processing peptidaseQ31458732
Mitochondrial processing peptidase: multiple-site recognition of precursor proteinsQ33796118
Homologues of insulinase, a new superfamily of metalloendopeptidasesQ34104644
Families of zinc metalloproteases.Q34325403
Protease-resistant form of insulin-like growth factor-binding protein 5 is an inhibitor of insulin-like growth factor-I actions on porcine smooth muscle cells in culture.Q37375061
Proteolytic cleavage of insulin-like growth factor binding protein 4 (IGFBP-4). Localization of cleavage site to non-homologous region of native IGFBP-4.Q38295427
Cleavage analysis of insulin-like growth factor (IGF)-dependent IGF-binding protein-4 proteolysis and expression of protease-resistant IGF-binding protein-4 mutantsQ38297936
THE PREPARATION OF I-131-LABELLED HUMAN GROWTH HORMONE OF HIGH SPECIFIC RADIOACTIVITYQ39512876
Biochemical properties, activities, and presence in biologic fluids of eosinophil granule major basic proteinQ40554902
Matrix metalloproteinase activity inactivates the CXC chemokine stromal cell-derived factor-1.Q40778640
Studies on the role of human insulin-like growth factor-II (IGF-II)-dependent IGF binding protein (hIGFBP)-4 protease in human osteoblasts using protease-resistant IGFBP-4 analogsQ40908680
Studies on human pregnancy-induced insulin-like growth factor (IGF)-binding protein-4 proteases in serum: determination of IGF-II dependency and localization of cleavage siteQ41714026
Evidence that the interaction between insulin-like growth factor (IGF)-II and IGF binding protein (IGFBP)-4 is essential for the action of the IGF-II-dependent IGFBP-4 proteaseQ41748050
Structural analysis of zinc substitutions in the active site of thermolysinQ41837299
Heparin-binding, highly basic regions within the thyroglobulin type-1 repeat of insulin-like growth factor (IGF)-binding proteins (IGFBPs) -3, -5, and -6 inhibit IGFBP-4 degradationQ42800345
Insulin-like growth factor (IGF)-binding protein-3 (IGFBP-3) functions as an IGF-reversible inhibitor of IGFBP-4 proteolysisQ42820555
Glu(191) and Asp(195) in rat mitochondrial processing peptidase beta subunit are involved in effective cleavage of precursor protein through interaction with the proximal arginineQ43742551
Pregnancy-associated plasma protein A as a marker of acute coronary syndromesQ43756514
P433issuePt 1
P407language of work or nameEnglishQ1860
P921main subjectproteolysisQ33123
P304page(s)31-40
P577publication date2002-10-01
P1433published inBiochemical JournalQ864221
P1476titleSubstrate specificity of the metalloproteinase pregnancy-associated plasma protein-A (PAPP-A) assessed by mutagenesis and analysis of synthetic peptides: substrate residues distant from the scissile bond are critical for proteolysis
P478volume367

Reverse relations

cites work (P2860)
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Q79125164Circulating Pregnancy-Associated Plasma Protein A Predicts Outcome in Patients With Acute Coronary Syndrome but No Troponin I Elevation
Q30378223Classification of signaling proteins based on molecular star graph descriptors using Machine Learning models.
Q28214228Complex of pregnancy-associated plasma protein-A and the proform of eosinophil major basic protein. Disulfide structure and carbohydrate attachment
Q42487658Cytokine stimulation of pregnancy-associated plasma protein A expression in human coronary artery smooth muscle cells: inhibition by resveratrol.
Q64360871Differential Functions of Two Metalloproteases, and , in Growth, Sporulation, Cell Wall Integrity, and Virulence in the Filamentous Fungus
Q33285291Discovery and characterization of human antibody inhibitors of pregnancy-associated plasma protein-A.
Q30371857Duplication and diversification of the hypoxia-inducible IGFBP-1 gene in zebrafish
Q33815529In vivo analysis of gene expression in long-lived mice lacking the pregnancy-associated plasma protein A (PappA) gene
Q40585039Inhibition of proteolysis by the proform of eosinophil major basic protein (proMBP) requires covalent binding to its target proteinase
Q52728979Insulin- like Growth Factor-Binding Protein Action in Bone Tissue: A Key Role for Pregnancy- Associated Plasma Protein-A.
Q28484592Integrated analysis of gene expression profiles associated with response of platinum/paclitaxel-based treatment in epithelial ovarian cancer
Q35947007Key questions and answers about pregnancy-associated plasma protein-A.
Q33868844Lack of functional pregnancy-associated plasma protein-A (PAPPA) compromises mouse ovarian steroidogenesis and female fertility
Q50296764PAAP-A proteolyzes IGF:IGFBP4
Q42040539Pappalysin-1 T cell receptor transgenic allo-restricted T cells kill Ewing sarcoma in vitro and in vivo.
Q59051182Pregnancy-Associated Plasma Protein-A Levels and Coronary Angiographic Features in Acute Coronary Syndrome Patients
Q36742290Pregnancy-associated plasma protein A (PAPP-A) modulates the early developmental rate in zebrafish independently of its proteolytic activity
Q37739378Pregnancy-associated plasma protein-A is a stronger predictor for adverse cardiovascular outcomes after acute coronary syndrome in type-2 diabetes mellitus
Q36624223Present and future biochemical markers for detection of acute coronary syndrome
Q55014471Prognostic value of the Stanniocalcin-2/PAPP-A/IGFBP-4 axis in ST-segment elevation myocardial infarction.
Q57801325Recombinant PAPP-A resistant insulin-like growth factor binding protein 4 (dBP4) inhibits angiogenesis and metastasis in a murine model of breast cancer
Q35055523Stanniocalcin-2 inhibits mammalian growth by proteolytic inhibition of the insulin-like growth factor axis
Q92716423Structure-based mechanism of cysteine-switch latency and of catalysis by pappalysin-family metallopeptidases
Q35690633The role of PAPP-A in the IGF system: location, location, location.

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